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All Journal Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) JNKI (Jurnal Ners dan Kebidanan Indonesia) (Indonesian Journal of Nursing and Midwifery) Pharmaceutical Journal of Indonesia Jurnal Ilmiah Farmako Bahari Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang INPHARNMED Journal (Indonesian Pharmacy and Natural Medicine Journal) FARMASAINKES Bangun Desa : Jurnal Pengabdian Masyarakat Jurnal Kefarmasian Indonesia Clinical and Pharmaceutical Sciences Journal
Estiningsih, Daru
Universitas Alma Ata, Yogyakarta, Indonesia
Religion Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Pengaruh Pemberian Fraksi n-Heksan Ekstrak Etanol Daun Kelor (Moringa oleifera L.) Terhadap Kadar Low-Density Lipoprotein (LDL) Tikus Jantan Galur Sprague dawley : Efek Antikolestrol Fraksi n-Heksan Ekstrak Etanol Daun Kelor (Moringa oleifera L.) Kusumawardani, Nurul; Fauzi, Rizal; Emelda, Emelda; Estiningsih, Daru; Sukma Ananda , RA Dewinta; Nabila , Lathifa
Pharmaceutical Journal of Indonesia Vol. 9 No. 2 (2024)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.pji.2024.009.02.9

Abstract

This study aimed to determine the effect of the n-hexane fraction of Moringa leaf ethanol extract (Moringa oleifera L.) on low-density lipoprotein (LDL) levels in Sprague Dawley male rat strains fed a high-fat diet. This study used a pre-test and post-test control design on male rats of the Sprague Dawley strain. Thirty-six male white rats of the Sprague Dawley strain were given high-fat diet and then divided into six groups: group I was normal group, group II negative control was given CMC Na, Group III positive control was given Simvastatin 10 mg, Group IV, V, VI was given n-hexane fraction of ethanol extract of Moringa leaves (Dose 3,722 mg/kgBW; 7.444 mg/kgBW; 14,888 mg/kgBW). The results of measuring low-density lipoprotein (LDL) levels in animals were measured after 14 days of research as a post-test. Based on statistical analysis, there was no significant difference between the positive control group and the three treatment groups (p=1,000). The results of this study can conclude that the dose of the n-hexane fraction of Moringa leaves has a significant effect on decreasing LDL levels in male Sprague Dawley rats with the best % reduction at a dose of 14.89 mg/kg BW (61.17%), with a linear regression equation y=-0.0408x + 1.079; (R2=0.986). The results of this study indicate that the n-hexane part of Moringa leaves may reduce low-density lipoprotein levels in male white Wistar rats induced by high-fat.
Co-Authors Aliza, Fidya Nur Amalia, Latifa Amukti, Danang Amukti, Danang Ariansyah, Diffa Zahra Aslam, M.Muzhil Astuti, Witri Susila Avista, Agriva Devaly Basuki, Adriyanto Rochmad Bulianto, Gerry Dwi Djaka Purwanto, Barkah Elfaradita, Lovysna Aulia emelda, emelda Fatmawati, Annisa Fauziyah, Laiza Nurannisa Herlina, Tetie Iin Purwanti, Iin Ika Puspitasari Imam Akbar, Imam Indrayana, Sofyan Kusumah, Dyah Aryanti Kusumawardani, Nurul Masfiyah, Lukluul Muhammad Ma’ruf Nabila , Lathifa Nadliroh, Lubabun Ninisita Sri Hadi Niswannabila, Himmah Nurinda, Eva Nurindah, Santi Nurwanti, Esti Nuryanti, Sundari Desi Prasetyaning Amukti, Danang Pratama, Joni Yoga Pratami, Ria Indah Puspitasari, Ade Putri, Febrianty Ratashya Rizal Fauzi Rizki Akbar, Rizki Rustandi, Henri Saiful Bachri, Moch Sarfana, Sarfana Sarwadhamana, Raden Jaka Setyaningrum, Ndaru Sholikhah, Hidayatus Sri Suprapti Suat, Winda Dheananda Sukma Ananda , RA Dewinta Sukma Ananda, RA Dewinta Suminingtyas, Ifa Aris Titik Nuryastuti Vitara, Debby Wijayanti, Adina Nugrahaeni Wulandari, Ari Susiana Wulandari, Metha Yosi Febrianti, Yosi