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All Journal Indonesian Journal of Cancer Chemoprevention INDONESIAN JOURNAL OF PHARMACY Journal of Islamic Pharmacy Jurnal Farmasi Sains dan Komunitas Majalah Kesehatan FKUB Journal of Islamic Medicine Biosel: Biologi Science and Education International Journal of Health and Pharmaceutical (IJHP) SEHAT : JURNAL KESEHATAN TERPADU Journal of Tropical Pharmacy and Chemistry
Rahmi Annisa
Universitas Islam Negeri Maulana Malik Ibrahim Malang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Education Energy Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Journal : INDONESIAN JOURNAL OF PHARMACY

 1 
Metabolite Profiling of Eleutherine palmifolia (L.) Merr. By HPTLC-Densitometry and its Correlation with Anticancer Activities and In Vitro Toxicity Mutiah, Roihatul; Hadya, Chorida Muhjatul; Ma'arif Z.A, Burhan; Bhagawan, Weka Sidha; Annisa, Rahmi; Indrawijaya, Yen Yen Ari; Huwaida, Fadhila Isma; Ramadhani D.A., Ria; Susilowati, Retno; Taufik, Imam
Indonesian Journal of Pharmacy Vol 30 No 3, 2019
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1608.73 KB) | DOI: 10.14499/indonesianjpharm30iss3pp157

Abstract

Eleutherine palmifolia (L.) Merr. (E. palmifolia) is a plant that used as raw material for herbal medicines. The difference of growing location the medicinal plants affects the difference of metabolite content, It also affects the pharmacological activity and toxicity of the plant. This study aims to determine the profile of metabolites (metabolite fingerprinting), anticancer profiles, toxicity/safety profiles from several different regions in Indonesia for the purpose of authentication, efficacy, safety and quality control of these plants. Samples were sampled from 6 different locations in Indonesia, they were West Java, Central Java, East Java, East Borneo, Central Borneo, and South Borneo. Metabolite fingerprinting was determined by HPTLC-densitometry method, the profile of anticancer activity and toxicity was known by the MTT-ELISA method. The difference between metabolite fingerprinting, anticancer profile, toxicity/safety profile was analyzed by Principal Component Analysis (PCA) and Hierarchical Component Analysis (HCA). Whereas the relation between metabolite fingerprinting, anticancer profile, toxicity/safety profile was analyzed by Partial Least Square (PLS). The results of the metabolite profile analysis with PCA showed that E. palmifolia from 6 different locations gave different metabolite profiles and there were 3 metabolites that had a significant effect on cluster formation. samples are Rf 055, 059, and 044. The results of the HCA analysis showed that the 6 regions are in one cluster the same one. The analysis of PLS-DA showed that the metabolites for anticancer activity are found in Rf 059, 076, 093 and Rf 034. While the metabolites for toxicity are Rf 002, Rf 044 and Rf 059.
Inhibition of Cell Cycle and Induction of Apoptosis y Ethanol Leaves Extract of Chrysanthemum cinerariifolium (Trev.) In T47D Breast Cancer Cells Roihatul Mutiah; Alfiyah Laily Inayatin; Rahmi Annisa; Yen Yen Ari Indrawijaya; Anik Listiyana
Indonesian Journal of Pharmacy Vol 31 No 1, 2020
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjpharm31iss1pp1

Abstract

Chrysanthemum cinerariifolium (C.cinerariifolium) is a plant of the Asteraceae family, which has been applied by the community as an ornamental plant and traditional medicine. In this study, the effect of C. cinerariifolium leaves extract on inhibition of cell cycle and induction of apoptosis in T47D breast cancer cells was tested and compared to the standard chemotherapy agent. The citotoxic activity of C. cinerariifolium leaves extract against T47D cancer cells and Vero normal cells was tested by MTT method. Profile of apoptosis and cell cycle were observed by flow cytometry method. Based on chemical compounds profil which is tested used TLC showed that C.cinerariifolium leaves extracts contained flavonoid and terpenoid chemical compounds. The result of cytotoxic test showed that leaves extract of C. cinerariifolium was able to inhibit the growth of T47D cancer cell at IC50 418.8μg/mL. Doxorubicin, extracted from Streptomyces peucetius used as treatment in several cancers including breast cancer. Doxorubicin could inhibit the growth of T47D cancer cells in 115.1μg/mL. The results of cell cycle analysis showed that the C. cinerariifolium leaves extract inhibited cell cycle in G0-G1 and S phase, whereas doxorubicin was able to inhibit cell cycle in G0-G1 phase but experienced cell accumulation in G2-M phase. The percentage of apoptosis in cycle was showed in M1 (sub G1) and M5 (multinuclear) phase which treatment of C. cinerariifolium leaves extract was higher than doxorubicin. Therefore, C. cinerariifolium leaves extract has potential activity as anticancer agent causes inhibition of cell cycle and induction apoptosis. 
Co-Authors Abdul Hakim Ach. Nashichuddin Afrinis, Nur Alfiyah Laily Inayatin Amir, Muhammad Ana Fikrotus Zakia Anik Listiyana Anik Listyana Atiza Fajrin Maulidya Bayyinatul Muchtaromah Ferry Sandra Hadi Kuncoro Hadya, Chorida Muhjatul Hening Laswati Putra Huwaida, Fadhila Isma Indradewa, Rhian Jatmiko, Ricky Arie Juwita Ramadhani Kirana, Farenza Okta Laily Nurul Azizah Lasepa, Wanda M. Artabah Muchlisin Ma'arif Z.A, Burhan Ma'arif, Burhan Mangestuti Agil Muhammad Zainuddin Muliyani Muliyani Mustofa, Muhammad Ragib Muti'ah, Roihatul Nazhipah Isnani Nurlaili Susanti Nurwijayanti Purwaningsih, Fauziyah Eni Ramadhani D.A., Ria Retno Susilowati Roihatul Mutiah Roihatul Mutiah Roihatul Mutiah Salsabila, Dhia Fadhilah Samah, Moh.Alfin Sitti Nurjannah Sofiya Sofiya Tanaya Jati Dharma Taufik, Imam Umami, Zahra Weka Sidha Bhagawan Wirda Anggraini Yen Yen Ari Indrawijaya Zahiro, Syayida Roisatus