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All Journal HAYATI Journal of Biosciences Biomedical Journal of Indonesia Universa Medicina Molecular and Cellular Biomedical Sciences (MCBS) Acta Biochimica Indonesiana Health and Medical Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Indonesian Journal of Cancer Makara Journal of Science
Febriana Catur Iswanti
Department Of Biochemistry And Molecular Biology, Faculty Of Medicine, Universitas Indonesia, Jakarta, Indonesia/Center Of Hypoxia And Oxidative Stress Study, Faculty Of Medicine, Universitas Indonesia, Jakarta, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Earth & Planetary Sciences Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Innate and Adaptive Immune Components in Human Breast Milk and Their Role in Early-Life Immunity Salsabila, Hanum; Sukmawati, Dewi; Iswanti, Febriana Catur
Biomedical Journal of Indonesia Vol. 11 No. 3 (2025): Vol 11, No 3, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v11i3.272

Abstract

Human breast milk is a uniquely complex biological fluid renowned for delivering essential nutrients to newborns. Beyond its nutritional value, it also contains important immunological components that play a fundamental role in infant health and development. This review explores the immunological characteristics of breast milk, highlighting its diverse array of immune cells and bioactive molecules, including secretory IgA, cytokines, and chemokines. These components actively contribute to the maturation of the infant’s immune system, strengthen defenses against infections, and facilitate the development of a balanced gut microbiome. This discussion also explores how the immune components in breast milk function to benefit infants, examining their protective mechanisms and developmental impacts. Additionally, it addresses how storage conditions—such as freezing, refrigeration, or pasteurization—may alter the integrity and effectiveness of these vital immune factors. Furthermore, the influence of external environmental factors, including maternal diet, stress, and exposure to pollutants, is considered for their potential effects on the immunological quality of breast milk. For this literature review, relevant studies were systematically searched across multiple academic databases, including PubMed, ScienceDirect, Google Scholar, ResearchGate, and Elsevier. The search was limited to publications from the past ten years. Emerging research underscores the adaptive nature of breast milk and its profound impact on early-life immunity, offering valuable insights for optimizing infant feeding practices and potential clinical applications.
Evasion of the Immune System by Mycobacterium tuberculosis: A Special Review on Macrophages Handayani, Kurnia Maidarmi; Iswanti, Febriana Catur
Health and Medical Journal Vol 6, No 2 (2024): HEME May 2024
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/heme.v6i2.1452

Abstract

Mycobacterium tuberculosis, the bacterium that caused tuberculosis, is estimated to affect 10 million people worldwide in 2019. This bacterium is an intracellular pathogen that is spread through the inhalation of bacterial aerosol particles. The innate immune system in the lungs is prepared to phagocytize these bacteria, particularly macrophages, dendritic cells, monocytes, and neutrophils. M. tuberculosis can evade attacks by the host immune system and has developed strategies to infect successfully, especially macrophages. This intracellular bacterium can inhibit phagolysosome fusion, which is associated with lipoarabinomannan (LAM) in the bacterial cell wall. M. tuberculosis also can persist in phagolysosomes by inhibiting acidification and also inhibiting the action of NOX2 from producing ROS. This ability also allows these bacteria to avoid autophagy within macrophages. Knowledge of the power of these bacteria to manipulate and evade the immune system, especially macrophages, is beneficial in developing medicines and vaccines in the future.
Macrophage modulation in activation process induced immune thrombocytopenia Mahdaleny, Mahdaleny; Bustami, Arleni; Iswanti, Febriana Catur
Universa Medicina Vol. 43 No. 1 (2024)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2024.v43.76-87

Abstract

The immune system operates like an orchestra that harmoniously maintains the homeostasis balance while protecting from external or internal pathogens attack. Inflammation is one of the key critical immune defenses to eradicate pathogens and encourage tissue repair and recovery by activating the host’s immune and non-immune cells. As a part of the immune response during inflammation, blood platelets serve various functions; however, their activation and involvement in inflammation can also contribute to pathological conditions, such as thrombosis, which results in myocardial infarction, stroke, and venous thromboembolism. Activated platelets can mobilize and release intracellular granules (alpha and dense granules), which include secondary mediators like chemokine PF4/CXCL4. In contrast to most other chemokines, PF4 participates in several long-term regulatory processes, such as cell differentiation, survival, and proliferation. However, recent findings suggest that PF4 is also responsible for modulating macrophage polarization, which can substantially impact the development of induced immune thrombotic thrombocytopenia. This review aims to explain how PF4 induced vascular problems by modulation of macrophage development during immunological thrombocytopenia. A literature search using the keywords PF4, CXCL4, macrophage M4, platelet macrophage M4, and induced immune thrombocytopenia was done using the following databases: Google Scholar, ProQuest, ScienceDirect, and Scopus for articles published from 2000 to 2023. The literature study was done to find the connection between platelet activation, macrophage modulation, and vascular problems such as atherosclerosis and thromboembolism in induced immune thrombotic thrombocytopenia. Several recent studies on PF4, macrophage modulation, and vaccine-induced thrombotic thrombocytopenia were carefully reviewed. This review concludes that macrophage polarization modulation is promising in managing vascular problems in patients with induced immune thrombotic thrombocytopenia.
Freediving, Hypoxia, and Inflammation: Physiological Adaptations and Interactions between HIF and NF-κB Amalina Fakhriah; Novi Silvia Hardiany; Iswanti, Febriana Catur
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 7 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i7.1026

Abstract

Freediving presents a unique set of physiological challenges and adaptations, making it a subject of interest for researchers studying the effects of extreme environmental conditions on the human body. There is a complex interplay between freediving, hypoxia, immune responses, and inflammation, shedding light on the physiological effects of freediving on the human body. This article describes how HIF and NF-κB interact during hypoxia and inflammation, including their synergistic effects and signaling pathways. The regulatory loop involving these transcription factors is highlighted, providing insight into their linked roles in modulating the cellular response to hypoxia and inflammation.
Senescence-Induced Atherosclerosis: The Potency of Senolytic Therapy Ratih, Udani Sari; Iswanti, Febriana Catur
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 8 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i8.1036

Abstract

The aging process is an inevitable occurrence that involves physiological changes at the cellular level. The presence of intrinsic and extrinsic stressors can cause cellular damage, leading to senescence and premature aging. Senescent cells undergo activation of the p53/p21 and p16INK4a pathways, induce cell cycle arrest, increased expression of senescence-associated beta-galactosidase (SA-β-Gal), and secretion of SASP (senescence-associated secretory phenotype), leading to "inflamm-aging" or chronic inflammation associated with senescence. These premature aging and “inflamm-aging” accelerates the occurrence of age-related diseases, one of which is atherosclerosis. The relationship between premature aging, senescence, and atherosclerosis has been a focus of research on pathogenesis, prevention, and therapy. Recent research has emphasized the crucial role of senolytics, compounds or agents capable of eliminating senescent cells, in inhibiting the progression of atherosclerosis and slowing down premature aging. Obtaining a more comprehensive understanding of the processes and effectiveness of senolytics in premature aging and atherosclerosis should facilitate the development of more potent medicines to mitigate side effects in the management of cardiovascular disease and extend longevity.
The Role of High Sensitivity C-Reactive Protein as an Inflammation Predictor in Cardiovascular Diseases Cici Nuriah; Iswanti, Febriana Catur; Ariel Pradipta
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 9 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i9.1075

Abstract

Inflammation can be measured by analyzing the levels of inflammatory markers, such as High Sensitivity C-reactive Protein (hs-CRP). This protein plays a crucial role as a strong independent predictor indicating the risk of cardiovascular. The hs-CRP can measure the levels of C-reactive protein with high sensitivity, making it a highly responsive marker to acute-phase inflammation. The presence of hs-CRP serves as an inflammation indicator that can predict the potential occurrence of heart attacks, strokes, peripheral artery diseases, and sudden death due to Acute Coronary Syndrome (ACS). Produced by the liver in response to inflammation, hs-CRP is nonspecific and can elevate various types of inflammation, including infections and chronic inflammatory conditions in cardiovascular. This study is a literature review using secondary data from related research. The hs-CRP has a very high sensitivity and specificity level compared to CRP as an inflammation marker. Therefore, hs-CRP serves not only as a diagnostic tool but also as a strong predictor of inflammation, capable of predicting cardiovascular risk.
Targeting T Cell Metabolism for Tumor Therapy: A Review Cinthya Karlina Wijaya; Febriana Catur Iswanti
Indonesian Journal of Cancer Vol. 20 No. 1 (2026): March
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v20i1.1426

Abstract

Background: Immunometabolism explores the connection between metabolism and the immune system. T cells require nutrients like glucose, lipids, and amino acids for proper function, but tumors compete for these resources and create a suppressive microenvironment that weakens T cell activity. This article examines how T cell metabolism affects antitumor immunity and whether targeting metabolic pathways can improve cancer treatment. Methods: A narrative review was conducted by searching databases like PubMed, Scopus, and Google Scholar using keywords such as "T cell metabolism AND cancer immunotherapy." The review focused on high-impact journals and included peer-reviewed articles, review papers, and experimental studies published in the last 10 years. Excluded studies were non-peer-reviewed, outdated, or unrelated to T cell metabolism in cancer. Key data were extracted, categorized into themes like metabolic pathways, immunosuppressive mechanisms, and therapeutic strategies, and critically analyzed. Results: The review highlights the essential role of T cell metabolism in antitumor immunity. Tumors create a nutrient-deprived environment that inhibits T cell function, competing for nutrients like glucose, lipids, and amino acids. Additionally, tumors express checkpoint receptors and immunosuppressive molecules that further reduce T cell activity. Recent research focusing on metabolic reprogramming to enhance T cell resilience, with strategies like boosting glycolysis, optimizing lipid metabolism, and targeting regulators like mTOR, shows promise. Combining these metabolic interventions with existing immunotherapies, such as checkpoint inhibitors, is gaining attention.Conclusions: The review emphasizes the importance of T cell metabolism in overcoming tumor-induced immunosuppression. Metabolic reprogramming, especially enhancing glycolysis and targeting metabolic regulators, can improve T cell activity and antitumor responses. Combining these strategies with immunotherapies offers promising potential, though further research is needed to refine approaches and address clinical challenges.
Co-Authors Alyssa Shafa Andiana Amalina Fakhriah Ani Retno Prijanti Arief Budi Witarto Ariel Pradipta Arleni Bustami Cici Nuriah Cinthya Karlina Wijaya Dewi Sukmawati Fadilah Fadilah Fadilah Fadilah, Fadilah Halim, Abdul Istiqomah Agusta Kenny Cantika Abadi Kurnia Maidarmi Handayani Linda Herlina Lusiyana Dwi Rahmawati Mahdaleny Mahdaleny, Mahdaleny Mohamad Sadikin Mohamad Sadikin Muhammad Faruqi Ni Made Wiasty Sukanty Nina Fitriana, Nina Novi Silvia Hardiany Nurfiyana, Wahyu Purba, Hastuti Handayani S Rahmawati Ridwan Ratih, Udani Sari Reni Paramita Reni Paramita Retno Wahyu Nurhayati Salsabila, Hanum Samsuridjal Djauzi Soleha, Winna Sri Widia A Jusman Sulfiana Sulfiana Syarifah Dewi Tomohiko Yamazaki