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All Journal Indonesian Journal of Pharmaceutical Science and Technology Pharmacology and Clinical Pharmacy Research CARADDE: Jurnal Pengabdian Kepada Masyarakat Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Lumbung Farmasi : Jurnal Ilmu Kefarmasian Jurnal Mandala Pengabdian Masyarakat Jurnal Buana Farma Jurnal Altifani Penelitian dan Pengabdian kepada Masyarakat Journal of Education Research Jurnal Pengabdian Masyarakat Bhinneka Jurnal Sains dan Teknologi Farmasi Indonesia Health Research Journal of Indonesia
Hesti Riasari
Sekolah Tinggi Farmasi Indonesia
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences

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AKTIVITAS ANTIHIPERGLIKEMIA DARI EKSTRAK ETANOL DAUN SUKUN (Artocarpus altilis (Park.) Fosberg) KUNING JATUH DAN JATUH KERING PADA MENCIT PUTIH JANTAN GALUR SWISS WEBSTER DENGAN METODE INDUKSI ALOKSAN Hesti - Riasari; Maria - Ulfah; Linda - Audina
JURNAL SAINS DAN TEKNOLOGI FARMASI INDONESIA Vol 7, No 1 (2018)
Publisher : Sekolah Tinggi Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (482.198 KB) | DOI: 10.58327/jstfi.v7i1.72

Abstract

AbstrakDiabetes melitus atau yang lebih dikenal dengan penyakit gula diakibatkan oleh kekurangan hormon insulin. Sukun merupakan salah satu tanaman yang dimanfaatkan masyarakat sebagai obat untuk penyakit diabetes. Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak etanol dari daun sukun jatuh kering dan kuning jatuh sebagai antihiperglikemia pada mencit putih jantan galur Swiss Webster yang diinduksi aloksan. Uji aktivitas antihiperglikemia dilakukan dengan menggunakan 27 ekor mencit yang dibagi menjadi 9 kelompok perlakuan. Masing-masing kelompok terdiri dari 3 ekor mencit. Kelompok perlakuan terbagi menjadi kelompok kontrol normal, kontrol negatif, kontrol positif dan kelompok uji, kelompok uji terdiri dari Kuning Jatuh 200, 400 dan 600 mg/KgBB, Jatuh Kering 200, 400 dan 600 mg/KgBB. Semua kadar gula darah awal diukur sebelum di induksi aloksan. Semua kelompok diinduksi aloksan sebesar 70mg/KgBB kecuali kelompok normal dan kontrol negatif. Setelah 7 hari diinduksi, hewan dipuasakan lalu diukur kadar gula darah. Kadar gula darah dicek pada hari ke-7, ke-14 dan ke-21. Data diuji secara statistik menggunakan one way ANOVA dengan tahap kepercayaan p<0,05. Hasil pengujian menunjukkan Ekstrak etanol daun sukun kuning jatuh dan jatuh kering memiliki aktivitas antihiperglikemia, daun sukun jatuh kering dosis 600mg/KgBB menunjukkan aktivitas antihiperglikemia yang paling baik diantara semua kelompok uji secara bermakna jika dibandingkan dengan kelompok kontrol.  Kata kunci : Antihiperglikemia, Daun Sukun, Aloksan, Swiss Webster  AbstractDiabetes mellitus or more commonly known as diabetes caused by insulin deficiency. Breadfruit (Artocapus altilis (Park.) Fosberg) is one of the plant that used by native people as diabetics medicin. This study aimed to determine the effect of ethanol extract of dried breadfruit leaf fall and yellow fall as antihyperglycemia in mice white male Swiss Webster strain induced alloxan. Antihyperglycemia activity test was performed using 27 mice were divided into 9 groups. Each group consisted of three mice. The treatment group was divided into normal control group, negative control, positive control and test group, test group consisted of Fallen dry 200, 400 and 600 mg/KgBW, Falen Yellowl 200, 400 and 600 mg / KgBW. All initial blood sugar levels were measured before induction of alloxan. All groups alloxan induced by 70mg/KgBW except the normal group and negative control. After 7 days induced, the animals were fasted and then measured blood sugar levels. Blood sugar levels are calculated on the 7th, 14th and 21st. Data were statistically tested using one-way ANOVA with the stage of confidence p<0.05. The test results showed the ethanol extract of leaves of breadfruit has antihyperglycemia activity, breadfruit leaves tumble drier dose of 600mg/KgBW showed activity antihyperglycemia the best among all of the test groups were significantly when compared with the control group.  Keywords: Antihyperglycemia, Breadfruit Leaves, Alloxan, Swiss Webster
Pelatihan Pembuatan Parem dan Minuman Herbal Sebagai Peningkat Imunitas dan Peluang Usaha Mandiri Siti Uswatun Hasanah; Diki Prayugo Wibowo; Hesti Riasari; Sani Nurlaela
CARADDE: Jurnal Pengabdian Kepada Masyarakat Vol. 5 No. 3 (2023): April
Publisher : Ilin Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31960/caradde.v5i3.1767

Abstract

Conditions after the COVD-19 pandemic still require residents to maintain their immunity, one of which is by using family medicinal plants. Ginger plant is a traditional spice that is found in many areas. This community service activity aims to provide knowledge about the benefits of herbal plants as immune boosters and processing ginger spices to become herbal drink products and parem, as daily consumption. The method of activity is to provide counseling to residents and make products directly, along with packaging and brochures as product companions. As a result of community service activities, people get additional knowledge about herbal plants that can increase body immunity as well as get knowledge about simple ways to process herbal plants.
PERBANDINGAN METODE FERMENTASI, EKSTRAKSI, DAN KEPOLARAN PELARUT TERHADAP KADAR TOTAL FLAVONOID DAN STEROID PADA DAUN SUKUN (Artocarpus altilis (Parkinson) Fosberg) Riasari, Hesti; Fitriansyah, Sani Nurlaela; Hoeriah, Irna Siti
JURNAL SAINS DAN TEKNOLOGI FARMASI INDONESIA Vol 11, No 1 (2022)
Publisher : Sekolah Tinggi Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (617.089 KB) | DOI: 10.58327/jstfi.v11i1.165

Abstract

Daun sukun mengandung metabolit sekunder antara lain flavonoid, polifenol, kuinon, dan steroid1. Proses biosintetik dapat menyebabkan perubahan warna, kandungan, dan jenis kandungan yang ada pada daun sukun. penelitian menggambarkan konsentrasi total metabolit sekunder yang dipisahkan berdasarkan polaritas pelarut dan metode ekstraksi. Proses biosintetik adalah fermentasi daun hijau segar menjadi daun hijau fermentasi (HF) melalui metode fermentasi aerob dan anaerob. Ekstraksi dilakukan dengan dua metode yaitu metode panas (sokletasi) dan metode dingin (maserasi) untuk membandingkan metode ekstraksi yang lebih baik. Ekstraksi dilakukan dengan kepolaran bergradasi menggunakan pelarut N-heksana, etil asetat, dan etanol. Ekstraksi kepolaran bertingkat akan menghasilkan senyawa-senyawa tertentu yang terpisah secara spesifik pada setiap pelarut yang digunakan, oleh karena itu tujuan dari penelitian ini adalah untuk memperoleh data ilmiah mengenai pengaruh metode fermentasi, metode ekstraksi, dan gradien polaritas pelarut terhadap kandungan flavonoid dan steroid total ekstrak daun. . sukun (Artocarpus altilis (Parkinson) Fosberg). Hasil kandungan flavonoid total tertinggi adalah ekstrak etil asetat dari daun sukun fermentasi aerobik dengan metode maserasi 0,3054 g QE/100g dan kandungan steroid total tertinggi pada ekstrak N-heksana dari daun sukun fermentasi aerobik maserasi 0 , 1169g/100g. Berdasarkan penelitian yang telah dilakukan, dapat disimpulkan bahwa metode ekstraksi terbaik untuk menentukan kadar total flavonoid dan steroid adalah metode maserasi. Sedangkan polaritas pelarut yang baik untuk penentuan kadar flavonoid total adalah etil asetat aerobik, dan N-heksana aerobik untuk penentuan kadar steroid total, metode fermentasi yang efektif dalam meningkatkan kadar metabolit sekunder pada daun sukun adalah metode fermentasi aerobik.
EXPLORATION OF POTENTIAL NATURAL COMPOUNDS THROUGH IN SILICO APPROACH: A CASE STUDY ON TOKARAMID COMPOUNDS Baroroh, Umi; Sin, Cindy Wan Yik; Riasari, Hesti
JURNAL SAINS DAN TEKNOLOGI FARMASI INDONESIA Vol 12, No 2 (2023)
Publisher : Sekolah Tinggi Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58327/jstfi.v12i2.225

Abstract

Indonesia, renowned for its rich biodiversity, boasts diverse marine ecosystems that have long remained untapped in the quest for novel therapeutic compounds. This shows the great potential of Indonesia's biodiversity, particularly within its marine habitats, as a treasure trove for exploring bioactive compounds for disease treatment. These compounds can be explored using in silico analyses, including activity prediction, ADME (absorption, distribution, metabolism, and excretion) prediction, toxicity prediction, and molecular docking, to accelerate the discovery of promising drug candidates. The compound TG-0205221, modified Tokaramide A from the sponge Theonella mirabilis, is reported to have potential as an anti-3CLPro from SARS-CoV-1, which is genomically similar to SARS-CoV-2 by 96%. 3CLPro is the most prospective working target of anti-COVID-19. In this study, the exploration of TG-0205221 and Tokaramide A as anti-3CLPro was conducted using in silico approach. It is shown that based on ADMET prediction, all compounds are anticipated to be suitable for oral consumption and exhibit a non-toxic profile. TG-0205221 is predicted to have activity as a 3CLPro inhibitor higher than others. Furthermore, the potential anti-3CLPro SARS-CoV-2 activity of all ligands in molecular docking is envisaged to be considerably high. The binding energy of Tokaramide A and TG-0205221 is relatively similar, -9.16 and -8.39 kcal/mol, respectively. Both Tokaramide A and TG-0205221 show potential as anti-SARS-CoV-2 agents and may aid in the exploration of natural compounds for drug discovery.
AKTIVITAS ANTIOKSIDAN DAN KADAR TOTAL FENOL DARI EKSTRAK JAMU BERAS KENCUR DENGAN PENAMBAHAN RIMPANG KUNYIT Fitriansyah, Sani Nurlaela; Riasari, Hesti; Melati, Novi; Simanjuntak, Nela
Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Vol 9 No 1 (2024): Pharma Xplore : Jurnal Sains dan Ilmu Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jpx.v9i1.6483

Abstract

Jamu is a traditional medicine from Indonesia. Jamu beras kencur is one of the most popular jamu in Indonesia. Jamu beras kencur are often added with other ingredients to increase the efficacy. Turmeric (Curcuma domestica) was a traditional medicinal plant that has high antioxidant and anti-inflammatory effects. Phenolic compound is the largest secondary metabolite in turmeric. The aimsf this research were to determine antioxidant activity and total phenolic content of extract jamu beras kencur wich was added of various concentrations of turmeric and the differences boiling time in processing jamu preparations. The processing of jamu beras kencur with the addition of turmeric with boiling time (15 minutes and 30 minutes). Variation of concentration of tumeric were 5%, 10% and 20%. The concentration of turmeric used addition 5%, 10% and 20. Each preparation was extracted using ethyl acetat. Aantioxidant activity of each extract was performed by DPPH method wich demonstrated as IC50 DPPH. Determination of total phenolic was performed by UV-Vis spectrophotometry and expressed in g GAE/100 g extract. The highest antioxidant activity (IC50 of 485 μg/mL) and the highest total phenolic (41.336 g GAE /100 g extract) was given by jamu beras kencur wich 20% turmeric and 15 min boiling time. Addition of turmeric and differences of boiling time in processing jamu preparations can affect antioxidant activity and total phenolic content.
A LITERATURE REVIEW: AKTIVITAS ANTIBAKTERI TANAMAN OBAT TERHADAP BAKTERI PENYEBAB PNEUMONIA Sinabutar, Rahel Margarenta; Nurfitriani, Iis; Maharani, Dinda Eka; Riasari, Hesti
Jurnal Buana Farma Vol. 5 No. 3 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i3.1382

Abstract

Pneumonia is an acute respiratory tract infection caused by various pathogenic bacteria, including Streptococcus pneumoniae, Staphylococcus aureus, and Klebsiella pneumoniae. The increasing prevalence of antibiotic resistance among these pathogens highlights the need for alternative therapeutic strategies derived from natural products. This study aimed to review the antibacterial potential of medicinal plants against pneumonia-causing bacteria and their underlying mechanisms. A systematic literature review was conducted by searching scientific articles in Google Scholar, PubMed, ScienceDirect, and MDPI. Articles were selected based on inclusion criteria covering antibacterial activity, active compounds, and reported mechanisms of action. A total of 30 eligible articles were analyzed descriptively. The medicinal plants reviewed include Etlingera elatior, Cassia alata, Morinda citrifolia, Melaleuca leucadendra, Momordica charantia, Guazuma ulmifolia, Artocarpus altilis, Acacia nilotica, Gynura procumbens, Trigona incisa propolis, and Ficus carica. These plants contain secondary metabolites such as flavonoids, alkaloids, saponins, tannins, and phenols, which exhibit antibacterial activity by disrupting cell membranes, inhibiting protein synthesis, interfering with essential enzymes, and inducing oxidative stress in bacteria. The findings indicate that medicinal plants hold great potential as complementary or alternative therapies for pneumonia caused by antibiotic-resistant bacteria; however, further research, particularly in vivo and clinical studies, is required to confirm their efficacy and safety.
REVIEW ARTIKEL: POTENSI FITOTERAPI DARI TANAMAN HERBAL DALAM PENANGANAN RHEUMATOID ARTHRITIS Nurhayati, Ismaya; Maulani, Sintia Putri; Lathifah, Meira H.; Riasari, Hesti
Jurnal Buana Farma Vol. 5 No. 3 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i3.1387

Abstract

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation of the joints, resulting in progressive damage and a decreased quality of life for patients. Conventional therapies such as NSAIDs and DMARDs are indeed effective, but their long-term use carries the risk of serious side effects and high costs. Therefore, safer and more affordable alternative therapies are needed, one of which is through the use of medicinal plants. This study aims to examine the potential of herbal plants as an additional or alternative therapy for rheumatoid arthritis. The method employed is a literature study, involving the search and analysis of 31 scientific journals retrieved from academic databases, including Google Scholar, PubMed, ScienceDirect, and MDPI. The articles analyzed were selected based on certain criteria and contained information about the content of active compounds, pharmacological activity, and the mechanism of action of plants on the RA inflammation process. The results of the study showed that various herbal plants such as Zingiber officinale, Curcuma longa, Boswellia serrata, and Nigella sativa have significant anti-inflammatory and immunomodulatory activities. The active compounds in these plants work by inhibiting the inflammatory pathway and reducing the production of pro-inflammatory cytokines. In conclusion, medicinal plants have great potential to be used as additional therapy in the treatment of rheumatoid arthritis. However, further research is needed, especially clinical trials, to ensure the long-term safety and effectiveness of their use.
Gambaran Tingkat Pengetahuan Masyarakat Dalam Pemanfaatan Daun Sukun Pada Penyakit Degenerative di Kecamatan Cinunuk, Cileunyi Kabupaten Bandung. Riasari, Hesti; Fitriansyah, Sani Nurlaela; Wibowo, Diki Prayugo; Hasanah, Siti Uswatun; Wirasutisna, Komar Ruslan; Restiasari, Anggi
Jurnal Mandala Pengabdian Masyarakat Vol. 5 No. 1 (2024): Jurnal Mandala Pengabdian Masyarakat
Publisher : Progran Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpm.v5i1.337

Abstract

Health is a very important aspect in human life. Degenerative diseases are a serious challenge faced by modern society. Community service aims to describe the level of knowledge of the community in Cinunuk District, Cileunyi, Bandung Regency, as well as analyzing the extent to which breadfruit leaves are used in efforts to prevent and treat degenerative diseases. This community service was carried out on October 26 2023 at the Sebaguna Building, Cinunuk Cileunyi District, Bandung Regency in collaboration with Medina Farma Pharmacy. A total of 78 people took part in counseling activities related to degenerative diseases, plants used as herbal medicines, healthy lifestyles to prevent degenerative diseases, workshops on making breadfruit leaf tea products, health checks such as blood pressure, instant blood sugar, total cholesterol levels, accompanied by health counseling and distribution of pamphlets, 45 of them filled out the questionnaire online using g-form. The results of respondents before the counseling and workshop were 45.89%, indicating that the level of knowledge of respondents was very poor, after the counseling and workshop on making herbal tea preparations there was an increase in the knowledge of the people of Cinunuk District by 81 .48% with a high category of respondents' knowledge regarding degenerative diseases, plants that can be used as herbal medicine, the use of breadfruit leaves and their processing in the form of herbal tea preparations which makes it easier for people to consume them in traditional treatment efforts as preventive and curative.
Penguatan Kapasitas Komunitas sebagai Strategi Pencegahan Stunting di Desa Karyamukti Fitriansyah, Sani Nurlaela; Astriany, Dewi; Riasari, Hesti; Nelvi, Nelvi; Nanda, Nanda; Widowaty, Windy
Jurnal Pengabdian Masyarakat Bhinneka Vol. 4 No. 2 (2025): Bulan November
Publisher : Bhinneka Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58266/jpmb.v4i2.824

Abstract

Stunting masih menjadi masalah kesehatan masyarakat yang signifikan di Desa Karyamukti, Kabupaten Garut. Berbagai upaya telah dilakukan namun prevalensi tetap tinggi. Program pengabdian kepada masyarakat oleh STFI yang berkerjasama dengan Rumah Tangguh Stunting (RTS) bertujuan untuk meningkatkan kesadaran dan pengetahuan masyarakat terkait pencegahan stunting. Program ini mentargetkan ibu-ibu serta kader posyandu melalui kegiatan edukasi terstruktur dan pendampingan langsung. Metode yang digunakan mencakup Focus Group Disussion (FGD), penyebaran kuisioner pre-test dan post-test, serta pengenalan produk tambahan gizi berbasis lokal seperti serbuk telur dan madu curcumin. Hasil program ini menunjukkan peningkatan yang signifikan dalam pengetahuan dan kesadaran peserta, dengan kader posyandu menjadi lebih proaktif dalam memantau tumbuh kembang anak. Inisiatif ini membuktikan bahwa edukasi terarah dan intervensi yang tepat dapat meningkatkan upaya pencegahan stunting, sekaligus menekankan pentingnya keterlibatan komunitas dan pemantauan berkelanjutan untuk mencapai hasil yang berkesinambungan
Pemanfaatan Isolat Katekin dari Gambir (Uncaria Gambir Roxb.) pada Essence Sheet Mask: Kajian Stabilitas, Antioksidan dan Cemaran Mikroba Sediaan Yola Desnera Putri; Retty Azka Djumar Danawiria; Hesti Riasari; Adit Andriyannto
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 7, No 2 (2026): Juli
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Isolat katekin dari gambir (Uncaria gambir Roxb.) merupakan golongan polifenol yang memiliki aktivitas antioksidan tinggi melalui kemampuan menetralisir radikal bebas ROS. Dalam upaya memanfaatkan bioaktivitasnya, isolat katekin diformulasikan sebagai essence sheet mask yang mendukung penetrasi transdermal optimal untuk mengatasi penuaan dini, hiperpigmentasi, dan stres oksidatif jaringan kulit. Penelitian ini bertujuan mengembangkan dan mengkarakterisasi essence sheet mask berbasis katekin untuk aplikasi topikal inovatif, meliputi aktivitas antioksidan metode DPPH, stabilitas sediaan, cemaran mikroba (ALT dan AKK), serta penetapan kadar isolat katekin dalam sediaan essense sheet mask. Sediaan dibuat dalam dua formula, (F1, F2; rasio basis 2:1). Hasil uji DPPH menunjukkan nilai IC₅₀ asam askorbat sebesar 3,879 ppm dan isolat katekin 3,010 ppm. Setelah diformulasikan, aktivitas antioksidan isolat katekin menurun menjadi 64,066 ppm (F1) dan 50,565 ppm (F2), yang menunjukkan pengaruh matriks sediaan terhadap aktivitas bioaktif. Uji cemaran mikroba menunjukkan nilai ALT dan AKK berada di bawah batas maksimum (<10³), serta tidak terdeteksi Staphylococcus aureus dan Pseudomonas aeruginosa. Formulasi F1 dengan xanthan gum 0,2% menunjukkan stabilitas fisik yang optimal dan nilai IC₅₀ sebesar 96,049 ppm setelah penyimpanan 28 hari, serta kemampuan mempertahankan kadar zat aktif lebih baik dibandingkan F2. Dengan demikian, sediaan ini memenuhi standar stabilitas fisik dan mikrobiologis yang berpotensi sebagai alternatif antioksidan topikal.
Co-Authors Achmad - Zainuddin Adit Andriyannto Anggi Restiasari Auilifa, Diah Lia Ayu Permatasari Dewi Astriany Diah Lia Auilifa Diah Lia Aulifa Diki Prayugo Wibowo Dini Yulia Handayani Febriana, Yessi Febriani, Yessi Ginanjar C. Gumilang Hisyam Abdu Rasyad Hoeriah, Irna Siti Irma Erika Herawati Komar Ruslan Wirasutisna Lathifah, Meira H. Linda - Audina Maharani, Dinda Eka Maria Ulfah Maulani, Sintia Putri Melati, Novi Nanda Nanda Nela Simanjuntak Nelvi, Nelvi Nurfitriani, Iis Nurhayati, Ismaya Oktamuman Putra Permatasari, Ayu Pupu Fujriani Wasngadiredja Retty Azka Djumar Danawiria Revika Rachmaniar Rianingsih Dwi Astuti Mundandar Sani N. Fitriansyah Sani Nurlaela Sani Nurlaela Fitriansyah Sani Nurlalela Sin, Cindy Wan Yik Sinabutar, Rahel Margarenta Siti Uswatun Hasanah Siti Uswatun Hasanah Sri Wahyuni Umi Baroroh Winda A. Nurfauziah Windy Widowaty Wiwin Winingsih Yessi Febriana Yessi Febriani Yessi Febriani Yola Desnera Putri