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All Journal VALENSI JURNAL KIMIA SAINS DAN APLIKASI Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Biology, Medicine, & Natural Product Chemistry KOVALEN: Jurnal Riset Kimia Jurnal Kesehatan Bakti Tunas Husada JMM (Jurnal Masyarakat Mandiri) Chemistry Indonesian Journal of Chemical Research JFL : Jurnal Farmasi Lampung PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Kreativitas PKM Molekul: Jurnal Ilmiah Kimia Kumawula: Jurnal Pengabdian Kepada Masyarakat Jurnal Ilmiah Farmako Bahari Molekul: Jurnal Ilmiah Kimia Jurnal Pengabdian Masyarakat (Jupemas) Jurnal Kesehatan Bakti Tunas Husada Jurnal Farmasi Galenika
Winda Trisna Wulandari, Winda Trisna
Universitas Bakti Tunas Husada
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Upaya Peningkatan Edukasi terhadap Masyarakat Mengenai Penyakit Infeksi Kulit dan Pengobatan di Desa Limbangan Kec. Wanareja Kab. Cilacap Jawa Tengah Wulandari, Winda Trisna; Rijkiyah, Gina Sheli; Yassinqi, Manita Cenda; Nurfadhilla, Dilla; Muhtar, Muhammad Wildan; Augie, Andrea; Maolana, Ananda
Jurnal Kreativitas Pengabdian Kepada Masyarakat (PKM) Vol 7, No 6 (2024): Volume 7 No 6 2024
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jkpm.v7i6.14600

Abstract

ABSTRAK Penyakit infeksi kulit adalah penyakit kulit yang disebabkan oleh mikroorganisme seperti virus, jamur, bakteri dan parasite. Kulit merupakan pelindung beberapa organ yang ada di dalam tubuh dan bagian tubuh yang cukup sensitive terhadap beberapa penyakit. Penyuluhan yang dilakukan bertujuan untuk meningkatkan pengetahuan dan kepedulian masyarakat Desa Limbangan Kec. Wanareja Kab. Cilacap Jawa Tengah untuk tetap menjaga kebersihan dan lingkungan sekitar serta pengobatan dari penyakit infeksi kulit. Pelaksanaan kegiatan penyuluhan yang dilakukan berupa pemaparan materi dan pre-test serta post-test pemahaman mengenai penyakit infeksi kulit Peserta kegiatan ini adalah masyarakat posyandu lestari 06 Dusun Saungluhur Desa Limbangan. Hasil test sebelum pemaparan materi memiliki nilai rata-rata 75.45 sedangkan setelah pemaparan materi menjadi 96.82. Terdapat perbedaan yang signifikan pengetahuan masyarakat posyanda antara sebelum dan sesudah kegiatan penyuluhan. Penyuluhan menganai pemberian penyakit infeksi kulit memberikan peningkatan pengetahuan masyarakat setempat. Kata Kunci: Penyakit, Kulit, Kesehatan, Penyuluhan  ABSTRACT Skin infections are skin diseases caused by microorganisms such as viruses, fungi, bacteria, and parasites. The skin is a protector of several organs in the body and parts of the body that are quite sensitive to several diseases. Counseling was carried out to increase the knowledge and awareness of the community to maintain cleanliness and the surrounding environment as well as treatment for skin infections. Implementation of counseling activities carried out in the form of presentation of material and an understanding test about skin infections. The test results before the presentation of the material had an average value of 75.45 while after the presentation of the material it became 96.82. There was a significant difference in the community's knowledge between before and after the extension activities. Education regarding the treatment of skin infections provides increased knowledge of the local community. Keywords: Disease, Skin, Health, Counseling
Physicochemical Characterization and Dissolution Enhancement of Mefenamic Acid–Isonicotinamide Crystalline Solid Dispersion Indra Indra; Nurul Apriani; Ade Yeni Aprillia; Winda Trisna Wulandari; Gatut Ari Wardani; Firman Gustaman
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.601-607

Abstract

Poor aqueous solubility limits the bioavailability of non-steroidal anti-inflammatory drugs like mefenamic acid. This study aims to improve the solubility and dissolution of mefenamic acid through crystalline solid dispersions using solvent evaporation and co-grinding techniques with selected co-formers. Solid dispersions were formulated at different drug-to-co-former ratios (1:1, 1:2, and 2:1) and characterized using differential scanning calorimetry, Fourier-transform infrared spectroscopy, and powder X-ray diffraction. DSC results revealed reduced crystallinity, indicated by the disappearance of melting peaks and the appearance of a single glass transition temperature. FTIR analysis confirmed hydrogen bonding between the drug and co-former, while PXRD patterns showed a loss of long-range order, supporting the formation of amorphous phases. Dissolution testing demonstrated a significant increase in drug release, particularly in the 1:2 formulation, which outperformed the pure drug and other ratios. These results confirm that the choice of preparation method and co-former ratio critically influence the performance of solid dispersions. This study provides valuable insights into the design of improved oral formulations for poorly soluble drugs, contributing to the advancement of pharmaceutical technology
Application of Quasi-Emulsion Solvent Diffusion for Spherical Crystallization of Atorvastatin with HPMC E50 Indra Indra; Ria Marliana Tika; Winda Trisna Wulandari
Biology, Medicine, & Natural Product Chemistry Vol 15, No 1 (2026)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2026.151.%p

Abstract

Poor solubility and inadequate flowability of active pharmaceutical ingredients are significant challenges in developing solid oral dosage forms, particularly for BCS Class II drugs such as atorvastatin calcium. This study aimed to improve the micromeritic and dissolution properties of atorvastatin through spherical crystallization using quasi-emulsion solvent diffusion. Methanol was used as a good solvent, dichloromethane as a bridging liquid, water as a poor solvent, and HPMC E50 as a polymeric stabilizer. Spherical agglomerates were prepared and characterized for morphology (SEM); crystallinity (DSC and PXRD); chemical compatibility (FTIR); micromeritic parameters; and dissolution performance. The crystallization process transformed irregular atorvastatin crystals into smooth spherical agglomerates with significantly enhanced flow properties, as evidenced by increased flow rate and improved angle of repose, bulk density, and compressibility index. FTIR analysis confirmed no chemical interaction with HPMC, while PXRD and DSC indicated reduced crystallinity. Dissolution studies showed spherical atorvastatin exhibited superior release, reaching over 80% in 30 minutes, compared with 51% for raw atorvastatin. In conclusion, spherical crystallization effectively improved the physicochemical and micromeritic properties of atorvastatin calcium, offering a promising approach for enhancing its manufacturability and oral bioavailability.
Cegah Dermatitis Sejak Dini melalui Edukasi Kesehatan Kulit Pada Siswa/I SMP N 1 Puspahiang, Kabupaten Tasikmalaya Firman Gustaman; Lusi Nurdianti; Gatut Ari Wardani; Fajar Setiawan; Ade Yeni Aprillia; Ai Rian Julyanti; Widia Primi Annissya; Winda Trisna Wulandari
Jurnal Kreativitas Pengabdian Kepada Masyarakat (PKM) Vol 9, No 6 (2026): Volume 9 Nomor 6 (2026)
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jkpm.v9i6.25692

Abstract

ABSTRAK Dermatitis merupakan salah satu masalah kesehatan kulit yang sering terjadi pada remaja akibat kurangnya pengetahuan serta belum optimalnya penerapan perilaku hidup bersih dan sehat (PHBS). Kegiatan ini bertujuan untuk meningkatkan pengetahuan siswa mengenai pencegahan dermatitis melalui edukasi kesehatan kulit. Metode yang digunakan adalah penyuluhan dengan pendekatan pretest dan posttest pada 35 siswa SMP N 1 Puspahiang. Kegiatan meliputi penyampaian materi terkait jenis, penyebab, gejala, serta pencegahan dermatitis yang dikombinasikan dengan diskusi interaktif. Hasil menunjukkan adanya peningkatan pengetahuan yang signifikan, ditandai dengan peningkatan rata-rata nilai dari 68,83 ± 6,67 menjadi 89,37 ± 6,39 dengan nilai p sebesar 0,026 (p0,05). Edukasi kesehatan kulit terbukti efektif dalam meningkatkan pengetahuan siswa terkait pencegahan dermatitis. Disarankan agar kegiatan edukasi dilakukan secara berkelanjutan dan terintegrasi dengan program PHBS di sekolah. Kata Kunci: Edukasi Kesehatan Kulit, Dermatitis, Siswa, Pengetahuan, PHBS. ABSTRACT Dermatitis is a common skin health problem among adolescents due to limited knowledge and inadequate implementation of clean and healthy lifestyle behaviors (PHBS). This activity aimed to improve students' knowledge regarding dermatitis prevention through skin health education. The method used was counseling with a pretest and posttest approach involving 35 students of SMP N 1 Puspahiang. The activity included delivering materials on types, causes, symptoms, and prevention of dermatitis, followed by interactive discussions. The results showed a significant increase in knowledge, indicated by an increase in the average score from 68.83 ± 6.67 to 89.37 ± 6.39 with a p-value of 0.026 (p0.05). Skin health education is effective in improving students' knowledge regarding dermatitis prevention. It is recommended that such programs be implemented continuously and integrated with school-based PHBS programs. Keywords : skin health education, dermatitis, students, knowledge, PHBS
Co-Authors Ade Putri Suci Lestari Ade Yeni Ade Yeni Aprilia Ade Yeni Apriliani Ade Yeni Aprillia Ade Yeni Aprillia Ai Rian Julyanti Alhikam Nazabullah Alma Meidina Anindita Tri Kusuma Pratita Anna Yuliana, Anna Annissya, Widia Primi Aprillia, Ade Yeni Arya Purba Wasana Augie, Andrea Ayu Geamul Maskur Bagas Pra Ramdani Cahyati, Keni Ida Cucu Nurpatonah Dea Dara Pamungkas Diana Sri Zustika Diana Sri Zustika, Diana Sri Dina Lestari Eka Yuniarti Estin Nofiyanti Estin Nofiyanti Fabillah Kurniadi Fajar Setiawan Fajar Setiawan Fajar Setiawan FAJAR SETIAWAN Fajar Setiawan Febby Pratama Feri Sandria Firman Gustaman Firman Gustaman Firman Gustaman Firman Gustaman Firman Gustaman Firman Gustaman Firmansya, Ardianes Fujianti Putri Nuraisah Gatut Ari Wardani Gatut Ari Wardhani Gina Nur Fitria Mulyana Putri Gustaman, Firman Hanna Nurul Husna Hanna Nurul Husna Hanna Nurul Husna Hisni Nurul Fajri Idacahyati, Keni Indah Alvina Damayanti Indah Cantika Indra Indra Indra Indra Indra, Indra Intan Gita Cahyani Itmam Milataka Julyanti, Ai Rian Keni Ida Cahyani Keni Idacahyati Keni Idacahyati Keni Idacahyati Keni Idacahyati Keni Idacahyati Laras Rizkia Widyastuti Lia Nuramalia Lilis tuslinah Lilis Tuslinah Lilis Tuslinah Lilis Tuslinah Lusi Nurdianti, Lusi Maolana, Ananda Meri Meri Meri, Meri Muhtar, Muhammad Wildan Mulya Tri Sugiharti Nur Laili Dwi Hidayati Nur Rahayuningsih, Nur Nurfadhilla, Dilla Nurfaiza Safitri Nurhidah, Mia Nurmalasari, Anisa Nurul Apriani Nurzaman Raras, Euis Reza Ariza Wildan Ria Marliana Tika Richa Mardianingrum Rijkiyah, Gina Sheli Rizky Nur Alam Rosmaya Dewi Rosmaya Dewi Ruswanto Ruswanto Ruswanto, Ruswanto Silvia Rahmawati Sugiharti, Mulya Tri Syahputra, Ricky Andi Taofik Hidayat Taufik Hidayat Tresna Lestari, Tresna Vera Nurviana Wawan rismawan Wawan Rismawan Widia Primi Annissya Widiyanti Widiyanti Yassinqi, Manita Cenda Zahrotun Naqiah Zain, Dichy Nuryadin Zakia Nurul Izzah