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The Potential Use of Red Ginger (Zingiber officinale Roscoe) Dregs as Analgesic Febriani, Yessi; Riasari, Hesti; Winingsih, Wiwin; Aulifa, Diah Lia; Permatasari, Ayu
Indonesian Journal of Pharmaceutical Science and Technology Suppl 1, No. 1 (2018)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Red ginger (Zingiber officinale Roscoe) had been used as excipient in jamu for most people in Indo- nesia. Based on recent research, ethanol extract of red ginger had analgesics activity. The purpose of this research to determine analgesic activity content in water extract of the fresh and dry red ginger and ethanol extract of fresh and dry of red ginger dregs. Fresh and dry of red ginger extracted using decoc- tion method, and the dregs of fresh and dry red ginger extracted using soxhletation method in ethanol 96% at 400C. Red ginger water extract and red ginger dregs extract had been examined for analgesic by witkin method. The results showed, fresh and dry red ginger water extract had analgesic activity for 25 minutes but the activity reduced in 30 minutes. Fresh and dry red ginger dregs ethanol extract still had analgesic activity until 30 minutes. TLC chromatogram was sprayed with FeCl3 and formed two spots with grey colour for both extracts. After sprayed with vanillin sulfate, it formed violet and blue spots from both extracts. From the retention factor (Rf) , possibility shogaol and gingerol contained in extract that have analgesic activity. Key words: Analgesic, dregs, phenolic, red ginger (Zingiber o cinale Roscoe), Witkin method.

Essential Oil Composition, Antioxidant and Antibacterial Activities of Nutmeg (Myristica fragrans Houtt) from Garut West Java Wibowo, Diki Prayugo; Febriana, Yessi; Riasari, Hesti; Auilifa, Diah Lia
Indonesian Journal of Pharmaceutical Science and Technology Vol 5, No 3 (2018)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

West Java is rich in essential oil-producing plants, essential oilsÂ known to beÂ responsible forÂ someÂ pharmacologicalÂ activitiesÂ amongÂ itsÂ antioxidant andÂ antimicrobial.Â This research aims to know antimicrobial, antioxidant activity and identify the components of a compound essential oil of nutmeg (Myristica fragrans Houtt.). Components chemistry identified with GC-MS (Gas Chromatography-Mass pectrometer). Antioxidant activity measured by using the DPPH method (2 2-diphenyl-1-picrylhydrazyl) at 516Â Î»Â wavelengthÂ absorbance. Antimicrobial activity determined Minimum Inhibitory Concentrations (MIC) and Minimum Bactericidal Concentrations (MBC) using microdilution method. The result of GC-MS showed the highest component on nutmeg containing 22.22% myristicin. The antioxidant test showed nutmeg had IC50 at 3,16%, essential oil showed antibacterial activity against Gram positive and Gram negative bacteria. Minimum inhibitory concentrations of essential oils range from 0.313% to 10%. The content of essential oils of nutmeg plants that grow in the area of West Java Garut can be used to overcome the problems of antioxidants and antimicrobial.Key words: Antioxidant, Antibacterial, Pala (Myristica fragrans Houtt), Chemical Composition.

Evaluation Patch of Rhizoma Extract Kencur (Kaempferia galanga L.) as Anti-Inflammatory with Enhancer Hesti Riasari; Revika Rachmaniar; Sri Wahyuni
Indonesian Journal of Pharmaceutical Science and Technology Vol 6, No 2 (2019)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Kencur (Kaempferia galanga L.) is a family of Zingiberaceae. Several studies have shown that kencur can help reduce inflammation because kencur is known to contain anti-inflammatory compounds, namely marker compounds from flavonoids, kaempferol. For the development of pharmaceutical preparations, research on anti-inflammatory plasters containing 96% ethanol extract, n-hexane extract, ethyl acetate extract and 70% ethanol extract from ginger rhizome with the addition of penetration enhancer (enhancer), namely propylene glycol. This anti-inflammatory plaster was tested for its activity in 5 groups of Wistar strain rat feet which had been induced 1% carrageenan (negative control); positive control (diclofenac sodium), ethanol96% extract, n-hexane extract, ethyl acetate extract and 70% ethanol extract from kencur rhizome and compared with plaster of kencur rhizome ethanol extract without enhancer. The results showed the effect of adding enhancers 30 minutes after administration. 96% ethanol extract and ethyl acetate extract had reduced inflammation by 79.99% in rat test animals compared to plaster ethanol extract of rhizome kencur without the addition of enhancers. Keywords : Kaempferia galanga. L., patch, anti-inflammatory, enhancer, propylene glycol

The Potential Use of Red Ginger (Zingiber officinale Roscoe) Dregs as Analgesic Yessi Febriani; Hesti Riasari; Wiwin Winingsih; Diah Lia Aulifa; Ayu Permatasari
Indonesian Journal of Pharmaceutical Science and Technology Suppl 1, No. 1 (2018)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Red ginger (Zingiber officinale Roscoe) had been used as excipient in jamu for most people in Indo- nesia. Based on recent research, ethanol extract of red ginger had analgesics activity. The purpose of this research to determine analgesic activity content in water extract of the fresh and dry red ginger and ethanol extract of fresh and dry of red ginger dregs. Fresh and dry of red ginger extracted using decoc- tion method, and the dregs of fresh and dry red ginger extracted using soxhletation method in ethanol 96% at 400C. Red ginger water extract and red ginger dregs extract had been examined for analgesic by witkin method. The results showed, fresh and dry red ginger water extract had analgesic activity for 25 minutes but the activity reduced in 30 minutes. Fresh and dry red ginger dregs ethanol extract still had analgesic activity until 30 minutes. TLC chromatogram was sprayed with FeCl3 and formed two spots with grey colour for both extracts. After sprayed with vanillin sulfate, it formed violet and blue spots from both extracts. From the retention factor (Rf) , possibility shogaol and gingerol contained in extract that have analgesic activity. Key words: Analgesic, dregs, phenolic, red ginger (Zingiber o cinale Roscoe), Witkin method.

Essential Oil Composition, Antioxidant and Antibacterial Activities of Nutmeg (Myristica fragrans Houtt) from Garut West Java Diki Prayugo Wibowo; Yessi Febriana; Hesti Riasari; Diah Lia Auilifa
Indonesian Journal of Pharmaceutical Science and Technology Vol 5, No 3 (2018)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

West Java is rich in essential oil-producing plants, essential oils known to be responsible for some pharmacological activities among its antioxidant and antimicrobial. This research aims to know antimicrobial, antioxidant activity and identify the components of a compound essential oil of nutmeg (Myristica fragrans Houtt.). Components chemistry identified with GC-MS (Gas Chromatography-Mass pectrometer). Antioxidant activity measured by using the DPPH method (2 2-diphenyl-1-picrylhydrazyl) at 516 λ wavelength absorbance. Antimicrobial activity determined Minimum Inhibitory Concentrations (MIC) and Minimum Bactericidal Concentrations (MBC) using microdilution method. The result of GC-MS showed the highest component on nutmeg containing 22.22% myristicin. The antioxidant test showed nutmeg had IC50 at 3,16%, essential oil showed antibacterial activity against Gram positive and Gram negative bacteria. Minimum inhibitory concentrations of essential oils range from 0.313% to 10%. The content of essential oils of nutmeg plants that grow in the area of West Java Garut can be used to overcome the problems of antioxidants and antimicrobial.Key words: Antioxidant, Antibacterial, Pala (Myristica fragrans Houtt), Chemical Composition.

Comparison of Anti-Inflammatory Activity between Fermented and Dried Breadfruit Leaves Extract Hesti Riasari; Sani N. Fitriansyah; Oktamuman Putra
Pharmacology and Clinical Pharmacy Research Vol 3, No 3
Publisher : Universitas Padjadjaran, Indonesia

Breadfruit leaves (Artocarpus altilis) have been empirically used to treat inflammation. Biosynthesis process such as fermentation can possibly changes the composition of secondary metabolites in breadfruit leaves. The aim of this study was to compare the anti-inflammatory activity between fermented and natural-dried breadfruit leaves extract. Fermented and dried breadfruit leaves were extracted with soxhlet device using methanol solvent. The anti-inflammatory activity of both extracts were evaluated using carrageenan (1% w/v) foot edema model of inflammation in male Wistar rats. The edema was measured with plethysmometer every 1 hour for 6 hours. The results showed that both extracts exhibited anti-inflammatory activity. 50 mg and 100 mg fermented leaves extracts exhibited 37.17% and 71.82% inhibition, while the same concentrations of dried extract exhibited 39.50% and 57.72%, inhibiton respectively. In conclusion, the best anti-inflammatory activity was shown by fermented breadfruit leaves extract.Keywords: Artocarpus altilis, anti-inflammatory, breadfruit, fermentation

Toxicity Assay of Fermented Artocarpus altilis Leaves Using Brine Shrimp Lethality Test Hesti Riasari; Yessi Febriani; Winda A. Nurfauziah
Pharmacology and Clinical Pharmacy Research Vol 4, No 2
Publisher : Universitas Padjadjaran, Indonesia

Fermented Artocarpus altilis leaves contains phenolic compound that has pharmacological activity. Differences in fermentation method, i.e., aerobic and anaerobic fermentation might change its characteristics and biological activity. The purpose of this study was to compare toxicity properties between aerobically and anaerobically fermented Artocarpus altilis leaves using brine shrimp lethality (BSL) test. Both types of fermented leaves were cold extracted using ethanol solvent (1:6) for 3 x 24 hours. Phytochemical screening was then performed to examine the presence of secondary metabolite compounds. BSL test was performed in 7 treatment groups, i.e., negative control, 1000, 500, 100, 50, 25, 12.5 ppm of extract. Each vial contained 10 Artemia larvae, extract, and sea water up to 10 ml. Toxicity is measured by calculating LC50 after 24 hours observation. The experiment was repeated three times. The results of the study showed that LC50 of aerobic extract was 712 ppm, thus it can be categorized as toxic, while that of anaerobic extract is 1.927 ppm, or non-toxic to the Artemia salina larvae. In conclusion, aerobically fermented Artocarpus altilis leaves had toxicity potency, while anaerobically fermented Artocarpus altilis leaves had no toxicity potency against Artemia salina in BSL test. Key words: Artocarpus altilis, brine shrimp lethality test, toxicity.

Anti-Inflammatory Activity of Artocarpus altilis (Parkinson) Fosberg in Wistar Male Rats Hesti Riasari; Sani Nurlalela; Ginanjar C. Gumilang
Pharmacology and Clinical Pharmacy Research Vol 4, No 1
Publisher : Universitas Padjadjaran, Indonesia

Inflammation is a local reaction in vascular tissue characterized by several symptoms, e.g., swelling, redness, and pain. Indonesia is one of the countries with high biodiversity, including traditional medicinal plants. Artocarpus altilis is one the plants that is widely used to treat inflammation. There is limited information on biological activity of A. altilis.This study was performed to evaluate anti-inflammatory properties of A. altilis detached and attached leaves in Wistar male rats. A. altilis was extracted using soxhlet method at 67.4 0C with methanol solvent. Inflammation was induced by the administration of carrageenan to the rats paw. Subsequently, the extract of A. altilis were orally administered. The edema were measured using plethysmometer for 6 hours. We found that there were differences in anti-inflammatory activity between detached and attached leaves. The inhibition of edema in attached leaves were 50% and 53.33% for the concentration of 50 mg and 100 mg, respectively. The greater inhibiton was observed in the detached leaves, with 73.33% and 76.67% inhibition, for the concentration of 50 mg and 100 mg, respectively. Nevertheless, the inhibition percentage was still below diclofenac sodium as a positive control (83.33%). In conclusion, A. altilis leaves extracts showed good anti-inflammatory properties and has the potential for development of anti-inflammatory drug. Keywords: Artocarpus altilis, carageenan, inflammation, edema

Kreasi Olahan Pangan Berbahan Buah Pepaya Dan Buah Naga dalam Kegiatan Pengabdian kepada Masyarakat Siti Uswatun Hasanah; Hesti Riasari; Sani Nurlaela Fitriansyah
Jurnal Altifani Penelitian dan Pengabdian kepada Masyarakat Vol. 2 No. 5 (2022): September 2022 - Jurnal Altifani Penelitian dan Pengabdian kepada Masyarakat
Publisher : Indonesian Scientific Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25008/altifani.v2i5.284

Kegiatan pengabdian kepada masyarakat merupakan salah satu dari tridarma seorang dosen. Kegiatan pengabdian kali ini dilaksanakan di Desa Sukaluyu, yang berada di kabupaten Tasikmalaya. Potensi alam desa tersebut diantaranya adalah buah naga dan buah pepaya. Desa tersebut memanfaatkan buah naga dan pepaya sebagai konsumsi harian dan dijual dalam bentuk buah segar tanpa diolah. Atas dasar kondisi tersebut, dilakukanlah pengabdian masyarakat dengan tema utama pengolahan potensi alam Desa Sukaluyu menjadi produk pangan dengan nilai jual tinggi. Sasaran dalam kegiatan ini adalah seluruh warga Desa Sukaluyu, melalui para ibi-ibu Pemberdayaan Kesejahteraan Keuarga. Pelaksanaan pengabdian terbagi atas dua sesi, yaitu sesi penyuluhan, dan sesi kedua adalah pelatihan pembuatan produk. Produk pangan yang diangkat dalam pengabdian ini adalah baso, chips/keripik, mie nature, serta dan satu produk kosmetik, berupa lulur tradisonal dengan memanfaatkan limbah kulit buah naga. Warga sekitar sangat antusias dengan diadakannya pelatihan tersebut, karena dapat memberikan tambahan pengetahuan, dan memberikan peluang usaha baru.

KARAKTERISASI SENYAWA FENOL DARI FRAKSI TERPILIH DAUN SUKUN (Artocarpus altilis (Parkinson) Fosberg) KUNING NEMPEL SEBAGAI ANTIOKSIDAN Hesti - Riasari; Achmad - Zainuddin; Dini Yulia Handayani
JURNAL SAINS DAN TEKNOLOGI FARMASI INDONESIA Vol 4, No 2 (2015)
Publisher : Sekolah Tinggi Farmasi Indonesia

AbstrakTumbuhan sukun (Artocarpus altilis) banyak dijumpai di Indonesia. Penelitian terdahulu menyatakan bahwa ekstrak metanol daun sukun kuning nempel memiliki aktivitas antioksidan. Tujuan penelitian ini adalah untuk mengetahui fraksi daun sukun kuning nempel yang memberikan aktivitas antioksidan paling baik, serta mengisolasi senyawa tersebut. Daun sukun kuning nempel diekstraksi menggunakan metode maserasi dan difraksinasi menggunakan metode ekstraksi cair-cair, sehingga diperoleh fraksi n-heksan, fraksi etil asetat dan fraksi air untuk dilakukan pengujian aktivitas antioksidan dengan metode DPPH. Fraksi etil asetat menunjukkan hasil paling baik dengan IC50 sebesar 17,11 dibandingkan dengan IC50 fraksi n-heksan sebesar 26,16 dan IC50 fraksi air sebesar 20,68 sehingga dilakukan pemisahan lebih lanjut pada fraksi etil asetat. Hasil identifikasi isolat 1 menggunakan spektrofotometri UV-Vis menunjukkan panjang gelombang 291 nm yang diduga merupakan senyawa fenol. Dan isolat 2 menunjukkan panjang gelombang 320 nm pada pita I dan pita II 276 nm yang merupakan ciri khas senyawa flavanon. Hasil diperkuat dengan penambahan pereaksi geser dan FTIR yang menunjukkan adanya gugus OH, gugus CH alifatik, ikatan rangkap C=O, gugus C=C aromatik dan gugus C-O pada isolat 2. Hal tersebut membuktikan bahwa isolat 2 merupakan senyawa fenol golongan flavonoid yaitu flavanon yang memiliki aktivitas antioksidan. Kata kunci : Daun sukun, antioksidan, DPPH, isolasi, flavanon AbstractPlant breadfruit (Artocarpus altilis) found in Indonesia. According to the previous research the methanol extract of leaves of breadfruit yellow has antioxidant activity. The purpose of this research is to know the fraction of breadfruit attached yellow leaves was given the most excellent antioxidant activity, and isolating the compound. Leaves of breadfruit attached yellow extracted using maceration method and fractination method using liquid-liquid extraction, obtained the n-hexan fraction, ethyl acetate fraction and the water fraction for tested antioxidant activity with DPPH method. Ethyl acetate fraction shows the best results with IC50 17.11 compared with IC50 n-hexan fraction 26.16 and IC50 water fraction 20.68 so that further separation carried out on ethyl acetate fraction. The results of isolates 1 identification used spectrophotometry UV-Vis a wavelength 291 nm was suspected phenol compound. And isolates 2 shows wavelength 320 nm the band I and band II 276 nm which is characteristic of the flavanon compound. The results reinforced with the addition of shift reagent and FTIR that indicate the presence of hydroxyl OH, aliphatic CH, double bond C = O , C = C aromatic and group of C-O of isolates 2. It proves that isolates 2 is phenol compound, flavonoid group, namely flavanon which has antioxidant activity. Keywords: Breadfruit leaves, antioxidant, DPPH, isolation, flavanon

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