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All Journal BioWallacea Journal of Biological Research Jurnal Pengabdian Masyarakat Peternakan As-syifaa Jurnal Farmasi Jurnal Pengabdian Pada Masyarakat JURNAL EDUCATION AND DEVELOPMENT ARSHI Veterinary Letters Jurnal Abdimas PHB : Jurnal Pengabdian Masyarakat Progresif Humanis Brainstorming Jurnal Pengabdian Kepada Masyarakat MEMBANGUN NEGERI JURNAL KAJIAN VETERINER Wellness And Healthy Magazine Indonesia Berdaya Jurnal Pengabdian kepada Masyarakat Nusantara Jurnal Farmasi Sains dan Praktis Jurnal Veteriner Nusantara Parapemikir Jurnal Ilmiah Farmasi
Novian, Dede Rival
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Uji farmakodinamik, drug-likeness, farmakokinetik dan interaksi senyawa aktif kayu ular (Strychnos lucida) sebagai inhibitor Plasmodium falciparum secara in silico Dede Rival Novian; Azra Zahrah Nadhirah Ikhwani; Aji Winarso
Jurnal Veteriner Nusantara Vol 2 No 1 (2019)
Publisher : Program Studi Kedokteran Hewan, Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/jvn.v2i1.1097

Abstract

Snakewood’s active compounds have known to be potential as anti-plasmodium by the in-vitro study. However, the inhibition activity mechanism of snakewood active compounds against Plasmodium is not yet known. In this study, we determined the activity of snakewood’s active compounds by in-silico approach. Firstly, We identified the pharmacodynamic properties of snakewood’s active compounds, which are SA1, SA2, SA3, SA4, and SA5. Furthermore, drug-likeness and pharmacokinetic: absorption-distribution-metabolism-excretion (ADME) analyses were also carried out against snakewood’s active compounds to determine the most potential candidate for anti-Plasmodium falciparum drug. Molecular docking analyses using Plasmodium falciparum lactate dehydrogenase (PfLDH) enzyme against the active compounds were undertaken to observe their specific interactions. The result of molecular docking based on binding energy and inhibitory constant showed that SA3 (3-ethoxyacetophenone (C9H10O2)) active compound is the most potential inhibitor of PfLDH than others. It’s caused by the binding energy and inhibitory constant of SA3 lower than the other snakewood’s active compound. Therefore, SA3 can be a potential candidate for the anti-plasmodium agent.
Resistensi Larva Strongyle sp. Terhadap Albendazole pada Kambing Kacang (Capra hircus) di Indonesia Natasha Imanuelle; Meity M Laut; Dede Rival Novian
Jurnal Veteriner Nusantara Vol 6 No 1 (2023): Februari 2023
Publisher : Program Studi Kedokteran Hewan, Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/jvn.v6i1.2791

Abstract

Nematodiasis is a disease of livestock which caused by nematode infestation. Nematodes in the digestive tract inhibit livestock productivity and increase mortality in young animal. Generally speaking, control of nematodiasis is done by administering anthelmintic from benzimidazole group. Albendazole is the most commonly used anthelmintic. However, continuous use of albendazole in ruminants leads to the development of resistance. The present study aims to not only investigate and evaluate Strongyle sp. larvae resistance to albendazole in Indonesia but also to determine the incident rate of albendazole resistance. This study and references were obtained through Google Scholar and PubMed then arranged using Mendeley. The references are scientific journals, scientific articles, Ebooks and proceedings with "keywords" resistance of Strongyle sp. larvae to albendazole. All references were analyzed and evaluated systematically. The result show that the resistence of Strongyle larvae against albendazole occurred in West Java, East Java, and Yogyakarta with the results of the resistence test was 67%to 89%; 77% and 83%. This results shows that the ability of the drug to treat nematodiasis is no longer optimal. The risk factors of strongyle larvae resistence to albendazole are administering sntihelmintic from the same group continously with inapropriate dose and the ability of worms to develop resistence genes against albendazole.
Analisis Pengaruh Obat Antituberkulosis Terhadap Nilai Sgpt dan Sgot pada Pasien Penderita Tuberkulosis Paru Nur Hasanah; Dede Rival Novian
Parapemikir : Jurnal Ilmiah Farmasi Vol 9, No 2 (2020): Parapemikir : Jurnal Ilmiah Farmasi
Publisher : Pusat Penelitian dan Pengabdian Masyarakat Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/pjif.v9i2.1881

Abstract

Tuberculosis (TB) is a direct infectious disease caused by Mycobacterium tuberculosis. Anti-tuberculosis drugs have a hepatotoxic effect that causes extensive liver injury and harvesters. The parameter to determine the presence or absence of liver damage is to look at SGPT and SGOT levels. The purpose of this study was to determine the effect of drugs on SGPT and SGOT values based on age and sex classification. The method is carried out with a retrospective approach. The results showed that the effect of drugs on the value of SGPT with a high value of 35 as much as 6.25%, on the value of SGOT with a high value 35 as much as 12.5%. Whereas at the age of 56-65 years the SGPT value was 2.5% and SGOT was 3.75%, at the age of 17-25 years the SGOT value was 3.75%. sex with a high SGPT score of 5%. While the SGOT value is equal to 6.25%. Then it can be concluded that the administration of anti-tuberculosis drugs to the value of SGPT and SGOT has an effect on the value of SGPT and SGOT based on age is productive age which is 15-49 years whereas based on gender is men.
Daya Hambat Ekstrak Daun Belimbing Wuluh (Averrhoa bilimbi L) Terhadap Bakteri Penyebab Jerawat (Propionibacterium acnes) Nur Hasanah; Dede Rival Novian
Parapemikir : Jurnal Ilmiah Farmasi Vol 9, No 1 (2020): Parapemikir : Jurnal Ilmiah Farmasi
Publisher : Pusat Penelitian dan Pengabdian Masyarakat Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/pjif.v9i1.1753

Abstract

One of the bacteria that causes acne is Propionibacterium acnes. Plants that are commonly used to treat zits are leaves of starfruit (Averrhoa bilimbi L), but their use is not so optimal, so a more practical formula needs to be developed. Face toner is one of the facial treatments that can help close the pores again. The purpose of this study was to determine the inhibitory power of the formulation of face toner preparation of starfruit leaf extract with a concentration of 1,25%, 2,5%, 5%, dan 10% towards the growth of Propionibacterium acnes bacteria. This study was an experimental laboratory using a disc diffusion method. Positive controls used were clindamycin a face toner of lime extract (commercial), while the negative controls used by sterile aqua dest. The test results of the formulation of face toner preparations for starfruit leaf extract have inhibitory effect on the bacteria Propionibacterium acnes, at concentration of 1,25% with an average diameter of 18,3 mm, a concentration of 2,5% with an average diameter of 18,6 mm, a concentration of 5% with an average diameter of 20,56 mm, and a concentration of 1,25% with an average diameter of 24,7 mm. Based on the results of the study, it can be concluded that the formulation of face toner extract of starfruit leaf extract has a zone of inhibition against Propionibacterium acnes with strong inhibitory response at concentrations (1.25% and 2.5%) and very strong at concentrations (5% and 10 %).Keyword : Inhibition, Starfruit leaf extract (Averrhoa bilimbi L), Disc                   Diffusion, Face toner, Propionibacterium acnes
Analisis Ekstrak Etanol Buah Labu Kuning (Cucurbita Moschata D.) Nur Hasanah; Dede Rival Novian
Parapemikir : Jurnal Ilmiah Farmasi Vol 9, No 1 (2020): Parapemikir : Jurnal Ilmiah Farmasi
Publisher : Pusat Penelitian dan Pengabdian Masyarakat Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/pjif.v9i1.1758

Abstract

The ethanol extract of yellow pumpkin fruit (Cucurbita Moschata D.) has been recognized to have flavonoid compounds using the colorimetric method (AlCl3). The purpose of this study was to determine the levels of flavonoids in the ethanol extract of yellow pumpkin fruit (Cucurbita Moschata D.). Ethanol extract of pumpkin fruit (Cucurbita Moschata D.) was obtained by maceration using 70% ethanol with a concentration of 5 ppm. The concentration of flavonoid compounds in yellow pumpkin fruit extract (Cucurbita Moschata D.) was carried out using a UV-Visible spectrophotometer with a comparative material namely quercetin using the colorimetric method (AlCl3). The measurement of the quercetin calibration curve used a concentration of 2,4,6,8,10 ppm, and the equation y = 0.18x + 0.2785 with the correlation coefficient (r) = 0.9877. The measurement of maximum wavelength absorption is carried out in the range of 200-600 nm. The maximum wavelength produced is 268 nm at a concentration of 2 ppm or 2 πg / mL. The absorbance value of the sample of ethanol extract of pumpkin fruit is 0,2875; 0,2894; 0,2976 with an average of 0,2915. Based on the results of the research that has been done, it can be concluded that the ethanol extract of yellow pumpkin fruit (Cucurbita Moschata D.) has a level of flavonoid compounds 0,00288 mg/g or 0,288% at concentration of 5 ppm. Keyword – level, Flavonoid, UV-Vis, Cucurbita moschata, Pumpkin
Identifikasi Senyawa Bioaktif Ekstrak Daun Semak Bunga Putih (Chromolaena odorata) Asal Kota Kupang, Nusa Tenggara Timur Laut, Meity Marviana; Ndaong, Nemay Anggadewi; Amalo, Filphin Adolfin; Maha, Inggrid Trinidad; Nitbani, Heny; Novian, Dede Rival
JURNAL KAJIAN VETERINER Vol 10 No 2 (2022): Jurnal Kajian Veteriner
Publisher : FAKULTAS KEDOKTERAN HEWAN UNIVERSITAS NUSA CENDANA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/jkv.v10i2.8693

Abstract

Chromolaena odorata, a member of Asteraceae, is a tropical shrub that grows throughout the year and can dominate pastures. The tropical weed is known as a medicinal plant and has the potential as a natural insecticide. For local people in NTT, the crude extract of the leaves is used to treat myasis on the livestock. C. odorata is also used as silage or food alternative for livestock. This study aims to determine the content of bioactive compounds in C. odorata leaves and determine the extract yield value, as scientific validation of local wisdom in NTT. This research began with the collection of fresh C. odorata leaves, extraction by maceration using 70% ethanol as solvent, solvent evaporation, and phytochemical screening. Phytochemical screening showed that the leaf extract of C. odorata from Kupang City contained high amounts of flavonoids, tannins, alkaloids, triterpenes and steroids and were tested negative for saponins. The extract yield value is 6.09%, means that the extract contains bioactive compunds in high concentration. Further research needs to be done to find out in more detail the content of secondary metabolites from C. odorata leaves and its activity in promote wound healing on livestock in NTT.
Formulasi dan Evaluasi Sediaan Salep Ekstrak Etanol Daun Semak Bunga Putih (Chromolaena odorata) sebagai Alternatif Terapi Topikal untuk Penyembuhan Luka Laut, Meity Marviana; Ngindang, Theodora Patrisia; Novian, Dede Rival
JURNAL KAJIAN VETERINER Vol 13 No 1 (2025): Jurnal Kajian Veteriner
Publisher : FAKULTAS KEDOKTERAN HEWAN UNIVERSITAS NUSA CENDANA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/jkv.v13i1.11543

Abstract

Chromolaena odorata is popular as a traditional medicine in Indonesia for wound healing. In East Nusa Tenggara Province, this plant is used for wound healing. The present study aims to formulate and evaluate the natural ointment containing C. Odorata leaves extract. A total of 3.2 Kg of fresh C. odorata leaves were ground into powder, 246 g. The leaf powder was then macerated with 70% ethanol solvent for 72 hours, followed by evaporation at 60°C, resulting in 14.61 g of concentrated extract with a yield of 5.94%. The extract was formulated into ointment preparations with concentrations of 10% and 20%, using white vaseline as a basis. Alpha-tocopherol and propyl paraben were added as antioxidants and preservatives. Evaluation of the ointment preparations included organoleptic assessment, homogeneity test, pH determination, and spreadability test. The results indicated that the semi-solid cream had a dark greenish colour with the characteristic aroma of C. odorata leaf extract. The ointment preparations were homogeneous and had a safe pH value of 6.2 and 6.3 for 10% and 20% concentrations, respectively. The natural ointment exhibited good spreadability with measurements of 5.57 cm and 5.23 cm for the 10% and 20% concentrations, respectively.
Studi Kepustakaan Profil Eritosit Ayam Broiler Dengan Pemberian Moringa Oleifera Lam. Sebagai Feed Additive Paremadjangga, Rambu L.A; Novian, Dede Rival; Laut, Meity M.
Jurnal Veteriner Nusantara Vol 7 No 2 (2024): November, 2024
Publisher : Program Studi Kedokteran Hewan, Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/jvn.v7i2.3586

Abstract

Broiler have a very fast growth rate, so that optimal production can be realized if their nutritional needs are sufficient. Erythrocytes are an indicator of adequate nutrition and nutritional value obtained by chickens through the feed they consume. This study aims to determine whether the addition of Moringa leaf meal in feed can affect the total erythrocyte, hemoglobin levels and hematocrit value of broiler. This study uses a literature study approach by searching and collecting data through Google Schoolar and Mendeley, then it is analyzed descriptively. Based on the results of the study, it was found that the addition of Moringa leaf meal in the feed had a good effect on increasing the number of erythrocytes values ​​ranging from 2,30 to 2,36 x 106/mm3; 2,01 to 3,41 x 106/mm3; 3,32 to 3,99 x 106/mm3; 3,07 to 3,81 x 106/mm3; 3,08 to 3,43 x 106/mm3; 2,78 to 3,54 x 106/mm3; 3,04 to 3,33 x 106/mm3; hemoglobin levels values ​​ranging from 9,54 to 11,12 g/dL; 8,80 to 13,90 g/dL; 8,72 to 9,73 g/dL; 5,53 to 7,99 g/dL; 13,73 to 14,83 g/dL; 8,20 to 9,70 g/dL; 9,92 to 10,25; and the hematocrit values ​​ranging from 24,10 to 27,30%; 29,00 to 44,00%; 29,91 to 31,79%; 16,67 to 24,00%; 35,13 to 37,93%; 17,77 to 28,10%; 29,76 to 30,77%. This is because Moringa leaf meal contains nutrients needed for the forming of erythrocytes (erythropoesis) such as protein, iron, vitamin B9 and vitamin B12, copper, and folic acid.
Uji Fungsi Hati Dan Performa Tumbuh Ayam Broiler Yang Diberikan Pakan Kombinasi Tepung Kelor (Moringa Oleifera Lam.) dan Jeruk Nipis (Citrus aurantifolia) Piran, Vinsensius Baba; Novian, Dede Rival; Ndaong, Nemay A
Jurnal Veteriner Nusantara Vol 7 No 1 (2024): April, 2024
Publisher : Program Studi Kedokteran Hewan, Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/jvn.v7i1.14066

Abstract

Penelitian ini bertujuan untuk mengetahui pengaruh pemberian pakan kombinasi tepung kelor (moringa oleifera Lam.) dan jeruk nipis (citrus aurantifolia) terhadap fungsi hati dan performa tumbuh ayam broiler. Materi yang digunakan adalah ayam broiler sebanyak 36 ekor, dengan 4 perlakuan, 9 ekor/perlakuan, dan dipelihara selama 35 hari. T0: Pakan komersial + air minum, T1: Pakan komersial + air minum + 4% tepung kelor (Moringa oleifera Lam.), T2: Pakan komersial + Air Minum + 4% perasan jeruk nipis (Citrus aurantifolia), T3: Pakan komersial + Air Minum + 2% tepung kelor (Moringa oleifera Lam.) + 2% perasan jeruk nipis (Citrus aurantifolia). Analisis data dengan uji deskriptif dan uji independent sample t-test. Hasil analisis didapatkan perbedaan yang signifikan rata-rata antara kadar SGOT dan SGPT serum darah ayam broiler pada tiap kelompok perlakuan. Dibuktikan dengan nilai (sig. (2-tailed) < 0,05) serta rata-rata pertambahan bobot badan tertinggi pada hasil penelitian ini adalah pada T3 (pakan komersial + Air Minum + 2% tepung kelor (Moringa oleifera Lam.) + 2% perasan jeruk nipis (Citrus aurantifolia). Kesimpulan: penambahan tepung kelor (Moringa oleifera Lam.) dan jeruk nipis (Citrus aurantifolia) berpengaruh pada fungsi hati ayam broiler dan performa tumbuh ayam broiler.
Studi Morfologi Kelenjar Parotis dan Mandibularis Babi Hutan (Sus scrofa) Djari, Dhino Christopel; Maha, Inggrid T; Novian, Dede Rival
Jurnal Veteriner Nusantara Vol 7 No 1 (2024): April, 2024
Publisher : Program Studi Kedokteran Hewan, Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/jvn.v7i1.14191

Abstract

Penelitian ini bertujuan untuk mengetahui struktur morfologi anatomi dan histologi kelenjar parotis dan mandibularis babi hutan (Sus scrofa). Organ kelenjar parotis dan mandibularis dikoleksi dari 3 ekor babi hutan (Sus scrofa) dengan kriteria sehat berasal dari Kecamatan Fatuleu, Camplong 1, Kabupaten Kupang. Hewan disembelih, dinekrospsi, dilakukan pengamatan makroskopik, kemudian kelenjar parotis dan mandibularis dipotong dengan ketebalan ± 1 cm dan difiksasi dalam formalin 10%, selanjutnya dilakukan pewarnaan Hematoksilin Eosin (HE), dan pengamatan mikroskopik di Laboratorium Anatomi, Fisiologi, Farmakologi dan Biokimia Fakutas Kedokteran dan Kedokteran Hewan, Universitas Nusa Cendana. Hasil penelitian menunjukkan kelenjar parotis mempunyai bentuk menyerupai segitiga tidak beraturan dan berwarna merah segar. Kelenjar mandibularis berbentuk tidak beraturan dan berwarna merah muda. Sel asinar kelenjar parotis babi hutan dominan asinus serosa sedangkan sel asinar kelenjar mandibularis babi hutan didominasi asinus mukus dan terdapat asinus serosa dan demilun serosa. Adapun duktus pada kelenjar parotis dan mandibularis babi hutan meliputi duktus interkalatus, duktus striatus dan duktus ekskretorius.
Co-Authors Aji Winarso Aji Winarso Aji Winarso Aji Winarso Aji Winarso Arif, Yudabbirul asrul, asrul asrul Azra Zahrah Nadhirah Ikhwani Chalies Diah Pratiwi Dewi F.L. Djungu Dewi Fesbayati Lestari Djungu Djari, Dhino Christopel Eka Puspitasari Elisabet Tangkonda Filphin Adolfin Amalo Gaina, Cynthia Dewi heny Nitbani Inggrid Trinidad Maha Jayusman A. Joesoef Laut, Meity M. Maha, Inggrid T Maha, Inggrid Trinidad Meity M Laut Meity Marviana Laut Natasha Imanuelle Ndaong, Nemay A Nemay Anggadewi Ndaong Ngindang, Theodora Patrisia Nitbani, Heny Nur Hasanah Paremadjangga, Rambu L.A Piran, Vinsensius Baba Turista, Dora Dayu Rahma Yeremia Yobellano Sitompul yudabbirul arif Yudabbirul Arif Yustinus Oswin Primajuni Wuhan