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All Journal Jurnal Mahasiswa Farmasi Fakultas Kedokteran dan Ilmu Kesehatan UNTAN Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Pharmaceutical Science and Technology Majalah Obat Tradisional Science and Technology Indonesia Majalah Farmaseutik BULETIN AL-RIBAATH Jurnal Ilmu Kefarmasian Indonesia Journal Syifa Sciences and Clinical Research (JSSCR) Sasambo Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian Pharmaceutical Sciences and Research (PSR) Jurnal Farmasi Sains dan Praktis Medical Sains : Jurnal Ilmiah Kefarmasian Journal Pharmacy of Tanjungpura
Rise Desnita, Rise
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health

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REVIEW : FORMULASI DAN EVALUASI SEDIAAN LIP GLOSS: EVIEW: LIP GLOSS FORMULATION AND EVALUATION Desy Siska Anastasia; Rise Desnita
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 2 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i2.644

Abstract

Bibir memiliki sifat yang lebih peka dibandingkan bagian kulit yang lain sehingga pemilihanbahan yang digunakan untuk sediaan kosmetik bibir harus tepat. Komposisi bahan dalam suatuformula lip gloss sangat menentukan tekstur sediaan yang dihasilkan. Sediaan lip gloss yangbaik yaitu semipadat, tidak terlalu keras, tidak lembek dan tidak berminyak. Review jurnalformulasi lip gloss ini bertujuan untuk memberikan gambaran formula dari sediaan lip gloss,bahan tambahan beserta informasi konsentrasinya. Penyusunan review jurnal dilakukandengan menelusuri pustaka yang berasal dari jurnal nasional dan internasional melalui Googlescholar dan Pubmed menggunakan kata kunci “lip gloss”AND”formulasi”, “lip gloss”AND”formulation” dengan rentang tahun publikasi 2012-2022. Hasil pencarian awaldiperoleh 51 artikel lalu ditemukan ada 4 artikel yang sama sehingga tersisa 47 artikel. Hasilskrining berdasarkan kriteria eksklusi dan inklusi diperoleh sebanyak 9 artikel yang layakdireview. Berdasarkan studi literatur yang telah dilakukan formula sediaan lip gloss terdiri atascampuran lilin atau wax, lemak, minyak, beserta bahan tambahan seperti pengawet, humektan,antioksidan, pewarna, pengaroma dan zat penyerap uv. Konsentrasi bahan berbentuk cairseperti minyak jarak, parafin cair dalam formula lip gloss lebih besar dibandingkan bahanpadatan seperti wax dan bahan semisolid seperti lanolin dan vaselin. Bahan yang paling seringdigunakan dalam formula lip gloss, ialah bees wax atau cera alba 3%, minyak jarak, lanolin10%, parrafin liquid 10%. Kata kunci : Lip gloss, formula, formulasi, bahan tambahan
Improving the in vitro penetration of niacinamide using span 60-based niosomal system in gel formulation Desnita, Rise; Luliana, Sri; Kasim, Zainab
Pharmaciana Vol. 8 No. 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v8i2.7696

Abstract

Niacinamide is one of the components of cosmeceutical products that reported to have skin benefits for the treatment of skin pigmentation, acne and wrinkles. However, the dermal penetration of niacinamide is poor. The carrier system which can be selected to carry the compound through the stratum corneum layer is the niosome system using span 60. This study was aimed to determine the concentration of span 60 that can trap niacinamide optimally and the ability of niosome system span 60 to increase in vitro penetration of niacinamide in gel formulation. The different formulations of nicotinamide niosome were formulated with variance concentrations of Span 60, that is, formula A 100 μmol, formula B 150 μmol, and formula C 200 μmol. The entrapment efficiency testing was conducted using dialysis membrane. The gel formulation was prepared in two formulas, niacinamide niosome gel and niacinamide gel (without niosomes) and tested diffusion using Franz diffusion cell flow-through type. The result show that Formula A provides the most optimum entrapment efficiency of 99.03±0.026%. The results of the in vitro skin penetration studies for 8 hours indicate that the niosomal formulation using Span 60 could increase skin penetration with the percent cumulative amount of niacinamide niosomes was 82.87±1.6932% compared to niacinamide in gel without noisome system about 70.27±5,3212%.
Development and Validation of the RP-HPLC Method for Dexamethasone Sodium Phosphate Determination in Nasal Chitosan Microsphere Preparations Desnita, Rise; Noviana, Eka; Zai, Khadijah; Sulaiman, Teuku Nanda Saifullah
Science and Technology Indonesia Vol. 10 No. 1 (2025): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.1.165-172

Abstract

The purpose of this work was to provide a robust, sensitive, accurate, and straightforward analytical method for measuring dexamethasone sodium phosphate (DSP) in chitosan microspheres preparedn using the spray drying method. DSP was quantitatively analyzed using RP-HPLC with an ultraviolet detector at 254 nm, a mobile phase that contained a mixture of acetonitrile and 0.1% sodium dihydrogen phosphate monohydrate (50:50) operating isocratically at a flow rate of 1.0 mL/min, and a stationary phase that was a C18 PrincetonSPHER-100 C18-QB 100A HPLC Column (250 × 4.6 mm, 5 um). The ICH recommendations were followed in the validation of the analytical method. DSP had a retention duration of 2.899 minutes and a tailing factor of 0.827. The RP-HPLC method was linear (R = 0.9992) in the 15-60 ug/mL concentration range. The limits of quantitation (LOQ) and detection (LOD) were 4.425 ug/mL and 1.327 ug/mL, respectively. The relative standard deviations for the intra-day and inter-day precisions were 0.057-0.876% and 0.780-0.949%, respectively. The recovery percentages at 50, 100, and 200% concentration levels were within the 99.269-100.980% range. The validated method has been successfully applied to determine DSP entrapment efficiency in chitosan microspheres. A linear, sensitive, accurate, precise, and robust technique of determining DSP in chitosan microsphere preparations is offered by the established RP-HPLC method.
The effect of sodium metabisulfite concentration on the physicochemical stability of an L-Ascorbic Acid face mist formulation Siska Anastasia, Desy; Desnita, Rise; Yuswar, Muhammad Akib; Halim, Clara Maretta
Sasambo Journal of Pharmacy Vol. 6 No. 2 (2025): September
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/sjp.v6i2.623

Abstract

Face mist is a cosmetic that is included in skin fresheners, is more practical to use, and has the potential to add antioxidants. Vitamin C is one source of antioxidants. Although water-soluble, vitamin C is an antioxidant that oxidizes readily. Sodium metabisulfite must be added to prevent oxidized vitamin C from becoming unstable. Topical treatments containing 0.01–1.0% sodium metabisulfite act as antioxidants. Therefore, a face mist preparation was made with variations in the concentration of sodium metabisulfite, namely 0.25%, 0.5%, and 1%. This study aims to see an increase in the stability of vitamin C face mist preparations with an increase in the concentration of sodium metabisulfite through physicochemical stability testing under real-time storage conditions for 28 days. The parameters to be observed in the stability test include organoleptic test, pH, specific weight, viscosity, and vitamin C levels. The F1 formula with the smallest concentration of sodium metabisulfite (0.25%) has been able to maintain the stability of vitamin C face mist preparations for 28 days of storage
INNOVATIVE DEVELOPMENTS IN AMLODIPINE DRUG DELIVERY SYSTEMS: A COMPREHENSIVE LITERATURE REVIEW Desnita, Rise
Journal Pharmacy Of Tanjungpura Vol 3, No 1 (2025): Oktober
Publisher : Universitas Tanjungpura

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Amlodipine is a dihydropyridine calcium channel antagonist massively prescribed in the management of hypertension and angina with favorable pharmacokinetics characterized by a long elimination half-life. Challenges associated with conventional formulations include dose-dependent side effects, specific patient populations, and therapeutic potential that has not been harnessed. Recent studies have led to a paradigm shift from merely enhancing basic bioavailability to optimizing pharmacokinetics, reducing side effects, and enabling the direct delivery of treatment to where it is needed. Some attempts have been made to use orodispersible tablets (ODTs) for improved patient compliance, as well as inclusion complexes and solid dispersions, among others, in nanotechnology systems, including nanostructured lipid carriers (NLCs), nanoemulsions, and nanodiamonds. Nanoemulsions showed an increase in oral bioavailability (475%) with heart targeting, while nanodiamonds discovered a pathway to the brain delivery of amlodipine for neuroprotective applications. Floating microspheres prepared have proved controlled release over 20 hours. Conventional formulations are still very attractive; however, the new drug delivery systems can optimize therapy, improve comfort and compliance of patients, and enhance the clinical scope amidst vast potential. Such development of nanoemulsions for better bioavailability, besides further clinical validation regarding trials on humans about safety and efficacy, constitutes one of the main recommendations.
Co-Authors ., Saraswati Anastasia, Desy Siska Anggraini, Silvana Anugrah, Gusti Alfi Apridamayanti, Pratiwi Arianda, Muhammad Fikri Arief Nurrochmad Dea Pertiwi Dean Vuai, Felix Ryan Eka Kartika Untari Eka Noviana Hairunnisa, Syarifah Halim, Clara Maretta Hariyanto IH Herlina, Tutun Isnindar Isnindar Kasim, Zainab kasim, zainab Kurniawan, Uray Sandy Luliana, Sri Mariasy, Henny Muhammad Akib Yuswar Mutiara Dinda Putri Nera Umilia Purwanti, Nera Umilia Nora Nurlina Sinaga Novi Yana Santika Nur Atikah Oktavia, Ayu Diah Pratiwi Apridamayanti Putri, Mutiara Dinda Ronny Martien Salim, Suaina Sari, Putri Kemala Sehro Sehro Sehro, Silvana Anggraini Siska Anastasia, Desy Sulaiman, Teuku Nanda Saifullah Tamara, Olivia Utia Mufliha Variandini Aldhila Kharis Variandini Aldhila Kharis, Variandini Aldhila VENI LESTIAWATI Yuswar, Muhammad Akib zai, Khadijah Zainab Kasim