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All Journal Jurnal Analis Farmasi Syntax Idea JAF (Jurnal Analis Farmasi) Proceeding of International Conference Health, Science And Technology (ICOHETECH) International Journal of Health, Engineering and Technology JURNAL FARMASI DAN KESEHATAN INDONESIA Jurnal Medika Nusantara Parapemikir Jurnal Ilmiah Farmasi Jurnal Riset Ilmu Kesehatan Umum dan Farmasi Aksi Nyata : Jurnal Pengabdian Sosial dan Kemanusiaan Mantra Bhakti Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Tatiana Siska Wardani
Universitas Duta Bangsa Surakarta
Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Mechanical Engineering Medicine & Pharmacology Nursing Physics Public Health Veterinary

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Antibacterial Activity Test Of Extracts And Fractionsn-Hexane, Ethyl Acetate, And Pineapple Peel Water (Ananas Comosus(L.) Merr.) Against Bacteria Propionibacterium Acnes ATCC 6919 Dian Fatimatus Salwa; Tatiana Siska Wardani; Bangkit Riska Permata
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.655

Abstract

Acne vulgaris is a common dermatological problem in adolescents in Indonesia's tropical climate related to the activity of Propionibacterium acnes bacteria. Long-term use of antibiotics risks causing resistance, so natural antibacterial alternatives are needed. This study aims to evaluate the antibacterial activity of ethanol extract and fractions of n-Hexane, ethyl acetate, and pineapple peel water against Propionibacterium acnes ATCC 6919, and to determine the most active fraction and MIC and MBC values. This study is a quantitative experimental study. The study population was the bacterial culture of P. acnes ATCC 6919, with samples in the form of pineapple peel extract and fraction. The research instruments included disc diffusion and liquid and solid dilution methods, while data analysis used the Shapiro-Wilk, Levene, and Kruskal-Wallis tests. The results showed that the ethanol extract had moderate to strong antibacterial activity, the ethyl acetate fraction showed the highest activity compared to other fractions, while the n-hexane fraction showed no activity. MIC and MBC values ​​were obtained at a concentration of 20 percent. The conclusion of this study is that pineapple peel has the potential as a natural antibacterial source against P. acnes and the ethyl acetate fraction is the most active fraction.
Antibacterial Activity Test Of Ethanol Extract And N-Hexane Fraction, Ethyl Acetate, Moringa Leaf Water (Moringa Oleifera L) Against Streptococcus Mutans ATCC 25175 Bacteria Wahdah Sri Rahayu; Tatiana Siska Wardani; Tiara Ajeng Listyani
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.662

Abstract

Dental caries remains a major oral health problem globally and in Indonesia, triggered by Streptococcus mutans biofilm. Chemical agents such as chlorhexidine have side effects, encouraging the use of natural alternatives from Moringa oleifera L. leaves. This study aims to evaluate the antibacterial activity of ethanol extracts and n-hexane, ethyl acetate, and water fractions against Streptococcus mutans ATCC 25175, identify the most active fraction, and determine the MIC and MBC. This quantitative study used diffusion and dilution methods. Bacteria: Streptococcus mutans ATCC 25175; samples: ethanol extract of Moringa oleifera L. leaves and n-Hexane, ethyl acetate, and water fractions. Data analysis used SPSS 25 One-Way ANOVA, Tukey (p<0.05). Results showed that the ethyl acetate fraction was the most active with 12.36 mm inhibition at 45%; MIC and MBC were 30% ANOVA significant (p=0.000). The ethyl acetate fraction has strong caries prevention potential, supporting herbal development.
Antibacterial Activity Test Of Extract And Fraction Of N-Hexane, Ethyl Acetate And Water Of Pineapple Peel (Ananas Comosus (L.) Merr.) Against Staphylococcus Epidermidis ATCC 12228 Bacteria Nadia Nurul Wachida; Tatiana Siska Wardani; Rahmat Hidayat
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.670

Abstract

Staphylococcus epidermidis is a bacteria that causes mild skin infections accompanied by abscesses, with a high  prevalence in Indonesia, requiring natural alternatives due to antibiotic resistance. This study aimed to evaluated antibacterial activity of 96% ethanol extract and n-hexane, ethyl acetate, water fractions of pineapple peel (Ananas comosus L. Merr.) against S. epidermidis ATCC 12228 and to determined MIC/MBC of the most active fraction. This quantitative and experimental study used the disk diffusion and liquid/solid dilution. methods. Population: pineapple peels from Blitar, East Java; sample: 700 g Simplicia powder. The nstruments included rotary evaporator, incubator, autoklaf, laminar air flow; data were analyzed using the Kruskal-Wallis (SPSS 25). Results showed that extract produced inhibition zones ranging from 5.63–11.43 mm, ethyl acetate fraction 3.80–7.55 mm, water 2.35–6.88 mm, n-hexane was inactive. The MIC and MBC values of the extract were 25%; ethyl acetate fraction MIC and MBC were 50%. Extract, ethyl acetate, and water fractions exhibited antibacterial activity aginst S. epidermidis, with extract being the most effective.
Formulation And Test Of Antioxidants And Effectiveness Of Toner Preparations From Pumpkin Fruit Extract (Cucurbita Moschata Duch) Using The Dpph (2,2 Diphenyl - 1-Picrylhydrazyl) Method Nora Pereira Pinto Nora Pereira Pinto; Tatiana Siska Wardani; Bangkit Riska Pertama
International Journal of Health Engineering and Technology Vol. 5 No. 1 (2026): IJHET MAY 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v5i1.746

Abstract

Pumpkin (Cucurbita moschata Duch.) is rich in natural antioxidants to overcome skin xerosis which has a high prevalence in Indonesia, but stable toner formulations are still limited. This study aims to develop a pumpkin extract toner and test its antioxidant activity. This type of quantitative experimental research with variations in extract concentration (0%, 5%, 10%, 20%). The population of fresh fruit from Karanganyar, simplicia samples and 9 female panelists aged 20-25 years. Instruments include a rotary evaporator, pH meter, skin moisture meter, UV-Vis spectrophotometer; SPSS analysis (One-Way ANOVA) and IC50 DPPH regression. The results showed that all formulas met physical standards (pH 4.6-5.6, homogeneous, non-irritant, moisture 46-55%), with very strong IC50 (F0: 44.02 µg/mL; F1: 40.19; F2: 39.65; F3: 38.86 µg/mL), a positive dose-response trend. Formula F3 is optimal as a natural antioxidant toner.
Uji Aktivitas Antibakteri Ekstrak Etanol dan Fraksi Daun Kelor (Moringa oleifera Lam.) terhadap Bakteri Salmonella typhi ATCC 13311 Tiara Nurul Hidayah; Tatiana Siska Wardani; Septian Maulid Wicahyo
Mantra Bhakti Vol. 3 No. 2: Juni 2026
Publisher : STIKES Bhakti Husada Mulia Madiun

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47575/mb.v3i2.907

Abstract

Samonella typhi merupakan bakteri penyebab demam tifoid yang telah mengalami resistensi terhadap antibiotik. Kondisi ini mendorong pengembangan antibakteri alternatif dari senyawa bioaktif tanaman obat. Daun kelor diketahui mengandung senyawa metabolit sekunder yang berpotensi sebagai antibakteri. Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri ekstrak etanol serta fraksi n-heksan, etil asetat, dan air daun kelor terhadap bakteri Samonella typhi, serta mengetahui nilai KHM dan KBM dari ekstrak atau fraksi teraktif terhadap Samonea typhi. Proses ekstraksi simpisia sebanyak 700 gram menggunakan metode maserasi dengan pelarut etanol 96%. Ekstrak hasil maserasi selanjutnya difraksinasi menghasilkan fraksi n-heksan, fraksi etil asetat, dan fraksi air. Uji aktivitas antibakteri dilakukan menggunakan metode difusi dan dilusi. Berdasarkan penelitian yang dilakukan ekstrak etanol, fraksi etil asetat, dan fraksi air memiliki aktivitas antibakteri terhadap Samonella typhi. Ekstrak menjadi yang paling aktif dalam menghambat Samonella typhi dilihat dari nilai zona hambatnya pada konsentrasi 80%. Sebesar 13,5 mm dengan kategori kuat. Ekstrak etanol daun kelor memiliki nilai KHM pada konsentrasi 10% dan nilai KBM pada konsentrasi 20%.
Uji Aktivitas Antioksidan Ekstrak dan Fraksi Daun Rambutan (Nephelium lappaceum L.) dengan Metode FRAP (Ferric Reducing Antioxidant Power) serta Penetapan Flavonoid Total Dian Pratiwi; Tatiana Siska Wardani; Bagas Ardiantoro
Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Vol. 5 No. 3 (2025): November : Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jikki.v5i3.8371

Abstract

Free radicals are unstable and highly reactive molecules that can cause oxidative stress, leading to cell damage and the development of degenerative diseases such as cancer, cardiovascular disorders, diabetes, and premature aging. To counteract these harmful effects, antioxidant compounds are required to inhibit oxidative reactions and protect cellular structures. Rambutan leaves (Nephelium lappaceum L.) are rich in bioactive compounds, including flavonoids, tannins, and saponins, which are reported to have strong antioxidant potential. The objective of this study was to evaluate the antioxidant activity of rambutan leaf extracts and their fractions, as well as to determine the IC₅₀ value using the Ferric Reducing Antioxidant Power (FRAP) method. Fractionation was performed using solvents of varying polarity, namely n-hexane, ethyl acetate, and water, to obtain different active fractions. Antioxidant activity was measured based on the ability of extracts and fractions to reduce Fe³⁺ ions to Fe²⁺ at a wavelength of 595 nm. The findings revealed that rambutan leaf extract exhibited very strong antioxidant activity, indicated by an IC₅₀ value of 20.65 ppm. Moreover, the activity increased proportionally with concentration, confirming a significant positive linear correlation. These results suggest that rambutan leaves are a promising natural source of antioxidants with potential applications in the development of pharmaceutical products, functional foods, and nutraceuticals aimed at preventing oxidative stress-related diseases.
Pemberdayaan PKK Serengan melalui Inovasi SEGARA (Serai, Cengkeh, dan Gaharu) Briket Antinyamuk Tatiana Siska Wardani; Dwi Lestari Mukti Palupi; Susanti Erikania; Angelia Permadani; David Valentino Iskandar
Aksi Nyata : Jurnal Pengabdian Sosial dan Kemanusiaan Vol. 3 No. 4 (2026): Oktober : Aksi Nyata : Jurnal Pengabdian Sosial dan Kemanusiaan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62383/aksinyata.v3i4.3557

Abstract

Mosquito control in community settings still relies heavily on chemical-based products, while the utilization of natural materials and biomass waste as alternative mosquito-repellent products remains limited. This Community Service (PkM) program aimed to improve the knowledge and practical skills of members of the Serengan Family Welfare Empowerment (PKK) group in utilizing lemongrass, cloves, agarwood, and coconut shell waste to produce SEGARA mosquito-repellent briquettes and promote a value-added product with economic potential. The program was implemented through educational sessions, demonstrations, hands-on briquette production training, and pre- and post-test evaluations. Three briquette formulations (F1, F2, and F3) were prepared and evaluated to determine the most suitable formulation. The results showed that 10 kg of coconut shell waste was successfully utilized as raw material. Formulation F2 was selected as the optimal formulation because it exhibited a strong aroma of lemongrass, cloves, and agarwood, good structural integrity, approximately 52 minutes of burning time, stable combustion, and relatively low smoke production. Participants’ knowledge improved, with the mean score increasing from 62% in the pre-test to 85% in the post-test. The program also successfully produced packaged SEGARA briquettes in labeled standing pouches, demonstrating potential as a community flagship product and source of productive economic activity.
Co-Authors Adhe Wibawa Mahardika Putra Agus Santoso, Aris Prio Aisyah Rabitha Alisi Angelia Permadani Anna Fitriawati Aprilia Rika Alvita Bagas Ardiantoro Bangkit Riska Permata Bangkit Riska Pertama Belinda Arbitya Dewi David Valentino Iskandar Desy Ayu Irma Permatasari Dian Fatimatus Salwa Dian Pratiwi Dwi Lestari Mukti Palupi Era Wandira Erick Ferdian Evi Eriani Galuh Puspita Sari Ilham Latansa Kusumaningtyas Siwi Artini Listyani, Tiara Ajeng Musniati Musniati Nadia Aisy Andika Nadia Nurul Wachida Nasya Bella Salsabilla Noka Riyani Nora Pereira Pinto Nora Pereira Pinto Novalisa Nindhi Soraya Nuraini Putri Rahmawati Nurul Nurhayati Putri Djatmiko Marchia Afifah Putri Martani Nur Afifah Rahmat Hidayat Regita Fortunata Rezky Ardika Pamungkas Septian Maulid Wicahyo Setianto, Rony Susanti Erikania Tiara Nurul Hidayah Veranita Weri Veranita, Weri Wahdah Sri Rahayu Yaya Sulthon Aziz