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All Journal Jurnal Ilmu Kefarmasian Indonesia JURNAL FARMASIMED (JFM) Jurnal Kesehatan Tambusai Archives Pharmacia Journal of Experimental and Clinical Pharmacy (JECP) Jurnal Sains dan Teknologi Duta Pharma Journal Proceeding of International Conference Health, Science And Technology (ICOHETECH) Prosiding Seminar Informasi Kesehatan Nasional International Journal of Health, Engineering and Technology Green Health: Journal of Health Sciences, Nursing and Nutrition
Rahmatillah, Annie
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Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Education Electrical & Electronics Engineering Energy Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Formulation Of Antifungal Solid Soap From 96% Ethanol Extract Of Neem Leaves (Azadirachta Indica A.Juss) Against Malassezia Furfur ATCC 14251 Diyah Nurayuni; Anna Fitriawati; Annie Rahmatillah
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.667

Abstract

Fungal skin infections are still a health problem in tropical regions, especially those caused by Malassezia furfur, so alternative natural skin cleansing preparations are needed that are safe and effective. Neem leaves (Azadirachta indica A. Juss) are known to have antifungal activity and have the potential to be developed into solid soap preparations. This study aims to formulate an antifungal solid soap made from 96 percent ethanol extract of neem leaves, evaluate the physical quality of the preparation, and test its antifungal activity against Malassezia furfur. This study is a laboratory experimental study with a pretest-posttest only control group design. The study population was neem leaves obtained from Mount Pati District, Semarang, with simplicia samples selected using a purposive sampling technique. The research instruments included formulation equipment, physical quality tests based on SNI 3532:2016, and antifungal activity tests using the well diffusion method, while data analysis was carried out using nonparametric statistical tests. The results showed that all soap formulas met the physical quality requirements, and the formulation with a 10 percent extract concentration produced the largest inhibition zone diameter against Malassezia furfur, although it was still relatively weak. The conclusion of this study is that neem leaf extract solid soap has potential as a natural skin cleanser with antifungal activity, but further development and optimization of the formulation are needed to increase its effectiveness.
The Relationship Of Antibiotic Rationality To Clinical Outcomes In Adult UTI Patients Using The Gyssens Method At The Inpatient Unit Of PKU Muhammadiyah Hospital, Surakarta Nabilla Aulia Khorifatunnisa; Aprilia Puteri Santika; Annie Rahmatillah
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.668

Abstract

Urinary Tract Infection (UTI) is a common infection with a high risk of antibiotic resistance due to irrational use. This study evaluated the rationality of antibiotics on the clinical outcomes of adult UTI patients using the Gyssens method at PKU Muhammadiyah Surakarta Hospital. To analyze the profile, rationality of antibiotics, and their relationship with clinical improvement. Retrospective descriptive study on 77 adult UTI inpatients from January to December 2024, purposive sampling, medical record instruments, Gyssens and Chi-Square analysis (SPSS 25). Rationality 53.25% (category 0), Cefuroxime most (38.96%), normal leukocytes 92.2%, p = 0.006 indicating a significant relationship between rationality and clinical improvement. Rational use of antibiotics significantly improves the clinical outcomes of UTI, supporting antimicrobial stewardship.
Evaluation Of The Antioxidant Activity Of Lotion Containing Ethanolic Extract Of Matoa Leaves (Pometia Pinnata J.R.Forst, & G.Forst.) Mei Vita Rachma Pertiwi; Anna Fitriawati; Annie Rahmatillah
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.672

Abstract

Skin exposure to environmental stress produces free radicals and ROS that accelerate aging and skin damage, while antioxidant Lotions from natural extracts such as Matoa leaves (Pometia pinnata) offer protection. This experimental study aimed to evaluate the antioxidant activity of ethanol extracts, the effect of concentration (0.5-6%) on the physical quality of Lotions, and the DPPH scavenging ability of the final Lotion. The population of all Matoa leaf extract Lotion formulations; a sample of 2 kg of fresh leaves from Matesih, Karanganyar was purposively selected. Instruments included a UV-Vis spectrophotometer (517 nm), a Brookfield viscometer, a pH meter; SPSS 28.0 was analyzed by ANOVA, regression for IC50. The extract was very potent (IC50 43.07 ppm) containing flavonoids, alkaloids, saponins, tannins; All Lotions met the standards (homogeneous, pH 5.22-6.34, viscosity 10,100-12,740 cP, spreadability 5-6.5 cm), FV (6%) was optimal (IC50 66.30 ppm, strong). High concentrations increased inhibition but increased viscosity, decreased spreadability (p<0.05). The findings confirm that Matoa Lotion is effective for herbal skin care; further in vivo and stability testing is recommended.
Comparison of Antioxidant Activity of Sheet Mask Ethanol Extract of Kesum Leaves (Polygonum Minus H) Using DPPH and FRAP Methods Ambararum, Tiara Rizki; Annie Rahmatillah; Vivin Marwiyati Rohmana
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.674

Abstract

Skin aging due to oxidative stress from free radicals requires natural antioxidants such as kesum leaves (Polygonum minus Huds.) which are rich in flavonoids and phenolics. This study aims to formulate a sheet mask from ethanol extract of kesum leaves at a concentration of 1-3%, evaluate the physicochemical properties, and compare antioxidant activity with DPPH and FRAP methods. Quantitative experimental research with a comparative design used purposive sampling of kesum extracts and formulations (F0-F3), with three replications per concentration (a total of 12 samples). Instruments include a UV-Vis spectrophotometer (DPPH 517 nm, FRAP 593 nm), pH meter, viscometer; linear regression data analysis for IC₅₀ and t/ANOVA test. The results showed that the IC₅₀ extract DPPH 38.12 ppm (very strong) and FRAP 67.37 ppm (strong); F3 sheet mask optimal IC₅₀ DPPH 41.59 ppm, pH 5.43, viscosity 385 mPa.s, spreadability 6.7 cm, non-irritant, increased humidity 50-60%. The DPPH method is more sensitive than FRAP. In conclusion, F3 sheet mask has the potential to be a strong antioxidant for anti-aging cosmetics, in vivo and stability tests are recommended.
Formulation And Antioxidant Activity Testing Of Ethanol Extract Moisturizing Gel From Kesum Leaves (Polygonum Minus Huds.) Using The DPPH (2,2-Diphenyl-1-Picrylhydrazyl) Method Windy Marcella; Bangkit Riska Permata; Annie Rahmatillah
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.684

Abstract

Free radicals are unstable molecules that can cause cell damage and play a role in premature aging and various skin disorders. One way to inhibit the effects of free radicals is through the use of topical preparations containing antioxidants. Kesum leaves (Polygonum minus Huds) are known to contain bioactive compounds, particularly flavonoids and phenolics, which have the potential to act as natural antioxidants. This study aims to formulate kesum leaf ethanol extract into a moisturizing gel preparation and evaluate its physical quality and antioxidant activity using the DPPH (2,2-diphenyl-1-picrylhydrazyl) method. This study was an experimental study with variations in the concentration of kesum leaf ethanol extract, namely F1 (1%), F2 (2%), and F3 (3%). The evaluation of the physical quality of the gel included organoleptic testing, homogeneity, pH, Viscosity and spreadability. Antioxidant activity was expressed as the IC₅₀ value. The results showed that all gel formulations met the physical quality requirements for preparations. The IC₅₀ values of the gel preparations in F1, F2, and F3 were 169.556 ppm, 150.759 ppm, and 125.396 ppm, respectively, while the positive control showed an IC₅₀ value of 44.792 ppm. An increase in the concentration of kesum leaf ethanol extract in the gel formulation showed a tendency to increase antioxidant activity. Formula F3 had the best antioxidant activity among the gel formulations tested. Thus, kesum leaf ethanol extract has potential as an antioxidant agent.
Co-Authors 'Arifah, Zainul Agustiningrum, Nurul Ambararum, Tiara Rizki Anisa Fadilah Kumala Putri Anna Fitriawati Aprilia Puteri Santika Apriliya, Intan Bagas Ardiyantoro Bangkit Riska Permata Diyah Nurayuni Fatika Puteri Rosyi Prabowo Ika Trisharyanti Dian Kusumowati Insani, Fitri Nur Irhamadi Malik Jayak Pratama, Kharisma Larasati, Karina Dwi Libin joseph Luthfiyanti, Niken Mahendra, Andika Dwi Marwiyati, Vivin Mei Vita Rachma Pertiwi Nabilla Aulia Khorifatunnisa Nurul Agustiningrum Pratama, Kharisma Jayak Puput Mulyono Puspita Sari, Mawar Dela Putri, Anisa Fadilah Kumala Qurniawati, Eka Rahmat Hidayat Riza Monasyifa Rizki Utami, Tiara Rohmana, Vivin Marwiyati Rosi Hayyu Anjani Saputri, Dina Tika Sari, Sindy Avita Septian Maulid Wicahyo Shinta Putri Rahmawati UTARI SITA ARDANI Wa Ode Nurani Arma Wardani, Tatiana Siska Windy Marcella YULIANA RIZQI DWI RATNA Yusuf, Dea Sagitarina ZAKIAH FATHIANA