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POLA PENGGUNAAN ANTIBIOTIK PADA PASIEN PNEUMONIA RAWAT INAP DI RSUD dr. GONDO SUWARNO TAHUN 2021 Iswandi Iswandi
JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER Vol 5, No 2 (2022): JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER
Publisher : AKADEMI FARMASI JEMBER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53864/jifakfar.v5i2.115

Abstract

Pneumonia is an infection at the ends of the bronchioles and alveoli which causes acute inflammation of the lung parenchyma caused by various pathogens such as bacteria, fungi, viruses and parasites. Most are caused by bacteria. Inappropriate use of antibiotics can lead to increased resistance, wasted costs and does not achieve optimal clinical benefits in the prevention and treatment of infections and bacterial resistance to drugs. The purpose of this study was to determine the suitability of the use of antibiotics according to therapy with the American Thoracic Society/Infectious Diseases Society of America (ATS/IDSA) guidelines. This research method is a type of descriptive non-experimental research with a retrospective approach using cross sectional. Data collection according to the prescription of inpatients at dr. Gondo Suwarno who received antibiotics. Then grouped by type of antibiotic, dose, class, and duration of antibiotic administration. The number of samples is 100. Then the data is adjusted between therapy and guidelines. Based on the results of the study, it was found that there were more male patients. The most widely used dosage form is injection. The most common class of antibiotics is the cephalosporin group. In CAP pneumonia, the number of patients was 46 with the accuracy of the type of drug levofloxacin as many as 12 (26.08%). In HAP pneumonia, the number of patients was 54, with the accuracy of the type of antibiotic levofloxacin in 16 (29.62%). The accuracy of the type of ceftriaxone drug was 22 (40.74%)
POLA PEMETAAN DAN KESESUAIAN PENGOBATAN ANTIHIPERTENSI PASIEN HIPERTENSI RSUD dr.GONDO SUWARNO TAHUN 2021 Fatmawati Fatmawati; Iswandi Iswandi; Sumaryana Sumaryana
Serulingmas Health Journal Vol. 2 No. 2 (2022): Desember
Publisher : Stikes Serulingmas Cilacap

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (290.645 KB)

Abstract

Tekanan darah tinggi atau sering disebut hipertensi merupakan kondisi ketika tekanan di dalam pembuluh darah meningkat. Hipertensi terjadi pada ± 50 juta orang di Amerika Serikat dan ± 1,5 miliar orang di seluruh dunia. Mengingat tingginya prevalensi hipertensi, penanganan yang benar sangat diperlukan untuk mengendalikan hipertensi. Salah satu penanganannya dengan pemberian obat antihipertensi. Tujuan dari penelitian ini yaitu untuk mengetahui pola pemetaan dan kesesuaian pengobatan antihipertensi pada pasien hipertensi di Instalasi Rawat Inap RSUD dr. Gondo Suwarno Kabupaten Semarang tahun 2021. Penelitian ini termasuk penelitian deskriptif yang dilakukan secara retrospektif dengan mengumpulkan data rekam medis pasien hipertensi. Analisis hasil pada pola peresepan meliputi jenis kelamin, usia pasien, jenis dan golongan obat, dosis obat, serta kesesuaian pengobatan berdasarkan JNC VIII dilakukan dengan menggunakan metode analisis secara deskriptif. Untuk jenis dan golongan obat yang sering digunakan pada terapi pengobatan tunggal pasien hipertensi tanpa/dengan komplikasi yaitu golongan CCB amlodipine. Sedangkan untuk kombinasi yang sering diberikan yaitu golongan CCB amlodipine dengan golongan ARB candesartan. Kesesuaian pengobatan yang mendapatkan terapi sesuai dengan guideline JNC 8 memiliki peluang 0,2 kali lebih besar dalam mencapai target tekanan darah dibandingkan kelompok yang menerima terapi tidak sesuai dengan guideline JNC 8.
UJI AKTIVITAS ANTIOKSIDAN KOMBINASI EKSTRAK BATANG PEPAYA (Carica payaya L) DAN EKSTRAK KULIT BATANG KELOR (Moringaaoleifera L.) DENGAN METODE DPPH: ANTIOXIDANT ACTIVITY TEST OF THE COMBINATION OF ACTIVE FRACTION OF PAPAYA (Carica papaya L.) AND OF ACTIVE FRACTION MORINGA STEM BARK (Moringa oleifera L) USING DPPH METHOD Bangkit Riska Permata; Iswandi; TN Saifullah
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 2 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i2.663

Abstract

Tanaman Indonesia banyak yang berpotensi memiliki aktivitas antioksidan, antara lain  tanaman pepaya (Carica papaya L.) dan tanamanakelor ( Moringanoleifera L). Tanaman pepaya dan kelor mengandung metabolit sekunder yang mempunyai aktivitas antioksidan. Tujuan dari penelitian ini menguji aktivitas antioksidan ekstrak/fraksi aktif dari batang pepaya dan kulit batang kelor sebagai antioksidan dengan DPPH. Penelitian ini bersifat  eksperimental, menentukan aktivitas penghambatan antioksidan tertinggi kombinasi ekstrak dan fraksi aktif batang pepaya dan kulit batang kelor dengan pelarut yang berbeda polaritasnya dengan metode spektrofotometri dengan senyawa DPPH. Berdasarkan uji antioksidan menggunakan DPPH didapatkan kombinasi ekstrak batang pepaya dan ekstrak kulit batang kelor yang paling poten sebagai antioksidan yaitu perbandingan (1:2) nilai IC50 47,517 µg/mL dan kombinasi fraksi etil asetat batang pepaya dan kulit batang kelor perbandingan 1:2 memiliki nilai IC50 31,590 µg/mL, Kata kunci: Batang Pepaya, Kulit Batang Kelor, Antioksidan, DPPH
WORKSHOP PEMBUATAN MINYAK ANGIN AROMA TERAPI Ika Purwidyaningrum; Iswandi Iswandi; Meta Kartika Untari
Journal of Community Engagement and Empowerment Vol 3, No 1 (2021)
Publisher : Institut Ilmu Kesehatah Bhakti Wiyata Kediri

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Abstract

Minyak angin aromaterapi adalah minyak alami yang diekstrak dari tumbuhan dengan tujuan meningkatkan kesehatan secara fisik maupun psikis. Minyak yang digunakan adalah minyak esensial yang terbuat dari berbagai tanaman obat, bunga, herbal, akar, buah, dan pepohonan yang tumbuh di seluruh dunia. Menurut sejumlah penelitian, beberapa jenis minyak esensial sudah terbukti memiliki efek positif untuk meningkatkan kondisi fisik dan emosional seseorang. Tujuan dari pengabdian ini adalah warga Kelurahan Nusukan RW 22 mampu membuat minyak angin aroma terapi dan menguraikan manfaatnya. Kelurahan Nusukan adalah salah satu kelurahan di Kota Surakarta dengan jumlah penduduk kurang lebih 27.537 jiwa. Sudah lebih dari 5000 tahun, minyak angina aromaterapi dipercaya sebagai penyembuh alami yang dapat berfungsi sebagai anti bakteri, antiradang, sekaligus memberikan efek antinyeri. Hasil pengabdian ini adalah warga Nusukan RW 22 mampu membuat aroma terapi dan mampu menguraikan manfaat aromaterapi. Minyak esensial dapat dimanfaatkan untuk aromaterapi dalam berbagai macam cara. Antara lain adalah menggunakan diffuser dengan mengubah minyak esensial menjadi uap yang wangi, menghirup minyak melalui hidung secara langsung lewat pakaian atau dari botol, melakukan terapi pijat dengan menggunakan minyak esensial, berendam pada air yang dicampur dengan minyak esensial, mengoleskan minyak esensial secara langsung pada kulit. Pada pengabdian kali ini minyak esensial digunakan dengan cara di masukkan kedalam botol roll on, di hirup secara langsung dari hidung atau dioleskan pada kulit.
PENETAPAN KADAR ASAM LEMAK BEBAS PADA BERBAGAI MINYAK GORENG SETELAH DAN SEBELUM PENGGORENGAN DENGAN METODE TITRASI ALKALIMETRI Iswandi Iswandi; Eva Widhia Saprini Sipa; Endang Sri Rejeki
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 12 No 1 (2023): MEDFARM: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v12i1.145

Abstract

Food is needed to develop individual actual knowledge so that food must be of good quality and nutritious. One of them is cooking oil which is used to fry food. Heating when frying causes an increase in free fatty acids. This study aims to determine the levels of free fatty acids in various cooking oils after and before frying with a variation of one time to meet government quality raw material standards. Free fatty acid content test in bulk cooking oil of palm oil, sunflower seed oil, soybean oil after and before frying using the alkalimetric titration method. The One Way Anova test was carried out to see if there was a difference in the increase in free fatty acid levels of the three cooking oils, and continued with the Tukey test. The government quality standard for palm oil and sunflower seed oil is a maximum of 0.30%. The results showed that palm cooking oil before frying was 0.44% and after one time frying was 0.61%, sunflower seed cooking oil before frying was 0.32% and after one frying time was 0.76%. Soybean oil at the time of research before frying 0.31% and after one frying 0.59%, this shows that it meets government quality standards with a maximum of 2.00%.
Peningkatan Kualitas dan Pemasaran Produk Wedang Rempah Khas Solo Bu Parti M. Aisy Akbar Firdaus Firdaus; Tri Nur Azizah; Fitra Indah Wiratantri; Sri Devi Rahma Suherman; Iswandi Iswandi
Hippocampus: Jurnal Pengabdian Kepada Masyarakat Vol 2 No 1 (2023): June 2023
Publisher : PPPM POLITEKNIK NEGERI SAMBAS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47767/hippocampus.v2i1.506

Abstract

The development and empowerment of micro, small and medium enterprises is needed to increase product sales value. The Solo government encourages the micro enterprise sector to develop further, one of the typical Solo enterprise has the potential to produce herbs and spices. The purpose of this activity is to increase people's purchasing for herbs and spices at online platforms. The method of this activity i.e the observation, preparation, implementation and evaluation stages. The results of the activity are shown by the new packaging design and creation of social media accounts as well as evaluation of purchases through the shopee marketplace. Realization of sales training through the shopee marketplace is carried out with training on creating a seller account, how to input goods, item details, promotions, and withdrawing balances from the seller's account.
Uji Antioksidan Ekstrak Etanol Bunga Telang (Clitoria ternatea L.) dan Formulasi Salep pada Penyembuhan Luka Sayat Punggung Kelinci Putih New Zealand Khusnul Hotimah; Iswandi Iswandi; Jena Hayu Widyasti
Journal Borneo Vol. 3 No. 2 (2023): Volume 3 Issue 2 tahun 2023
Publisher : Politeknik Kaltara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57174/j.born.v3i2.85

Abstract

Telang flower (Clitoria ternatea L.) has antioxidant effects because it contains compounds such as phenols, anthocyanins, flavonol glycosides, kaempferol glycosides, terpenoids, steroids, flavonoids, and tannins. This study aims to determine whether telang flower ethanol extract has antioxidant activity, whether telang flower ethanol extract ointment can heal cuts in rabbits and determine the effective concentration of telang flower ethanol extract ointment for healing cuts in rabbits. This study used telang flower extract macerated with 70% ethanol. The concentration of the extract was made as much as 3, namely 0.1%, 0.2%, 0.4%. The extract was tested for antioxidant activity using the DPPH method. The tested extract was then made into an ointment and applied to the rabbit's back, and wound healing was observed. Based on the results of statistical tests using SPSS®, variations in the concentration of the ethanol extract of the butterfly pea flower affected the antioxidant activity. The 0.2% concentration gave a significant difference compared to the 0.1% and 0.4% concentrations.  Telang flower ethanol extract ointment can heal the incision wound on the rabbit's back. Based on the results of statistical tests using SPSS® on the healing of cuts in rabbits showed a significant difference. The 0.2% concentration differed significantly from the 0.4% concentration, where the time required for the 0.2% concentration was faster than the 0.4% concentration.
Evaluation of Pharmaceutical Services and Drug Use (PKPO) in Hospital Pharmacy Installation Susiyarti Susiyarti; Gunawan Pamudji; Iswandi Iswandi
Jurnal Ilmiah Kesehatan (JIKA) Vol. 4 No. 3 (2022): Volume 4 Nomor 3 Desember 2022
Publisher : Sarana Ilmu Indonesia (salnesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36590/jika.v4i3.332

Abstract

Good and professional service is a hope for all levels of society, especially health services in hospitals, especially pharmaceutical services and drug use. The research was conducted at the Pharmacy Installation of the Mutiara Bunda General Hospital of Brebes. The purpose of this study was to determine the level of conformity of the seven PKPO standards to SNARS Edition 1 and their improvement strategies based on the priority of the percentage of achievement of accreditation and hospital needs. This research was a non-experimental research design, data collection using PKPO survey instruments with interview and observation methods. The research subjects were pharmacists and other pharmacy installation staff. The data result were processed in tabular form, the level of conformity of each PKPO standard was compared to SNARS Edition 1 of 2018 with a minimum standard of 80%. The results of the PKPO level of conformity at the Pharmacy Installation of RSU Islami Mutiara Bunda was not fully in accordance with SNARS. The percentages were obtained PKPO 1 of 100%, PKPO 2 of 8,00%, PKPO 3 of 69,04%, PKPO 4 of 84,61%, PKPO 5 of 80,0%, PKPO 6 of 100% and PKPO 7 of 87,50 %. Based on the percentage of achievement and the level of need for IFRS, the priority order of improvement strategies that need to be immediately carried out by hospitals are PKPO 3 standards, namely storage, PKPO 2 standards regarding selection and procurement, then PKPO 7, PKPO 4 and PKPO 5.
Uji Toksisitas Akut Ekstrak Etanol Daun Salam (Syzygium polyanthum) pada Mencit Jantan (Mus musculus) Safira Prasita Dewanti; Iswandi Iswandi; Nur Anggreini Dwi Sasangka
BORNEO JOURNAL OF PHARMASCIENTECH Vol 7 No 2 (2023): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51817/bjp.v7i2.470

Abstract

The use of bay leaves in traditional medicine basically cannot be separated from the safety aspect. The purpose of this study was to determine the safe limit for using bay leaf extract as well as the qualitative and quantitative indicators of the safe limit for LD50. Thirty animals test were divided into 5 treatment groups, each containing 6 mice at a dose of 0.5% CMC and 800% ethanol extract; 1600; 3200; and 6400. The results obtained with the LD50 based on the decrease in the weight of the test animals at 800 mg decreased to 15.33 grams, 1600 mg decreased to 9.16 grams, 3200 mg decreased to 8.83 grams, and 6400 mg decreased to 8.16 grams. Toxic symptoms in the form of anxiety were the highest in the 800 mg group, the highest decrease in movement activity in the 3200 mg group, the highest weight loss in the 3200 mg and 6400 mg groups, and the highest death in the 6400 mg group. Doses of 800 mg occur in 20% of deaths, doses of 1600 mg and 3200 mg occur in 30% of deaths, and doses of 6400 mg occur in 50% of deaths. The r value obtained is 1,2,2,3 with an f value of 0.50 so that the LD50 value obtained is 2262.03 which is included in the mild toxic category.
Variasi Jenis Diluent Terhadap Mutu Fisik Tablet Temu Putih (Curcuma Zedoaria) menggunakan Metode Cetak Langsung iswandi iswandi; Pudiastuti
Jurnal Farmasi Indonesia AFAMEDIS Vol. 4 No. 2 (2023): AFAMEDIS || JURNAL FARMASI INDONESIA
Publisher : Akademi Farmasi Mitra Sehat Mandiri Sidoarjo

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Abstract

Abstract White Tumeric (Curcuma zedoaria) is a plant that contains curcuminoid compounds and essential oils on its rhizomes which are useful as anticancer. The purpose of this study is to find out which type of filling material (diluent) is good as a filler for white meeting tablets (Curcuma zedoaria). Tablets are made using the direct printing method with the types of fillers (diluent) used are ludipress, starch 1500, and Spray Dried Lactose. The resulting tablets were carried out still angle and flow properties tests, compression index tests, weight uniformity tests, size uniformity tests, tablet hardness tests, tablet brittleness tests, and crush time tests. In the test of stationary angle and flow properties and compression index in ludipress filler materials, the flow property value was 10.42 g/s, the stationary angle value was 27.77º, and the compression index was 10%. In the starch filler material 1500 obtained a flow property value of 4.17 g / s, a stationary angle of 34.40º, and a compression index of 30%, in the formulation of Spray Dried Lactose obtained a flow property value of 10.18 g/s, a stationary angle of 27.74º, and a compression index of 5%. Variations of the type of diluent Spray Dried Lactose show optimal results for white temu tablet filler (Curcuma zedoaria).