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All Journal Alchemy : Journal of Chemistry Current Biochemistry The Journal of Pure and Applied Chemistry Research JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Chimica et Natura Acta QARDHUL HASAN: MEDIA PENGABDIAN KEPADA MASYARAKAT Jurnal Kartika Kimia Journal of Science Innovare EKOLOGIA : Jurnal Ilmiah Ilmu Dasar dan Lingkungan Hidup Jurnal Abdimas Kartika Wijayakusuma Jurnal Sains dan Teknologi International Journal of Ethno-Sciences and Education Research Pharmaceutical Sciences and Research (PSR) Helium: Journal of Science and Applied Chemistry Jurnal Abdi Inovatif : Pengabdian kepada Masyarakat Advances In Social Humanities Research Jurnal Pengabdian Masyarakat Inovatif Jurnal Pengabdian Masyarakat Inovatif
Siti Warnasih
Universitas Pakuan
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Identification of Active Compounds and Antidiabetic Activity of Red Shoot (Syzygium myrtifolium) Leaves Extract With In Vitro and In Silico Methods Prakoso, Muhamad Iqbal; Warnasih, Siti
Pharmaceutical Sciences and Research
Publisher : UI Scholars Hub

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Abstract

Diabetes mellitus (DM) is a chronic metabolic disease that affects approximately 537 million people worldwide (1 in 10 individuals), and its prevalence is projected to reach 783 million by 2045. One of the plants that has the potential to be an antidiabetic is red shoots (Syzygium myrtifolium) since it contains various secondary metabolite compounds such as flavonoids, triterpenoids, steroids, saponins, phenolics, and anthocyanins. This study aimed to evaluate the antidiabetic properties of red shoot leaves extract and to identify and predict interactions between its active compounds and the α-glucosidase receptor. Ethanol, ethyl acetate, and n-hexane extracts of red shoot leaves were tested in vitro method for α-glucosidase inhibitory activity. The most active extract was analyzed using gas chromatography–mass spectrometry (GC–MS) to identify its chemical constituents. The identified compounds were then tested in silico using the molecular docking method to simulate interactions with the α-glucosidase receptor. The ethanol extract showed the strongest α-glucosidase inhibitory activity (IC₅₀ = 83.69 ppm), as compared to the ethyl acetate and n-hexane extracts. GC–MS analysis identified 5 secondary metabolites, predominantly terpenoids. Molecular docking revealed that three compounds includes α-Gurgujene, farnesyl acetate and Neophytadiene exhibited strong binding affinities (ΔG), hydrogen bonds and nteractions with the same amino acid residues as the standard control acarbose, indicating potential α-glucosidase inhibitory activity. These findings suggest that red shoot leaves extract, particularly its ethanol extract, contains bioactive compounds with promising potential as natural antidiabetic agents, warranting further pharmacological and clinical investigation.
PEMANFAATAN KOTORAN TERNAK KAMBING SEBAGAI PUPUK ORGANIK CAIR DI DESA KALONG LIUD Ikrimah Nur Sabania; Silvia Indriyani; Alista Dwis Gymnasti; Sutanto Sutanto; Eka Herlina; Siti Warnasih
Jurnal Abdi Inovatif : Pengabdian kepada Masyarakat Vol. 3 No. 2 (2024): Jurnal Abdi Inovatif : Pengabdian kepada Masyarakat
Publisher : Universitas Nusa Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31938/jai.v3i2.752

Abstract

The decrease in crop yields was caused by dry soil quality due to prolonged drought and excessive inorganic fertilizers in Kalong Liud village that were not adapted to plant needs, which could lead to a decrease in soil productivity. On the other hand, livestock waste (goat manure) that has not been managed optimally, often faced by livestock breeders and farmers, has good potential to help increase soil fertility on agricultural land at a reasonably low cost. The proposed solution to this problem is to switch to environmentally friendly organic fertilizer because it reduces the use of chemical substances. One of them is the use of goat manure, which contains high levels of nutrients such as phosphorus (P), nitrogen (N), and potassium (K). This community service activity aims to increase farmers' understanding that the use of organic fertilizer is a solution to overcome the problem of poor soil quality due to drought and excessive use of chemical fertilizers, as well as providing skills to farmers and breeders in Kalong Liud village in making liquid organic fertilizer from goat droppings. The method used includes the first stage of determining targets and implementing activities. The second stage of community outreach, Focus Group Discussion (FGD) and evaluation uses the test method, namely, comparing the pre-test and post-test results. The first stage of activities is determining targets, including surveys, outreach with breeders and farmers, observation, licensing, and activity planning, and then manufacturing liquid organic fertilizer. The second stage of activities carried out outreach with two topics: outreach to the community, discussions with the formed farmer groups, and evaluation through filling out questionnaires. After conducting community outreach and farmer group discussions, the results of this activity were that they understood how to make liquid organic fertilizer from goat manure and the dangers of using excess inorganic fertilizer on plants. After joint practice, the farmer group's understanding of liquid organic fertilizer obtained a post-test score of 98% of people who understood this program.
Co-Authors Achmad, Dinar Munggaran Ade Heri Mulyati Ade Heri Mulyati Ade Heri Mulyati, Ade Heri Agustine, Dine Alawiyah, Hanis Alista Dwis Gymnasti Amelia, Nisa Anak Agung Istri Sri Wiadnyani Anna Muthia Soliha Artika, I. M Deden Ardiansyah Dhiandani, Sri Boedi Diana Widiastuti Diana Widiastuti Dianda Namira Azzahra Dinar Munggaran Achmad Effendi, Herlinda Eka Herlina Eka Herlina Elly Sukmanasa Eneng Tita Tosida Faliha Arinda Lestari Farid Ramadhan Farida Nuraeni Fredi Andria Gita Syahputra Gymnasti, Alista Dwis I. M Artika Ikrimah Nur Sabania Intan Wulandari Irma Anggraeni Iryani, Ani Junita Darmawarni Kholisoh, Siti LAKSMI AMBARSARI Leny Heliawati Linda Jati Kusumawardani Lisa Giovanny Marom, Muhamad Fathul Mastri Juniarto Novi Fajar Utami Nurmayani, Reni Nurul Marfira Prakoso, Muhamad Iqbal Prihastuti Harsani Purwantiningsih Sugita R. T. Sasmono Sadjarwa, Boedi Samsudin Samsudin Sasmono, R. T. Silvia Indriyani Sinaga, Siska Elisahbet Siska Juliani Simalango Siti Fatimah Siti Kholisoh Sofian, Yayan Susanto Susanto Sutanto Sutanto . Sutanto Sutanto Sutanto Sutanto Sutanto Sutanto Sutoyo, Muhammad Rayhan Tamimah Shafwatul Ishlah Tri Panji Triastinurmiatiningsih, Triastinurmiatiningsih Uswatun Hasanah Uswatun Hasanah USWATUN HASANAH Vevi Hikmafitri Rizali W Yulia Yuli Wahyuni Yuli Wahyuni Yulia, W Yulian Syahputri Zahra, Mutiara Zuniar Subastian