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All Journal Medical Journal of Indonesia MNJ (Malang Neurology Journal) The Indonesian Biomedical Journal Majalah Kedokteran Neurosains Journal of General Procedural Dermatology and Venereology Indonesia Neurona Acta Neurologica Indonesia
Fitri Octaviana
Departemen Neurologi Fakultas Kedokteran Universitas Indonesia/RSUP Cipton Mangunkusumo, Jakarta
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience Public Health

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Optimal time point for evaluation in a chronic peripheral nerve injury rat model: a preclinical study Widodo, Wahyu; Dilogo, Ismail Hadisoebroto; Kamal, Achmad Fauzi; Antarianto, Radiana Dhewayani; Wuyung, Puspita Eka; Siregar, Nurjati Chairani; Octaviana, Fitri; Kekalih, Aria; Suroto, Heri; Aprilya, Dina; Canintika, Anissa Feby
Medical Journal of Indonesia Online First
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.257778

Abstract

BACKGROUND Peripheral nerve injury (PNI) can cause severe functional disabilities and progresses dynamically over time. Since evaluations held at different time points will yield different results, finding an optimal model for PNI comparison is needed. This study aimed to create an animal model of chronic denervation that simulates the progress of nerve injury. METHODS 6 male Sprague-Dawley rats underwent complete sciatic nerve transection in their right hind limbs, with severed nerve ends secured to a nearby muscle to prevent nerve regrowth. The rats were sacrificed at 2, 3, and 4 weeks. The assessment included walking analysis (pre- and post-injury), wet muscle weight measurement, and histological examination. RESULTS Progressive gastrocnemius muscle degeneration was observed at 3 different time points. Minimal degenerative changes were noted at 2 weeks, while extensive fibrosis (83.25 [12.19]% collagen area) appeared in the 4th week. The 3rd-week samples showed lymphocyte infiltrations, muscular atrophy, and progressive fibrosis, making it the best model for chronic PNI. CONCLUSIONS A 3-week chronic denervation model is proposed as a long-term PNI for further regenerative research.
Co-Authors Achmad Fauzi Kamal Amelia, Ria Angelita, Michelle Cancera Aprilya, Dina Ardiansyah, Irfani Ryan Aria Kekalih Astri Budikayanti Canintika, Anissa Feby Dewi Wulandari Erial Bahar, Erial Erni Hernawati Purwaningsih, Erni Hernawati Fachniadin, Ande Fadli, Nurul Hadiweijaya, Antonia Hakim, Manfaluthy Handayani, Sri Harsono, Adrian Ridski Harun, Yusril Heri Suroto Imran, Darma Indrawati, Luh Ari Ismail Hadisoebroto Dilogo Maharani, Kartika Marissa, Melani Mustika, Alyssa Putri Nova Lestari Nurjati Chairani Siregar Olivia, Taruli Pangeran, David Parindra, Cakra Pasmanasari, Elta Diah Pramudya, Hermawan Pratiwi, Astri Dewina Purba, Jan Sudir Puspita Eka Wuyung Radiana Dhewayani Antarianto Radiyati Umi Partan, Radiyati Umi Retnaningsih Retnaningsih Ricky Rusydi Satriawan Riwanti Estiasari Safri, Ahmad Yanuar Santoso, Fabianto Sari, Waode Satriana Savitri, Irma Sjamsoe-Daili, Emmy Soedarmi Sri L. Menaldi Wahyu Widodo Widi Nugroho, Setyo Widiawaty, Alida Wiguna, Fikry Ichsan Wiratman, Winnugroho Zen Hafy