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All Journal Indonesian Journal of Pharmaceutical Science and Technology Biota Syntax Literate: Jurnal Ilmiah Indonesia JFL : Jurnal Farmasi Lampung Jurnal Inovasi Pembangunan Jurnal Media Pengabdian Kepada Masyarakat (JM-PKM)

Widodo, Subur

Program Studi Farmasi, Fakultas MIPA, Universitas Tulang Bawang Lampung

Author-ID : 867657

Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Transportation Other

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ANALISA TINGKAT PENGETAHUAN DAN PERILAKU TERHADAP PENGGUNAAN OBAT INFLUENZA DAN BATUK SECARA SWAMEDIKASI DI DESA MUARA BURNAI I KABUPATEN OGAN KOMERING ILIR Mashuri Yusuf; Subur Widodo; Aqbar Raka Irwansyah
JFL : Jurnal Farmasi Lampung Vol. 9 No. 2 (2020): JFL: Jurnal Farmasi Lampung
Publisher : Fakultas MIPA Universitas Tulang Bawang Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v9i2.341

Abtract Many Indonesian people do self-medication as an attempt to treat complaints / pain they experience, the benefit of self-medication is safe when used according to the rules, effective for eliminating complaints, cost efficiency, can play a role in making therapeutic decisions, self-medication is usually done to overcome complaints and minor illnesses that are often experienced by people, such as fever, pain, dizziness, cough, influenza, ulcers, intestinal worms, diarrhea, skin diseases and others. This study aims to determine the level of knowledge and behavior towards the use of influenza drugs and cough by self-medication in Muara Burnai I Village, Ogan Komering Ilir district. The research analyzed was descriptive observational. The sampling technique uses the accindental sampling method. The instrument used in this study was a questionnaire. The results of the analysis of the level of knowledge and behavior analysis showed that there was a relationship between the level of knowledge and the behavior of influenza drug use and cough by self-medication was analyzed using the Chi-Square test sample of 100 respondents. The results of this study indicate that 36% have high knowledge and 64% have low knowledge in self-influencing and cough swamedication while 43% have high behavior and 57% have low behavior in influenza and cough swamedication in Muara Burnai I Village, Ogan Komering Ilir District. Based on the Chi-Square test results showed that the value of p = 0,000 (0.05). Shows that there is a relationship between the level of knowledge and swamedication behavior in Muara Burnai I Village, Ogan Komering Ilir district. Keywords : Influenza and cough, drug use behavior, swamedication, knowledge level.

UJI EFEK STIMULAN FRAKSI N-HEKSAN DAUN PEGAGAN (Centella asiatica (L.)Urban) Nurma Suri; Subur Widodo; Mega Intan Yulianti
JFL : Jurnal Farmasi Lampung Vol. 10 No. 2 (2021): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v10i2.703

Abstract Current condition related to fulfilling stimulating in the societies is by energy drinks and vitamins which have side effects restless, nervous, tremor, and seizures. Alternative stimulant can derived from herbs. One of the plants has potention of stimulant is Centella asiatica. This study was to examine the effect of stimulant on fraction n-hexane of C.asiatica leaves. The simplisia of C.asiatica leaves was extracted with ethanol 70% using a maceration method. Thereafter, extract was fractionated using n-hexane. Phytochemical screening was carried out to determine the content of secondary metabolites in order to find out the potential utilization by testing the active compounds. Stimulant effect was evaluated using induced sleeping time, swimming endurance time, hanging time, and rotarod method with the dose 2.59 mg/KgBW, 5.185mg/KgBW, 10.37 mg/KgBW, and 15.55 mg/KgBW, caffeine as the positive control, and Na-CMC as the negative control. The phytochemical screening showed positive results for triterpenoids and alcaloid. All of the dose fraction n-hexane had effect stimulant however dose 5.185 mg/KgBW and 10.37 mg/KgBW had as same stimulant effect as positive control and dose15.55 mg/BW had higher stimulant effect. N-hexane fractionation of C.asiatica leaves demonstrated the presence of secondary metabolites with potential biological activities as stimulant. Keywords: Alkaloids, C. asiatica, Triterpenoids, Stimulants test

Pengembangan Sediaan Gel Ekstrak Daun Kacang Panjang (Vigna sinensis L.) dan Ekstrak Seledri (Apium graveolens L.) untuk Pertumbuhan Rambut Kelinci Widodo, Subur; Purba, Anny Victor
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : CV. Ridwan Publisher

Kerontokan rambut merupakan masalah umum yang terjadi di masyarakat sehingga mendorong para peneliti untuk berinovasi mengembangkan suatu formula efektif yang dapat mencegah kerontokan rambut dan merangsang pertumbuhan rambut. Tujuan dari penelitian ini adalah untuk memperoleh kombinasi ekstrak daun kacang panjang dan ekstrak herba seledri yang paling efektif dan dapat diformulasi ke dalam sediaan gel yang memiliki aktifitas terhadap pertumbuhan rambut. Metode penelitian ini adalah penelitian eksperimental kualitatif dan kuantitatif dengan teknik in vivo. Ekstrak daun kacang panjang dan ekstrak herba seledri diperoleh dari maserasi dengan menggunakan etanol 70% kemudian evaporasi didapat ekstrak kental. Perbandingan konsentrasi ekstrak daun kacang panjang dan ekstrak herba seledri yang digunakan (3,75% : 5%), (7,5% : 10%) dan (15% : 20%). Uji aktifitas pertumbuhan rambut dilakukan menggunakan metode Tanaka dengan pengamatan selama 35 hari dengan menggunakan kelinci jantan, parameter yang diamati adalah panjang rambut dan bobot rambut. Kesimpulan penelitian ini adalah kombinasi ekstrak daun kacang panjang dan ekstrak herba seledri yang paling baik terhadap pertumbuahn rambut pada perbandingan 7,5% : 10% kemudian dibuat dalam sediaan gel,mempercepat pertumbuhan rambut dengan rata-rata panjang rambut 2,307 cm dan bobot rambut 388,7 mg, sediaan gel yang dibuat stabil pada suhu 4°C dan 25°C selama 3 bulan, serta tidak mengiritas kulit kelinci.

PENETAPAN NILAI SPF (SUN PROTECTION FACTOR) SEDIAAN KRIM TABIR SURYA DI KOTA BANDAR LAMPUNG DENGAN METODE SPEKTROFOTOMETRI UV-VIS Subur Widodo; Akhmad Rokiban; Lilik Koernia Wahidah; Ikhrami Nurjannah
JFL : Jurnal Farmasi Lampung Vol. 12 No. 1 (2023): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v12i1.978

Nowadays people awareness of the healthy skin importance is increasing, this is evident by the increasing cosmetic brands and there are many beauty clinics. Cosmetic products marketed should have the same efficacy as those listed on the packaging. Therefore, determining the efficacy of sunscreen preparations is very important to see the compliance of cosmetics manufacturers. The purpose of this study was to determine the suitability of the SPF product efficacy. The samples are the products which have SPF 30, the sample was tested by in vitro method using UV-Vis spectrophotometer, every 5 nm with the wavelength range 290 nm - 320 nm absorbance was measured, then analyzed with the mansur equation. Also did antioxidant activity tested with vitamin C as a control positive using the DPPH method. The principle of the DPPH method is the measurement of absorbance of DPPH radicals which are degraded due to the presence of antioxidant compounds using a UV-Vis spectrophotometer. The decrease in DPPH absorbance intensity is proportional to the increase in the concentration of antioxidant compounds expressed in IC50 (Inhibition Concentration 50). Sample 4 has an SPF value close to the value written on the packaging. Samples 2, 5, 1, 3, 6, 7 and 8 have SPF values smaller than those listed on the packaging. The antioxidant activity obtained is rateable to the SPF value, sample 4 has the highest antioxidant activity followed by sample 2, sample 5, sample 1, sample 3, sample 6, and sample 7 and sample 8 have the lowest antioxidant activity. Keywords: Antioxidant , DPPH, UV-Vis spectrophotometry, SPF, Sunscreen

Formulasi Dan Uji Aktivitas Sediaan Krim Fraksi Etanol Bunga Pepaya (Carica Papaya L.) Terhadap Bakteri Staphylococcus Aureus Penyebab Jerawat Widodo, Subur; Rokiban, Akhmad; Susanti, Laila; Riyanti, Deski
JFL : Jurnal Farmasi Lampung Vol. 12 No. 2 (2023): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v12i2.1248

Papaya flowers in the community are believed to be antidiabetics, prevent cancer, lower cholesterol, and as antibacterial. Based on its antibacterial properties, the ethanol fraction of papaya flowers will be made in the form of cream preparations. This study aims to find out the activity of papaya flower ethanol fraction cream preparations against the bland growth power of acne-causing Staphylococcus aureus bacteria. Ethanol fractions of papaya flower are formulated into cream preparations with fraction concentrations of F1 (2%), F2 (4%), F3 (6%), and F4 (8%) using oil phases (stearic acid, paraffin liquidum, and adeps lanae), water phase (TEA and aquadest) and preservatives (methyl parabens). Furthermore, the cream tested antibacterial activity and physical properties include homogeneity, organoleptic, pH, viscosity, scattering power, adocity and stability. The results showed F1, F2, F3, and F4 each had antibacterial activity against Staphylococcus aureus bacteria as evidenced by the presence of bland zones in F1 (17.35 mm), F2 (17.77 mm), F3 (18.90 mm), and F4 (19.73 mm). The resulting data is normal and homogeneous distributed data so that the results of the ANOVA test show a significant difference of 0.0000 (p ≤ 0.05) and Tukey Post Hoc test results are obtained significant differences between formulas. The results of the evaluation of cream preparations on observation of homogeneity are less stable and organoleptic have stable results, pH values of 5.62-6.62, viscosity of 4122-4432 cps, scatter power of 5.13-5.70 cm, and akat for 4.86-6.43 seconds. Cycling tests showed stable results in F1, F2 and F3 and less stable in F4. The conclusion of this research is that the formulation ethanol fraction of papaya flower cream preparations has activity against the inhibition of the growth of acne-causing Staphylococcus aureus bacteria. Keywords: Acne, Antibacterial, Carica papaya, Cream, Fraction, Papaya Flower

Formulasi Sediaan Pewarna Pipi Dari Ekstrak Daun Jawer Kotok (Plectranthus scutellarioides (L.) R.Br) Dalam Bentuk Compact Powder Susanti, Laila; Widodo, Subur; Nurjanah, Siti; Sivitha, Sivitha
JFL : Jurnal Farmasi Lampung Vol. 12 No. 2 (2023): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v12i2.1305

Blush on was cosmetic used to color the cheeks so that it can improve fresh impression in makeup. Plectranthus scutellarioides (L.) R.Br has anthocyanin content could be used as a natural dye. This research aims to make a rouge from Plectranthus scutellarioides (L.) R.Br extract in the form of compact powder. To get Plectranthus scutellarioides (L.) R.Br extraction we had to macerate 3 kilogram Plectranthus scutellarioides (L.) R.Br into 96% etanol liquid then the maserate is evaporated with rotary evaporator to obtained thick extract. Further more rouge were formulated with kaolin, talc, zinc stearate, oleum rosae, isopropyl myristate, lanolin, and nipagin. Plectranthus scutellarioides (L.) R.Br extract with variations in concentration 6% (F1), 8% (F2) and 10% (F3). After that could be evaluated (color dispersion test, crack test, polishing test, irritation test, hedonic test, and stability test. The results from Plectranthus scutellarioides (L.) R.Br extract result color light brown for F1, red brown for F2 and dark red for F3. Based on the test result all formulation had a homogeny color, not cracked in the crack test qualify for the irritation test. Dosage formulations with concentration 10% many liked. While on the method low temperature stability all preparations no changed organoleptic (color, smell and shape) but in the test high temperature stability of all formulations the preparation has a slight discoloration at thefourth week. The color looks faded not like the beginning. It is because the content of anthocyanin contained in Plectranthus scutellarioides (L.) R.Br extract decreases. Plectranthus scutellarioides (L.) R.Br extract cannot be formulated as a rouge because does not give color in the polish test, powder is rough so the color cannot stick to the skin. Keywords : Plectranthus scutellarioides (L.) R.Br, Coleus atropurpureus (L.) Benth, rounge, formulation

suburwidodo Formulasi Krim Anti Acne Ekstrak Etanol Kulit Kentang (Solanum Tuberosum L.) Dan Aktivitas Antibakteri Terhadap Staphylococcus epidermidis Dan Propionibacterium acnes.: Anti Acne Cream Formulation Of Potato Ethanol Extracts (Solanum Tuberosum L.) And Antibacterial Activities On Staphylococcus epidermidis And Propionibacterium acnes. Widodo, Subur; Susanti, Laila; Samsuar; Hartono, Adityo; Safitri, Andika
JFL : Jurnal Farmasi Lampung Vol. 13 No. 1 (2024): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v13i1.1646

Pengobatan jerawat di klinik kulit biasanya menggunakan antibiotik yang dapat menghambat inflamasi dan membunuh bakteri. Penggunaan antibiotik jangka panjang dapat menimbulkan resistensi antibiotik. Efek samping penggunaan antibiotik dapat dikurangi dengan mengganti bahan aktif obat yang diperoleh dari alam seperti kulit kentang yang mampu menghambat pertumbuhan bakteri penyebab jerawat. Penelitian ini bertujuan untuk membuktikan bahwa ekstrak kulit kentang dapat di formulasikan menjadi sediaan krim dan memiliki aktivitas antibakteri terhadap S.epidermidis dan P.acnes. Ekstrak diformulasikan dalam sediaan krim dengan konsentrasi ekstrak berbeda yaitu F1 (15%), F2 (30%) dan F3 (45%) dengan menggunakan asam stearat, paraffin liquidum, adeps lanae sebagai fase minyak dan TEA, aquadest sebagai fase air, dan metil paraben sebagai pengawet. Kemudian diuji sifat fisik sediaan meliputi ,homogenitas, pemeriksaan organoleptis, pengukuran pH, viskositas, daya sebar, daya lekat, uji stabilitas dan uji antibakteri. Hasil evaluasi sediaan memiliki nilai pH berkisar antara 6,2 - 8,1, viskositas berkisar antara 3120 - 4920 cps, daya sebar antara 5,3 - 6,7 cm, dan daya lekat 4,2 - 5,3 detik. Setiap formula stabil dalam penyimpanan cycling test serta penyimpanan suhu 40ºC ± 2ºC, 28ºC ± 2ºC, 4ºC ± 2ºC dan ketiga formula memiliki sifat antibakteri terhadap S.epidermidis dan P.acnes. Luas zona hambat F1 (7,61 mm), F2 (8,47 mm) dan F3 (9,92 mm) terhadap S.epidermidis dan Luas zona hambat F1 (7,58 mm), F2 (7,86 mm) dan F3 (9,65 mm) terhadap P.acnes. Kesimpulan penelitian ini yaitu ekstrak kulit kentang dapat diformulasikan dalam sediaan krim dan memiliki zona hambat terhadap S.epidermidis dan P.acnes.

AKTIVITAS ANTIHIPERURISEMIA KOMBINASI EKSTRAK DAUN KERSEN (MUNTINGIA CALABURA L.) DAN DAUN SIRSAK (ANNONA MURICATA L.) TERHADAP TIKUS PUTIH JANTAN: ANTIHYPERURICEMIA ACTIVITY OF EXTRACT COMBINATION OF KERSEN LEAF (MUNTINGIA CALABURA L.) AND SOURSOP LEAF (ANNONA MURICATA L.) ON MALE WHITE RATS Susanti, Laila; Samsuar; Ariawan, M Wahyu; Widiyastuti, Asih; Isbiyantoro; Widodo, Subur
JFL : Jurnal Farmasi Lampung Vol. 13 No. 2 (2024): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v13i2.1908

Kersen (Muntingia calabura L.) and soursop (Annona muricata L.) have many properties to cure several diseases, including antihiperurisemia, which is a disorder of purine metabolism in which patients experience increased uric acid levels. This study aimed to examine the antihiperuricemia effect of a combination of kersen leaf extract and soursop in male rats orally. Extraction was carried out by maceration using 70% ethanol. This research is a laboratory experimental study using male white mice as test animals. Data were processed in the form of ANOVA and LSD (Least Significant Difference) test results to compare between groups P0 (normal control), PI (negative control), P2 (Allopurinol 9 mg/Kg BW), P3 (410 and 3.5 mg/Kg BW), P4 (410 and 7 mg/Kg BW), P5 (410 and 10.5 mg/Kg BW), P6 (610 and 3.5 mg/Kg BW), P7 (610 and 7 mg/Kg BW), P8 (610 and 10.5 mg/Kg BW), P9 (910 and 3.5 mg/Kg BW), P10 (910 and 7 mg/Kg BW) ), P11 (910 and 10.5 mg/Kg BW). Giving the test material starting on the 8th to 14th day. On the 15th day blood was taken by slaughtering to measure uric acid levels using a UV-Vis spectrophotometer. On examination of uric acid levels, the administration of beef liver can significantly increase uric acid levels in male rats. and the administration of kersen leaf extract and soursop leaves can significantly reduce uric acid levels in male rats. The administration of kersen leaf extract and soursop leaves for 7 days at doses of 910 and 10.5 mg/Kg BW most effectively reduced uric acid levels in hyperuricemic mice. Keywords: Hyperuricemia, kersen leaves extract, soursop leaves extract

FORMULATION AND ANTIBACTERIAL ACTIVITY OF MOUTHWASH COMBINATION OF GUAVA LEAF (Psidium guajava L.) AND BASIL LEAF (Ocinum basilicum L.) EXTRACT AGAINST Streptococcus mutans : FORMULASI SEDIAAN MOUTHWASH KOMBINASI EKSTRAK DAUN JAMBU BIJI (Psidium guajava L.) DAN DAUN KEMANGI (Ocinum basilicum L.) TERHADAP AKTIVITAS BAKTERI Streptococcus mutans Samsuar, Samsuar; Ariawan, M Wahyu; Pratiwi, Inda; Widodo, Subur; Susanti, Laila; Luthfiyah, Yosi
JFL : Jurnal Farmasi Lampung Vol. 14 No. 1 (2025): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v14i1.2427

Dental caries is basically caused by cariogenic bacteria, including Streptococcus mutans, which are found in the oral cavity, especially dental plaque. To treat dental caries, antiseptics packaged in the form of mouthwash use unnatural active ingredients which often cause side effects. Therefore, it is necessary to carry out preventive measures to reduce side effects by using waste from guava leaves and basil leaves. This research purpose were to making mouthwash formulation with the active ingredients guava leaf extract and basil leaf extract and determine the antibacterial activity of mouthwash formulation. The method used is the diffusion method, a combination of concentrations of guava leaf extract and basil leaves, namely F1(0%+20%), F2(5%+15%), F3(10%+10%), F4( 15%+ 5.0%), F5(20%+0%), F6(15%+15%). In this study, the variable measured in this study was the diameter of the inhibition zone formed by the combination of extracts. Data analysis was tested using One Way Anova. The significant value obtained was 0.00 ≤ 0.05, indicating a significant difference from the formulation containing a combination of extracts. The results of this research showed that the largest inhibitory zone was at F5 with the largest average value of 15.07mm which had a strong inhibitory response. This research can be concluded that the mouthwash formulation of extracts meets the physical requirements and can inhibit S. mutans. Keywords : Guava, basil, mouthwash, S. mutans

Standarisasi Bahan Alam Sebagai Bahan Obat Tradisional Samsuar; Pratiwi, Inda; Susanti, Laila; Widodo, Subur; M. Wahyu Ariawan
Jurnal Media Pengabdian Kepada Masyarakat Vol 4 No 2 (2025): JM-PKM
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jm-pkm.v4i2.3053

Obat yang berasal dari bahan alam memiliki efek samping yang lebih sedikit dibandingkan obat-obatan kimia, karena obat herbal bersifat alamiah. Hal ini mendorong pemanfaatan tumbuhan obat sebagai bahan baku obat. Kegiatan pengabdian kepada masyarakat ini bertujuan untuk meningkatkan kapasitas pengetahuan Kelompok Wanita Pengurus PKK, kader posyandu dan ibu-ibu rumah tangga Desa Tambahrejo Kabupaten. Kegiatan pengabdian kepda masyarakat menggunakan metode ceramah dan diskusi. Materi pelatihan mencakup berbagai aspek penting seperti teknik budidaya tanaman untuk obat bahan alam, dan cara pembuatan simplisi strandar dimulai dari cara pengambilan bahan tanaman obat, pencucian, pengerinagn pengahalusan dan penyimpanan. Hasil kegiatan menunjukkan peningkatan pengetahuan peserta sebesar 24% terkait cara pembuatan simplisia standar dimulai dari budidaya tanaman obat sampai penyimpanan simplisia. Secara keseluruhan, kegiatan ini mampu meningkatkan pengetahuan dan keterampilan dalam standarisasi simplisia.

Co-Authors Ade Kristanto Anita Setiawati Anny Victor Purba Aqbar Raka Irwansyah Dhearani , Chairunnisa Diah Pitaloka Dwi Efayanti Dyah Rahmawati Hartono, Adityo Ikhrami Nurjannah Isbiyantoro Lea Yekti Utami Lilik Koernia Wahidah Lisa Selviani Luthfiyah, Yosi M. Desirwan Dinata M. Wahyu Ariawan Mashuri Yusuf Masyuri Yusuf Mega Intan Yulianti Merinda Setyowati Novita Tri Wahyuni Pratiwi, Inda qurrota aini Rahmawati, Dyah Retno Fardila Sari Riyanti, Deski Rokiban, Akhmad Rokiban, Akhmad Safitri, Andika Samsuar Samsuar, Samsuar Siti Nurjanah Sivitha, Sivitha Suri, Nurma Susanti, Laila Syaiful Bahri Wenny Indriasari Widiyastuti, Asih Yuli Wahyu Tri Mulyani

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