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All Journal VALENSI Indonesian Journal of Applied Sciences STOMATOGNATIC- Jurnal Kedokteran Gigi Insisiva Dental Journal : Majalah Kedokteran Gigi Insisiva Dentino: Jurnal Kedokteran Gigi Chimica et Natura Acta ALCHEMY Jurnal Penelitian Kimia Indonesian Journal of Chemistry JSFK (Jurnal Sains Farmasi & Klinis) B-Dent, Jurnal Kedokteran Gigi Universitas Baiturrahmah Jurnal Kreativitas PKM Jurnal Review Pendidikan dan Pengajaran (JRPP) JPP Jurnal Kesehatan Poltekkes Palembang Indonesia Berdaya Jurnal Pengabdian Masyarakat Kebidanan Jurnal Kesehatan Gigi dan Mulut (JKGM) Denta: Jurnal Kedokteran Gigi Indonesian Journal of Dentistry Molekul: Jurnal Ilmiah Kimia Prosiding Seminar Kesehatan Masyarakat
Risyandi Anwar
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Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Kaempferol and Quercetin Isolated from The Leaves of Atingia Excelsa to Arrest Cell Cycle in G0/G1 Phase Human Tongue Cancer SP-C1 Cell Lines Risyandi Anwar; Arlette Setiawan; Supriatno; Unang Supratman
Denta Journal Kedokteran Gigi Vol 14 No 1 (2020): Februari
Publisher : Fakultas Kedokteran Gigi Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/denta.v14i1.4

Abstract

The leaves of Altingia excelsa were found to strongly inhibit SP-C1 human tongue cancer cell lines. This study was focused on identifying the antiproliferative compound found in A. excelsa leaves and assessing its mechanism of action. The active compound was isolated using column chromatography and identified by the spectroscopic method and was also tested for its anti-proliferative properties and the cell cycle analysis in SP-C1 cells by flowcytometry analysis. This work resulted in the isolation of a flavonoid, which was identified to be kaempferol and quercetin. The compounds inhibited SP-C1 cell proliferation in a time- and dose-dependent manner with IC50 values of 0.72 µg/mL and 0. 70 µg/mL for the 24 hours treatments, respectively. Furthermore, the flowcytometry analysis suggested that the compounds exerted its anticancer activities by inhibiting cell cycle. These results suggested that compounds found in A. excelsa providies a basis for its potential use in cancer disease management.
Activity and Characterization of ZnO Nanoparticles from Ethanol Extract of Plantago major L. as Antibacterial against Propionibacterium acnes Sudartayasa, I Kadek; Anwar, Risyandi; Rakhmawatie, Maya Dian
JSFK (Jurnal Sains Farmasi & Klinis) Vol 12 No 3 (2025): J Sains Farm Klin 12(3), December 2025
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.12.3.226-235.2025

Abstract

Acne infections are common in tropical regions such as Indonesia and are mainly caused by Propionibacterium acnes. Long-term use of antibiotics for acne treatment may lead to bacterial resistance, highlighting the need for safer natural antibacterial alternatives. Ethanol extract of broadleaf (Plantago major L.) has been reported to exhibit antibacterial activity, which can be enhanced through the application of nanotechnology in the form of zinc oxide nanoparticles (ZnO-NPs). Therefore, this study aims to synthesize and evaluate the antibacterial activity of ZnO-NPs derived from ethanol extract of broadleaf against P. acnes. The broadleaf extract was obtained through maceration with 96% ethanol, and ZnO-NPs were prepared by a precipitation method using zinc nitrate and zinc acetate precursors. The disc diffusion test results showed that 20 mg of ZnO-NPs acetate from broadleaf extract had strong antibacterial activity, with an inhibition zone of 18.11 ± 0.10 mm. The minimum inhibitory concentration of ZnO-NPs acetate from broadleaf extract is 0.078 mg/mL. The morphological characterization of ZnO-NPs acetate from broadleaf extract using Scanning Electron Microscopy-Energy Dispersive X-Ray (SEM-EDX) show a uniform granular particle shape with a size range of 200-228 nm. Based on the research results, the ZnO-NPs acetate from ethanolic extract of broadleaf has the potential to be an effective topical antibacterial alternative for treating acne infections. Based on these findings, ZnO-NPs synthesized from ethanol extract of broadleaf are expected to enhance antibacterial effectiveness and have potential as a safer and more effective topical antibacterial alternative for acne treatment
Co-Authors Ace Tatang Hidayat Al Arofatus Naini Al Arofatus Naini Amiza Zam, Syarifah Nova Anisdyasarathi, Fitri Anjari, Intan Hawina Aprillia, Zita Arlette Setiawan Arlette Setiawan Arlette Setiawan Arlette Setiawan Arlette Suzy Puspa Pertiwi Asti, Salma Mei Darwati Darwati Delia Ilfani Desi Harneti Desi Harneti Putri Huspa Deviana Adinda Nurfatimah Dewi, Anisa Candra Erina Hilmayanti Etny Dyah Harniati Faizah Maira Farabi, Kindi Faridia Puspita Lestari Febriyani, Ita Hadi Kuncoro Intan Hawina Anjari Jayanti, Lira Wiet Khalijah Awang Kindi Farabi Kindi Farabi Lilis Siti Aisyah Lisa Oktaviana Mayasari Mastura, Nurul Izzah Maya Dian Rakhmawatie Mayasari, Lisa Oktaviana Mohamad Nurul Azmi Muhamad Nurul Azmi Naini, Al Arofatus Nikmaturrizqi, Nada Nisma Dinastiti Nisma Dinastiti Nurhidayah, Rizky Nurlelasari Nurlelasari Nurlelasari Nurlelasari Pebrian Diki Prestya Prajarini, Megawati Puspito Ratih Hardhani Putri, Ghesta Alifka Rachmawati, Ika Rani Maharani Rani Maharani Ratna Sulistyorini, Ratna Rizky Nurhidayah Samuel San Parulian Sarni Sayono Sekarningrum, Galih Prawesty Ayu Sinaga, Siska Elisahbet Siti Aminah Sofa Fajriah Steffi Triany Arnov Suaeni Kurnia Wirda Sudartayasa, I Kadek Supriatno Supriatno Supriatno Supriatno Supriatno Supriatno Supriatno Supriatno Supriatno Supriatno Supriatno Sutiyono, Triagus Nursasongko Tri Mayanti Tri Mayanti Tripermata, Anita Novia Tyas Nurfadlilah Amaliah Unang Supratman Vidia Afina Nuraini Yenny Febriani Yun Yoshihito Shiono