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All Journal Journal of Food and Pharmaceutical Science Jurnal Tumbuhan Obat Indonesia JURNAL FARMASIMED (JFM) ad-Dawaa : Journal of Pharmaceutical Sciences Acta Chimica Asiana Current Research on Biosciences and Biotechnology Journal of Multidisciplinary Applied Natural Science Sasambo Journal of Pharmacy Journal of Health Science Sinteza Scientica: Jurnal Ilmiah Sains dan Teknologi Journal of Food and Pharmaceutical Sciences Indonesian Journal of Cosmetics Medical Sains : Jurnal Ilmiah Kefarmasian
Arif Setiawansyah
Akademi Farmasi Cendikia Farma Husada
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Aerobe Fermentation Enhanced Antioxidant Activity Index of Citrus limon Leaves Herlina, Santi; Setiawansyah, Arif; Hidayati, Nurul
Journal of Food and Pharmaceutical Sciences Vol 12, No 2 (2024): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.12005

Abstract

The chemical composition and antioxidant activity of a natural product are directly correlated with the preparation process which can alter certain enzymatic pathways, leading to the alteration of the production of secondary metabolites affecting its biological activity. This study aims to observe the effects of the pre-extraction process of Citrus limon on its TFC, TPC, and antioxidant activity. Samples were prepared by two different pre-extraction techniques (solar drying and aerobe fermentation) and extracted using ultrasound-assisted extraction with ethanol 96%. The TFC and TPC were measured by a colorimetric method using a spectrophotometer UV-Vis. The antioxidant activity was tested on DPPH and calculated as AAI with ascorbic acid as a standard. The result showed that solar dried sample exhibited higher TFC and TPC than the fermented sample with TFC and TPC values of 32.165 mg QE/g and 335.80 mg GAE/g extract. In contrast, the antioxidant activity assay revealed that fermented samples provided higher antioxidant activity than solar-dried samples and even better than ascorbic acid with an IC50 value of 2.52 µg/mL. The pre-extraction process significantly influences the TFC, TPC and antioxidant activity of Citrus limon.
IDENTIFICATION OF PORK'S CYTOCHROME B GEN IN PROCESSED MEAT NUGGETS IN SUKABUMI VILLAGE, BUAY BAHUGA SUB-DISTRICT USING THE POLYMERASE CHAIN ??REACTION (PCR) METHOD Setiawati, Diah Ayu; Marpaung, Mauritz Pandapotan; Setiawansyah, Arif
Jurnal FARMASIMED (JFM) Vol 5 No 2 (2023): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v5i2.1470

Abstract

Nugget adalah jenis olahan daging restrukturisasi yang sangat rentan terhadap cemaran daging lainnya sehingga mempengaruhi kehalalan suatu produk makanan. Penelitian ini bertujuan untuk mengidentifikasi cemaran sitokrom b pada nugget yang beredar di Desa Sukabumi dengan menggunakan metode Polymerase Chain Reaction (PCR). Sebanyak 3 buah sampel nugget di desa Sukabumi diambil dari produsen yang berbeda dan divisualisasi dengan elektroforesis gel agarose 0,75%, dan divisualisasikan dengan alat documentation system. Hasil penelitian menunjukkan berupa pita-pita marker DNA ledder yang masing-masing berjarak 100 bp. Untuk kontrol positif yang digunakan daging babi dengan marker 130 bp. Kesimpulan dari penelitian ini adalah seluruh sampel tidak terindentifikasi adanya gen sitokrom b.
PERBANDINGAN UJI MUKOLITIK EKSTRAK DAN FRAKSI DAUN LAMTORO (Leucaena leucocephala (Lam) de Wit) HALUS DAN KASAR SECARA IN VITRO Diah Ayu. S; Hengki Adi. P; Nanda Puspita. S; Nugraheni Febrianti S; Nyimas Rahma. K; Putri Adelia. M; Rindi Permata.S; Salsabilla Nur. C; Sephia Panorama; Siti Aminah; Arif Setiawansyah
Scientica: Jurnal Ilmiah Sains dan Teknologi Vol. 2 No. 4 (2024): Scientica: Jurnal Ilmiah Sains dan Teknologi
Publisher : Komunitas Menulis dan Meneliti (Kolibi)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.572349/scientica.v2i4.1154

Abstract

Dalam pengobatan tradisional daun lamtoro (Leucaena leucocephala (Lam) de Wit) dapat digunakan sebagai obat batuk. Khasiat mukolitik dari daun lamtoro diduga dapat mengobati batuk karena dipengaruhi oleh senyawa metabolit sekunder saponin dan tannin. Penelitihan ini bertujuan untuk mengetahui efek mukolitik dan perbedaan ukuran partikel sampel daun lamtoro (Leucaena leucocephala (Lam) de Wit). Sampel yang digunakan dalam penelitihan ini adalah ekstrak kental daun lamtoro (Leucaena leucocephala (Lam) de Wit) halus dan kasar. Ekstraksi dengan metode Ultrasonic Assisted Extraction (UAE) dan diuapkan lalu dilakukan uji ekstrak meliputi uji organoleptis, uji fitokimia, uji mukolitik, uji penegasan dengan menggunakan Kromatografi Lapis Tipis (KLT) dan fraksinasi. Hasil yang didapat menunjukan bahwa ekstrak kental daun lamtoro (Leucaena leucocephala (Lam) de Wit) kasar memiliki aktivitas mukolitik yang baik dari pada ekstrak halus.
Utilization of Avocado Leaves (Persea americana Mill) Ethanol Extract in Acne Spot Gel Formulation Hidayati, Nurul; Amanda, Putri Fadillah; Setiawansyah, Arif
Indonesian Journal of Cosmetics Vol. 2 No. 1 (2024): Indonesian Journal of Cosmetics
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat (LPPM), Institut Teknologi Sumatera, Lampung Selatan, Lampung, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35472/ijcos.v2i1.1793

Abstract

Avocado leaves (Persea americana Mill) are classified as a type of herbal plant that has many benefits and can be used as traditional medicine. The components in avocado leaves that have antibacterial properties are flavonoids, saponins, and tannins. To increase public interest in utilizing avocado leaves, the development of a formulation in the form of acne spot gel from avocado leaf ethanol extract can be undertaken. The base used in this study is carbopol 934, the base that commonly used in gel production. The purpose of this study is to determine the effect of variations in the concentration of avocado leaf ethanol extract on the physical properties of acne spot gel. The extract was obtained by macerated 50.06 grams of avocado leaves (yield 25.03%). The formulation was produced in gel form with four formulas that had variations in the concentration of ethanol extract, those are formula 0 (0%), formula 1 (5%), formula 2 (10%), and formula 3 (15%). The acne spot gel was subjected to physical property tests including organoleptic, pH, spreadability, and adhesion. All tested formulas met the quality requirements of the acne spot gel formulation. The evaluation data were analyzed using One-Way ANOVA to determine significant differences. Based on the evaluation results, the variation in ethanol extract concentration had a significant effect (p < 0.05) on adhesion, where higher concentrations of ethanol extract could increase the adhesion of the formulation.
Aerobe Fermentation Enhanced Antioxidant Activity Index of Citrus limon Leaves Herlina, Santi; Setiawansyah, Arif; Hidayati, Nurul
Journal of Food and Pharmaceutical Sciences Vol 12, No 2 (2024): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.12005

Abstract

The chemical composition and antioxidant activity of a natural product are directly correlated with the preparation process which can alter certain enzymatic pathways, leading to the alteration of the production of secondary metabolites affecting its biological activity. This study aims to observe the effects of the pre-extraction process of Citrus limon on its TFC, TPC, and antioxidant activity. Samples were prepared by two different pre-extraction techniques (solar drying and aerobe fermentation) and extracted using ultrasound-assisted extraction with ethanol 96%. The TFC and TPC were measured by a colorimetric method using a spectrophotometer UV-Vis. The antioxidant activity was tested on DPPH and calculated as AAI with ascorbic acid as a standard. The result showed that solar dried sample exhibited higher TFC and TPC than the fermented sample with TFC and TPC values of 32.165 mg QE/g and 335.80 mg GAE/g extract. In contrast, the antioxidant activity assay revealed that fermented samples provided higher antioxidant activity than solar-dried samples and even better than ascorbic acid with an IC50 value of 2.52 µg/mL. The pre-extraction process significantly influences the TFC, TPC and antioxidant activity of Citrus limon.
Fermentation Influences the Total Flavonoid Content and Antioxidant Activity of Syzygium polyanthum Saputri, Aurya; Christian, Yulius Evan; Hidayati, Nurul; Indah, Indah; Setiawansyah, Arif
Ad-Dawaa: Journal of Pharmaceutical Sciences
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v7i2.51645

Abstract

Introduction: Syzygium polyanthum are widely recognized for their rich phytochemical profile, including flavonoids and phenolics. However, the bioavailability of these compounds can be limited, prompting exploration of methods to enhance their accessibility and potency. Aims: This study investigates the effects of fermentation on the bioactive compounds and antioxidant properties of Syzygium polyanthum. Methods: Three sample groups were examined: fresh leaves, leaves fermented for 3 days, and leaves fermented for 5 days. Qualitative and quantitative analyses were conducted to assess flavonoid content, phenolic compounds, and antioxidant activity in each sample. Result: The results demonstrated that fermentation significantly impacted these properties, with the 5-day fermented sample exhibiting the highest values: total flavonoid content of 279.850 mg QE/g, total phenol content of 135 mg GAE/g, and antioxidant activity with an IC50 of 51.89 ppm. Conclusion: These findings suggest that fermentation can be an effective method to enhance the nutritional and medicinal properties of Syzygium polyanthum leaves. This research provides valuable insights into the potential applications of fermented Syzygium polyanthum in the food and pharmaceutical industries, paving the way for further exploration of its health-promoting properties.
Organic Nanoparticle Genotoxicity: Current Understanding and Future Testing Needs Sadaqa, Ebrahim; Setiawansyah, Arif; Nugroho, Bambang Hernawan; Hidayati, Nurul; Arsul, Muhammad Ikhlas
Ad-Dawaa: Journal of Pharmaceutical Sciences
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v7i2.52943

Abstract

Organic nanoparticles derived from biocompatible materials like chitosan, alginate, and lipids have garnered immense interest for drug delivery, bioimaging, and other biomedical applications. However, as their use rapidly expands, a comprehensive evaluation of their potential genotoxicity is crucial to ensure safe implementation. This review provides an in-depth analysis of the genotoxic risks associated with these organic nanoparticles. The review elucidates how the unique physicochemical properties of organic nanoparticles can induce genetic damage through mechanisms such as direct DNA binding, oxidative stress, inflammation, and impairment of DNA repair pathways. Importantly, this genotoxicity can occur even in the absence of overt cytotoxicity, leading to heritable mutations and long-term adverse effects like cancer and reproductive abnormalities. A critical assessment of established and emerging genotoxicity testing methods, including their strengths, limitations, and opportunities for standardization, is presented. The review synthesizes findings from existing in vitro and in vivo studies, revealing the contrasting genotoxic profiles of different organic nanoparticle formulations and exposure scenarios. Furthermore, the review provides insights into the multifaceted factors influencing nanoparticle genotoxicity, guiding the strategic engineering of safer designs. This comprehensive analysis underscores the pivotal importance of rigorous genotoxicity screening in the responsible development of organic nanomaterials. By harmonizing their innovative capabilities with a commitment to genetic integrity, this review paves the way for realizing the vast potential of organic nanoparticles while safeguarding human and environmental health.
Integrating The Network Pharmacology and Molecular Docking Confirmed with In Vitro Toxicity to Reveal Potential Mechanism of Non–Polar Fraction of Cyperus rotundus Linn as Anti-Cancer Candidate Susianti Susianti; Syaiful Bahri; Sutopo Hadi; Arif Setiawansyah; Lanang Rachmadi; Ibnu Fadilah; Maya Ganda Ratna
Journal of Multidisciplinary Applied Natural Science Vol. 5 No. 1 (2025): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.228

Abstract

Cyperus rotundus Linn is a plant that is historically used in traditional medicine with anti-cancer potential. Despite the evidence of C. rotundus anti-cancer effect on various human carcinoma cell lines, its pharmacological mechanism remains unclear, particularly its non-polar fraction. This study was employed to provide mechanistic insight regarding the anti-cancer properties of C. rotundus non-polar fraction by integrating in silico and in vitro approach. The network pharmacology study was used to observe the molecular targets of n-hexane fraction of C. rotundus, confirmed by molecular docking simulation using Autodock 4.2. The in vitro toxicity using BSLT method was used to strengthen the in silico result. The network pharmacology investigation revealed several core targets including PI3K, MAPK1, mTOR, RAF1, and NF-κB in the potential anti-cancer mechanism of C. rotundus. The molecular docking study illustrated that compound 3 (Isopetasol) and compound 9 (alpha-cyperone) as the most promising compound in n-hexane fraction of C. rotundus, with free binding energies consistently less than -7 kcal/mol in all targets. The in vitro BSLT signified the in silico results, highlighting the highest toxicity of fraction 3 exhibited among others. Integrating the network pharmacology and molecular docking simulation along with in vitro toxicity have provided evidence of the anti-cancer potential of n-hexane fraction of C. rotundus. Specific compounds and the molecular targets responsible for its anti-cancer properties have been identified, warranting further investigations.
Uncovering The Pharmacological Mechanism of Ficus elastica as Anti-hyperlipidemia Candidate: LC-HRMS, Network Pharmacology, In vitro and In vivo Studies Gita Susanti; Yufri Aldi; Dian Handayani; Friardi Ismed; Arif Setiawansyah
Journal of Multidisciplinary Applied Natural Science Vol. 5 No. 1 (2025): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.249

Abstract

Hyperlipidemia is a major risk factor for cardiovascular diseases. While conventional treatments exist, there is a growing interest in natural remedies with fewer side effects. Ficus elastica has promising medicinal properties, yet its potential as an anti-hyperlipidemic agent remains unexplored. This study aimed to investigate the anti-hyperlipidemic effects of F. elastica using an integrated approach of LC-HRMS-based chemical bioinformatics and in vitro/in vivo experimental validation. The anti-hyperlipidemic potential of F. elastica and its mechanism of action were screened using integrative computational network pharmacology followed by in vitro HMG-CoA reductase inhibition and in vivo lipid-lowering activity in a hyperlipidemia rat model. Network pharmacology analysis identified STAT3, HSP90AA1, and TLR4 as potential core targets involved in lipid and atherosclerosis-related KEGG pathways. Molecular docking simulations revealed high-affinity interactions between F. elastica compounds and the identified targets, notably compound 41 and compound 61. In vitro assay demonstrated that ethanolic extract of F. elastica inhibited HMG-CoA reductase with an IC50 of 297.73 µg/mL. In vivo experiment using a hyperlipidemic rat model showed significant reductions in total cholesterol, triglycerides, and increased HDL levels. The reduction of triglycerides and elevation of HDL level after F. elastica ethanolic extract supplementation is similar to the effect from supplementation of simvastatin. These findings suggest that F. elastica ethanolic extract possesses notable anti-hyperlipidemic properties, likely mediated through multiple molecular targets and pathways. The study highlights the potential of F. elastica ethanolic extract as a promising candidate for anti-hyperlipidemic therapy and underscores the efficacy of integrating computational and experimental approaches in natural product research.
Network pharmacology and molecular docking simulation uncovered the potential of hexacyclinic acid as anti-osteoarthritis by regulating IL-17 signaling pathway Setiawansyah, Arif
Acta Chimica Asiana Vol. 8 No. 1 (2025)
Publisher : The Indonesian Chemical Society, Chapter Nusa Tenggara and The University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/aca.v8i1.238

Abstract

Hexacyclinic acid has shown promising pharmacological activities, yet its molecular mechanisms and therapeutic potential remain largely unexplored. This study aimed to identify potential disease targets and elucidate the mechanism of action of hexacyclinic acid using an integrated computational approach. We employed network pharmacology analysis to predict potential targets and pathways of hexacyclinic acid using SuperPred and Swiss Target server, followed by protein-protein interaction network construction via STRING database. Pathway enrichment analysis was performed using ShyniGO and DAVID databases. Molecular docking studies were conducted using AutoDock Vina to evaluate binding affinities between hexacyclinic acid and identified target proteins. Binding poses and interactions were visualized using Biovia Discovery Studio Visualizer. Disease prediction analysis identified osteoarthritis as the most promising target, with the IL-17 signaling pathway emerging as the most significant KEGG pathway. TNF-α and IL-1β were identified as key molecular targets within this pathway. Molecular docking simulations corroborated these findings, revealing favorable binding energies between hexacyclinic acid and TNF-α (-8.62 kcal/mol) and IL-1β (-8.76 kcal/mol). These results suggest that hexacyclinic acid may exert its anti-osteoarthritis effects by modulating the IL-17 signaling pathway, particularly through interactions with TNF-α and IL-1β. The strong binding affinities observed indicate a potentially high efficacy of hexacyclinic acid in targeting these inflammatory mediators. These results have significant clinical implications, potentially leading to the development of new therapeutic strategies for osteoarthritis management with reduced side effects compared to current treatments. Future research should focus on experimental validation through in vitro and in vivo models to confirm these computational predictions and establish hexacyclinic acid as a viable candidate for clinical development
Co-Authors Agnesia, Agnesia Aliefman Hakim Alrayan, Reza Amanda, Putri Fadillah Amelia, Nanda Arsul, Muhammad Ikhlas Baiq Maylinda Gemantari Bambang Hernawan Nugroho, Bambang Hernawan Daryono Hadi Tjahjono Dewantara, Jeisen Pajar Dewi Luthfiana Diah Ayu. S Dian Handayani Doloking, Haeria Dwi Handayani Dyke Gita Wirasisya Enggy Erwansani Erwansani, Enggy Evifani, Dinda Silvia Fendi Fendi Fong, Siau Friardi Ismed Gita Susanti Gita Susanti, Gita Hadi, Ismanurrahman Hakim, Aditia Rahman Hengki Adi. P Herlina, Santi Ibnu Fadilah Ikhlas Arsul, Muhammad Indah Indah Jaya, Farrel Septian Khairunnisa Lanang Rachmadi Luthfiana, Dewi maha rani Maharani, Andi Rani Gustia MAURITZ PANDAPOTAN MARPAUNG Maya Ganda Ratna Muh Ikhlas Arsul Muhammad Andre Reynaldi Mutiara, Berkah Nanda Puspita. S Nugraheni Febrianti S Nur Adliani Nurul Hasanah Nurul Hidayati Nweze, Leonard Chinecherem Nyimas Rahma. K Perdana Priya Haresmita Putra, Teguh Adiyas Putri Adelia. M Putri, Stella Anatasya Putri Reza Alrayan Rico Saputra RINA SE SITINDAON Rindi Permata.S Sadaqa, Ebrahim Salsabila, Salwa Salsabilla Nur. C Saputri, Aurya Sephia Panorama Setiawati, Diah Ayu Siti Aminah Stevia, Tessa Sukrasno Susianti Susianti Sutopo Hadi Syaiful Bahri Valentina, Febriani Wismayani, Leni Yufri Aldi Yulius Evan Christian