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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Journal of Robotics and Control (JRC) International Journal of Robotics and Control Systems Sewagati Svāsthya: Trends in General Medicine and Public Health
Rangkuti, Rahmah Yasinta
Faculty Of Medicine And Health, Institut Teknologi Sepuluh Nopember
Aerospace Engineering Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Control & Systems Engineering Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Mechanical Engineering Medicine & Pharmacology Public Health Social Sciences Other

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Effect of Vitamin D3 Supplementation to 25(OH)D, IL-17, and HbA1c Level in Pediatric Type 1 Diabetes Mellitus Rangkuti, Rahmah Yasinta; Tjahjono, Harjoedi Adji
Journal of Tropical Life Science Vol 7, No 1 (2017)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.07.01.06

Abstract

Type 1 Diabetes Mellitus (T1DM) is the consequence of autoimmune destruction process of β cells which associated with Th17 activity and low 25(OH)D level. This study was aimed to investigate the effect of vitamin D3 supplementation toward 25(OH)D level, Th17 activity (IL-17) and glycemic control (HbA1c) in pediatric T1DM. This study was designed as randomized clinical trials (RCT), double-blind, pre and post-test controlled study. Subject was children with T1DM who were divided into two groups: K1: subjects were treated with insulin 0.5–2 IU/day + vitamin D3 2000 IU/day for 3 months, K2: subjects were treated with insulin 0.5–2 IU/day + placebo for 3 months. Levels of 25(OH)D, IL-17 and HbA1c were evaluated after 3 months treatment using ELISA. After 3 months treatment, results showed that 25(OH)D level was significantly higher in K1 compared with K2 (p = 0.00), IL-17 level was significantly lower K1 compared with K2 (p= 0.022). Surprisingly, HbA1c level in K1 was not significantly different with K2 (p = 0.93). Furthermore, in vitamin D-treated group, 25(OH)D level was elevated significantly after 3 months treatment with vitamin D (p = 0.00), IL-17 level was reduced significantly after 3 months treatment with vitamin D (p= 0.001)  and HbA1c level was reduced insignificantly after 3 months treatment with vitamin D (p= 0.76). Correlation study showed that there was no correlation between 25(OH)D level with IL-17 level (p= 0.160, r= -0.284) and 25(OH)D with HbA1c (p= 0.62, r= -0.10). This study can be conclude that vitamin D3 supplementation may elevate the 25(OH)D and reduce IL-17 level but did not change HbA1c level in pediatric T1DM.
Co-Authors Abdul Karim Abdurahman Abdurrahman Adhi Dharma Wibawa, Adhi Dharma Alvin Hartanto Kurniawan, Alvin Hartanto Dwinka Syafira Eljatin Evi Triandini Fadhlina, Afia Nuzila Fadli, Sonny Fira Soraya, Fira Fitriani, Fatimah Nur Furaidah, Erna Haque, Sayidah Aulia Ul Harjoedi Adji Tjahjono, Harjoedi Adji Hashim, Uda Haykal, Muhammad Nazhif Hedianto, Tri Hidayah, Rizka Nurul Imam Susilo Indriani, Ratri Dwi Indriastuti, Endah Karimah, Rumman Mahdi, Faizal Nakkliang, Kanittha Njoto, Edwin Nugroho Nurhayati, Lely Parlindungan, Putra Gelar Putra, Gumilar Fardhani Ami Putri Alief Siswanto Putri, Atina Irani Wira Radiansyah, Riva Satya Ridhoi, Ahmad Sakina Sangsawang, Thosporn Sari, Desiana Widityaning Syulthoni, Zain Budi Uda, Muhammad Nur Afnan Wawan Yunanto Yuri Pamungkas