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All Journal e-Journal Pustaka Kesehatan STOMATOGNATIC- Jurnal Kedokteran Gigi The Indonesian Journal of Dental Research Majalah Kedokteran Gigi Indonesia ODONTO Dental Journal Insisiva Dental Journal : Majalah Kedokteran Gigi Insisiva Jurnal Kesehatan Gigi Dental Journal (Majalah Kedokteran Gigi) Jurnal Kedokteran Gigi Universitas Padjadjaran Padjadjaran Journal of Dentistry Health Notions Meditory : The Journal of Medical Laboratory SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Medica Hospitalia Jurnal Kesehatan Denta: Jurnal Kedokteran Gigi Odonto dental journal Jurnal Hasil Pengabdian Kepada Masyarakat Universitas Jember Dental Agromedis
Agustin Wulan Suci Dharmayanti
Bagian Biomedik, Fakultas Kedokteran Gigi, Universitas Jember
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Control & Systems Engineering Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : e-Journal Pustaka Kesehatan

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(Kadar LDL dan HDL Dalam Darah Model Tikus Periodontitis (Blood Level of LDL and HDL in Periodontitis Rat Model ) Nugraha Agung Marda; Suci Wulan Agustin; Susilawati Ayu Dewa
Pustaka Kesehatan Vol 2 No 1 (2014)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Backgroud. Increased levels of low density lipoprotein (LDL) and decreased levels of high density lipoprotein (HDL) in the blood is a risk factor for atherosclerosis leading to Coronary Heart Disease (CHD). Risk factor of atherosclerosis are multifactorial such as consuming high lipid diet, excessive eating, sedentary, and inflammatory response. According to the recent study indicated that inflammatory response could affect LDL and HDL blood levels that related to the risk of atherosclerosis lesion formation. Therefore, we suspected that periodontitis could affect LDL and HDL. Purpose. The purpose of this study was to show the effect of periodontitis in LDL and HDL. Methods. This experimental study used the post test only control group design. The object were 8 male wistar rats (Rattus norvegicus) with inclusion criterias were male rats, ±200 gr body weight, 3-4 months age, having a healthy condition, good appetite, and normal behavior. The rats were devided into two groups, i. e. control group and treatment group (periodontitis group) with 4 rats in each group. Periodontitis rat model was created by fitting cervical left low molar tooth with wire ligature and injected with 0,02 ml P. gingivalis ATCC 33277 (dosage 5µg/0,05 ml) in bucal sulcus, three times a week for 4 weeks (28 days), all of the rats were fed with standard diet. On day 29th all groups of rats were sacrificed and intracardial blood were taken 3 cc for examination of LDL and HDL blood levels by electrospectrophotometric method. Data were analyzed by T-test. Result. Result showed that periodontitis rat model had a significantly higher LDL levels compared to control group (P <0,05) and HDL levels were lower than controls, but the difference was not significant (P >0,05). Conclusion and suggestion. Based on this study periodontitis increase LDL blood levels. Further research related with duration of periodontitis are needed because periodontitis is usually a chronic disease and have a long lasting effect . In addition, the role of the severity of periodontitis are required to learn.   Keywords: HDL, LDL, Periodontitis.
Kadar Fosfor (P) dalam Cairan Sulkus Gingiva pada Penderita Periodontitis Kronis (Phosphorus Level of Gingival Crevicular Fluid of Chronic Periodontitis) Deasy Kusuma Ardiani; Agustin Wulan Suci Dharmayanti; Peni Pujiastuti
Pustaka Kesehatan Vol 4 No 1 (2016)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Background: The prevalence of periodontal disease in Indonesia is 60%. Chronic periodontitis is one of periodontal disease which affects Indonesian. The primary cause of periodontal disease is bacterial plaque. Adhesions and accumulation of bacterial plaque can cause inflammation and destruction of periodontal tissue following by increasing of gingival crevicular fluid flows and releasing of its components, one of the components is phosphorus that excreted from sulcular epithelium. Soluble phosphorus along blood stream is from gingival crevicular fluid which the flow is increased and excreted by sulcular epithelium. Objective: To know phosphorus levels in the gingival sulcus of chronic periodontitis. Methods: The subjects of the study were patients who came to the Dental Hospital University of Jember and occupied as inclusion and exclusion criteria. The subjects who had inclusion criteria were divided into 2 groups based intra-oral examination; gingivitis and chronic periodontitis. Gingival crevicular fluid sampling was taken from tooth with gingivitis or chronic periodontitis using paperpoint. Phosphorus level measurement used UV-Vis Spectrophotometer with a wavelength of 883 nm. The results were analyzed by Mann-Whitney test. Results: There were phosphorus in the gingival crevicular fluid of chronic periodontitis and it higher than gingivitis. Conclusion: There is phosphorus level in the gingival crevicular fluid in patients with chronic periodontitis.   Keywords: Chronic periodontitis, gingival crevicular fluid, phosphorus
Pengaruh Daun Katuk (Sauropus androgynus (L.) Merr.) terhadap Waktu Perdarahan (Bleeding Time) pada Tikus Wistar Jantan sebagai Alternatif Obat Antitrombotik (The Effect of Star Gosseberry (Sauropus androgynus (L.) Merr.) to bleeding time of Male Wistar Selvia Magdalena; Budi Yuwono; Agustin Wulan Suci Dharmayanti
Pustaka Kesehatan Vol 3 No 2 (2015)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Background: Cardiovascular disease can be treated with synthetic or traditional antithrombotic drugs (herbal). Synthetic antithrombotic drugs have a lot of side effects, so as an alternative antithrombotic is used traditional drugs, star gosseberry. Star gosseberry have many active compounds which are suspected to inhibit platelet aggregation. Objective: to know the effect of star gosseberry on bleeding time of male Wistar rats as an alternative antithrombotic drugs. Methods of research: this study was experimental laboratory research with post-test only control group design. The research samples were 24 male wistar rats and divided into 4 groups: negative control (distilled water), positive control (aspirin 5,85 mg dose), treatment 1 (star gosseberry 4,5 mg/g dose), and treatment 2 (star gosseberry 2.25 mg/g dose). The treatment was given for 8 days then the tail of samples were cut by 0.5 cm from the tip of the tail. Every 30 seconds the blood that dripped out was absorbed on absorbent papers until the bleeding stops. Bleeding time was measured from initial point of bleeding until the cessation of the bleeding point. Result: star gosseberry dose 4,5 mg/g had the same effect as aspirin that was prolonged bleeding time. Conclusion: star gosseberry could be prolonged bleeding time so it can be used as an alternative antithrombotic drugs. Keywords: Katuk leaf, bleeding time, antithrombotic, platelet
Co-Authors Amandia Dewi Permana Shita Amandia Dewi Permana Shita Amelia Nur Ilahi Anggun Kharisma Putri Anya Tania Larasati Arifin, Grandissyaikhu Kamila Asadi, Ahmad Ahya Bangun Febrianto Banun Kusumawardani Banun Kusumawardani Budi Yuwono Deasy Kusuma Ardiani Dhea Ayu Dewanti Dian Nurjannah Dina Tsalis Wildana Dina Tsalis Wildana Dwi Aji Nugroho, Dwi Dwi Kartika Apriono Dwi Kartika Apriono, Dwi Kartika Dwi Merry Christmarini Robin Dwi Warna Aju Fatmawati Dwi Warna Aju Fatmawati Dwi Warna Aju Fatmawati Edwyn Saleh Endah Aryati Eko Ningtyas Erfin Ramadana Pratama Erlina Sih Mahanani, Erlina Sih Ernie Maduratna Setiawatie Fajar Risqi Zaenulloh Farizan Zata Hadyan, Farizan FEBRIANTO, BANGUN Fitriyana, Nurul Isnaini Galau, Argha Sirna Hendy Hendarto I Dewa Ayu Susilawati Ita Kurniawati Kosasih, Jane Kusuma Ardiani, Deasy Kusuma Ardiani, Deasy Lusi Hidayati Lusi Hidayati Lusi Hidayati, Lusi Lutfi Meiga Sari Lutfia Siti Hanifatunnisa Mei Syafriadi Muhammad Nurul Amin Nanda Afnita Nugraha Agung Marda Octaviana Putri Puspita Sari Oktavia Nur Vitasari Paramudibta Lungit Kuncaraningtyas Peni Pujiastuti Permata, Dea Permatasari, Sabania Dinar Permatasari, Yulita Indah Prafitasari, Dinar Pudji Astuti PUDJI ASTUTI Ratna Dewanti, I Dewa Ayu Ratu Millenia Dua Rendra Chriestedy Prasetya Rido Tri Andika Firdyansyach Roedy Budirahardjo Rothschildi, Dhesyarmani Putri Rudi Budirahardjo, Rudi Safira Niza Ulfita Safitri, Rizkiya Agnes Sari Setyaningsih Sartika Puspita Selvia Magdalena Setyaningsih, Sari Sri Lestari Suhartini Suhartini Suhartini Suhartini Syafira Az Zahro Tarmizi, Thariq Ibnu Tecky Indriana Tsalis, Dina Widodo, Alaya Dwi Salvahira Yani Corvianindya Rahayu Yunianti, Ervisya Nandya Zahara Meilawaty Zahara Meylawaty Zahreni Hamzah Zain, Adi Pradana Rahmatullah Zainul Cholid