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All Journal Jurnal Analis Farmasi Syntax Idea JAF (Jurnal Analis Farmasi) Proceeding of International Conference Health, Science And Technology (ICOHETECH) International Journal of Health, Engineering and Technology JURNAL FARMASI DAN KESEHATAN INDONESIA Jurnal Medika Nusantara Parapemikir Jurnal Ilmiah Farmasi Jurnal Riset Ilmu Kesehatan Umum dan Farmasi
Tatiana Siska Wardani
Universitas Duta Bangsa Surakarta
Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Mechanical Engineering Medicine & Pharmacology Nursing Physics Public Health Veterinary

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Antibacterial Activity Test Of Extracts And Fractionsn-Hexane, Ethyl Acetate, And Pineapple Peel Water (Ananas Comosus(L.) Merr.) Against Bacteria Propionibacterium Acnes ATCC 6919 Dian Fatimatus Salwa; Tatiana Siska Wardani; Bangkit Riska Permata
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.655

Abstract

Acne vulgaris is a common dermatological problem in adolescents in Indonesia's tropical climate related to the activity of Propionibacterium acnes bacteria. Long-term use of antibiotics risks causing resistance, so natural antibacterial alternatives are needed. This study aims to evaluate the antibacterial activity of ethanol extract and fractions of n-Hexane, ethyl acetate, and pineapple peel water against Propionibacterium acnes ATCC 6919, and to determine the most active fraction and MIC and MBC values. This study is a quantitative experimental study. The study population was the bacterial culture of P. acnes ATCC 6919, with samples in the form of pineapple peel extract and fraction. The research instruments included disc diffusion and liquid and solid dilution methods, while data analysis used the Shapiro-Wilk, Levene, and Kruskal-Wallis tests. The results showed that the ethanol extract had moderate to strong antibacterial activity, the ethyl acetate fraction showed the highest activity compared to other fractions, while the n-hexane fraction showed no activity. MIC and MBC values ​​were obtained at a concentration of 20 percent. The conclusion of this study is that pineapple peel has the potential as a natural antibacterial source against P. acnes and the ethyl acetate fraction is the most active fraction.
Antibacterial Activity Test Of Ethanol Extract And N-Hexane Fraction, Ethyl Acetate, Moringa Leaf Water (Moringa Oleifera L) Against Streptococcus Mutans ATCC 25175 Bacteria Wahdah Sri Rahayu; Tatiana Siska Wardani; Tiara Ajeng Listyani
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.662

Abstract

Dental caries remains a major oral health problem globally and in Indonesia, triggered by Streptococcus mutans biofilm. Chemical agents such as chlorhexidine have side effects, encouraging the use of natural alternatives from Moringa oleifera L. leaves. This study aims to evaluate the antibacterial activity of ethanol extracts and n-hexane, ethyl acetate, and water fractions against Streptococcus mutans ATCC 25175, identify the most active fraction, and determine the MIC and MBC. This quantitative study used diffusion and dilution methods. Bacteria: Streptococcus mutans ATCC 25175; samples: ethanol extract of Moringa oleifera L. leaves and n-Hexane, ethyl acetate, and water fractions. Data analysis used SPSS 25 One-Way ANOVA, Tukey (p<0.05). Results showed that the ethyl acetate fraction was the most active with 12.36 mm inhibition at 45%; MIC and MBC were 30% ANOVA significant (p=0.000). The ethyl acetate fraction has strong caries prevention potential, supporting herbal development.
Antibacterial Activity Test Of Extract And Fraction Of N-Hexane, Ethyl Acetate And Water Of Pineapple Peel (Ananas Comosus (L.) Merr.) Against Staphylococcus Epidermidis ATCC 12228 Bacteria Nadia Nurul Wachida; Tatiana Siska Wardani; Rahmat Hidayat
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.670

Abstract

Staphylococcus epidermidis is a bacteria that causes mild skin infections accompanied by abscesses, with a high  prevalence in Indonesia, requiring natural alternatives due to antibiotic resistance. This study aimed to evaluated antibacterial activity of 96% ethanol extract and n-hexane, ethyl acetate, water fractions of pineapple peel (Ananas comosus L. Merr.) against S. epidermidis ATCC 12228 and to determined MIC/MBC of the most active fraction. This quantitative and experimental study used the disk diffusion and liquid/solid dilution. methods. Population: pineapple peels from Blitar, East Java; sample: 700 g Simplicia powder. The nstruments included rotary evaporator, incubator, autoklaf, laminar air flow; data were analyzed using the Kruskal-Wallis (SPSS 25). Results showed that extract produced inhibition zones ranging from 5.63–11.43 mm, ethyl acetate fraction 3.80–7.55 mm, water 2.35–6.88 mm, n-hexane was inactive. The MIC and MBC values of the extract were 25%; ethyl acetate fraction MIC and MBC were 50%. Extract, ethyl acetate, and water fractions exhibited antibacterial activity aginst S. epidermidis, with extract being the most effective.
Formulation And Test Of Antioxidants And Effectiveness Of Toner Preparations From Pumpkin Fruit Extract (Cucurbita Moschata Duch) Using The Dpph (2,2 Diphenyl - 1-Picrylhydrazyl) Method Nora Pereira Pinto Nora Pereira Pinto; Tatiana Siska Wardani; Bangkit Riska Pertama
International Journal of Health Engineering and Technology Vol. 5 No. 1 (2026): IJHET MAY 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v5i1.746

Abstract

Pumpkin (Cucurbita moschata Duch.) is rich in natural antioxidants to overcome skin xerosis which has a high prevalence in Indonesia, but stable toner formulations are still limited. This study aims to develop a pumpkin extract toner and test its antioxidant activity. This type of quantitative experimental research with variations in extract concentration (0%, 5%, 10%, 20%). The population of fresh fruit from Karanganyar, simplicia samples and 9 female panelists aged 20-25 years. Instruments include a rotary evaporator, pH meter, skin moisture meter, UV-Vis spectrophotometer; SPSS analysis (One-Way ANOVA) and IC50 DPPH regression. The results showed that all formulas met physical standards (pH 4.6-5.6, homogeneous, non-irritant, moisture 46-55%), with very strong IC50 (F0: 44.02 µg/mL; F1: 40.19; F2: 39.65; F3: 38.86 µg/mL), a positive dose-response trend. Formula F3 is optimal as a natural antioxidant toner.
Co-Authors Adhe Wibawa Mahardika Putra Aisyah Rabitha Alisi Anna Fitriawati Aprilia Rika Alvita Aris Prio Agus Santoso Bangkit Riska Permata Bangkit Riska Pertama Belinda Arbitya Dewi Desy Ayu Irma Permatasari Dian Fatimatus Salwa Era Wandira Erick Ferdian Evi Eriani Galuh Puspita Sari Ilham Latansa Kusumaningtyas Siwi Artini Listyani, Tiara Ajeng Musniati Musniati Nadia Aisy Andika Nadia Nurul Wachida Nasya Bella Salsabilla Noka Riyani Nora Pereira Pinto Nora Pereira Pinto Novalisa Nindhi Soraya Nuraini Putri Rahmawati Nurul Nurhayati Putri Djatmiko Marchia Afifah Putri Martani Nur Afifah Rahmat Hidayat Regita Fortunata Rezky Ardika Pamungkas Septian Maulid Wicahyo Setianto, Rony Veranita Weri Veranita, Weri Wahdah Sri Rahayu Yaya Sulthon Aziz