Article Per Year (5 Year)
p-Index From 2021 - 2026
1.295
P-Index
This Author published in this journals
All Journal Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) JNKI (Jurnal Ners dan Kebidanan Indonesia) (Indonesian Journal of Nursing and Midwifery) Pharmaceutical Journal of Indonesia Jurnal Ilmiah Farmako Bahari Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang INPHARNMED Journal (Indonesian Pharmacy and Natural Medicine Journal) Jurnal Kefarmasian Indonesia
Estiningsih, Daru
Universitas Alma Ata, Yogyakarta, Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Other

Published : 9 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
Pengaruh Pemberian Fraksi n-Heksan Ekstrak Etanol Daun Kelor (Moringa oleifera L.) Terhadap Kadar Low-Density Lipoprotein (LDL) Tikus Jantan Galur Sprague dawley : Efek Antikolestrol Fraksi n-Heksan Ekstrak Etanol Daun Kelor (Moringa oleifera L.) Kusumawardani, Nurul; Fauzi, Rizal; Emelda, Emelda; Estiningsih, Daru; Sukma Ananda , RA Dewinta; Nabila , Lathifa
Pharmaceutical Journal of Indonesia Vol. 9 No. 2 (2024)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.pji.2024.009.02.9

Abstract

This study aimed to determine the effect of the n-hexane fraction of Moringa leaf ethanol extract (Moringa oleifera L.) on low-density lipoprotein (LDL) levels in Sprague Dawley male rat strains fed a high-fat diet. This study used a pre-test and post-test control design on male rats of the Sprague Dawley strain. Thirty-six male white rats of the Sprague Dawley strain were given high-fat diet and then divided into six groups: group I was normal group, group II negative control was given CMC Na, Group III positive control was given Simvastatin 10 mg, Group IV, V, VI was given n-hexane fraction of ethanol extract of Moringa leaves (Dose 3,722 mg/kgBW; 7.444 mg/kgBW; 14,888 mg/kgBW). The results of measuring low-density lipoprotein (LDL) levels in animals were measured after 14 days of research as a post-test. Based on statistical analysis, there was no significant difference between the positive control group and the three treatment groups (p=1,000). The results of this study can conclude that the dose of the n-hexane fraction of Moringa leaves has a significant effect on decreasing LDL levels in male Sprague Dawley rats with the best % reduction at a dose of 14.89 mg/kg BW (61.17%), with a linear regression equation y=-0.0408x + 1.079; (R2=0.986). The results of this study indicate that the n-hexane part of Moringa leaves may reduce low-density lipoprotein levels in male white Wistar rats induced by high-fat.
Co-Authors Amalia, Latifa Amukti, Danang Ariansyah, Diffa Zahra Aslam, M.Muzhil Astuti, Witri Susila emelda, emelda Fatmawati, Annisa Herlina, Tetie Ika Puspitasari Kusumawardani, Nurul Masfiyah, Lukluul Nabila , Lathifa Nadliroh, Lubabun Ninisita Sri Hadi Nurinda, Eva Nuryanti, Sundari Desi Pratami, Ria Indah Puspitasari, Ade Rizal Fauzi Sarwadhamana, Raden Jaka Sukma Ananda , RA Dewinta Suminingtyas, Ifa Aris Titik Nuryastuti Wijayanti, Adina Nugrahaeni Wulandari, Ari Susiana Yosi Febrianti, Yosi