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All Journal JURNAL GIZI INDONESIA Jurnal Media Gizi Indonesia (MGI) GANEC SWARA Jurnal Gizi Prima JURNAL GIZI DAN KESEHATAN ARTERI : Jurnal Ilmu Kesehatan AgriHealth: Journal of Agri-food, Nutrition and Public Health Jurnal Gizi Kerja dan Produktivitas Nutriology: Jurnal Pangan, Gizi, Kesehatan ADMA: Jurnal Pengabdian dan Pemberdayaan Masyarakat Media Publikasi Promosi Kesehatan Indonesia (MPPKI) Jurnal Ilmiah Pengabdian dan Inovasi Alamtana
Novia Zuriatun Solehah
Bumigora University
Agriculture, Biological Sciences & Forestry Humanities Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : JURNAL GIZI INDONESIA

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The Effect of Red Dragon Fruit (hylocereus polyrhizus) Juice on Leptin Levels in Sprague Dawley Rats Using an Overweight Model Solehah, Novia Zuriatun; Herviana, Herviana; Anggriany, Nissa; Anindita, Karina
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) 2026: Just Accepted Manuscript and Article In Press 2026
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jgi.0.0.%p

Abstract

Background: Obesity is strongly linked to elevate leptin levels and oxidative stress, both of which contribute to the development of various metabolic disorders. Leptin, a hormone that regulates metabolism and appetite, becomes less effective in obese individuals due to leptin resistance, thereby exacerbating metabolic dysfunction.Objective: This study aims to evaluate the effect of red dragon fruit (hylocereus polyrhizus) juice on leptin levels in Sparague Dawley rats using an overweight model.Method: This experimental study used a pre-post test control group design and involved six groups of rats (n=6 per group), including a normal group, a negative control group, a positive control group (orlistat), and three treatment groups receiving different doses of red dragon fruit juice (3.5 g, 7 g, and 10.5 g per 200 g body weight). The intervention was carried out for 14 days following a 14- day induction of obesity using a high-fat and high-carbohydrate diet. Leptin levels were measured before and after the intervention.  Results: The results showed that administration of red dragon fruit juice significantly reduced leptin levels (p<0,001) in all treatment groups. The greatest reduction was observed in the group receiving the 10.5 g dose, with an average decrease of 75.03%, which was nearly equivalent to the orlistat group that reduced leptin levels by 79.93%.Conclusion: Red dragon fruit juice has the potential to serve as a non-pharmacological agent in reducing leptin levels and oxidative stress under obesity conditions, with an effectiveness approaching that of orlistat.
Co-Authors Adi Prayitno Aida Putri Deyantari Anggriany, Nissa Astawan, Wanda Januar BAIQ IKE NURSOFIA Dedi Aprianto Dewi, Linda Siska Dewi, Novianti Tysmala Dewi, Novianty Tysmala Eti Poncorini Pamungkasari Farida Ariani Farida Ariani Febriyanti, Putri Ayu Herviana Herviana, Herviana Jauhari, M. Thonthowi Jauhari, M. Thontowi Jauhari, Thonthowi Karina Anindita Laksmi Nur Fajriani Lastyana, Wiwin Lina Yunita Linda Siska Dewi M. Thonthowi Jauhari M. Thonthowi Jauhari M. Thontowi Jauhari M.Thontowi Jauhari Naktiani, Wayan Canny Naktiany, Wayan Canny Ni Made Wiasty Sukanty Rahmiati, Baiq Fitria Rizqika Mahardika Sabtana, Fayruziyah Ifroch Santika, I Gede Panji Sirojul Hadi SOFIA ROHANI Sofya, Sri Winarni Sukanthy, Ni Made Wiasty Sukanty, Ni Made Wiasty Syahnara, Shakira Dinda Thonthowi Jauhari Tresia Ayu Saputri Wanda Januar Astawan Wayan Canny Naktiany Widani Darma Isasih Wiwin Lastyana Wiwin Lastyana Wiwin Lastyana Yunita, Lina