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All Journal METAMORFOSA Journal of Biological Sciences Folia Medica Indonesiana Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Riset Kesehatan Nasional LOSARI: Jurnal Pengabdian Kepada Masyarakat MAHESA : Malahayati Health Student Journal Jurnal Pijar MIPA JRKN Jurnal Pengabdian West Science Jurnal Pengabdian Kepada Masyarakat Itekes Bali Jurnal Pengabdian Masyarakat Sundaram Jurnal Medika Usada Berita Biologi
Ni Wayan Sukma Antari
Institut Teknologi Dan Kesehatan Bali
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Transportation Other

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Comparison of the Effects of a Combination of Centella asiatica and Mentha piperita Leaf Extracts on the Number of Normal Brain Cells in Male Mice (Mus musculus) Padmiswari, Anak Agung Istri Mas; Antari, Ni Wayan Sukma; Gandamayu, Ida Bagus Maha; Adiana, I Nengah
Jurnal Pijar Mipa Vol. 20 No. 6 (2025)
Publisher : Department of Mathematics and Science Education, Faculty of Teacher Training and Education, University of Mataram. Jurnal Pijar MIPA colaborates with Perkumpulan Pendidik IPA Indonesia Wilayah Nusa Tenggara Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpm.v20i6.9998

Abstract

Chronic stress is known to cause neuronal damage in the hippocampus, particularly in the CA1 and CA3 areas, which play a crucial role in memory and learning. One way to prevent this damage is by using natural ingredients with neuroprotective properties. This study aimed to compare the effects of Centella asiatica and Mentha piperita leaf extracts, either singly or in combination, on the number of normal neurons in the hippocampus of male mice exposed to stress. Twenty-five male mice were divided into five treatment groups: K− (control without treatment), K+ (stress without extract), P1 (stress + Centella asiatica extract), P2 (stress + Mentha piperita extract), and P3 (stress + combination of Centella asiatica and Mentha piperita). Stress was induced using a restraint stress method, while the extracts were administered orally at the prescribed dosage. After the treatment period, the hippocampus was removed, and histological slides were prepared with Hematoxylin-Eosin staining to count the number of normal neurons in the CA1 and CA3 areas. The results showed that the K+ group experienced a significant decrease in the number of normal neurons compared to the K− group. Administration of gotu kola (P1) and mint (P2) extracts increased the number of neurons compared to K+, but not to the same extent as K−. The combination of Centella asiatica and Mentha piperita extracts (P3) showed the most optimal effect, with the number of normal neurons approaching that of the negative control group. These findings indicate that the combination of Centella asiatica and Mentha piperita has synergistic potential in protecting hippocampal neurons from stress-induced damage. Further research is needed to explore the molecular mechanisms underlying this neuroprotective effect.
Activity of Zuriat Fruit Extract (Hyphaene thebaica) on The DNA Fragmentation and Spermatozoa Quality of Male Mice (Mus musculus) Given Balinese Arak Antari, Ni Wayan Sukma; Damayanti, Ida Ayu Manik
Jurnal Penelitian Pendidikan IPA Vol 11 No 8 (2025): August
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i8.11855

Abstract

Alcohol in the body is metabolized into acetaldehyde with the assistance of the enzyme alcohol dehydrogenase (ADH). Acetaldehyde, the metabolic byproduct of alcohol, plays a role in the formation of Reactive Oxygen Species (ROS). The effects of alcohol can lead to damage and death of spermatogenic cells caused by acetaldehyde, which is produced through the breakdown of alcohol by liver cells. Increased ROS levels generated by free radicals in sperm producing tissues may cause damage to the sperm membrane, thereby disrupting its stability and function. High concentrations of ROS may also exert toxic effects on sperm quality and function. This study aimed to examine the activity of Zuriat fruit (Hyphaene thebaica) extract on sperm quality and DNA fragmentation in male mice (Mus musculus) administered Balinese Arak. This research employed an experimental study design using a post-test only control group design. The results show that Zuriat fruit (Hyphaene thebaica) extract at doses of 1 g/kg body weight and 2 g/kg body weight significantly influenced sperm count, motility, viability, morphology, and DNA fragmentation (p < 0,05).
The Activity Test of Dewandaru Fruit (Eeugenia uniflora L.) in Trachea of Male Mice (Mus musculus L.) Which Exposed to Cigarette Smoke Antari, Ni Wayan Sukma
Jurnal Pijar Mipa Vol. 19 No. 1 (2024): January 2024
Publisher : Department of Mathematics and Science Education, Faculty of Teacher Training and Education, University of Mataram. Jurnal Pijar MIPA colaborates with Perkumpulan Pendidik IPA Indonesia Wilayah Nusa Tenggara Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpm.v19i1.6385

Abstract

Smoking has a serious negative impact on health because cigarettes contain harmful chemical compounds. To combat these negative effects, using natural antioxidants such as Dewadaru fruit has become the research focus. Dewandaru contains high antioxidants, namely flavonoids, anthocyanins, saponins, and tannins, which can fight free radicals in the body. The trachea is an air channel between the larynx and bronchi. To identify the activity test of dewandaru fruit (Eugenia uniflora L.) in the trachea of male mice (Mus musculus L.) exposed to cigarette smoke. This study employed true experimental di laboratory with post-test only control group design, probability sampling. The data were analyzed by using Shapiro Wilk and followed by the ANOVA test and Duncan's test. The finding showed that administering a Dewadaru fruit filter could maintain the histopathology of the male mice trachea exposed to cigarette smoke (P<0.05). Dewandaru fruit filter (Eugenia uniflora L.) has activity in the trachea exposed to cigarette smoke among male mice. Using a Dewadaru fruit filter also affects the presence of cilia, goblet cells, epithelial height, and lumen diameter in the trachea of male mice.
Formulation and Physical Stability Aromatherapy Medicated Oil of Red Ginger (Zingiber officinale var rubrum) Pramana, I Kadek Bagus Ari; Dira, Made Asmarani; Damayanti, Ida Ayu Manik; Antari, Ni Wayan Sukma
Jurnal Pijar Mipa Vol. 19 No. 4 (2024): July 2024
Publisher : Department of Mathematics and Science Education, Faculty of Teacher Training and Education, University of Mataram. Jurnal Pijar MIPA colaborates with Perkumpulan Pendidik IPA Indonesia Wilayah Nusa Tenggara Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpm.v19i4.6934

Abstract

Aromatherapy products for health relax the body, refresh the mind, and act as a placebo in treating diseases. The more modern aromatherapy medicated oil innovation has high competitiveness in its distinctive aroma and packaging without reducing pharmacological effectiveness. One source of essential oil is red ginger (Zingiber officinale var rubrum), which has pharmacological effects such as antioxidant, anti-inflammatory, analgesic, and anti-carcinogenic. This research aims to prepare, formulate, perform a physical evaluation, and conduct hedonic testing of red ginger aromatherapy medicated oil. This research is experimental research with a posttest group design research design. The physical evaluation results, including organoleptic tests on color, showed that preparations F0 to F3 were precise, yellow +, yellow ++, and yellow +++, respectively. The aroma shows preparations F0 to F3, respectively, the smell of menthol to the typical aroma of red ginger (strong), and the texture F0 to F3 shows a liquid texture. The homogeneity test showed that preparations F0 to F3 were homogeneous. The pH test showed that the pH value of the preparation ranged between pH 5.5 and 6.2 for preparations F0 to F3. This study concluded that the red ginger aromatherapy medicated oil formulation with a concentration of 2%, 4%, and 6% has good physical quality.
Gambaran Histologi Ovarium dan Fluktuasi Hormon Estrogen pada Mencit Betina (Mus musculus L.) yang diberi Ekstrak Buah Zuriat (Hyphaene thebaica) sebagai Antioksidan Alami Antari, Ni Wayan Sukma; Damayanti, Ida Ayu Manik; Padmiswari, anak agung istri mas; Harditya, Kadek Buja
MAHESA : Malahayati Health Student Journal Vol 3, No 4 (2023): Volume 3 Nomor 4 (2023)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (307.134 KB) | DOI: 10.33024/mahesa.v3i4.10260

Abstract

ABSTRACT Hyphaene thebaica belongs to the Palmae family which is often referred to as zuriat fruit. Hyphaene thebaica has properties as an antimicrobial, antioxidant, and antidiabetic. This study aims to determine the effect of zuriat extract on the number of follicles on the ovaries in female mice (Mus musculus) given exposure to cigarette smoke. This research have conducted for 6 months from January to June 2021. This type of research was pure experimental (true experimental) with a post test only control group design approach. This study was conducted by giving zuriat fruit extract as treatment for 42 days to female mice. The sample in this study was calculated using the Federer formula (1991). After treatment for 42 days, observations were made on ovarian histology which included: a. primary follicles, b. secondary follicles c. tertiary follicles and estrogen hormone. The research data were processed using a computer statistical program (SPSS 22.0 for Windows) using the OneWay Anova test. The results showed that the administration of zuriat fruit extract can increase the number of follicles in the ovary and increase estrogen hormone.  Keywords: (Mus musculus L.), free radicals, smoking, Hyphaene thebaica  ABSTRAK Hyphaene thebaica termasuk dalam keluarga Palmae yang sering disebut dengan buah zuriat. Hyphaene thebaica memiliki khasiat sebagai antimikroba, antioksidan, dan antidiabetes Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak zuriat terhadap jumlah folikel pada ovarium pada mencit betina (Mus musculus) yang diberi paparan asap rokok. Penelitian ini akan dilaksanakan selama 6 bulan pada bulan Januari sampai dengan Juni 2021. Jenis penelitian ini adalah eksperimental murni (true experimental) dengan pendekatan post test only control group design. Penelitian ini dilakukan dengan memberikan ekstrak buah zuriat sebagai perlakuan selama 42 hari pada mencit betina. Sampel yang akan digunakan dalam penelitian ini dihitung menggunakan rumus Federer (1991). Setelah dilakukan pemberian perlakuan selama 42 hari selanjutnya dilakukan pengamatan pada histologi ovarium yang meliputi: a. folikel primer, b. folikel sekunder c. folikel tersier dan hormone estrogen. Data hasil penelitian diolah menggunakan program statistik komputer (SPSS 22.0 for Windows) dengan menggunakan uji One Way Anova. Hasil penelitian menunjukan bahwa pemberian ekstrak buah zuriat dapat meningkatkan jumlah folikel pada ovarium dan meningkatkan hormone estrogen. Kata Kunci: (Mus musculus L.), Radikal Bebas, Rokok, Hyphaene Thebaica
Edukasi Pola Makan Sehat dalam Upaya Pengendalian Kadar Gula Darah pada Masa Pandemi COVID-19 Damayanti, Ida Ayu Manik; Antari, Ni Wayan Sukma; Lumbantobing, Gita Vidya Natalia; Tohir, Wa. Aniyda M.
LOSARI: Jurnal Pengabdian Kepada Masyarakat Vol. 3 No. 2 (2021): Desember 2021
Publisher : LOSARI DIGITAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53860/losari.v3i2.47

Abstract

Diabetes mellitus (DM) merupakan jenis penyakit menahun yang akan diderita seumur hidup oleh penderitanya bila tidak mendapat penanganan secara baik. Komplikasi yang ditimbulkan menjadikan diabetes mellitus sebagai penyakit penyerta yang menyebabkan tingginya angka keparahan dan kematian pada masa pandemi covid-19 yang terjadi  hampir di seluruh negara di dunia. Salah satu kota yang terdapat kasus ini adalah Kota Denpasar tepatnya wilayah Denpasar Selatan. Angka kejadian hipertensi serta DM di kelurahan Denpasar Selatan, didapatkan merupakan penyakit yang cukup tinggi diantara penyakit tidak menular lainnya. Berdasarkan permasalahan tersebut perlu dilakukan upaya preventif untuk menurunkan risiko komplikasi yang tinggi pada penderita penyakit tidak menular seperti diabetes mellitus. Hal ini dilakukan bertujuan untuk meningkatkan kesadaran kepada masyarakat di kelurahan Denpasar Selatan sehingga dilakukan edukasi mengenai pola asupan makanan sehat dan seimbang sebagai salah satu upaya pencegahan dan pengendalian kadar gula darah pada masa pandemi Covid-19. Metode pelaksanaan kegiatan diawali dengan tahap persiapan selanjutnya pelaksanaan dengan memberi edukasi berupa leaflet serta tanya jawab lisan dan diakhiri dengan evaluasi kepada masyarakat. Berdasarkan hasil kegiatan diketahui adanya peningkatan sebesar 50% terhadap pengetahuan responden tentang pola makan sehat dalam upaya pengendalian diabetes mellitus di masa pandemi covid-19.
POTENSI EKSTRAK KULIT ANGGUR BALI (Vitis vinifera L. Var. Alphonso Lavallee) TERHADAP BERAT BADAN: SKRINING FITOKIMIA DAN STUDI IN VIVO Damayanti, Ida Ayu Manik; Antari, Ni Wayan Sukma; Megayanti, Sri Dewi
Berita Biologi Vol 24 No 1 (2025): Berita Biologi
Publisher : BRIN Publishing (Penerbit BRIN)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/berita_biologi.2025.9564

Abstract

Sebanyak 51,7% penduduk Indonesia mengonsumsi makanan berlemak/berkolesterol/gorengan sebanyak 1-6 kali per minggu. Pada umumnya masyarakat mengonsumsi beberapa obat sintetik untuk mengatasi masalah berat badan dengan efek samping yang sangat mungkin terjadi. Dalam upaya mengatasi hal tersebut, penelitian mengenai potensi bahan alami sebagai agen penurun berat badan menjadi sangat relevan. Salah satu bahan alami yang menarik perhatian adalah kulit anggur Bali (Vitis vinifera L. Var. Alphonso Lavallee). Penelitian ini bertujuan untuk mengeksplorasi potensi ekstrak kulit anggur Bali dalam menurunkan berat badan melalui skrining fitokimia dan studi in vivo dengan memanfaatkan sumber daya lokal dalam pengembangan strategi penanganan penurunan berat badan yang efektif. Design penelitian yang digunakan adalah true experimental study dengan posttest only control group design. Kelompok yang digunakan yaitu kontrol negative, kontrol positif, P1 (100 mg/kgBB), P2 (250 mg/kgBB), dan P3 (500 mg/kgBB). Skrining fitokimia ekstrak kulit anggur Bali menunjukkan bahwa kulit anggur Bali mengandung senyawa flavonoid, fenol, alkaloid, tanin dan terpenoid. Penelitian ini menunjukkan bahwa ekstrak kulit anggur Bali (Vitis vinifera L. Var. Alphonso Lavallee) memiliki potensi signifikan dalam menurunkan berat badan mencit yang diberikan pakan tinggi lemak. Kelompok P3 menunjukkan total penurunan paling tinggi sebesar 2,4% dari hari ke-0 hingga hari ke-21dibandingkan P1 dan P2.  
Co-Authors A.A.S. A. Sukmaningsih AA Istri Mas Padmiswari Adiana, I Nengah Alfiah Hayati Aristadewi, Ida Ayu Mas Artha, I Wayan Oktapratama Deni Redita, I Komang Dharmapatni , Ni Wayan Kesari Dira, Made Asmarani Dwi Arymbhi Sanjaya Dwi Winarni Erlyn Nurul Fauziah Gandamayu, Ida Bagus Maha Gede Surya Indrawan Harditya, Kadek Buja I GEDE PUTU DARMA SUYASA I Made Bayu Jaya Kusuma Ida Ayu Manik Damayanti Ida Bagus Separsa Kusuma Inne Ninda Resita Kadek Ayu Ananda Maharini Kadek Buja Harditya Kadek Buja Harditya Lumbantobing, Gita Vidya Natalia Manik Damayanti, Ida Ayu Mas Aristadewi, Ida Ayu Nadya Treesna Wulansari Ni Kadek Sutini Ni Wayan Desi Bintari Ni Wayan Kesari Dharmapatni Nyoman Eta Risnawati Padmiswari, A.A. Istri Mas Pramana, I Kadek Bagus Ari Sri Dewi Megayanti Sri Dewi Megayanti Strisanti, Ida Ayu Suptika Sutrisna, Putu Gede Suweca, I Gede Tohir, Wa. Aniyda M. Wicaksana, IGA Tresna Widiatmaja, Gusti Panji Widyas Pranata, Gst. Kade Adi