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Journal : Molecular and Cellular Biomedical Sciences (MCBS)

Neutrophil Extracellular Traps and Its Correlation with Several Pathological Conditions: Prosperities and Deleterious Implications Phey Liana; Krisna Murti; Zen Hafy; Iche Andriyani Liberty; Tungki Pratama Umar
Molecular and Cellular Biomedical Sciences Vol 6, No 1 (2022)
Publisher : Cell and BioPharmaceutical Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21705/mcbs.v6i1.224

Abstract

Neutrophil extracellular traps (NETs) are immune components found in a variety of pathological states. It has been shown to have either beneficial or harmful implications, depending on how it is controlled and has been particularly observed in three major scenarios: infection, autoimmune disease, and cancer. In this article, we compiled some of the roles of NETs in pathological conditions, as well as the benefits of targeting them for improved patient outcomes. The role of NETs were primarily positive in infectious disease, whether caused by bacteria, virus, or fungal infection. In non-infectious inflammatory scenarios, on the other hand, it's the complete opposite, with the effects being mainly deleterious and even worse than the original disease states. Targeting NETs directly or indirectly may help to prevent complications and improve patient outcomes. A plethora of compounds, including immunomodulators, anti-thrombosis, nicotinamide adenine dinucleotide phosphate (NADPH)/reactive oxygen species (ROS) inhibitors, nuclease, and other compounds, may be used to accomplish the therapeutic goals.Keywords: autoimmune disease, cancer, DNase, infection, neutrophil extracellular traps
Co-Authors Afifah, Salwa Nur Agustin, Berliana Agustin, Berliana Amalia Amalia Ari L. Runtunuwu Aseptianova Aseptianova Astari Rahayu Afifah Baity Indriani Banun, Syahri Berliana Agustin Berliana Agustin Bhagaskara Bhagaskara Budi Santoso Calvin Ienawi Catherine Ieawi Chris Alberto Amin Cornelia Agatha Desi Oktariana Desi Oktariana Dini Cahyani Dodi Maulana Eka Intan Fitriana Eny Rahmawati Eny Rahmawati, Eny Erial Bahar Evi Lusiana Fadhilatul Hilda Gita D. Prasasty Gita Dwi Prasasty Gita Dwi Prasasty Gita Dwi Prasasty Hafizzanovian, Hafizzanovian Hertanti Indah Lestari Hidayatullah Iche Andriyani Liberty, Iche Andriyani Ieawi, Catherine Ieawi, Catherine Ienawi, Calvin Ienawi, Calvin Irfanuddin Irfanuddin Iza Netiasa Haris Jayawarsa, A.A. Ketut Jeanette I. Ch. Manoppo Jesica Sidabutar Jose M. Mandei Karina Rahma Meidiarti Kemas M. Yakub Kemas M. Yakub Kemas Y. Rahadiyanto Kemas Ya’kub Rahadiyanto Kemas Ya’kub Rahadiyanto Krisna Murti Kusumo Haryadi Kusumo Haryadi Laksono Trisnantoro Larasati, Veny Legiran Legiran Lusia Hayati Mastiar Endang Frida Siahaan Mediarty Syahrir Mirza Gifari Maulana Mita Al Maida Muhammad Irsan Saleh Nelda Aprilia Salim Nia S. Tamzil Nia Savitri Tamzil Norlaila Binti Chahril Nova Kurniati Novita, Emma Nurmalia Purnama Sari Oktariana, Desi Oktarina, Desi Patricia, Venny Patwa Amani, Patwa Rahadiyanto, Kemas Ya’kub Rahmi Widiyawati Rahnowi Pradesta Rahnowi Pradesta Rocky Wilar Ronald Chandra SEPTI WULANDARI Soilia Fertilita Sri Nita Sri noviyanty Yusuf Sulistiani Sulistiani, Sulistiani Susilawati Susilawati Swanny Swanny Tungki Pratama Umar Tungki Pratama Umar Tungki Pratama Umar Tungki Pratama Umar Tungki Pratama Umar Vena Sabputri Sutrisno Venny Patricia Verdiansah Verdiansah Yakub, Kemas M Yakub, Kemas M Yan Effendi Hasyim Yulia Nugraha Karsita Yunni Diansari Zen Ahmad Zen Hafy