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All Journal Medical Journal of Indonesia MNJ (Malang Neurology Journal) The Indonesian Biomedical Journal Majalah Kedokteran Neurosains Journal of General Procedural Dermatology and Venereology Indonesia Neurona Acta Neurologica Indonesia
Fitri Octaviana
Departemen Neurologi Fakultas Kedokteran Universitas Indonesia/RSUP Cipton Mangunkusumo, Jakarta
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience Public Health

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ENSEFALITIS ANTIRESEPTOR NMDA ENSEFALITIS DENGAN GEJALA AWAL PSIKOSIS Riwanti Estiasari,* Darma Imran,* Kartika Maharani,* David Pangeran,* Fitri Octaviana,* Dewi Wulanda
NEURONA Vol. 35 No. 1 Desember 2017
Publisher : Neurona Majalah Kedokteran Neuro Sains

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Abstract

ANTI NMETHYLDASPARTATE NMDA RECEPTOR ENCEPHALITIS IS SELDOM FOUND IN INDONESIA THE ATYPICAL INITIAL PRESENTATION OF PSYCHOSIS AND COGNITIVE DISTURBANCE RESULTS IN UNDERDIAGNOSED OR EVEN UNDIAGNOSED CASE THIS REPORT DESCRIBED A 12YEAROLD GIRL PRESENTING WITH INITIAL PSYCHIATRIC SYMPTOM FOLLOWED BY SEIZURE AND OROPHARYNGEAL DYSTONIA
HUBUNGAN KADAR ANTIBODI RESEPTOR ASETILKOLIN DENGAN DERAJAT KEPARAHAN PENYAKIT MIASTENIA GRAVIS DI RS CIPTO MANGUNKUSUMO Manfaluthy Hakim,* Fika Tiara,* Ahmad Yanuar,* Winnugroho Wiratman,* Luh Ari Indriawati,* Astri Budi
NEURONA Vol. 37 No. 3 Juni 2020
Publisher : Neurona Majalah Kedokteran Neuro Sains

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INTRODUCTION ACETYLCHOLINE RECEPTOR ACHR ANTIBODY IS MAIN ANTIBODY IN PATHOGENESIS OF MYASTHENIA GRAVIS MG ACHR ANTIBODY IS AN IMPORTANT DIAGNOSTIC TESTS MYASTHENIA GRAVIS CLINICAL FEATURES CAN BE DIVIDED INTO OCULAR GENERALIZED AND BULBAR MG SEVERITY OF MG CAN BE ASSESSED BASED ON MG COMPOSITE SCORE MGCS
UJI VALIDITAS DAN RELIABILITAS KUESIONER THE 15ITEM MYASTHENIA GRAVIS QUALITY OF LIFE SCALE VERSI BAHASA INDONESIA MGQOL15 INA Ahmad Yanuar Safri* Fitri Octaviana,* Fikry Syahrial,* Luh Ari Indrawati,* Winnugroho Wiratman,* Man
NEURONA Vol. 37 No. 4 September 2020
Publisher : Neurona Majalah Kedokteran Neuro Sains

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INTRODUCTION MYASTHENIA GRAVIS MG IS A CHRONIC AUTOIMMUNE DISEASE IN THE NEUROMUSCULAR JUNCTION CHARACTERIZED WITH FLUCTUATING WEAKNESS SYMPTOMS ADVANCE IN THE DIAGNOSIS AND MANAGEMENT OF MG CASES INCREASES THE PATIENTS LIFE EXPECTANCY THEREFORE THE EVALUATION OF THERAPEUTIC SUCCESS IS NO LONGER BASED SOLELY ON COPING WITH THE SYMPTOMS BUT ALSO IN EVALUATING THE QUALITY OF LIFE OF PATIENTS THE 15ITEM MYASTHENIA GRAVIS QUALITY OF LIFE SCALE MGQOL15 IS A QUESTIONNAIRE UTILIZED TODAY TO EVALUATE THE QUALITY OF LIFE OF MG PATIENTS
Neural Leprosy: A case report Widiawaty, Alida; Sjamsoe-Daili, Emmy Soedarmi; Olivia, Taruli; Menaldi, Sri Linuwih; Marissa, Melani; Octaviana, Fitri
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 1, No. 3
Publisher : UI Scholars Hub

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Abstract

Neural leprosy is characterized by neurological deficit without skin lesions, with a prevalence ranging from 1% to 17.7%. Diagnosis might be difficult and need a multidisciplinary approach. This is a case of axonal type motor and sensory polyradiculoneuropathy of the peripheral facial nerve. A 26-year-old woman was referred from the neurology clinic with facial paralysis, suspected as leprosy. Physical examinations were as follows: no skin lesions, left eye lagophthalmos, thickening of right lateral peroneal and bilateral posterior tibial nerves, sensory impairment, peripheral bilateral facial palsy, and wasting of bilateral distal small muscles of the hands, with normal autonomic function. Nerve Conduction Study revealed multiple demyelinating mononeuropathy of upper and lower extremities. Her serum anti-PGL-1 IgM level was 1721 μ/mL, but after three months of treatment with MDT-PB regimen, it increased to 2815μ/mL. Therefore, the treatment was switched to MDT-MB regimen and 30 mg prednisone. The patient is still undergoing treatment. There has been a slight improvement after treatment with MDT-MB regimen. Nerve biopsy is the gold standard for diagnosis but has its limitations. However, serological test of anti PGL-1 can be a marker and a useful tool as an additional test to confirm the diagnosis, especially for patients with nerve impairments. Difficulties are due to the absence of skin lesions and neuropathy which may be caused by other diseases. Both diagnosis and treatment require multidisciplinary approach. Treatment given is intended to correct nerve damage and prevent further disabilities. Click here to edit this text or paste your document here to convert it to HTML �� This demo allows you to test the features of this online HTML converter. Type in one of the fields and see the other one changing in real time! Set up the cleaning options and press ▼ Clean Work with any of the text areas and see the other one changing in real time: Left: Preview Right: Source code Preview how your document will look when published. Adjust the syntax highlighted HTML code. Check out Pranx.com for nice online pranks.
THE RELATIONSHIP OF THE CHARACTERISTICS OF ANTI-EPILEPSY DRUGS WITH THE C OGNITIVE FUNCTION OF EPILEPSY PATIENTS Handayani, Sri; Partan, Radiyati Umi; Hafy, Zen; Octaviana, Fitri; Harun, Yusril; Bahar, Erial; Lestari, Nova
MNJ (Malang Neurology Journal) Vol. 11 No. 2 (2025): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2025.011.02.02

Abstract

Background: One of the side effects of the use of antiepileptic drugs (AEDs) is cognitive disorder. Several studies show a relationship between the type of AEDs and cognitive disturbance in people with epilepsy. Dose-dependent side effects of AEDs have also been reported in prior research. However, there are results from different studies on different populations. Objective: This research aims to evaluate the relationship between AEDs characteristics and the cognitive function of epilepsy patients. Methods: This cross-sectional study was conducted in the Neurology Department of Dr. Mohammad Hoesin General Hospital Palembang, from 1 November 2021 to 31 March 2022. Researchers used the MoCA-Ina questionnaire to collect medical record data and conduct interviews. Results: In this research, the number of research subjects obtained was 70 people with epilepsy. Characteristics of sociodemographic sufferer Epilepsy in this study was mostly (44.3%) aged 26 – 45 years with type sex most were women (71.4%), and the majority subjects (52.9%) had level high school education. Characteristics of antiepileptic drugs consumed by people living with epilepsy: most of them, i.e., amounting to 57.1%, have consumed antiepileptic drugs for > 12 months. Most of the research subjects (64.3%) had function-impaired cognitive range MoCA-Ina scores of 8 – 30. The function most cognitively disturbed, namely in the memory domain, cancels that am, counting to 82.9%. Education level is the only variable from characteristics of sociodemographic and clinical features connected significantly to cognitive function in general (p-value 0.013). The number, duration, and type of antiepileptic drugs do not determine a significant relationship with cognitive function in general. Conclusion: There is a significant relationship between valproic acid and the number of AEDs with the naming domain, as well as between valproic acid and the duration of AEDs with the abstraction domain.
FENOMENA OTOT POSITIF PADA KELAINAN NEUROMUSKULAR Angelita, Michelle Cancera; Indrawati, Luh Ari; Hakim, Manfaluthy; Octaviana, Fitri; Budikayanti, Astri; Safri, Ahmad Yanuar; Wiratman, Winnugroho; Fadli, Nurul; Harsono, Adrian Ridski
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 40 No 2 (2024): Vol 40 No 2 (2024): Volume 40, No 2 - Maret 2024
Publisher : PERDOSNI

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Abstract

Positive muscle phenomena arise due to various forms of spontaneous muscle hyperactivity originating from motor neurons or the muscle itself. The presence of this phenomenon can constringe the possible diagnosis to be more specific, so if presence it is necessary to be identified in patients with potential neuromuscular disease. However, the presence of positive muscle phenomena is often overlooked. This gap in our knowledge regarding definitions, clinical findings, electrodiagnostic findings, and pathophysiological mechanisms hampers effective diagnosis and treatment. In this article, we review the clinical characteristics approach to diagnosis of various positive muscle phenomena originating from the lower motor neuron (LMN) and muscle, including tetany, cramps, fasciculations, myokymia, neuromyotonia, rippling muscle, percussion induced rapid contractions (PIRCs), myoedema, and contractures. Keywords: fasciculation, muscle phenomena, hyperactivity, myotonia, rippling muscle
The Injected Plasma of Myasthenia Gravis Patient with A Low T-reg Level Caused Clinical Myasthenic Syndromes in Swiss-Webster Mice Pasmanasari, Elta Diah; Purwaningsih, Erni Hernawati; Retnaningsih, Retnaningsih; Purba, Jan Sudir; Octaviana, Fitri
The Indonesian Biomedical Journal Vol 16, No 4 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i4.3086

Abstract

BACKGROUND: Myasthenia gravis (MG) is a rare autoimmune disease affecting neuromuscular junction involvement. The finding that T-reg level in MG patients was lower than that in normal persons leads to the idea that the primary pathology of the disease is T-reg dependent. The T-reg level of MG patients seems to be decreasing compared to that of normal persons. The study was conducted to observe the contribution of T-reg level in plasma injected into Swiss-Webster mice to develop clinically and pathologically myasthenic syndromes.METHODS: Swiss-Webster mice were grouped into three groups: the groups received plasma with normal, low, and high T-reg levels, respectively. The T-reg levels of the mice were measured with flow cytometry analysis and a human regulatory T-cell cocktail for T-cell surface cell marker. The motor function, interleukin (IL)-2, interferon (IFN)-γ, and thymus weight of mice were measured after the injection. Histopathological examination was performed to analyze mice’s muscles and thymus.RESULTS: The result identified that the motor function (2-week treatment group: p=0.021 and 3-week treatment group: p=0.032) and muscle width (p=0.014, p=0.032 and p≤0.001) were significantly lower in the low T-reg level plasma group compared to control and high T-reg level plasma groups. The thymus showed an increase in weight without an increase in the cortex-medulla ratio of the thymus, indicating hyperplasia. Both IL-2 and IFN-γ levels were lower in the low and high T-reg level groups compared with the control group, indicating the autoimmune process.CONCLUSION: Low T-reg level was associated with lower motor function, muscle width, increased thymus weight, as well as lower IL-2 and IFN-γ levels. T-reg level contributed to clinical myasthenic syndromes but not pathological findings. This research method is expected to be a basis for the development of animal models with Swiss-Webster mice.KEYWORDS: animal model, Myasthenia gravis, Swiss-Webster mice
The Effectiveness of Plasmapheresis Compared to Intravenous Immunoglobulin in Guillain-Barre Syndrome Patients Mustika, Alyssa Putri; Hakim, Manfaluthy; Sari, Waode Satriana; Octaviana, Fitri; Budikayanti, Astri; Safri, Ahmad Yanuar; Wiratman, Winnugroho; Indrawati, Luh Ari; Fadli, Nurul; Harsono, Adrian Ridski; Savitri, Irma
Acta Neurologica Indonesia Vol. 2 No. 02 (2024): Acta Neurologica Indonesia
Publisher : Departemen Neurologi Fakultas Kedokteran Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69868/ani.v2i02.24

Abstract

Introduction : Guillain-Barré syndrome (GBS) is the second most common cause of acute and subacute general paralysis. The management is symptom-adjusting, but plasmapheresis (plasma exchange/PE) and intravenous immunoglobulin immunotherapy (IVIG) can be administered to accelerate the return of neurological function. This study aim to determine PE's effectiveness compared to IVIG in GBS patients and the side effects or complications that may arise. Method : The literature study is carried out on four databases. Selection is carried out using inclusion and exclusion criteria. The articles were screened and extracted independently by two investigators. Results : The literature study obtained three systematic review studies. In the first study, shows the outcomes in the form of improved Hughes Score (OR 1.9; 95% CI 1.11-3.28) and mortality (OR 0.8; 95% CI 0.31-2.29) against IVIG. The second study, outcomes shown in the form of improved disability scores (WMD -0.02, p: 0.83), and secondary outcomes such as mortality or relapse (p >0.05, respectively). The third study showed that IVIG had higher efficacy (OR 1.6, p: 0.067, 95% CI 0.972-2.587), shorter duration of hospitalization, 38 days, compared to 49-day PE therapy (SMD -3.389, 95% CI -11.601-4.824; p: 0.419), however, had higher side effect (OR 0.8, p: 0.430, 95% CI 0.389-1.495). Conclusion : PE efficacy is generally lower than IVIG, as indicated by disability scores/motor ability scores in various studies, as well as the duration of hospitalization. The safety of therapy is assessed by the side effects that appear and appear-more-often in IVIG therapy rather than PE.
Adipose-derived mesenchymal stem cells enhance regeneration in a chronic peripheral sciatic nerve injury Sprague-Dawley rat model Widodo, Wahyu; Dilogo, Ismail Hadisoebroto; Kamal, Achmad Fauzi; Antarianto, Radiana Dhewayani; Wuyung, Puspita Eka; Siregar, Nurjati Chairani; Octaviana, Fitri; Kekalih, Aria; Suroto, Heri; Aprilya, Dina; Canintika, Anissa Feby
Medical Journal of Indonesia Vol. 34 No. 3 (2025): September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.257780

Abstract

BACKGROUND Obtaining optimal functional outcomes in patients with chronic peripheral nerve injuries (PNIs) remains challenging due to the limited regeneration of the neuromuscular junction (NMJ). Adipose-derived mesenchymal stem cells (AD-MSCs) can differentiate into Schwann-like cells, secrete neurotrophic factors, and recruit native Schwann cells. This study aimed to analyze the effects of AD-MSCs on functional outcomes in a chronic PNI model. METHODS An in vivo study was performed using 20 male Sprague-Dawley rats with chronic PNI of the right sciatic nerve. Rats were divided into two groups: the AD-MSC group (n = 10), receiving human AD-MSC injections in the NMJ; and the control group (n = 10), receiving normal saline injections. Walking track analysis and electrophysiological assessments were performed 8 weeks after the nerve repair. Postmortem gastrocnemius muscle weights and immunohistochemical examinations were also performed. RESULTS The AD-MSCs showed significantly larger fiber diameters than the control group (45.54 [13.1] versus 35.46 [6.64]; p = 0.011). While clinical, electrophysiological, and gastrocnemius muscle weight data suggested a trend toward improved outcomes in the AD-MSCs group, the differences were not statistically significant. CONCLUSIONS AD-MSC implantation may enhance nerve regeneration, as demonstrated by a better outcome profile in the AD-MSCs group.
Co-Authors Achmad Fauzi Kamal Amelia, Ria Angelita, Michelle Cancera Antarianto, Radiana Dhewayani Aprilya, Dina Ardiansyah, Irfani Ryan Aria Kekalih Budikayanti, Astri Canintika, Anissa Feby Dewi Wulandari Erial Bahar, Erial Erni Hernawati Purwaningsih, Erni Hernawati Fachniadin, Ande Fadli, Nurul Hakim, Manfaluthy Handayani, Sri Harsono, Adrian Ridski Harun, Yusril Heri Suroto Imran, Darma Indrawati, Luh Ari Ismail Hadisoebroto Dilogo Maharani, Kartika Marissa, Melani Mustika, Alyssa Putri Nova Lestari Nurjati Chairani Siregar Olivia, Taruli Pangeran, David Pasmanasari, Elta Diah Pramudya, Hermawan Pratiwi, Astri Dewina Purba, Jan Sudir Puspita Eka Wuyung Radiyati Umi Partan, Radiyati Umi Retnaningsih Retnaningsih Ricky Rusydi Satriawan Riwanti Estiasari Safri, Ahmad Yanuar Santoso, Fabianto Sari, Waode Satriana Savitri, Irma Sjamsoe-Daili, Emmy Soedarmi Sri L. Menaldi Wahyu Widodo Widi Nugroho, Setyo Widiawaty, Alida Wiratman, Winnugroho Zen Hafy