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Journal : JURNAL GIZI INDONESIA

Correlation between HbA1c level and monocyte percentage in obesity Limijadi, Edward Kurnia Setiawan; Hendrianingtyas, Meita
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 8, No 1 (2019)
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (298.001 KB) | DOI: 10.14710/jgi.8.1.75-78

Abstract

Background : HbA1c is one of the parameters that can be useful for diagnosing diabetes mellitus that can occur in obesity. Monocyte as an inflammatory cell is widely studied in relation to diabetes mellitus and obesity. The purpose of this study is to analyze the correlation between HbA1c levels and monocyte percentage in obesity.Methods : A Cross-sectional study of 30 medical students at a private laboratory in Semarang on March – April 2017 was done. The monocyte percentage included incomplete blood count was examined with the Sysmex XS-800i hematology analyzer, while HbA1c level was examined with Hemocue HbA1c 501 System. Spearman test was done for analyzing data with p <0.05 was considered statistically significant. Result and discussion : Median of HbA1c level was 5.8 ± 0.23%. Medians of leukocyte count, lymphocyte percentage, neutrophil percentage, and monocyte percentage were 8,600 ± 339,77 /μl, lymphocyte percentage 33% ± 1.19%, neutrophil percentage 56% ± 1.35%, and monocyte percentage of 9.0% ± 0.26%, respectively. Spearman test showed that correlation value (r) was 0.131 (p = 0.489).Conclusion and suggestion : There was no correlation between HbA1c levels and monocyte percentage in obesity. The increased of monocyte percentage can be used as monitoring and evaluation parameters in obesity that can lead to diabetes mellitus. Further study can be done in an obese population with older age as well as other parameters related to obesity and diabetes mellitus.
Difference of thrombocyte profile between obesity and central obesity in women Hadisasmitajaya, Melki; Hendrianingtyas, Meita; Limijadi, Edward Kurnia Setiawan
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 12, No 1 (2023): December
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jgi.12.1.21-30

Abstract

Background: Obesity considered as a low-grade inflammation. Increased body fat has known to trigger inflammation. Platelet profile is a number of platelet-related parameters that can predict inflammation consisting of: platelet count (PLT), Platelet Larger Cell Ratio (P-LCR), Mean Platelet Volume (MPV). Differences in platelet profiles (PLT, P-LCR, MPV) in women with and without central obesity have only been investigated in a few studies.Objective: To prove differences in platelet profiles in women with and without central obesity.Materials and Methods: A cross-sectional observational study was conducted on 88 women with and without central obesity in RSND during July-September 2021. Data included age, abdominal circumference, hip circumference, PLT, P-LCR, and MPV. PLT, P-LCR, and MPV were measured using Sysmex XS-500i instrument. Statistical analysis was using Mann-Whitney test.Results: Mean of women PLT with and without central obesity were 338.72±71.09x103/uL and 309.09±44.36x103/uL. Difference platelet levels in women with and without central obesity was p=0.022. Median MPV of women with and without central obesity were 10.5 (8.5-11.8)fL and 9.7 (8.5-11.6)fL. Difference MPV values in women with and without central obesity was p=0.000. Median P-LCR of women with and without central obesity were 28.2 (12.3-44.3)% and 21.5 (15.2-37.1)%, respectively. Difference P-LCR value in women with and without central obesity was p=0.002.Conclusion: Platelet profiles (PLT, MPV, P-LCR) can be used as a marker of chronic low-grade inflammation in women with central obesity.Keywords : central obesity; MPV; PLT; P-LCR