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All Journal Majalah Kedokteran Bandung Biomedical Journal of Indonesia Indonesian Journal of Medicine Jurnal Respirasi (JR) Jurnal Keperawatan Priority Indonesian Journal of Global Health research Narra J Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) International Journal of Health and Pharmaceutical (IJHP) Reflection Journal The Journal of Society Medicine (JSOCMED) The International Journal of Tropical Veterinary and Biomedical Research
Siregar, Jelita
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Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Age and Diabetes Mellitus Associated with Hematological Disorders and Peripheral Neuropathy in MDR-TB Patients Treated with the BPaL/M Regimen Tako, Frida Welhelmina; Sinaga, Bintang Yinke Magdalena; Harahap, Juliandi; Daulay, Rini Savitri; Siregar, Jelita; Samodra, Yoseph Leonardo
Jurnal Respirasi Vol. 11 No. 3 (2025): September 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.3.2025.241-249

Abstract

Introduction: Tuberculosis (TB) is a disease with a significant treatment burden. Current multidrug-resistant (MDR)-TB therapy uses the bedaquiline, pretomanid, linezolid, and moxifloxacin (BPaL/M) combination. This combination is effective with a short treatment duration. Linezolid is one of the components of the BPaL/M regimen. However, despite its effectiveness, it has side effects that impact treatment management and success. This study aimed to find the association between characteristics and comorbidities with the incidence of linezolid side effects in patients with MDR-TB treated with the BPaL/M regimen. Methods: This was a retrospective analytic study of MDR-TB patients receiving BPaL/M combination. Data were collected from medical records and analyzed using Fisher's exact test to analyze the association between patient characteristics and comorbidities with the incidence of linezolid side effects, namely hematological disorders, peripheral neuropathy, and visual disturbances. Results: There was no significant association between overall patient characteristics and the incidence of linezolid adverse events. However, the results of bivariate analysis showed a significant association in age >50 years old with the incidence of hematological disorders, as well as in patients who have diabetes mellitus (DM) with the incidence of peripheral neuropathy as a side effect of linezolid. Conclusion: Monitoring of MDR-TB patients aged >50 years old and those with DM to minimize the incidence of side effects during treatment is essential. This effort is expected to support the success of the national TB control and treatment program.
Effectiveness of red palm oil supplementation on motor impairment in a Paraquat-induced Parkinsons disease rat mode Siregar, Ari Ramadhan; Ichwan, M; Siregar, Jelita; Anggraini, Dwi; Hasibuan, Hasrul
The International Journal of Tropical Veterinary and Biomedical Research Vol 9, No 1 (2024): Vol. 9 (1) May 2024
Publisher : The Faculty of Veterinary Medicine of Syiah Kuala University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/ijtvbr.v9i1.36536

Abstract

Parkinson's is a neurological disease that is rapidly increasing to surpass Alzheimer's disease. Parkinson's disease causes a decrease in the number of dopaminergic neurons, which can lead to disturbances in attention, memory, and motivation. Damage to dopaminergic nerve cells is caused by increased free radicals (ROS) levels in tissues and cells, thus inducing cell death signals. This study aims to determine whether red palm oil affects the acute level of Parkinson's syndrome in rats induced with paraquat. This study uses the BEAM and Cylinder tests to measure the effect of red palm oil because one of the alternative therapies for neurodegenerative illnesses like Parkinson's is red palm oil. The treatment was administered to paraquat-induced rats with injections given weekly for four weeks. Carotenoids are present in red palm oil at concentrations of 600 to 1000 ppm and are thought to have neuroprotective properties. As many as 30 rats were divided into three groups: K (control), PQT (paraquat 7 mg/kg body weight), and PQT+MSM (paraquat 7 mg/kg body weight + 2 ml of red palm oil). The data were then checked using the normality test Shapiro-Wilk and analyzed statistically using One-way ANOVA. The Cylinder and Beam tests were significant, with a P value of 0.00. Parkinsonian rats receiving red palm oil at a dose of 2 ml/kg body weight per week for four weeks showed improved motor function compared to those receiving only paraquat. The group with red palm oil had a lower beam test value. This indicates motor improvement in Parkinson's model rats. Similarly, the cylinder test showed higher performance in the group treated with red palm oil. Based on this, it can be concluded that red palm oil influences the motor movements of Parkinson's rats. The beam test and cylinder test methods prove this. Red palm oil could decrease the acute level of motor impairments in rats with Parkinson's induced by paraquat.
RASIO MONOSIT LIMFOSIT SEBAGAI PREDIKTOR KEPARAHAN NEFROPATI DIABETIK PADA PASIEN DIABETES MELITUS TIPE 2 Bernando, Andri; Siregar, Jelita; Syafril, Santi
Jurnal Keperawatan Priority Vol. 6 No. 2 (2023)
Publisher : Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jukep.v6i2.4073

Abstract

Diabetic nephropathy is a complication that often occurs in diabetics. In this disease, there is damage to the kidney filter, known as the glomerulus. Due to glomerular damage, diabetic nephropathy is closely related to the mechanism of inflammation. The Monocyte-Lymphocyte Ratio is a relatively new marker of inflammation. This study aims to explore the significance of the prediction of the Monocyte-Lymphocyte Ratio as a predictor of the severity of diabetic nephropathy in Type 2 Diabetes Mellitus (DMT2) patients at H. Adam Malik Hospital, Medan. The research was conducted using the cross-section method. This study took blood samples from 44 patients with type 2 diabetes mellitus with diabetic nephropathy, 22 patients with macroalbuminuria, and 22 patients with microalbuminuria. Then blood was drawn from the vein, and the Monocyte-Lymphocyte Ratio was assessed in all patients. In this study, the average MLR for all patients was 0.41±0.037. There was a significant difference between MLR values ​​in diabetic nephropathy patients with macroalbuminuria compared to diabetic nephropathy patients with microalbuminuria (p<0.001). The optimal cut-off value of MLR in predicting diabetic nephropathy with macroalbuminuria and microalbuminuria was 0.37 with a specificity of 81.8% and a sensitivity of 81.8%. The MLR value in type 2 diabetic patients with diabetic nephropathy can be used as a prognostic factor for the incidence of microalbuminuria and macroalbuminuria.
Pengembangan Media Virtual Laboratorium Kromatografi Gas Berbasis Proyek Dalam Membangun Keterampilan HOTS Untuk Meningkatkan Hasil Belajar Siregar, Jelita; Situmorang, Manihar
Reflection Journal Vol. 5 No. 2 (2025): Desember
Publisher : Lembaga Penelitian dan Pemberdayaan Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/rj.v5i2.3595

Abstract

Penelitian ini bertujuan mengembangkan media virtual laboratorium berbasis proyek pada pengajaran Kromatografi Gas serta menguji kelayakan, efektivitas, dan respon siswa terhadap penggunaannya. Jenis penelitian yang digunakan adalah penelitian dan pengembangan dengan model ADDIE melalui analisis kebutuhan pembelajaran, desain dan pengembangan virtual laboratorium, standarisasi, uji coba, dan evaluasi. Subjek penelitian adalah 68 mahasiswa, yaitu kelas PSKM 23A dan PSKM 23B Jurusan Kimia Universitas Negeri Medan. Instrumen penelitian mencakup rubrik HOTS, pretest-posttest, lembar validasi ahli, serta angket respon mahasiswa. Hasil validasi virtual laboratorium berbasis proyek berada pada kategori sangat baik, dengan skor (M= 3.595 ± 1,25) dari ahli materi dan media. Uji coba menunjukkan terbangunnya HOTS mahasiswa pada kategori sangat baik (M= 87,55 ± 0,121). Selain itu, hasil belajar mahasiswa meningkat dengan nilai n-gain kelas eksperimen sebesar 77,47% kategori sangat tinggi dan kelas kontrol 45,09% kategori sedang berdasarkan data pretest-posttest. Respon mahasiswa terhadap media virtual laboratorium memperoleh skor 80,61% (sangat positif). Terdapat korelasi antara keterampilan berpikir tingkat tinggi dengan peningkatan hasil belajar mahasiswa kelas eksperimen dengan rhitung 0.551 kategori korelasi cukup tinggi. Temuan ini membuktikan bahwa virtual laboratorium berbasis proyek efektif dalam membangun keterampilan berpikir tingkat tinggi dan meningkatkan hasil belajar mahasiswa, sekaligus berpotensi menjadi alternatif sumber belajar digital yang relevan dengan kebutuhan mahasiswa. Development of Virtual Media for a Project-Based Gas Chromatography Laboratory in Building HOTS Skills to Improve Learning Outcomes This study aims to develop a project-based virtual laboratory media in teaching Gas Chromatography and to test the feasibility, effectiveness, and student responses to its use. The type of research used is research and development with the ADDIE model through learning needs analysis, design and development of virtual laboratories, standardization, trials, and evaluation. The subjects of the study were 68 students, namely PSKM 23A and PSKM 23B classes of the Chemistry Department, State University of Medan. The research instruments included HOTS rubrics, pretest-posttest, expert validation sheets, and student response questionnaires. The results of the project-based virtual laboratory validation were in the very good category, with a score (M = 3.595 ± 1.25) from material and media experts. The trial showed that students' HOTS was built in the very good category (M = 87.55 ± 0.121). In addition, student learning outcomes increased with an n-gain value of 77.47% in the experimental class (very high category) and 45.09% in the control class (moderate category) based on pretest-posttest data. Student responses to the virtual laboratory media obtained a score of 80.61% (very positive). There is a correlation between high-level thinking skills and increased learning outcomes for students in the experimental class with rcount 0.551, a fairly high correlation category. This finding demonstrates that project-based virtual laboratories are effective in developing higher-order thinking skills and improving student learning outcomes, while also having the potential to become an alternative digital learning resource relevant to student needs.
Association Between Mean Platelet Volume to Lymphocyte Ratio (MPVLR) and Diabetic Nephropathy Incidence in Type 2 Diabetes Mellitus Maisharah; Siregar, Jelita; Syafril, Santi
Biomedical Journal of Indonesia Vol. 12 No. 1 (2026): Vol 12, No 1, 2026 (In Press)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v12i1.295

Abstract

Introduction. Diabetic nephropathy is a microvascular complication of uncontrolled diabetes mellitus (DM), with inflammation among its underlying pathogenesis. Inflammation causes fibrosis, increased vascular permeability, and podocytopathy, which lead to albuminuria. Mean Platelet Volume (MPV) measures thrombocyte size, which may mark increased metabolic and enzymatic activity of thrombocytes. An absolute decrease in lymphocytes occurs due to inflammation-induced decrease in apoptosis. MPVLR value can be used to assess low-grade inflammation in diabetic nephropathy in type 2 DM patients. This study aimed to determine the association between MPVLR values and diabetic nephropathy incidence in type 2 DM. Methods. This study was a cross-sectional study on type 2 DM patients at the Endocrinology outpatient clinic of Adam Malik Hospital aged ≥ 18 years. Sixty patients met the inclusion criteria. Complete blood count, creatinine, and albumin creatinine ratio (ACR) were performed to determine the incidence of diabetic nephropathy. Results. There was a significant difference in age between the diabetic nephropathy and non-nephropathy groups. There were significant differences in absolute lymphocyte count, Hb, HbA1c, and renal parameters such as estimated Glomerular Filtration Rate (eGFR) and creatinine between diabetic nephropathy and non-nephropathy groups. MPVLR showed a significant negative correlation with eGFR and Hb (r = -0.325, p = 0.011), showing that MPVLR increased in line with eGFR and Hb decrease. MPVLR was not significantly associated with diabetic nephropathy incidence based on semiquantitative ACR (p = 0.139). Conclusion. MPVLR was not associated with diabetic nephropathy in type 2 DM patients.
Co-Authors Adisasmito, Wiku Bakti Bawono AIRLANGGA, EKA Ayodhia P. Pasaribu, Ayodhia P. Bernando, Andri Bugis M. Lubis, Bugis M. Dwi Anggraini Elsha, Elsha Sinulingga Elvira Fithria Aldy Ginting, Almaycano Hadi, Denny Harahap, Juliandi Hasan, Refli Hasibuan, Hasrul Herman Hariman Ichwan, M Inke Nadia Diniyanti Lubis, Inke Nadia Diniyanti M. Nafchi, Asgar Maisharah Malisie, Ririe F. manihar Situmorang, manihar Merlin, Asri Muhammad Zarlis, Muhammad Novisari Soeroso, Noni Rahma, Hadiyatur Ratna Akbari Ganie, Ratna Akbari Rini Savitri Daulay, Rini Savitri Samodra, Yoseph Leonardo Santi Syafril, Santi Siallagan, Delpiana Sinaga, Bintang Yinke Magdalena Siregar, Ari Ramadhan Siregar, Dewi Indah Sari Situmorang, Immanuel Tako, Frida Welhelmina Taufik Sungkar, Taufik Wahyuni, Arlinda S. Yanni, Gema Nazri