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All Journal Indonesian Journal of Cancer Chemoprevention INDONESIAN JOURNAL OF PHARMACY Journal of Islamic Pharmacy Jurnal Farmasi Sains dan Komunitas Majalah Kesehatan FKUB Journal of Islamic Medicine Biosel: Biologi Science and Education J-Dinamika: Jurnal Pengabdian Kepada Masyarakat International Journal of Health and Pharmaceutical (IJHP) SEHAT : JURNAL KESEHATAN TERPADU Journal of Tropical Pharmacy and Chemistry
Rahmi Annisa
Universitas Islam Negeri Maulana Malik Ibrahim Malang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Education Energy Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Journal : Journal of Islamic Pharmacy

 1 
TOXICITY STUDY OF PARE LEAF EXTRACTS (MOMORDICA CHARANTIA) TO CULEX PIPIENS MOSQUITO LARVAE Annisa, Rahmi; Amir, Muhammad; Kuncoro, Hadi
Journal of Islamic Pharmacy Vol 2, No 2 (2017): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v2i2.4506

Abstract

This study aims to determine the yield, toxicity, and toxic concentration of crude extracts of ethanol, n-hexane fraction extract, ethyl acetate fraction extract and n-butanol fractions extract pare leaf (Momordica charantiaL.) larvae Culex pipiens. The method used to determine the toxicity of extract larvasida test larvae Culex pipiens to obtain the LC99 values obtained using the analysis of Reed and Muench. Extraction and fractionation processis known to yield a ethanol crude extract obtained 8.86%, n-hexane fraction extract of 1%, ethyl acetate fraction extract 1.80% and n-butanol fractions extract of 0.80% and the toxicity obtained test results that pare leaf (Momordica charantia L.) have the potential toxicity larvae larvae of Culex pipiens as indicated by the value by Lethality Concrentation 99 % (LC99) in the crude extract ethanol 7416.52  ppm, n-hexane fraction extract of 2564.48 ppm, ethyl acetate fraction extract 2702.09 ppm and n-butanol fractions extract of 2665.63 ppm. Keywords: Pare leaf (Momordica charantia L.), toxicity, larvae Culex pipiens
Analisis in Silico Senyawa Fitokimia dari Fraksi n-Heksana Daun Semanggi (Marsilea crenata Presl.) sebagai Agen Neuroprotektif Ma'arif, Burhan; Jatmiko, Ricky Arie; Megawati, Dewi Sinta; Annisa, Rahmi; Sugihantoro, Hajar; Muchlisin, Muhammad Artabah; Laswati, Hening; Agil, Mangestuti
Journal of Islamic Pharmacy Vol 5, No 1 (2020): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v5i1.9180

Abstract

Estrogen deficiency causes various health problems in postmenopausal women, including neurodegenerative disease. Phytoestrogens emerged as a group of compounds that can replace the estrogen function in the body, and prevent the neurodegenerative disease to occur. Semanggi (Marsilea crenata Presl.) is a typical plant in Surabaya, Indonesia, that contain phytoestrogens. The aim of this research was to determine the metabolite profile of n-hexane fraction of Semanggi leaves using UPLC-QToF-MS/MS, and then to predict the neuroprotective activity of compounds with in silico study using PyRX 0.8 software. The 100 ppm of n-hexane fraction of Semanggi leaves in DCM and methanol were injected 5 µl each into the UPLC-QToF-MS/MS, and then analyzed by Masslynx 4.1 software to determine the compounds. The compounds from metabolite profiling then prepared with SwissADME webtool and Avogadro 1.90.0 software, molecular docking was done using Autodock Vina and Biovia Discovery Studio Visualizer 2016 to 3OLS protein. Metabolite profiling process shows a total of 34 predictable compounds and 28 unknown compounds. From in silico study, it shows a total of 7 compounds that are predicted to have activities similar to estrogen. This result indicate that n-hexane fraction of Semanggi leaves has potential as a neuroprotective agent for treatment for postmenopausal women who experience estrogen deficiency.Keywords: Marsilea crenata Presl., phytoestrogens, metabolite profiling, in silico, neuroprotective
Co-Authors Abdul Hakim Ach. Nashichuddin Afrinis, Nur Alfiyah Laily Inayatin Amir, Muhammad Ana Fikrotus Zakia Anik Listiyana Anik Listyana Atiza Fajrin Maulidya Bayyinatul Muchtaromah Ferry Sandra Hadi Kuncoro Hadya, Chorida Muhjatul Hening Laswati Putra Huwaida, Fadhila Isma Indradewa, Rhian Jatmiko, Ricky Arie Juwita Ramadhani Kirana, Farenza Okta Laily Nurul Azizah Lasepa, Wanda M. Artabah Muchlisin Ma'arif Z.A, Burhan Ma'arif, Burhan Mangestuti Agil Muhammad Zainuddin Muliyani Muliyani Mustofa, Muhammad Ragib Muti'ah, Roihatul Nazhipah Isnani Nurlaili Susanti Nurwijayanti Purwaningsih, Fauziyah Eni Ramadhani D.A., Ria Retno Susilowati Roihatul Mutiah Roihatul Mutiah Roihatul Mutiah Salsabila, Dhia Fadhilah Samah, Moh.Alfin Siti Maimunah Sitti Nurjannah Sofiya Sofiya Tanaya Jati Dharma Taufik, Imam Umami, Zahra Weka Sidha Bhagawan Wirda Anggraini Yen Yen Ari Indrawijaya Zahiro, Syayida Roisatus