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Journal : International Journal of Health and Pharmaceutical (IJHP)

Test The Growth Process of Hair Follicles by Administering Coconut and Candlenut Oil to The Entire Back of White Rats (Rattus Norvegicus) Of the Wistar Strain Mulan, Mulan; Hendrianto, Hendrianto; Ferdinand, Sahna
International Journal of Health and Pharmaceutical (IJHP) Vol. 4 No. 3 (2024): August 2024
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v3i4.309

Abstract

Hair serves a variety of purposes, including thermoregulation and protection. Hair regulates temperature in nonhuman animals, including primates, by holding heat or preventing cold. Hair can also be used for disguise and as a sexual attractant. Human hair is thinner and lighter than that of primates. The purpose of this study was to determine and test the efficacy of providing a coconut oil and candlenut oil mixture in the process of hair development in Wistar rats (Rattus norvegicus). The study's findings indicate that a combination containing 80% coconut oil and 20% candlenut oil is the most efficient in stimulating hair development in white rats (Rattus norvegicus) of the Wistar strain. This hair growth acceleration is possible because coconut oil contains a high concentration, precisely 80%. Because coconut has a high amount of lauric acid, it has numerous health benefits, including good hair.
The Concordance of Physical Examination and Radiological Examination With Histopathological Findings In Breast Cancer Patients Kharen, Kharen; Hendrianto, Hendrianto
International Journal of Health and Pharmaceutical (IJHP) Vol. 5 No. 4 (2025): November 2025
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v5i4.466

Abstract

Breast cancer is a malignancy arising from the mammary glands and is the most common cancer found in women. The diagnosis of breast cancer is established using the triple assessment method, which involves physical examination, radiological assessment, and histopathological examination of the breast. This study aims to determine the concordance between physical and radiological examinations with histopathology, which serves as the gold standard. The study utilized an observational analytic cross-sectional design, gathering data from the medical records of breast cancer patients at Royal Prima General Hospital and Dr. Pirngadi General Hospital in Medan. Statistical testing using Chi-Square showed no significant concordance between physical examination and histopathological examination (p>0.05). The radiological examination, however, showed significant concordance but with a negative correlation, suggesting that a higher histopathological grade is associated with a lower BI-RADS level (r=-0.189; p=0.039). Radiological examination demonstrated better concordance with histopathology compared to the physical examination, but it still cannot replace the role of histopathology as the gold standard for breast cancer diagnosis.
The Relationship Between Hormonal Contraceptive Use and Breast Cancer Incidence at Dr. Pirngadi Regional General Hospital, Medan Aqilatul Hanisah, Filzah; Hendrianto, Hendrianto
International Journal of Health and Pharmaceutical (IJHP) Vol. 5 No. 4 (2025): November 2025
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v5i4.497

Abstract

Breast cancer remains a significant public health concern in Indonesia, with emerging evidence suggesting that hormonal contraceptive type influences not only cancer incidence but also tumor aggressiveness. This cross-sectional study examined the relationship between hormonal contraceptive formulations and histopathological grading of breast cancer at RSUD Dr. Pirngadi Hospital, Medan. The study included 100 women with confirmed invasive breast cancer who were selected using the Lemeshow formula for sample size calculation. A structured data extraction form collected information on contraceptive type, duration of use, and Nottingham grading classification. Fisher's Exact Test and chi-square test analyzed associations between contraceptive types and grading categories. Results demonstrated that oral pill users predominantly developed well-differentiated cancers (51.7%), while injectable users predominantly developed poorly-differentiated tumors (56.3%), representing a highly significant inverse relationship (p-value = 0.000, OR = 0.105). Moderately-differentiated grading showed no significant association with contraceptive type. These findings indicate that contraceptive formulation substantially influences tumor characteristics beyond cancer occurrence alone. The study's cross-sectional design limits causal inference, and future prospective cohort studies with larger samples and comprehensive molecular characterization are needed. The pronounced predominance of aggressive tumor phenotypes among injectable contraceptive users necessitates more intensive breast cancer screening protocols and improved patient counseling regarding differential cancer risks across contraceptive formulations in Indonesian populations.