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All Journal Majalah Obat Tradisional Jurnal Surya Medika Jurnal Peduli Masyarakat Jurnal Farmasi dan Sains Indonesia (JFSI) Journal of Innovation Research and Knowledge International Journal of Health and Pharmaceutical (IJHP) Journal of Pharmaceutical and Sciences. Inovasi Jurnal Pengabdian Masyarakat (IJPM) Jurnal Riset Ilmu Kesehatan Umum dan Farmasi GEMASSIKA: Jurnal Pengabdian kepada Masyarakat Awal Bros Journal of Community Development Science and Community Pharmacy Journal Jejak digital: Jurnal Ilmiah Multidisiplin Jurnal Kesehatan (JK)
Silvy Aldila
Universitas Telogorejo Semarang
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Penyuluhan DAGUSIBU dan Pengumpulan Sampah Obat Rumah Tangga Warga Kelurahan Miroto Kota Semarang Gloria, Fransisca; Adrianto, Madyo; Alfiyaturrakhma, Untsa; Santoso, Rizky Budi; Maharani, Putri; Aldila, Silvy; Nurainy, Farah Destyana; Hardiyati, Siti Farah; Arini, Yovita Dwi; Dahliyanti, Novita Dwi
Inovasi Jurnal Pengabdian Masyarakat Vol 3 No 3 (2025): IJPM - Desember 2025
Publisher : CV Firmos

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54082/ijpm.1078

Abstract

Pengetahuan mengenai obat merupakan suatu hal yang wajib dimiliki oleh masyarakat. Hasil observasi dengan wawancara masyarakat di wilayah Kelurahan Miroto Semarang, diperoleh keterangan bahwa masyarakat belum memahami pentingnya untuk mengetahui batas kedaluwarsa obat (Expired Date/ED), periode setelah kemasan obat dibuka (Period After Opening/PAO), serta batas penggunaan obat yang sudah diracik (Beyond Use Date/BUD). Kondisi ini menunjukkan masih rendahnya kesadaran masyarakat terhadap aspek keamanan penggunaan obat di rumah tangga sehingga perlu adanya edukasi kepada masyarakat melalui program DAGUSIBU (Dapatkan, Gunakan, Simpan, dan Buang). Tujuan dari DAGUSIBU adalah untuk meningkatkan pemikiran dan kesadaran masyarakat tentang cara yang tepat untuk menggunakan obat dan pengumpulan sampah obat di rumah tangga. DAGUSIBU adalah sebuah program yang dipelopori oleh Ikatan Apoteker Indonesia (IAI) untuk meningkatkan kesadaran penggunaan obat. Program ini dilakukan di kelurahan Miroto Semarang pada bulan Oktober 2024. Kegiatan ini dilakukan dengan memberikan penyuluhan/edukasi tentang DAGUSIBU yang baik dan benar serta pengumpulan sampah obat di rumah tangga dan diskusi tanya jawab pada akhir kegiatan. Dari kegiatan tersebut didapatkan bahwa masyarakat meningkat pemahamannya terkait dengan DAGUSIBU dan dapat mengumpulkan sampah obat berdasarkan nama obat, bentuk sediaan, dan jumlahnya
PENGARUH KONSENTRASI GELLING AGENT CARBOMER 940 TERHADAP KARAKTERISTIK FISIK ORABASE EMULGEL NISTATIN Censa Lumayung; Silvy Aldila, Ummi Kalsum, Tunik Saptawati
Jurnal Kesehatan Vol. 1 No. 10 (2024): Jurnal Kesehatan (JK)
Publisher : CV. Adiba Aisha Amira

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Abstract

Nystatin is the first line drug for oral candidiasis which is very difficult to dissolve in water. The Orabase Emulgel dosage form has good drug delivery capacity, as gel formulations generally provide faster drug release compared to ointments and creams. Gelling agent components play a role in determining the physical characteristics and permeability of emulgel. The type of gelling agent that will be used is carbomer 940 because it is a strong mucoadhesive. Nystatin is formulated in the form of orabase emulgel with 3 concentrations of carbomer 940, namely F1 (0.5%), F2 (1%), and F3 (2%). The physical characteristics of the preparations observed were organoleptic, homogeneity, pH, emulgel type, viscosity, adhesive power, spreadability, protective power and washability, and stability was tested. The results of the orabase emulgel nystatin preparation on physical characteristics using the MANOVA test (p<0.05) had an effect on pH, viscosity, spreadability and protective power.
Optimization of Labrasol and Tween 80 in Self Nano-Emulsiying Drug Delivery System (SNEDDS) Mefenamic Acid Using The Simplex Lattice Design Method Silvy Aldila; Anifatus Sa’adah; Valentina Girsang; Farah Destyana Nurainy; Ummi Kalsum; Rossalina Nurul Agustin; Novita Dwi Dahliyanti
International Journal of Health and Pharmaceutical (IJHP) Vol. 6 No. 2 (2026): May 2026
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v6i2.608

Abstract

Mefenamic acid is a derivative of anthranilic acid that functions as a nonsteroidal anti-inflammatory drug (NSAID), antipyretic, and analgesic. Mefenamic acid is included in the Biopharmaceutical Classification System (BCS) class II which has low solubility and high permeability. The manufacture of SNEDDS requires a non-ionic surfactant with an HLB (Hydrophilic-Lipophilic Balance) value of more than 10. Mefenamic acid has high solubility in the surfactant Labrasol which has HLB 12 and Tween 80 which has HLB 15. This study aims to develop mefenamic acid into a Self Nano-Emulsifying Drug Delivery System (SNEDDS) with the optimization of labrasol and tween 80 as surfactants. The optimization of mefenamic acid SNEDDS is made using the simplex lattice design method. In the optimization, 6 running SNEDDS formulas were obtained with mefenamic acid. Chemical physics testing includes organoleptic evaluation, pH, viscosity, percent of transmitters, emulsification time, stability, particle size, potential zeta, and level determination. The results showed that the optimal combination of labrasol and tweenat SNEDDS mefenamic acid 80, namely 24% Labrasol and 1% Tween 80, with a desirability value of 0.984, had a clear, non-rancid, homogeneous, liquid-shaped color, pH of 4.69, viscosity 31.33 cP, transmitter percentage 96.80%, emulsification time 29.11 seconds, particle size 44.30 nm, zeta potential -28.87 mV, and a polydispersivity index of 0.563, with a percentage of levels of 100.08%, 100.70%, and 99.87%, respectively. Key words: Self Nano-Emulsifying Drug Delivery System (SNEDDS), Labrasol, Tween 80
Optimasi Minyak Atsiri Daun Nilam (Pogostemon cablin Benth) dan Minyak Atsiri Daun Sereh Wangi (Cymbopogon nardus L) sebagai Antibakteri Staphylococcus aureus pada Masker Gel Peel-Off Vinca Yustisia Maharani; Anifatus Sa’adah; Silvy Aldila
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 3 No. 4 (2025): Oktober : Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v3i4.889

Abstract

Acne is a disease that is of particular concern among teenagers and adults. Acne appears due to excessive activity of the oil glands and is made worse by infection with the Staphylococcus aureus bacteria. This problem can be overcome by using a combination of essential oils in a peel off gel mask which can inhibit Staphylococcus aureus bacteria. Purpose: : to analyze the optimum combination of essential oils, information on their physical characteristics and their ability to inhibit Staphylococcus aureus. Method: Simplex Lattice Design in Design Expert version 13.0, disk diffusion method, and Follin Ciaocelteau's Reagent (RFC) method. Results: The essential oils of patchouli and citronella leaves contain alkaloid, flavonoid, terpenoid and phenolic compounds, as well as patchouli alcohol, citronellal, genariol and citronellal which hav have the ability to inhibit Staphylococcus aureus bacteria with a very strong classification of 31.88 ± 2.74 mm, the total phenolic content values were 21.35 ± 0.15 mgGAE/g and 20.86 ± 0.04 mgGAE/g. In the SLD, the optimum combination is found to be 9.932%:10.068% with a desirability value of 0.976. Conclusion: The optimum formula is 9.932%:10.068% with a desirability value of 0.976. The optimum combination of patchouli essential oil and citronella has an influence on inhibitory power, spreadability, viscosity, pH, and dry time.
EFEKTIVITAS PENYEMBUHAN LUKA SAYAT SALEP TAMANU OIL (CALOPHYLLUM INOPHYLLUM L.) Madyo Adrianto; Silvy Aldila; Gilang Rizki Al Farizi; Viony Naulita Sidauruk
Journal of Innovation Research and Knowledge Vol. 5 No. 8 (2026): Januari 2026
Publisher : Bajang Institute

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Abstract

Luka sayat merupakan cedera kulit yang memerlukan terapi topikal untuk mempercepat penyembuhan dan mencegah infeksi. Tamanu oil (Calophyllum inophyllum L.) mengandung asam oleat dan asam linoleat yang berperan dalam regenerasi jaringan, sehingga berpotensi sebagai terapi alternatif penyembuhan luka. Penelitian ini bertujuan mengetahui efektivitas salep tamanu oil terhadap penyembuhan luka sayat pada mencit putih jantan (Mus musculus). Sebanyak 20 ekor mencit dibagi menjadi lima kelompok: kontrol negatif (basis salep), kontrol positif (povidone iodine 10%), serta salep tamanu oil dengan konsentrasi 10%, 15%, dan 20%. Evaluasi meliputi uji organoleptik, homogenitas, pH, viskositas, daya sebar, daya lekat, dan stabilitas. Analisis menggunakan One-Way ANOVA dan uji Post Hoc Duncan menunjukkan adanya perbedaan signifikan antar kelompok (p<0,05), dengan formula tamanu oil (F1, F2, F3) berada pada subset yang sama dengan kontrol positif. Hasil ini menunjukkan bahwa salep tamanu oil konsentrasi 10%, 15%, dan 20% efektif dalam mempercepat penyembuhan luka sayat pada mencit putih jantan.
Determination of Caffeine Content in Green Coffea liberica Beans by UV–Visible Spectrophotometry and Evaluation of Its Effect on Weight Reduction Danik Sulistyoningsih; Firstca Aulia Rachma; Silvy Aldila; Suksi Riani; Winnie Kristiyanti; Recta Syifa Dwimart
Jejak digital: Jurnal Ilmiah Multidisiplin Vol. 2 No. 5 (2026): AGUSTUS-SEPTEMBER
Publisher : INDO PUBLISHING

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63822/6zgx4v30

Abstract

Background: Green coffee beans (Coffea liberica) are a rich source of bioactive compounds, including caffeine, chlorogenic acid, flavonoids, and polyphenols, which have potential health-promoting properties. Caffeine has been reported to enhance thermogenesis, stimulate fat oxidation, and increase energy expenditure, making it a promising natural compound for weight management. This study aimed to determine the caffeine content of green Coffea liberica beans using UV–Visible spectrophotometry and to evaluate the implementation of green coffee extract consumption on body weight reduction. Methods: An experimental study was conducted by extracting green coffee beans with 96% ethanol followed by phytochemical screening and quantitative determination of caffeine using UV–Visible spectrophotometry at a maximum wavelength of 272 nm. The analytical method was validated by assessing linearity, accuracy, and precision. A one-group pretest–posttest design was employed to evaluate the implementation of green coffee extract in overweight adults with a body mass index (BMI) ≥25 kg/m². Body weight was measured before and after the intervention, and statistical analysis was performed at a 95% confidence level. Results: The spectrophotometric method demonstrated satisfactory linearity, accuracy, and precision, indicating its suitability for caffeine determination. Green Coffea liberica beans were confirmed to contain caffeine and other bioactive compounds that contribute to antioxidant activity. Consumption of green coffee extract showed a tendency to reduce body weight following the intervention period. Conclusion: UV–Visible spectrophotometry is a reliable method for determining caffeine content in green Coffea liberica beans. The presence of caffeine and other bioactive compounds supports the potential application of green Liberica coffee as a functional food ingredient for weight management.
Formulation and In Vitro Antibacterial Activity of Limonia acidissima Bark Patch against C.acnes and S.epidermidis Valentina Girsang; Anak Agung Pradnya Paramitha Vidiani; Anisa Devi Kharisma Wibowo; Silvy Aldila
Majalah Obat Tradisional Vol 31, No 2 (2026)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.109141

Abstract

Acne vulgaris is a common skin disorder, particularly among adolescents, often caused by the bacteria Cutibacterium acnes and Staphylococcus epidermidis. Antibiotic resistance in acne treatment necessitates the development of natural-based alternatives. This study aims to formulate and evaluate the antibacterial activity of acne patches based on kawista bark extract (Limonia acidissima L.) at varying concentrations of 25%, 50%, and 75%. Extraction was performed by maceration using 96% ethanol, and patches were formulated with a combination of HPMC and PVP polymers. Physical property tests included organoleptic evaluation, weight uniformity, drying shrinkage, thickness, folding endurance, and pH. Antibacterial activity was tested using the diffusion method against Cutibacterium acnes and Staphylococcus epidermidis. Results showed that all formulations met good physical patch standards, being : homogeneous, stable, thickness less than 1 mm, folding endurance greater than 300 times, and pH of 6. Antibacterial activity increased with higher extract concentration, with the largest inhibition zones observed at 75% concentration (15.16 mm for C. acnes and 18.05 mm for S. epidermidis), approaching the effectiveness of the positive control (clindamycin 10%). This study demonstrates that kawista bark extract acne patches have potential as an alternative topical acne therapy with strong antibacterial activity and physical characteristics that meet modern patch preparation standards.
Co-Authors Alfiyaturrakhma, Untsa Anak Agung Pradnya Paramitha Vidiani Anifatus Sa’adah Anifatus Sa’adah Anisa Devi Kharisma Wibowo Arini, Yovita Dwi Ariyani, Destiana Putri Bunga Eloystina, Laurencia Julia Censa Lumayung Dahliyanti, Novita Dwi Danik Sulistyoningsih Desi Soraya Farah Destyana Nurainy Firstca Aulia Rachma Gilang Rizki Al Farizi Gloria, Fransisca Hardiyati, Siti Farah Madyo Adrianto Maharai, Daniel Mianti Nurrizky Ni Made Ayu Wulansari Novita Dwi Dahliyanti Nurainy, Farah Destyana Nurhanifah, Tia Nurwidianingsih, Silvia Puruhita, Ranatri Putri Maharani Rahmawati, Ina Sonia Recta Syifa Dwimart Rissa Maharani Dewi Rizky Budi Santoso Rossalina Nurul Agustin Sa'adah, Anifatus Saadah , Anifatus Sa’adah, Anifatus Suksi Riani Suksi Riani Tri, Elin Tunik Saptawati Uliana, Syahkhirotul Exma Ummi Kalsum Ummi Kalsum Valentina Girsang Veronica Bellacaesa Vinca Yustisia Maharani Viony Naulita Sidauruk Winnie Kristiyanti