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All Journal Bioscience El-Hayah : Jurnal Biologi Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Biosfer: Jurnal Tadris Biologi Biogenesis: Jurnal Ilmiah Biologi Quagga Jurnal Florea JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Al-Kimia BIOEDUSCIENCE Jurnal Biologi Tropis Diklabio: Jurnal Pendidikan dan Pembelajaran Biologi Jurnal Saintek Lahan Kering Jurnal BIOEDUIN : Program Studi Pendidikan Biologi Qalam: Jurnal Ilmu Kependidikan Edubiotik : Jurnal Pendidikan, Biologi dan Terapan Biota Jurnal Mangifera Edu Jurnal Penelitian dan Pengkajian Ilmu Pendidikan: e-Saintika JURNAL PENDIDIKAN MIPA Jurnal Pendidikan dan Konseling Biopendix: Jurnal Biologi, Pendidikan dan Terapan Jurnal Jejaring Matematika dan Sains Jurnal ABDINUS : Jurnal Pengabdian Nusantara Jurnal Biogenerasi Journal On Teacher Education (Jote) JSMARTech : Journal of Smart Bioprospecting and Technology Spizaetus: Jurnal Biologi dan Pendidikan Biologi Jurnal Ilmiah Medicamento Mattawang: Jurnal Pengabdian Masyarakat Jurnal Biosense Jurnal Ilmiah Wahana Pendidikan Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Pengabdian Mandiri Makara Journal of Science Medical Sains : Jurnal Ilmiah Kefarmasian Edubiotik : Jurnal Pendidikan, Biologi dan Terapan
Bare, Yohanes
Program Studi Pendidikan Biologi, Fakultas Keguruan Dan Ilmu Pendidikan, Universitas Nusa Nipa, Indonesia
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Physics Public Health Social Sciences Other

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Journal : Makara Journal of Science

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Capsaicinoids from Capsicum annuum as an Alternative FabH Inhibitor of Mycobacterium Tuberculosis: In Silico Study Krisnamurti, Gabriella Chandrakirana; Sari, Dewi Ratih Tirto; Bare, Yohanes
Makara Journal of Science Vol. 25, No. 4
Publisher : UI Scholars Hub

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Abstract

The number of tuberculosis (TB) cases worldwide reached 1.5 million in 2018; thus, TB is considered a deadly disease. TB is caused by Mycobacterium tuberculosis and involves lipid synthesis. Considering the importance of lipid metabolism in bacteria, FabH may be an essential protein target for repressing lipid synthesis. Capsaicinoids from Capsicum annuum demonstrate potent antibacterial activity. This study predicted the ability of capsaicinoid compounds to inhibit FabH. In silico analysis was performed by retrieving the structure of FabH from PDB and those of selected capsaicinoid derivatives from PubChem. The compounds were docked using AutoDock Vina in PyRx 0.8 software. The interactions of FabH and different capsaicinoid derivatives showed identical binding characteristics. The bonding type most frequently observed was hydrogen bonds. In conclusion, capsaicinoid derivatives could block lipid synthesis through FabH. The relevant mechanism and biological processes should be studied further.
Co-Authors Agustina Elizabeth Ahmad, Nurul Imaniyah Andri Maulidi Andri Maulidi Angeliana Desimaris Nita Angeliana Desimaris Nita Anselmus Dawa Apriani Herni Rophi Aprianus Pani Pili Aprianus Pani Pili Daeng Tiring, Sri Sulistyaningsih Natalia Dewi Ratih Tirto Sari Dewi Ratih Tirto Sari Dewi Ratih Tirto Sari Dewi Ratih Tirto Sari Eci, Margaretha Nona Elfi, Theresia Nona fatchiyah . Fitra Arya Dwi Nugraha Fransiskus Xaverius Ndia Frederiksen Novenrius Sini Timba Gabriella Candrakirana Krisnamurti Gabriella Candrakirana Krisnamurti Gabriella Chandrakirana Krisnamurti Gabriella Chandrakirana Krisnamurti Galis, Rofinus Gaso, Maria Triswanti Hejo, Yosefina Suryanti Heny Yusuf Hiko, Maria Filestina Indahsari, Lilin Ika Nur Jatmiko Eko Witoyo Kari, Magdalena Letek Klementinus Bhato Krisna Pada Krisna Pada Krisnamurti, Gabriella Candrakirana Krisnamurti, Gabriella Chandrakirana Kristina Novita Kuki, Agustina Dua Lailiyah, Fatinatul Laily Sifaiyah Lele, Maria Nona Elci Lopa, Maria Imelda Lorenza, Margaretha Rika Wahyu Gabrella Lute, Maria Alvensia Lydia Efliani Coriessa Meak M A Yohanita Nirmalasari Magdalena Letek Kari Mansur S Mansur s Margaretha Rika W G L Margaretha Rika Wahyu Gabrella Lorenza Maria Alvensia Lute Maria Fatima Neno Maria Filestina Hiko Maria Helvina Maria Marcelina Dua Nurak Maria Marcelina Dua Nurak Maria Yuniati Nona Ade Marsiana Coo Mogi Marsiana Coo Mogi Maximus M Taek Meak, Lydia Efliani Coriessa Mira Kurniawati Misa, Aljefridus Mogi, Marsiana Coo Ngongo, Yosefina Nita, Angeliana Desimaris Nur Dina Camelia Nurak, Maria Marcelina Dua Nurul Imaniyah AHmad Oktavius Yoseph Tuta Mago Paula Yunita Seku Ra'o Paula Yunita Seku Ra'o Paulina Bewu Lele Ratna Susana Dawa S, Mansur Saputra, Mansur Sari, Dewi Ratih Tirto Selmin, Yosefina Sizi, Yosefina Sri Sulistyaningsih Natalia Daeng Tiring Sri Sulystyaningsih Natalia Daeng Tiring Sukarman Hadi Jaya Putra Taek, Maximus M Tematan, Yohanes Boli Theopilus W Watuguly Theresia Nona Elci Theresia Nona Elfi Ujiana, Wa Ode Ule, Kristina Novita Ustiatik, Reni Vincentius, Angelinus Wa Ode Ujiana Yoga Tribakti Rachmad Yoga Tribakti Rachmad Yohanes Boli Tematan Yohanes Boli Tematan Yohanes Nong Bunga