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All Journal Medical Journal of Indonesia MNJ (Malang Neurology Journal) The Indonesian Biomedical Journal Majalah Kedokteran Neurosains Journal of General Procedural Dermatology and Venereology Indonesia Neurona Acta Neurologica Indonesia Journal of Neurointervention and Stroke (JNeViS)
Fitri Octaviana
Departemen Neurologi Fakultas Kedokteran Universitas Indonesia/RSUP Cipton Mangunkusumo, Jakarta
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience Public Health

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Optimal time point for evaluation in a chronic peripheral nerve injury rat model: a preclinical study Widodo, Wahyu; Dilogo, Ismail Hadisoebroto; Kamal, Achmad Fauzi; Antarianto, Radiana Dhewayani; Wuyung, Puspita Eka; Siregar, Nurjati Chairani; Octaviana, Fitri; Kekalih, Aria; Suroto, Heri; Aprilya, Dina; Canintika, Anissa Feby
Medical Journal of Indonesia Online First
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.257778

Abstract

BACKGROUND Peripheral nerve injury (PNI) can cause severe functional disabilities and progresses dynamically over time. Since evaluations held at different time points will yield different results, finding an optimal model for PNI comparison is needed. This study aimed to create an animal model of chronic denervation that simulates the progress of nerve injury. METHODS 6 male Sprague-Dawley rats underwent complete sciatic nerve transection in their right hind limbs, with severed nerve ends secured to a nearby muscle to prevent nerve regrowth. The rats were sacrificed at 2, 3, and 4 weeks. The assessment included walking analysis (pre- and post-injury), wet muscle weight measurement, and histological examination. RESULTS Progressive gastrocnemius muscle degeneration was observed at 3 different time points. Minimal degenerative changes were noted at 2 weeks, while extensive fibrosis (83.25 [12.19]% collagen area) appeared in the 4th week. The 3rd-week samples showed lymphocyte infiltrations, muscular atrophy, and progressive fibrosis, making it the best model for chronic PNI. CONCLUSIONS A 3-week chronic denervation model is proposed as a long-term PNI for further regenerative research.
Indonesian Stroke Management Neurointerventional Services Challenges Usman, Fritz Sumantri; Sani, Achmad Firdaus; Octaviana, Fitri; Kastilong, Merlin Prisilia; Kurnia, Leny; Hendartono, Theodorus K; Atmadja, Andika S; Tambunan, Yan Leo; Syahrul, Syahrul; Pramukarso, Dodik Tugasworo
Journal of Neurointervention and Stroke Vol. 1 No. 1: MAY 2025
Publisher : Neurointervention Working Group of Indonesian Neurological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63937/jnevis-2025.11.3

Abstract

Highlight: Stroke burden in Indonesia Challenges for Indonesian neurointerventionst ABSTRACT Introduction: Stroke is a leading cause of death and disability in Indonesia. Currently, stroke management has become more aggressive, and neurointerventionists are required to optimize acute stroke management. Objective: To determine the distribution of neurointerventionists in Indonesia and identify the obstacles faced in neurointervention services. Method: This cross-sectional study used an online questionnaire distributed to neurointerventionists in Indonesia between October and November 2024. Result: A total of 105 neurointerventionists completed the questionnaires. The distribution of neurointerventionists remains concentrated in Java, especially in Jakarta. The highest ratio of neurointerventionists to stroke cases was observed in Jakarta, while the lowest was in Lampung. West Java identified the largest gap in the number of neurointerventionists compared to Jakarta. Notably, 20.9% of neurointerventionists had not performed any neurointerventional procedures, and 46.8% reported challenges related to the funding of neurointerventional procedures through government insurance. Conclusion: Despite the increasing number of neurointerventionists in Indonesia, their distribution remains concentrated in Java. The main barrier was the funding of neurointerventional procedures through government insurance.
Co-Authors Achmad Fauzi Kamal Achmad Firdaus Sani, Achmad Firdaus Amelia, Ria Angelita, Michelle Cancera Aprilya, Dina Ardiansyah, Irfani Ryan Aria Kekalih Astri Budikayanti Atmadja, Andika S Canintika, Anissa Feby Dewi Wulandari Erial Bahar, Erial Erni Hernawati Purwaningsih, Erni Hernawati Fachniadin, Ande Fadli, Nurul Fritz Sumantri Usman, Fritz Sumantri Hadiweijaya, Antonia Hakim, Manfaluthy Handayani, Sri Harsono, Adrian Ridski Harun, Yusril Hendartono, Theodorus K Heri Suroto Imran, Darma Indrawati, Luh Ari Ismail Hadisoebroto Dilogo Kastilong, Merlin Prisilia Kurnia, Leny Maharani, Kartika Marissa, Melani Mustika, Alyssa Putri Nova Lestari Nurjati Chairani Siregar Olivia, Taruli Pangeran, David Parindra, Cakra Pasmanasari, Elta Diah Pramudya, Hermawan Pramukarso, Dodik Tugasworo Pratiwi, Astri Dewina Purba, Jan Sudir Puspita Eka Wuyung Radiana Dhewayani Antarianto Radiyati Umi Partan, Radiyati Umi Retnaningsih Retnaningsih Ricky Rusydi Satriawan Riwanti Estiasari Safri, Ahmad Yanuar Santoso, Fabianto Sari, Waode Satriana Savitri, Irma Sjamsoe-Daili, Emmy Soedarmi Sri L. Menaldi Syahrul Syahrul Tambunan, Yan Leo Wahyu Widodo Widi Nugroho, Setyo Widiawaty, Alida Wiguna, Fikry Ichsan Winnugroho Wiratman Zen Hafy