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All Journal Indonesian Journal of Cancer Chemoprevention Journal of Islamic Pharmacy Jurnal Riset Kesehatan Poltekkes Depkes Bandung Sainstech Farma: Jurnal Ilmu Kefarmasian Medfarm: Jurnal Farmasi dan Kesehatan PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID) Indonesian Journal of Cancer Innovative: Journal Of Social Science Research Journal of Engineering Science and Technology Management Komunita: Jurnal Pengabdian dan Pemberdayaan Masyarakat International Journal of Contemporary Sciences (IJCS) Jurnal Ilmu Kesehatan Joong-Ki
Salmasfattah, Novyananda
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Religion Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Education on the Benefits of Red Ginger (Zingiber officinale) to Overcome Menstrual Pain in Adolescent Girls in Gembleb Trenggalek: Edukasi Manfaat Jahe Merah (Zingiber officinale) Untuk Mengatasi Nyeri Haid Pada Remaja Putri di Dusun Gembleb Trenggalek Saristiana, Yuneka; Prasetyawan, Fendy; Salmasfattah, Novyananda; Savitri, Lisa; Megasari, Elly; Indrayanti, Dian
KOMUNITA: Jurnal Pengabdian dan Pemberdayaan Masyarakat Vol 4 No 2 (2025): Mei
Publisher : PELITA NUSA TENGGARA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60004/komunita.v4i2.178

Abstract

This community service program aimed to educate adolescent girls in Dusun Gembleb, Trenggalek, on the benefits of red ginger (Zingiber officinale) as a natural remedy for alleviating menstrual pain. Menstrual pain, or dysmenorrhea, is a common health issue affecting a significant number of adolescent girls, often leading to disruption in daily activities. While conventional pain relief medications are commonly used, their long-term side effects can be detrimental. Red ginger, known for its anti-inflammatory and analgesic properties, offers a safer alternative. The program, held on May 3, 2025, at the Gembleb Village Office, included educational sessions on the medicinal properties of red ginger, practical demonstrations on how to prepare red ginger tea, and discussions on its health benefits. The results showed a significant improvement in participants' understanding of red ginger's therapeutic effects, as evidenced by pre-test and post-test comparisons. This initiative successfully raised awareness about alternative treatments and empowered the community to utilize locally available resources for health improvement.
Praktik Kolaboratif Antarprofesi pada Agenda Pemeriksaan Kesehatan dan Pengobatan Gratis bagi Masyarakat di Wilayah Universitas Kadiri Laili, Nur Fahma; Ilmi, Tsamrotul; Probosiwi, Neni; Salmasfattah, Novyananda
Joong-Ki : Jurnal Pengabdian Masyarakat Vol. 4 No. 4: Agustus 2025
Publisher : CV. Ulil Albab Corp

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56799/joongki.v4i4.9509

Abstract

Penyakit degeneratif semakin banyak terjadi akibat penurunan gaya hidup makanan dan olahraga. Penyakit tidak menular merupakan penyakit degeneratif yang berkaitan dengan proses penuaan, seperti diabetes mellitus, hipertensi, penyakit jantung, dan stroke. Banyak dari masyarakat yang tidak menyadari akan perlunya memeriksakan kesehatan lebih rutin dan mengatur gaya hidup yang baik. Pemeriksaan kesehatan dan pengobatan gratis merupakan bentuk pengabdian kepada masyarakat. Pemeriksaan kesehatan dan pengobatan gratis bertujuan agar masyarakat semakin sadar akan perlunya memeriksakan diri dan mengatur gaya hidup yang baik, sehingga dapat menjaga kondisi kesehatan diri sendiri dan keluarga terutama lansia. Pemeriksaan kesehatan dan pengobatan gratis dilakukan kepada 43 warga desa di wilayah Universitas Kadiri yang berupa pengecekan gula darah acak, asam urat, dan kolesterol, pemeriksaan lanjutan oleh dokter, pemberian obat, dan edukasi kesehatan. Kegiatan ini disambut dengan baik oleh warga maupun perangkat desa setempat. Kegiatan ini juga dapat mengurangi beban biaya masyarakat untuk berobat, serta memberikan akses yang lebih mudah dan terjangkau terhadap layanan kesehatan yang penting bagi kesejahteraan mereka. Diharapkan melalui kegiatan ini kesadaran masyarakat khususnya lansia dapat meningkat, sehingga dapat meningkatkan kualitas hidup dan derajat kesehatan yang optimal.
Identification of Active Compounds from Sambung Nyawa Leaves (Gynura procumbens (Lour.) Merr) as Potential Natural Antioxidant and Anti-inflammatory Agents Saristiana, Yuneka; Salmasfattah, Novyananda; Prasetyawan, Fendy; Savitri, Lisa; Kadir, Mujtahid Bin Abd
PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS Vol. 4 No. 3 (2025): JULY
Publisher : Transpublika Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55047/comorbid.v4i3.1865

Abstract

Diseases caused by oxidative stress and inflammation are global health problems that encourage the search for alternative treatments from natural materials. Grapevine leaves (Gynura procumbens (Lour.) Merr.) have long been empirically used, but scientific validation of their potential is still limited. The objective of this research is to identify and describe the active substances in sambung nyawa leaves and assess their effectiveness as natural antioxidants and anti-inflammatory agents. The study involves conducting laboratory experiments, starting with the extraction of sambung nyawa leaves using 96% ethanol solvent through a maceration process. The extract obtained is then analysed for its phytochemical composition. The antioxidant activity is evaluated using the DPPH method to determine the IC₅₀ value. On the other hand, the anti-inflammatory properties are tested in male Wistar rats following the induction of rat hind paw edema with 1% carrageenan, using extract doses of 75, 150, and 300 mg/kgBW. The findings indicate a 13.4% yield from the extraction process. The phytochemical analysis reveals the presence of flavonoids, alkaloids, saponins, tannins, phenols, and steroids/triterpenoids. The antioxidant test results show a moderate level of activity with an IC₅₀ value of 89.26 µg/mL. In the anti-inflammatory test, the 150 mg/kgBW dose demonstrates the highest efficacy with a 52.00% reduction in edema, comparable to the positive control triamcinolone (55.00%). In summary, the ethanol extract of sambung nyawa leaves exhibits promising potential as an antioxidant and anti-inflammatory agent, indicating its suitability for further development as a botanical pharmaceutical ingredient.
Evaluation of Rational Antibiotic Use (RAU) in Cerebrovascular Accident (CVA) Patients in the ICU Using the Gyssens Criteria Prasetyawan, Fendy; Saristiana, Yuneka; Savitri, Lisa; Salmasfattah, Novyananda; Ilmi, Tsamrotul; Herman, Herman
PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS Vol. 4 No. 3 (2025): JULY
Publisher : Transpublika Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55047/comorbid.v4i3.1818

Abstract

Cerebrovascular accident (CVA) is a major cause of morbidity and mortality, often requiring intensive care unit (ICU) treatment. Patients with CVA are at high risk for secondary infections, which commonly lead to the use of antibiotics. This study aimed to evaluate the patterns and rationality of antibiotic use in CVA patients treated in the ICU of a regional hospital using the Gyssens method. A retrospective observational study was conducted involving 30 CVA patients who received antibiotics during their ICU stay. Data collected included patient demographics, comorbidities, types of antibiotics used, route of administration, combination patterns, and evaluation of prescription rationality based on the Gyssens criteria. The most frequently used antibiotic class was third-generation cephalosporins (60%), with ceftriaxone being the most prescribed (46.7%). All antibiotics were administered intravenously. Combination therapy was used in 20% of cases. Based on Gyssens categorization, only 33.3% of prescriptions were considered rational (category 0). The remaining 66.7% were irrational, including delayed initiation or discontinuation (13.3%), incorrect dosing (16.7%), unnecessarily broad-spectrum (10%), and no indication (6.7%). The study highlights a substantial proportion of irrational antibiotic use in ICU CVA patients, mainly due to suboptimal timing, dosing errors, and unnecessary broad-spectrum antibiotics. These findings underline the importance of antimicrobial stewardship and routine rationality assessments to ensure optimal antibiotic use and patient outcomes.
Aphrodisiac Effect of Ethanol Extract of Tapak Liman (Elephantopus scaber L.) Leaves on Testosterone Levels and Testicular Histology in Rats Saristiana, Yuneka; Salmasfattah, Novyananda; Prasetyawan, Fendy; Savitri, Lisa
PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS Vol. 4 No. 4 (2025): OCTOBER
Publisher : Transpublika Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55047/comorbid.v4i4.1935

Abstract

The demand for aphrodisiac use is substantial, however, many marketed herbal products contain synthetic drugs, underscoring the urgent need for safer natural therapeutic alternatives. This study aimed to evaluate the aphrodisiac potential of ethanol extract of Elephantopus scaber (Tapak Liman) leaves on serum testosterone levels and testicular histology in male Wistar rats. The extract was obtained through maceration with 70% ethanol and subjected to phytochemical screening, which revealed the presence of flavonoids, tannins/phenolics, and triterpenoids. Healthy male Wistar rats were divided into five groups: normal control, negative control, positive control (sildenafil), and two treatment groups receiving 100 mg/kg BW and 200 mg/kg BW of the extract for 21 days. Serum testosterone levels were measured using ELISA, while histological examination focused on the diameter of seminiferous tubules. The results demonstrated that the 200 mg/kg BW dose significantly increased testosterone levels (209.41 ± 0.62 ng/dL) compared with the negative control (120.32 ± 1.55 ng/dL) and restored the diameter of seminiferous tubules (220.56 ± 4.98 µm) close to normal conditions (225.30 ± 5.12 µm). The 100 mg/kg BW dose produced a moderate effect, while the positive control also showed notable improvement. The observed increase in testosterone and recovery of seminiferous tubule diameter indicate that the extract enhances spermatogenic activity and testicular function. In conclusion, the ethanol extract of E. scaber leaves at 200 mg/kg BW demonstrated significant aphrodisiac activity through hormonal stimulation and improvement of testicular histology, suggesting its potential as a natural agent to support male reproductive health.
Hubungan Kepatuhan Minum Obat Dengan Kualitas Hidup Pasien Hipertensi di Fasilitas Kesehatan Tingkat Pertama Kota Malang Nur Jannah, Ilfi; Permata, Agung; Salmasfattah, Novyananda
Innovative: Journal Of Social Science Research Vol. 3 No. 5 (2023): Innovative: Journal of Social Science Research
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Artikel ini membahas hubungan antara kepatuhan minum obat dan kualitas hidup pada pasien hipertensi di fasilitas kesehatan tingkat pertama di Kota Malang. Hipertensi adalah penyakit kronis yang dapat menyebabkan komplikasi berbahaya seperti penyakit jantung, stroke, dan gagal ginjal. Ketidakpatuhan dalam minum obat merupakan penyebab utama kematian di seluruh dunia. Pasien yang tidak patuh terhadap pengobatan dapat mengalami komplikasi dan penurunan kualitas hidup. Penelitian ini bertujuan untuk menganalisis hubungan antara kepatuhan minum obat dan kualitas hidup pada pasien hipertensi serta memberikan wawasan untuk pengelolaan hipertensi yang lebih baik di Kota Malang. Penelitian ini menggunakan metode penelitian kuantitatif dengan desain penelitian cross-sectional. Data dikumpulkan melalui lembar data demografi, kuesioner MARS-5, dan kuesioner EQ-5D-5L. Hasil penelitian menunjukkan bahwa mayoritas responden adalah lansia awal dengan usia 46-55 tahun. Jumlah responden perempuan lebih banyak daripada laki-laki. Mayoritas responden bekerja sebagai wiraswasta dan memiliki tingkat pendidikan SMA. Tingkat kepatuhan minum obat mayoritas tinggi. Serta rata-rata skor utilitas sebesar 0,86. Terdapat adanya hubungan antara kepatuhan minum obat dengan kualitas hidup pasien hipertensi.
Virtual Screening on Molecules Targeting the Interaction Between Estrogen Receptor Beta and Murine Double Minute 2 Salmasfattah, Novyananda; Nurulita, Nunuk Aries; Dhiani, Binar Asrining
Indonesian Journal of Cancer Chemoprevention Vol 13, No 3 (2022)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev13iss3pp184-194

Abstract

Estrogen receptor beta (ERβ) is an isoform of estrogen receptor that plays a role in breast cancer. An E3 ubiquitin ligase, murine double minute 2 (MDM2), can bind to ERβ and degrade it. Virtual screening and protein-protein docking studies are one of the approaches that can be performed to discover FDA-approved drugs targeting the interaction of the ERβ-MDM2 complex. This study aimed to conduct virtual screening of 1615 compounds targeting the interaction between ERβ-MDM2 as an initial study to discover potential breast cancer drugs. Biovia Discovery Studio 2021, ClusPro 2.0, PyRx 8.0, and PyMOL software were utilized in this study. ERβ (PDB ID: 3OLS) and MDM2 (PDB ID: 1T4E) receptors were docked to obtain the ERβ-MDM2 protein complex. The ligands used in the virtual screening were FDA-approved drugs downloaded from the ZINC database. PIC and PLIP web tools were also utilized to analyze the amino acid residues involved in the interaction. The virtual screening results showed that ergotamine was the drug with the lowest energy score (-12.0 kcal/mol) among 1057 drugs and was able to establish the strongest interaction between ERβ-MDM2. In conclusion, based on this computational study, ergotamine strengthens the interaction between ERβ-MDM2 and thus could be used as a candidate for breast cancer drug. Thorough validation of in vitro, biochemical, and in vivo studies are needed to confirm this finding.Keywords: Estrogen receptor beta, breast cancer, protein-protein interaction, MDM2.
ADMET Prediction of the Dominant Compound from Mangosteen (Garcinia mangostana L.) using pkCSM: A Computational Approach Muslikh, Faisal Akhmal; Kurniawati, Evi; Ma'arif, Burhan; Zenmas, Syendriva Zeptyan; Salmasfattah, Novyananda; Dhafin, Anis Akhwan; Prasetyawan, Fendy
International Journal of Contemporary Sciences (IJCS) Vol. 1 No. 1 (2023): November 2023
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/ijcs.v1i1.7271

Abstract

Mangosteen (Garcinia mangostana L.) is a plant belonging to the Guttiferae family with origins in Southeast Asia. The primary components in mangosteen peel consist of xanthones, particularly α-mangostin, which displays diverse pharmacological effects such as anti-diabetic properties, antioxidant activity, and anti-inflammatory effects. However, due to the insufficient information regarding studies on pharmacokinetics (administration, distribution, metabolism, excretion, and toxicity), the objective of this investigation is to explore pharmacokinetic predictions utilizing the pkCSM web tool. The α-mangostin compound, acquired from PubChem accessible at https://pubchem.ncbi.nlm.nih.gov/, underwent pharmacokinetic analysis using the web tool available at https://biosig.lab.uq.edu.au/pkcsm/prediction. The study findings revealed that the α-mangostin compound, subjected to pharmacokinetic analysis with pkCSM, exhibited limited distribution capability.
Co-Authors Abdullah, Muhammad Rizal Afiansyah, Ahmad Gasya Aldesra Fitri Anggyadinata, Frisma Anis Akhwan Dhafin Ardianto, Nanang Besan, Emma Jayanti Binar Asrining Dhiani Evi Kurniawati, Evi Faisal Akhmal Muslikh Fendy Prasetyawan Galih Satrio Putra Herman Ibrahim, Kevvy Buana Indrayanti, Dian Kadir, Mujtahid Bin Abd Kadir, Mujtahid Bin And Laili, Nur Fahma Ma'arif, Burhan Megasari, Elly Mildawati, Ratna Muhammad Nurul Fadel Neni Probosiwi Nunuk Aries Nurulita Nur Jannah, Ilfi Permata, Agung Prayogi, Syaiful Raden Mohamad Herdian Bhakti Salsabila, Dia savitri, Lisa Shinta Mayasari Sugeng Santoso Tsamrotul Ilmi Yuneka Saristiana Zenmas, Syendriva Zeptyan