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All Journal VALENSI Indonesian Journal of Applied Sciences STOMATOGNATIC- Jurnal Kedokteran Gigi Insisiva Dental Journal : Majalah Kedokteran Gigi Insisiva Dentino: Jurnal Kedokteran Gigi Chimica et Natura Acta ALCHEMY Jurnal Penelitian Kimia Indonesian Journal of Chemistry JSFK (Jurnal Sains Farmasi & Klinis) B-Dent, Jurnal Kedokteran Gigi Universitas Baiturrahmah Jurnal Kreativitas PKM Jurnal Review Pendidikan dan Pengajaran (JRPP) JPP Jurnal Kesehatan Poltekkes Palembang Indonesia Berdaya Jurnal Pengabdian UNDIKMA Jurnal Pengabdian Masyarakat Kebidanan MAHESA : Malahayati Health Student Journal Jurnal Kesehatan Gigi dan Mulut (JKGM) Denta: Jurnal Kedokteran Gigi Indonesian Journal of Dentistry Molekul: Jurnal Ilmiah Kimia Prosiding Seminar Kesehatan Masyarakat
Risyandi Anwar
Unknown Affiliation
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Kaempferol and Quercetin Isolated from The Leaves of Atingia Excelsa to Arrest Cell Cycle in G0/G1 Phase Human Tongue Cancer SP-C1 Cell Lines Risyandi Anwar; Arlette Setiawan; Supriatno; Unang Supratman
Denta Journal Kedokteran Gigi Vol 14 No 1 (2020): Februari
Publisher : Fakultas Kedokteran Gigi Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/denta.v14i1.4

Abstract

The leaves of Altingia excelsa were found to strongly inhibit SP-C1 human tongue cancer cell lines. This study was focused on identifying the antiproliferative compound found in A. excelsa leaves and assessing its mechanism of action. The active compound was isolated using column chromatography and identified by the spectroscopic method and was also tested for its anti-proliferative properties and the cell cycle analysis in SP-C1 cells by flowcytometry analysis. This work resulted in the isolation of a flavonoid, which was identified to be kaempferol and quercetin. The compounds inhibited SP-C1 cell proliferation in a time- and dose-dependent manner with IC50 values of 0.72 µg/mL and 0. 70 µg/mL for the 24 hours treatments, respectively. Furthermore, the flowcytometry analysis suggested that the compounds exerted its anticancer activities by inhibiting cell cycle. These results suggested that compounds found in A. excelsa providies a basis for its potential use in cancer disease management.
Activity and Characterization of ZnO Nanoparticles from Ethanol Extract of Plantago major L. as Antibacterial against Propionibacterium acnes Sudartayasa, I Kadek; Anwar, Risyandi; Rakhmawatie, Maya Dian
JSFK (Jurnal Sains Farmasi & Klinis) Vol 12 No 3 (2025): J Sains Farm Klin 12(3), December 2025
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.12.3.226-235.2025

Abstract

Acne infections are common in tropical regions such as Indonesia and are mainly caused by Propionibacterium acnes. Long-term use of antibiotics for acne treatment may lead to bacterial resistance, highlighting the need for safer natural antibacterial alternatives. Ethanol extract of broadleaf (Plantago major L.) has been reported to exhibit antibacterial activity, which can be enhanced through the application of nanotechnology in the form of zinc oxide nanoparticles (ZnO-NPs). Therefore, this study aims to synthesize and evaluate the antibacterial activity of ZnO-NPs derived from ethanol extract of broadleaf against P. acnes. The broadleaf extract was obtained through maceration with 96% ethanol, and ZnO-NPs were prepared by a precipitation method using zinc nitrate and zinc acetate precursors. The disc diffusion test results showed that 20 mg of ZnO-NPs acetate from broadleaf extract had strong antibacterial activity, with an inhibition zone of 18.11 ± 0.10 mm. The minimum inhibitory concentration of ZnO-NPs acetate from broadleaf extract is 0.078 mg/mL. The morphological characterization of ZnO-NPs acetate from broadleaf extract using Scanning Electron Microscopy-Energy Dispersive X-Ray (SEM-EDX) show a uniform granular particle shape with a size range of 200-228 nm. Based on the research results, the ZnO-NPs acetate from ethanolic extract of broadleaf has the potential to be an effective topical antibacterial alternative for treating acne infections. Based on these findings, ZnO-NPs synthesized from ethanol extract of broadleaf are expected to enhance antibacterial effectiveness and have potential as a safer and more effective topical antibacterial alternative for acne treatment
Hubungan Pengetahuan tentang Kebersihan Rongga Mulut dan Perilaku Menggosok Gigi dengan Status Kebersihan Rongga Mulut pada Santri Pondok Pesantren Al Marhabaniyyah Sabila, Amelia; Nurullita, Ulfa; Sholekhah, Nur Khamilatusy; Anwar, Risyandi
MAHESA : Malahayati Health Student Journal Vol 6, No 5 (2026): Volume 6 Nomor 5 (2026)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v6i5.22261

Abstract

ABSTRACT Oral health contributes significantly to general body health. The purpose of this study was to assess the relationship between oral hygiene knowledge and tooth brushing behavior  with oral hygiene status among students of Pondok Pesantren Al Marhabaniyyah. The research design was observational with a cross-sectional approach. The population consisted of 82 students, selected using a total sampling technique. Data were collected through a knowledge questionnaire, observation of tooth brushing behavior, and oral hygiene examination using the Simplified Oral Hygiene Index (OHI-S). Data analysis was conducted using the Spearman Rank test. The results showed a significant relationship between knowledge of oral hygiene and oral hygiene status (p = 0.032; r = -0.237), indicating that higher knowledge was associated with better oral hygiene status. However, no significant relationship was found between tooth brushing behavior and oral hygiene status (p = 0.481; r = -0.079). In conclusion, knowledge plays an important role in influencing oral hygiene, whereas tooth brushing behavior did not show a significant correlation. Keywords: Knowledge, Tooth Brushing Behavior, OHI-S, Oral Hygiene.  ABSTRAK Kesehatan gigi dan mulut memiliki fungsi utama dalam menjaga kesehatan tubuh secara menyeluruh. Penelitian ini memiliki tujuan untuk mengetahui hubungan pengetahuan tentang kebersihan rongga mulut dan perilaku menggosok gigi dengan status kebersihan rongga mulut pada santri Pondok Pesantren Al Marhabaniyyah. Penelitian ini dirancang menggunakan metode observasional dengan desain cross-sectional. Populasi dalam penelitian ini mencakup seluruh santri berjumlah 82 responden dengan teknik total sampling. Data dikumpulkan melalui kuesioner pengetahuan, observasi perilaku menggosok gigi, serta pemeriksaan status kebersihan rongga mulut menggunakan Oral Hygiene Index-Simplified (OHI-S). Analisis data menggunakan uji Rank Spearman. Hasil penelitian menunjukkan adanya hubungan yang signifikan antara pengetahuan tentang kebersihan rongga mulut dengan status kebersihan rongga mulut (p = 0,032; r = -0,237). Hal ini mengindikasikan semakin tinggi pengetahuan, maka semakin baik status kebersihan rongga mulut. Namun, tidak terdapat hubungan yang signifikan antara perilaku menggosok gigi dengan status kebersihan rongga mulut (p = 0,481; r = -0,079). Kesimpulannya, pengetahuan berperan penting dalam memengaruhi kebersihan rongga mulut, sedangkan perilaku menggosok gigi belum menunjukkan hubungan yang berarti. Kata Kunci: Pengetahuan, Perilaku menggosok Gigi, OHI-S, Kebersihan Rongga Mulut.
Deteksi Dini Karies Gigi sebagai Upaya Pencegahan Penyakit Gigi dan Mulut pada Siswa Diaspora di Sekolah Indonesia Jeddah dan Mekkah, Arab Saudi Failasufa, Hayyu; Sholekhah, Nur Khamilatusy; Prajarini, Megawati; Anwar, Risyandi; Rachmawati, Ika; Ramdhani, Gelar Subhakti; Pratiwi, Putri Dhianita; Irfani, Muhammad Destyatosa
Jurnal Pengabdian UNDIKMA Vol. 7 No. 2 (2026): May (IN PRESS)
Publisher : LPPM Universitas Pendidikan Mandalika (UNDIKMA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/jpu.v7i2.19482

Abstract

This community service activity aims to conduct early detection of oral health problems through simple preliminary examinations using clinical instruments, while improving students’ knowledge through oral health education as an effort to prevent dental and oral diseases. The program involved 110 students from the Indonesian Schools in Jeddah and Mecca. The activity was implemented using a health empowerment approach, with dental and oral examinations conducted using the Oral Health Surveys: Basic Methods issued by the World Health Organization (WHO). The collected data were analyzed based on frequencies and percentages. The screening results showed a high prevalence of dental caries, with 51.8% of students having a DMF-T score > 0. The 10–12-year age group accounted for the highest proportion of caries cases at 73.6%. The most commonly required treatment recommendation was dental fillings, representing 38.2% of cases. The high prevalence of caries among diaspora students highlights the importance of sustainable early detection programs and oral health education. This intervention is expected to foster good oral hygiene habits from an early age in order to prevent more severe dental diseases in the future.
Co-Authors Ace Tatang Hidayat Al Arofatus Naini Al Arofatus Naini Amiza Zam, Syarifah Nova Anisdyasarathi, Fitri Anjari, Intan Hawina Aprillia, Zita Arlette Setiawan Arlette Setiawan Arlette Setiawan Arlette Setiawan Arlette Suzy Puspa Pertiwi Asti, Salma Mei Darwati Darwati Delia Ilfani Desi Harneti Desi Harneti Putri Huspa Deviana Adinda Nurfatimah Dewi, Anisa Candra Erina Hilmayanti Etny Dyah Harniati Failasufa, Hayyu Faizah Maira Farabi, Kindi Faridia Puspita Lestari Febriyani, Ita Hadi Kuncoro Intan Hawina Anjari Irfani, Muhammad Destyatosa Jayanti, Lira Wiet Khalijah Awang Kindi Farabi Kindi Farabi Lilis Siti Aisyah Lisa Oktaviana Mayasari Mastura, Nurul Izzah Maya Dian Rakhmawatie Mayasari, Lisa Oktaviana Mohamad Nurul Azmi Muhamad Nurul Azmi Naini, Al Arofatus Nikmaturrizqi, Nada Nisma Dinastiti Nisma Dinastiti Nurhidayah, Rizky Nurlelasari Nurlelasari Pebrian Diki Prestya Prajarini, Megawati Pratiwi, Putri Dhianita Puspito Ratih Hardhani Putri, Ghesta Alifka Rachmawati, Ika Ramdhani, Gelar Subhakti Rani Maharani Rani Maharani Ratna Sulistyorini, Ratna Rizky Nurhidayah Sabila, Amelia Samuel San Parulian Sarni Sayono Sekarningrum, Galih Prawesty Ayu Sholekhah, Nur Khamilatusy Sinaga, Siska Elisahbet Siti Aminah Sofa Fajriah Steffi Triany Arnov Suaeni Kurnia Wirda Sudartayasa, I Kadek Supriatno Supriatno Supriatno Supriatno Supriatno Supriatno Supriatno Supriatno Supriatno Supriatno Supriatno Sutiyono, Triagus Nursasongko Tri Mayanti Tri Mayanti Tripermata, Anita Novia Tyas Nurfadlilah Amaliah Ulfa Nurullita Unang Supratman Vidia Afina Nuraini Yenny Febriani Yun Yoshihito Shiono