Claim Missing Document
Check
Articles

Found 35 Documents
Search

Antiinflammatory Activity Patch Ethanol Extract Of Leaf Katuk (Sauropus Androgynus L. Merr) Rise Desnita; Sri Luliana; Desy Siska Anastasia
JURNAL ILMU KEFARMASIAN INDONESIA Vol 16 No 1 (2018): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1958.31 KB) | DOI: 10.35814/jifi.v16i1.493

Abstract

The leaf katuk (Sauropus androgynus L. Merr) extract at a dose of 400 mg / kg BW had antiinflammatory activity in rat by induction of carrageenan. Patch are adhesive plasters containing medicinal substances placed on the skin to delivery active substances. Patch can offer practicality, comfort and accuracy of dosage in the application of leaf S. androgynus extract.This research was a laboratory experimental research by making patch of leaf S. androgynus extract and inflammation effect used rats as its animal test. Inflammatory healing activity was seen from the percentage reduction in inflammation in rats after patch application. Patch of leaf S. androgynus extract dose 400 mg / kg BW has percentage of inflammatory inhibition ranged between 66,67-100%. Statistical test results using one-way anova patch leaf S. androgynus extract showed good effectiveness in curing inflammation. Effectiveness between leaf S. androgynus extract patch and diclofenac sodium patch relatively the same in curing inflammation.
Penetrasi Natrium Askorbil Fosfat dalam Sistem Niosom Span 40 secara In Vitro RISE DESNITA; VENI LESTIAWATI; PRATIWI APRIDAMAYANTI
JURNAL ILMU KEFARMASIAN INDONESIA Vol 14 No 2 (2016): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1381.569 KB)

Abstract

Natrium askorbil fosfat adalah senyawa hidrofilik yang sulit melewati stratum korneum. Salah satu upaya untuk meningkatkan penetrasi obat melalui stratum korneum adalah dengan mengembangkan sistem niosom. Penelitian ini bertujuan untuk mengetahui konsentrasi optimal span 40 dalam meningkatkan efisiensi penjerapan niosom yang diformulasikan dalam sediaan gel dan menentukan kestabilan serta kemampuan penetrasi sediaan secara in-vitro. Konsentrasi span 40 divariasikan ke dalam tiga formula: F1 (100 μmol), F2 (150 μmol) dan F3 (200 μmol). Sediaan gel dibuat dalam dua formula dengan menggunakan viskolam MAC 10 sebagai basis gel: G1 (natrium askorbil fosfat dengan sistem niosom) dan formula G2 (natrium askorbil fosfat tanpa dibuat sistem niosom). Uji stabilitas sediaan gel dilakukan selama 28 hari meliputi organoleptis, pH dan penetapan kadar. Uji penetrasi dilakukan secara in-vitro menggunakan membran kulit ular. Data dianalisis secara statistik menggunakan program SPSS. Hasil penentuan efisiensi penjerapan menunjukkan formula F1 memiliki efisiensi penjerapan optimal sebesar 99,13±0,10%. Formula G1 lebih stabil selama 28 hari penyimpanan dibandingkan formula G2. Penggunaan span 40 sebagai penyusun niosom dapat meningkatkan penetrasi natrium askorbil fosfat dalam sediaan gel dengan jumlah kumulatif persen difusi selama 8 jam sebesar 89,04±0,01%.
Pengaruh Variasi Gula Terhadap Karakteristik Sediaan Minuman Serbuk Instan Kombinasi Rimpang Jahe Dan Temu Putih Desy Siska Anastasia; Sri Luliana; Rise Desnita; Isnindar Isnindar; Nur Atikah
Journal Syifa Sciences and Clinical Research Vol 4, No 2 (2022): Volume 4 Edisi 2 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i2.14003

Abstract

The combination of ginger and white turmeric is the right way to make instant powder drink preparations. The content of gingerol in ginger and curcumin in white turmeric is useful as a natural diuretic (urine laxative). Instant powder drink preparations are made of 2 formulas with different variations of sweeteners, namely formula 1 with 100% granulated sugar and formula 2 with a combination of granulated sugar and brown sugar (3:1). This study was to determine the effect of variations in sugar on physical characteristics and the level of preference of panelists for the preparation of an instant powder drink containing a combination of ginger rhizome and white turmeric. Making instant powder drinks using the crystallization method Physical test data was analyzed by the Independent Sample T-Test. The test results showed that the two formulas met the powder test requirements with the pH value, setting, moisture content, flow time, and angle of repose in formula 1 each being 6.53; 9.3%; 0.26%; 15.63 grams/second; and 31.62, while formula 2 is 6.19; 5.6%; 1.04%; 11.55 grams/second; and 36.44. The hedonic test shows that there is a significant difference in preference values where formula 2, with a combination of sugar and brown sugar (3:1), is more preferred by the panelists.
IPTEKS BAGI MASYARAKAT (IBM) PEMBUATAN SABUN KESEHATAN KULIT Rise Desnita; Sri Luliana
Jurnal Buletin Al-Ribaath Vol 14, No 2 (2017): Buletin Al-Ribaath
Publisher : Universitas Muhammadiyah Pontianak

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (391.378 KB) | DOI: 10.29406/br.v14i2.875

Abstract

Science for Society (IbM) is a program of dedication to society funded by Research and Technology Directorate of Higher Education. Ibm Leather Health Soap Making proposed by the group of Lecturers Prodi Pharmacy Faculty of Medicine UNTAN aims to help the first partner of Bidikmisi Student Enterprises Group of Pharmaceutical Technology in terms of improving skills in processing natural ingredients into skin health soap preparations. IbM proponents help provide business capital, provide guidance on making skin health soap and provide information on how to apply for permission to circulate skin health soap products. In addition, the proposer of IbM also provides pharmacy management consultancy according to the growing pharmacoeconomics and their pharmacy business will grow better in the future. The result of training, mentoring and guidance to Bidikmisi Student Enterprises Group of Pharmaceutical Technology run well and smoothly. The publication of IbM's Leather Health Soap Program publication seminar held for pharmacy students and open to the public. The hope of the seminar is the students and the general public can get knowledge about the manufacture of soap, cosmetic business opportunities such as soap and soap product registrations so that the future in West Kalimantan can appear business actors in the field of skin health soap products.Keywords: Soap, Health, Skin, IbM
Evaluation of Peptic Ulcer Medication Use in Patients with Peptic Ulcer at Inpatient Installation RSUD Sultan Syarif Mohamad Alkadrie Novi Yana Santika; Rise Desnita; Muhammad Akib Yuswar
Majalah Farmaseutik Vol 15 No 1, (2019)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (458.011 KB) | DOI: 10.22146/farmaseutik.v15i1.45261

Abstract

Peptic ulcer is an upper gastrointestinal tract disease caused by hypersecretion of acids and pepsin of gastric mucosa. Peptic ulcer disease can be caused by several factors such as smoking, fast food, alcoholic beverages, NSAIDs and Helycobacter pylori. The purpose of this research was to obtain the distribution of antiulcer and itsrationality on peptic ulcer inpatients at the RSUD Sultan Syarif Mohamad Alkadrie Pontianak. This study is a descriptive observational study with cross sectional design. Data from medical record collected retrospectively.  This research using medical record peptic ulcer inpatients from January to December in 2017. The samples used were 34 of 44 patients who met  the  inclusion criteria. Based on results, the distribution of anti ulcer were omeprazole (2.94%), pantoprazole (73.53%), lansoprazole (26.47%), ranitidine 5.89%, 58.82% antacids and 85.29% sucralfat. The result of rationality evaluation on criteriaof appropriate indication (100%);appropriate drug (55.88%); appropriate patient (97.06%); and appropriate (61.76%). Overall,the rationality of treatment that meets all four rational treatment criterias was 78.68%.
Pengaruh pH Terhadap Stabilitas Alpha Arbutin dalam Gel Niosom Dea Pertiwi; Rise Desnita; Sri Luliana
Majalah Farmaseutik Vol 16, No 1 (2020)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (362.347 KB) | DOI: 10.22146/farmaseutik.v16i1.49446

Abstract

Alpha arbutin merupakan salah satu agen pencerah kulit yang terdegradasi dalam sediaan larutan pada pH kurang dari 3,0 dan pH lebih dari 6,5. Sistem penghantaran niosom dapat meningkatkan stabilitas alpha arbutin dalam sediaan gel. Penelitian ini bertujuan untuk mengetahui pengaruh pH terhadap stabilitas gel niosom alpha arbutin. Uji stabilitas dilakukan menggunakan formulasi gel alpha arbutin dan gel niosom alpha arbutin yang dibuat dalam pH sediaan 6, 7 dan 8 selama 28 hari. Pengukuran kadar alpha arbutin menggunakan spektrofotometer UV-Vis. Hasil penelitian menunjukkan waktu kadaluarsa gel alpha arbutin dengan sistem niosom lebih lama dibandingkan tanpa sistem niosom pada setiap pH. Sediaan gel niosom alpha arbutin dan gel alpha arbutin pada pH 7 memiliki kestabilan lebih baik daripada sediaan gel pH 6 dan 8. Gel niosom alpha arbutin dan gel alpha arbutin pada pH 7 tidak mengalami perubahan organoleptis selama penyimpanan 28 hari. Hasil uji analisis Independent-Sampel T Test dengan nilai p<0,05 menunjukkan pada pH 7 berbeda signifikan antara formula gel alpha arbutin dan gel niosom alpha arbutin. Waktu kadaluarsa sediaan gel alpha arbutin pH 7 dengan sistem niosom dan tanpa sistem niosom masing-masing selama 24 hari dan 14 hari. Kesimpulannya adalah sistem niosom dapat meningkatkan stabilitas alpha arbutin pada rentang pH yang diteliti. 
Formulasi Sediaan Losio Ekstrak Etanol Meniran (Phyllanthus niruri L.) Sebagai Penumbuh Rambut Terhadap Tikus Putih (Rattus norvegicus) Jantan Galur Wistar Luliana, Sri; Desnita, Rise; Sehro,
Pharmaceutical Sciences and Research Vol. 6, No. 1
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Meniran (Phyllanthus niruri L.) is a plant used to promote hair growth. In this research, ethanolic extract of P.niruri was formulated into lotion because it was more evenly distributed and non sticky in use compared to cream and gel. The aims of this research is to determine the hair growth activity of the ethanolic extract of P.niruri and the effect of using menthol 1% as an enhancer in lotion formulation. In this research two formula were being tested where Formula I (F1) without menthol 1% and Formula II (F2) with menthol 1%. The 5% of extract was being used in the formulation. The lotion was applied to the rats skin and the hair length was measured on day 7, 14 and 21, while the hair weight was measured on day 21. The results showed that the average hair length on F2 (12.68 3.13 mm) was longer than the F1 (11.21 2.58 mm) although there was no significant difference between both formulas. The average hair weight on F2 (23.00 10.74 mg) was greater that the F1 which was only 15.83 6.11 mg. Both formulas have a longer hair growth activity compared to normal controls (10.74 0.86 mm). It can be concluded that the lotion of ethanolic extract of P. niruri could promote hair growth in white wistar rats and the addition of 1% menthol as an enhancer gave better hair growth activity in F2 group.
Evaluasi Kesesuaian Dosis pada Pasien Pediatri Bronkitis Akut di Rumah Sakit Tentara Kartika Husada Kubu Raya Kharis, Variandini Aldhila; Desnita, Rise; IH, Hariyanto
Pharmaceutical Sciences and Research Vol. 4, No. 2
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Selection and usage of rational drugs determine the success of expected therapeutic effect, especially for pediatrics. Acute bronchitis in pediatrics is one of the highest incidents of Acute Respiratory Infection (ARI) in Army Hospital Kartika Husada Kubu Raya. This study aimed to evaluate rationality of drug doses conformity in outpatient pediatric acute bronchitis in Army Hospital Kartika Husada Kubu Raya on 2015. This research was a descriptive observational research with cross-sectional design. The sample was taken with purposive sampling amounted to 36 prescriptions. Then the evaluation of drug doses conformity was counted according to the literature. The results showed that drugs which were used for acute bronchitis were mucolitics and expectorants, antibiotics, bronchodilators, multivitamins, decongestans, analgesics, and antihistamins. The result of drug dosage conformity evaluation showed that the under-dose drug item (R/) was 51%, over-dose was 15% and appropriate dose was 34%.
FORMULATIONS AND PHYSICAL STABILITY TEST OF OLIVE OIL (Olea europaea L.) LIP BALM WITH ILLIPE BUTTER Rise Desnita; Desy Siska Anastasia; Mutiara Dinda Putri
Jurnal Farmasi Sains dan Praktis Vol 8 No 1 (January-April 2022)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v8i1.4977

Abstract

Lip balm is a preparation that is applied on the lips to protect the lips from damage. Olive oil is an oil that has emollient properties that are able to maintain moisture, flexibility, and smoothness in the skin. Oleic acid content in olive oil has the ability to improve skin permeability. Tengkawang fat is known to have characteristics similar to cocoa fat so it is used as a base. This study will provide an overview of the physical properties of olive oil lip balm (olive oil) with tengkawang fat based on storage for 28 days. Lip balm preparations are made in three concentration variations for 10%, 15%, and 20%, Then the preparation will be observed organoleptically changes, homogeneity of the preparation, pH and temperature of the melting point. The results ANOVA test of pH showed there was no significant difference between storage time to pH for each formula. Organoleptic and homogeneity test show good results in the absence of discoloration, odor, and texture and homogeneity during the storage period. The evaluation of lip balm preparations for each formula showed that the preparations were physically stable during the 28-day storage period.
REVIEW : FORMULASI DAN EVALUASI SEDIAAN LIP GLOSS: EVIEW: LIP GLOSS FORMULATION AND EVALUATION Desy Siska Anastasia; Rise Desnita
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 2 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i2.644

Abstract

Bibir memiliki sifat yang lebih peka dibandingkan bagian kulit yang lain sehingga pemilihanbahan yang digunakan untuk sediaan kosmetik bibir harus tepat. Komposisi bahan dalam suatuformula lip gloss sangat menentukan tekstur sediaan yang dihasilkan. Sediaan lip gloss yangbaik yaitu semipadat, tidak terlalu keras, tidak lembek dan tidak berminyak. Review jurnalformulasi lip gloss ini bertujuan untuk memberikan gambaran formula dari sediaan lip gloss,bahan tambahan beserta informasi konsentrasinya. Penyusunan review jurnal dilakukandengan menelusuri pustaka yang berasal dari jurnal nasional dan internasional melalui Googlescholar dan Pubmed menggunakan kata kunci “lip gloss”AND”formulasi”, “lip gloss”AND”formulation” dengan rentang tahun publikasi 2012-2022. Hasil pencarian awaldiperoleh 51 artikel lalu ditemukan ada 4 artikel yang sama sehingga tersisa 47 artikel. Hasilskrining berdasarkan kriteria eksklusi dan inklusi diperoleh sebanyak 9 artikel yang layakdireview. Berdasarkan studi literatur yang telah dilakukan formula sediaan lip gloss terdiri atascampuran lilin atau wax, lemak, minyak, beserta bahan tambahan seperti pengawet, humektan,antioksidan, pewarna, pengaroma dan zat penyerap uv. Konsentrasi bahan berbentuk cairseperti minyak jarak, parafin cair dalam formula lip gloss lebih besar dibandingkan bahanpadatan seperti wax dan bahan semisolid seperti lanolin dan vaselin. Bahan yang paling seringdigunakan dalam formula lip gloss, ialah bees wax atau cera alba 3%, minyak jarak, lanolin10%, parrafin liquid 10%. Kata kunci : Lip gloss, formula, formulasi, bahan tambahan