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All Journal Indonesian Journal of Cancer Chemoprevention INDONESIAN JOURNAL OF PHARMACY Journal of Islamic Pharmacy Jurnal Farmasi Sains dan Komunitas Majalah Kesehatan FKUB Journal of Islamic Medicine Biosel: Biologi Science and Education International Journal of Health and Pharmaceutical (IJHP) SEHAT : JURNAL KESEHATAN TERPADU Journal of Tropical Pharmacy and Chemistry
Rahmi Annisa
Universitas Islam Negeri Maulana Malik Ibrahim Malang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Education Energy Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Formulation and Evaluation of Halal Non-Aromatic Moisture and Protection Cream Preparations for Hajj and Umroh Pilgrims Annisa, Rahmi; Anggraini, Wirda; Purwaningsih, Fauziyah Eni; Salsabila, Dhia Fadhilah; Samah, Moh.Alfin; Mutiah, Roihatul
Journal of Islamic Medicine Vol 8, No 2 (2024): JOURNAL OF ISLAMIC MEDICINE EDISI SEPTEMBER 2024
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v8i2.26427

Abstract

Background: Protective moisturizer cream can be used by Hajj and Umrah pilgrims.They can use sunscreen moisturizer cream as a moisturizer and sunscreen to protect their skin from exposure to the sun because it does not contain alcohol or certain fragrances. Objective: This research aims to determine the halalness of ingredients, the presence or absence of aromatic content, the suitability of physical characteristics, and the effectiveness of the SPF value of halal non-aromatic Sunscreen moisturizer cream preparations using pre-experimental design research methods. Methods: The physical characteristics were evaluated, including organoleptic, homogeneity, spreadability, adhesive power, pH, and viscosity. Results: The organoleptic test results show that the Sunscreen moisturizer cream preparation has a yellowish-white color, is scentless, and has a soft texture. Homogeneity testing shows that this preparation is homogeneous. The spreadability test value of the preparation is 6.50 cm; the sticking power value is 3.77 seconds; the pH value is 5.00; the viscosity value is 5.64 cPs. The research results also show that the preparation contains halal ingredients and does not contain fragrances. Halal non-aromatic sunscreen moisturizer cream. Formula SPF value 38.332 ± 1.526 with ultra protection type. Conclusion: All evaluations of the physical characteristics of the Sunscreen moisturizer cream preparation have met the requirements for a good cream preparation, except for the viscosity test. It contains halal ingredients and has ultraprotective protection against UV light. Keyword : Cream, Sunscreen, Moisturizer, Non Aromatic, Hajj Care
Molecular Insights into Breast Cancer Treatment: An Integrated Approach of Network Pharmacology and Component Analysis for Lansium parasiticum Bark Extract Mutiah, Roihatul; Annisa, Rahmi; Zahiro, Syayida Roisatus
Indonesian Journal of Cancer Chemoprevention Vol 15, No 2 (2024)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev15iss2pp96-107

Abstract

Medicinal plants containing multi-components have the potential for multi-target genes, multi-pathways, and various effects on diverse diseases. With the increasing technological advancements, understanding the complex interactions between multi-component substances and biological systems is becoming more crucial. In this context, conventional experimental research might have limitations as it typically focuses on the impact of one component on one gene. The objective of this research is to identify compounds in the bark extract of Lansium parasiticum and elucidate the molecular mechanisms of these compounds in inhibiting the progression of breast cancer cells using a network pharmacology approach. Compound identification in Lansium parasiticum bark extract (LPBE) has been conducted using Liquid Chromatography Tandem Mass Spectrophotometry (LC-MS/MS) technique. ADMET predictions were utilized to determine the absorption and bioavailability profiles. A network pharmacology approach employing Cytoscape 3.9.1, GeneCards, Disgenet, STRING 2.0.0, SRplot, and Kyoto Encyclopedia of Genes and Genomes (KEGG) was used to predict the anti-cancer molecular mechanisms of these compounds. Seventeen active compounds have been successfully identified via LC-MS/MS. Among these, the compounds Moronic Acid, 4-Morpholineacetic Acid, and Ursolic Aldehyde were found in the highest concentrations. The results of the network pharmacology analysis indicate that the compounds in LPBE are involved in three potential pathways for breast cancer treatment: the NF-κß signaling pathway (hsa 04064), microRNA in cancer (hsa05206), and apoptosis (hsa04210). Target genes implicated in these pathways include BAX, BCL2, TNF-α, PARP1, STAT3, NOTCH1, and NF-κß1. It can be concluded that LPBE contains compounds with potential for treating breast cancer, as they are predicted to interact with relevant target pathways and genes. Therefore, further research is highly recommended, particularly in the development of drugs for breast cancer.Keywords: apoptosis, microRNA, NF-κß, TNF-α, STAT3.
GAMBARAN PENGETAHUAN IBU TENTANG MAKANAN PENDAMPING AIR SUSU IBU (MP-ASI) DENGAN PEMBERIAN MP-ASI DINI PADA BAYI DI DESA PULAU GADANG KECAMATAN XIII KOTO KAMPAR Annisa, Rahmi; Afrinis, Nur; Lasepa, Wanda
SEHAT : Jurnal Kesehatan Terpadu Vol. 2 No. 3 (2023): AGUSTUS 2023
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/sjkt.v2i3.19172

Abstract

Pengetahuan merupakan hasil tahu setelah seseorang melakukan penginderaan melalui panca indera. Edukasi tentang pemberian MP-ASI yang baik kepada ibu menyusui dengan meninjau dari pengetahuan ibu menyusui tentang pemberian MP-ASI sangat penting dilakukan. Pemberian MP-ASI yang sesuai dan bernilai zat gizi yang baik untuk kecupukan balita sehingga dengan demikian dapat mencegah stunting dapat tercapai. Tujuan penelitian ini adalah  mengetahui hubungan pengetahuan ibu tentang MP-ASI dengan pemberian MP-ASI di desa Pulau Gadang Kec XIII Koto Kampar. Jenis penelitian yang digunakan adalah penelitian observasional dengan pendekatan cross sectional dimana variabel dependen dan variabel independent di ukur dalam waktu yang bersamaan. Teknik pengambilan sampel dalam penelitian ini adalah sampling jenuh. Artinya semua populasi dijadikan sampel penelitian. Dengan demikian jumlah sampel dalam penelitian ini adalah 30 orang. Alat pengumpul data yang digunakan adalah angket. Penelitian ini menggunakan analisa Bivariat.  Hasil penelitian menemukan 6 dari 30 ibu menyusui di Desa Pulau Gadang memilih pengetahuan yang kurang tentang MP-ASI dini, 15 dari 30 ibu menyusui di Desa Pulau Gadang memilih pengetahuan yang kurang tentang MP-ASI dini, 9 dari 30 ibu menyusui di Desa Pulau Gadang memilih pengetahuan yang baik tentang MP-ASI dini. Maka rata-rata ibu menyusui di Desa Pulau Gadang memilih pengetahuan yang cukup tentang MP-ASI dini. Penelitian menemukan 20 orang dari 30 orang ibu menyusui di Desa Pulau Gadang memberikan MP-ASI Dini kepada bayinya. Artinya 66,70% bayi di Desa Pulau Gadang sudah diberikan MP-ASI Dini.
Extract of Yellow Root (Arcangelisia Flava (L.) Merr.) from Several Regions in Kalimantan: Alkaloid Content and Cytotoxicity towards WiDr Colorectal Cancer Cells Mutiah, Roihatul; Kirana, Farenza Okta; Annisa, Rahmi; Rahmawati, Ana; Sandra, Ferry
Indonesian Journal of Cancer Chemoprevention Vol 11, No 2 (2020)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev11iss2pp84-89

Abstract

Yellow root (Arcangelisia flava (L.) Merr.) has been scientifically known to have potential as an antimalarial, antibacterial, antioxidant, and anticancer. The purpose of this study was to determine the profile of alkaloid content and cytotoxicity of yellow root extract from several regions in Kalimantan. The alkaloid content was tested using the thin layer chromatography (TLC) method with dragendorf reagent. Cytotoxic in vitro test was conducted against WiDr colorectal cancer cells using the 3-(4,5-dimethylthiazol-2-il)-2,5-diphenyltetrazolium bromide (MTT) assay. Yellow roots were collected from Samarinda city, Banjarmasin city, Barito Timur regency, Malinau district, and Balikpapan City. The MTT inhibitory concentration 50 (IC50) of yellow root extracts were 573.308 μg/mL; 582.857 μg/mL; 296.326 μg/mL; 114.119 μg/mL; and 320.162 μg/mL respectively. Results of the compound identification indicated that alkaloid was found in A. flava from all regions. Alkaloids of A. flava extract should be investigated further in order to find possible active agent that could decrease the viability of WiDr colorectal cancer cells.Keywords: Arcangelisia flava, Borneo, colorectal cancer, Kalimantan, WiDr cells.
Exposure of Murattal Al-Quran Audio Enhances Cisplatin Activity on Growth Inhibition and Cell Cycle Modulation on Hela Cells Mutiah, Roihatul; Mustofa, Muhammad Ragib; Indrawijaya, Yen Yen Ari; Hakim, Abdul; Annisa, Rahmi; Susanti, Nurlaili; Nashichuddin, Ach; Zainuddin, Muhammad
Indonesian Journal of Cancer Chemoprevention Vol 10, No 2 (2019)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev10iss2pp71-79

Abstract

Cancer is a disease characterized by abnormal cell mechanisms. The development of alternative cancer treatments is still needed. One of them is the music therapy. The music therapy uses sound vibrations to improve healing. Al-Quran, the Holy book of muslims, recites with measured recitation produces beautiful tones. Reading and recitating of Al-Quran is an important form of worship for which a Muslim can expect reward and benefit in the Hereafter. Al-Fatihah is one of surahs in Al-Qur'an that is often read by Muslims and used as a prayer for healing. The purpose of this study was to determine the effect of cytotoxic activity and cell cycle modulation on Hela cells with exposure of murattal Al-Quran and cisplatin combination. Audio exposure murattal Al-Fatihah and its combination with cisplatin to HeLa cells were tested using the MTT method assay. Induction of apoptosis and modulation of cell cycle evaluated by flow cytometry method. Treatment used 30 minutes Audio Murattal (AM), Cisplatin 10 µg/mL (Cis), and the combination of AM + Cis caused a decrease in the viability of HeLa cells respectively 80.14%, 69.86%, and 64.32%. The results of flow cytometry explained that in treatment of AM there was inhibition in the G2-M phase and induction of apoptosis in the M5 phase. Whereas in treatment AM + Cis inhibition occurs in the S, G2-M phase, and induction of apoptosis in the M5 phase. Audio Murattal Al-Quran presents cytotoxic effects on HeLa cells and to provide a synergistic impact on cisplatin so that disclosure therapy murattal can be recommended for supporting therapy in the treatment of cancer (supportive therapy).Keywords: Al-Quran, Audio murottal, HeLa Cells, Cell Viability, Flow cytometry
Qualitative Analysis of COVID-19 Vaccine Reactogenicity in Banjarmasin City, South Kalimantan During the Pandemic Muliyani, Muliyani; Isnani, Nazhipah; Annisa, Rahmi; Ramadhani, Juwita
International Journal of Health and Pharmaceutical (IJHP) Vol. 5 No. 4 (2025): November 2025
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v5i4.457

Abstract

The World Health Organization (WHO) officially recognized COVID-19 as a pandemic. By March 29, 2020, global cases had reached 634,835 with 33,106 fatalities. In Indonesia, there were 1,528 confirmed infections and 136 deaths. According to Indonesia's Presidential Regulation No. 99 of 2020, the government is expediting the acquisition of COVID-19 vaccines and the vaccination program to combat the pandemic. COVID-19 has spread extensively across nearly all provinces in Indonesia. The government remains committed to gradually delivering safe, high-quality, and effective vaccines. Despite these efforts, many people remain hesitant about vaccination due to concerns over side effects and vaccine safety. This study aims to qualitatively analyze the reactogenicity of COVID-19 vaccines. Using a descriptive observational qualitative design, informants were selected through purposive sampling. Reported side effects include drowsiness, injection site pain, increased appetite, fever around 38-39°C, weakness, recurrence of asthma, chest tightness, cough, and runny nose. The most common reactions observed were fever up to 39°C (18.51%) and vomiting (11.11%).
Co-Authors Abdul Hakim Ach. Nashichuddin Afrinis, Nur Alfiyah Laily Inayatin Amir, Muhammad Ana Fikrotus Zakia Anik Listiyana Anik Listyana Atiza Fajrin Maulidya Bayyinatul Muchtaromah Ferry Sandra Hadi Kuncoro Hadya, Chorida Muhjatul Hening Laswati Putra Huwaida, Fadhila Isma Jatmiko, Ricky Arie Juwita Ramadhani Kirana, Farenza Okta Laily Nurul Azizah Lasepa, Wanda M. Artabah Muchlisin Ma'arif Z.A, Burhan Ma'arif, Burhan Mangestuti Agil Muhammad Zainuddin Muliyani Muliyani Mustofa, Muhammad Ragib Muti'ah, Roihatul Nazhipah Isnani Nurlaili Susanti Nurwijayanti Purwaningsih, Fauziyah Eni Ramadhani D.A., Ria Retno Susilowati Roihatul Mutiah Roihatul Mutiah Roihatul Mutiah Salsabila, Dhia Fadhilah Samah, Moh.Alfin Sitti Nurjannah Sofiya Sofiya Tanaya Jati Dharma Taufik, Imam Umami, Zahra Weka Sidha Bhagawan Wirda Anggraini Yen Yen Ari Indrawijaya Zahiro, Syayida Roisatus