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All Journal HAYATI Journal of Biosciences Biomedical Journal of Indonesia Universa Medicina Molecular and Cellular Biomedical Sciences (MCBS) Acta Biochimica Indonesiana Bioscientia Medicina : Journal of Biomedicine and Translational Research Health and Medical Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Indonesian Journal of Cancer Makara Journal of Science
Febriana Catur Iswanti
Department Of Biochemistry And Molecular Biology, Faculty Of Medicine, Universitas Indonesia, Jakarta, Indonesia/Center Of Hypoxia And Oxidative Stress Study, Faculty Of Medicine, Universitas Indonesia, Jakarta, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Earth & Planetary Sciences Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Detection of latent tuberculosis infection in household contacts of drug-resistant tuberculosis patients using interferon-gamma release assay: a study at Universitas Indonesia Hospital Indratmo, Muhammad Faris; Handayani, Diah; Kusumaningrum, Ardiana; Iswanti, Febriana Catur; Sadikin, Mohamad
Acta Biochimica Indonesiana Vol. 8 No. 2 (2025): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.214

Abstract

Background: Drug-resistant tuberculosis (DR-TB) poses significant public health challenges in Indonesia. Household contacts of DR-TB patients face elevated risk of Mycobacterium tuberculosis infection, which may remain latent and asymptomatic. Objective: This study aimed to assess the prevalence of latent tuberculosis infection (LTBI) among household contacts of DR-TB patients using interferon-gamma release assay (IGRA). Methods: This cross-sectional study was conducted at Universitas Indonesia Hospital from February to May 2023. Eighteen asymptomatic household contacts from six confirmed DR-TB index cases were enrolled. Participants underwent clinical evaluation, chest radiography, and LTBI screening using the QuantiFERON-TB Gold Plus (QFT-Plus) assay. Results: Among 18 participants (mean age 33.3 years; 55.6% female), 8 (44.4%) tested positive for LTBI, while 10 (55.6%) tested negative. The highest IGRA positivity rates were observed in adolescents aged 12–16 years (66.7%) and young adults aged 17–25 years (60.0%). All participants were clinically asymptomatic with normal chest radiographs. Conclusion: This study demonstrates substantial LTBI prevalence among household contacts of DR-TB patients. The findings underscore the importance of systematic contact tracing, IGRA-based screening, and timely tuberculosis preventive therapy to reduce disease transmission and progression in high-risk populations.
Targeting T Cell Metabolism for Tumor Therapy: A Review Wijaya, Cinthya Karlina; Iswanti, Febriana Catur
Indonesian Journal of Cancer Vol 20, No 1 (2026): March
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v20i1.1426

Abstract

Background: Immunometabolism explores the connection between metabolism and the immune system. T cells require nutrients like glucose, lipids, and amino acids for proper function, but tumors compete for these resources and create a suppressive microenvironment that weakens T cell activity. This article examines how T cell metabolism affects antitumor immunity and whether targeting metabolic pathways can improve cancer treatment. Methods: A narrative review was conducted by searching databases like PubMed, Scopus, and Google Scholar using keywords such as "T cell metabolism AND cancer immunotherapy." The review focused on high-impact journals and included peer-reviewed articles, review papers, and experimental studies published in the last 10 years. Excluded studies were non-peer-reviewed, outdated, or unrelated to T cell metabolism in cancer. Key data were extracted, categorized into themes like metabolic pathways, immunosuppressive mechanisms, and therapeutic strategies, and critically analyzed. Results: The review highlights the essential role of T cell metabolism in antitumor immunity. Tumors create a nutrient-deprived environment that inhibits T cell function, competing for nutrients like glucose, lipids, and amino acids. Additionally, tumors express checkpoint receptors and immunosuppressive molecules that further reduce T cell activity. Recent research focusing on metabolic reprogramming to enhance T cell resilience, with strategies like boosting glycolysis, optimizing lipid metabolism, and targeting regulators like mTOR, shows promise. Combining these metabolic interventions with existing immunotherapies, such as checkpoint inhibitors, is gaining attention.Conclusions: The review emphasizes the importance of T cell metabolism in overcoming tumor-induced immunosuppression. Metabolic reprogramming, especially enhancing glycolysis and targeting metabolic regulators, can improve T cell activity and antitumor responses. Combining these strategies with immunotherapies offers promising potential, though further research is needed to refine approaches and address clinical challenges.
Co-Authors Alyssa Shafa Andiana Amalina Fakhriah Ani Retno Prijanti Ardiana Kusumaningrum Arief Budi Witarto Ariel Pradipta Arleni Bustami Cici Nuriah Dewi Sukmawati Diah Handayani Fadilah Fadilah Fadilah Fadilah, Fadilah Halim, Abdul Indratmo, Muhammad Faris Istiqomah Agusta Kenny Cantika Abadi Kurnia Maidarmi Handayani Linda Herlina Lusiyana Dwi Rahmawati Mahdaleny Mahdaleny, Mahdaleny Mohamad Sadikin Mohamad Sadikin Muhammad Faruqi Ni Made Wiasty Sukanty Nina Fitriana, Nina Ninik Mudjihartini Novi Silvia Hardiany Nurfiyana, Wahyu Purba, Hastuti Handayani S Purwosunu, Yuditiya Rahmawati Ridwan Ratih, Udani Sari Reni Paramita Reni Paramita Retno Wahyu Nurhayati Salsabila, Hanum Samsuridjal Djauzi Soleha, Winna Sri Widia A Jusman Sulfiana Sulfiana Syarifah Dewi Tomohiko Yamazaki Wijaya, Cinthya Karlina