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All Journal Bioscience El-Hayah : Jurnal Biologi Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Biosfer: Jurnal Tadris Biologi Biogenesis: Jurnal Ilmiah Biologi Quagga Jurnal Florea JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Al-Kimia BIOEDUSCIENCE Jurnal Biologi Tropis Diklabio: Jurnal Pendidikan dan Pembelajaran Biologi Jurnal Saintek Lahan Kering Jurnal BIOEDUIN : Program Studi Pendidikan Biologi Qalam: Jurnal Ilmu Kependidikan Edubiotik : Jurnal Pendidikan, Biologi dan Terapan Biota Jurnal Mangifera Edu Jurnal Penelitian dan Pengkajian Ilmu Pendidikan: e-Saintika JURNAL PENDIDIKAN MIPA Jurnal Pendidikan dan Konseling Biopendix: Jurnal Biologi, Pendidikan dan Terapan Jurnal Jejaring Matematika dan Sains Jurnal ABDINUS : Jurnal Pengabdian Nusantara Jurnal Biogenerasi Journal On Teacher Education (Jote) JSMARTech : Journal of Smart Bioprospecting and Technology Spizaetus: Jurnal Biologi dan Pendidikan Biologi Jurnal Ilmiah Medicamento Mattawang: Jurnal Pengabdian Masyarakat Jurnal Biosense Jurnal Ilmiah Wahana Pendidikan Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Pengabdian Mandiri Makara Journal of Science Medical Sains : Jurnal Ilmiah Kefarmasian Edubiotik : Jurnal Pendidikan, Biologi dan Terapan
Bare, Yohanes
Program Studi Pendidikan Biologi, Fakultas Keguruan Dan Ilmu Pendidikan, Universitas Nusa Nipa, Indonesia
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Physics Public Health Social Sciences Other

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Journal : jurnal florea

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STUDI AKTIVITAS BIOLOGI SECARA IN SILICO SENYAWA NONIVAMIDE DAN NORDIHYDROCAPSAICIN SEBAGAI ANTI INFLAMASI Theresia Nona Elfi; Yohanes Nong Bunga; Yohanes Bare
Florea : Jurnal Biologi dan Pembelajarannya Vol 8, No 2 (2021)
Publisher : UNIVERSITAS PGRI MADIUN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25273/florea.v8i2.9983

Abstract

Cabai Merah Besar (Capsicum Annum L) merupakan tanaman holtikultura yang dibudidayakan dalam skala kecilnamun memiliki manfaat kesehatan. Cabai Merah Besar (Capsicum Annum L.) juga digunakan untuk pengobatan sakit gigi, bisul, anti parasit, anti inflamasi, antitusif dan juga digunakan sebagai antiseptik, nafsu makan. Penelitian ini memiliki tujuan untuk menganalisis potensi senyawa nonivamide dan nordihydrocapsaicin sebagai anti-inflamasi. Kajian penelitian metode in silico. Senyawa Nonivamide (CID :2998) dan Nordihydrocapsaicin (CID: 168836) diperoleh dari PubChem sedangkan COX-2 (6cox) dari Protein Data Bank. Analisis menggunakan HEX 8.0.0 dan ditampilkan Discovery studio client 4.1. Interaksi yang terjadi antara senyawa Nonivamide dan COX-2 membentuk ikatan hidrogen dengan tipe ikatan hidrogen konvensional (CYS47) dan ikatan hidrofobik (LEU152). Selain ikatan hidrogen, juga terdapat sembilan belas residu asam amino menunjukkan adanya gaya Van Der Waals membentuk energi -339.48 cal/mol. Ikatan Nordihydrocapsaicin dengan COX-2 membentuk ikatan pada residu asam amino TRP139 bersifat Pi-Alkyl dan ikatan hidrogen sebagai donor dengan Residu asam amino SER143 energi ikatan sebesar -248.47 cal/mol.
Senyawa Fucodiphlorethol Dan Phloroglucinol Alga Coklat Sebagai Inhibitor Lipase Secara In Silico Yohanes Bare; Dewi Ratih Tirto Sari; Marsiana Coo Mogi; Maria Marcelina Dua Nurak
Florea : Jurnal Biologi dan Pembelajarannya Vol 9, No 1 (2022)
Publisher : UNIVERSITAS PGRI MADIUN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25273/florea.v9i1.11743

Abstract

Brown algae is a marine functional food that high fibers, vitamins, and bioactive compounds. Brown algae improved blood glucose and lipid profile. This study investigated the potential activity of two bioactive compounds from brown algae, as anti-obesity through pancreatic lipase inhibition. Molecular docking was conducted for investigating the lipase inhibition of bioactive compounds. Lipase structure (PDB ID 1ETH) was obtained from protein data bank and docked with fucodiphlorethol and phloroglucinol in specific position. Then, the complex was analyzed by PyMol following by Discovery Studio version 21.1.1. Phloroglucinol - pancreatic lipase showed five amino acid residues by hydrogen bonds, hydrophobic and electrostatic.  Fucodiphlorethol - pancreatic lipase generated binding energy -392 kJ/mol and consisted of eight hydrogen bonds, three electrostatic, and 4 hydrophobic interactions. The active sites of fucodiphlorethol and phloroglucinol with lipase were not considered as active sites or catalytic sites. Therefore, we predicted that both of fucodiphlorethol and phloroglucinol inhibit lipase allosterically by altering the protein structure conformations. molecular docking analysis suggested that fucodiphlorethol and phloroglucinol have potential antiobesity effect by inhibiting lipase. Molecular dynamic are needed for further investigation.
Co-Authors Agustina Elizabeth Ahmad, Nurul Imaniyah Andri Maulidi Andri Maulidi Angeliana Desimaris Nita Angeliana Desimaris Nita Anselmus Dawa Apriani Herni Rophi Aprianus Pani Pili Aprianus Pani Pili Daeng Tiring, Sri Sulistyaningsih Natalia Dewi Ratih Tirto Sari Dewi Ratih Tirto Sari Dewi Ratih Tirto Sari Dewi Ratih Tirto Sari Eci, Margaretha Nona Elfi, Theresia Nona fatchiyah . Fitra Arya Dwi Nugraha Fransiskus Xaverius Ndia Frederiksen Novenrius Sini Timba Gabriella Candrakirana Krisnamurti Gabriella Candrakirana Krisnamurti Gabriella Chandrakirana Krisnamurti Gabriella Chandrakirana Krisnamurti Galis, Rofinus Gaso, Maria Triswanti Hejo, Yosefina Suryanti Heny Yusuf Hiko, Maria Filestina Indahsari, Lilin Ika Nur Jatmiko Eko Witoyo Kari, Magdalena Letek Klementinus Bhato Krisna Pada Krisna Pada Krisnamurti, Gabriella Candrakirana Krisnamurti, Gabriella Chandrakirana Kristina Novita Kuki, Agustina Dua Lailiyah, Fatinatul Laily Sifaiyah Lele, Maria Nona Elci Lopa, Maria Imelda Lorenza, Margaretha Rika Wahyu Gabrella Lute, Maria Alvensia Lydia Efliani Coriessa Meak M A Yohanita Nirmalasari Magdalena Letek Kari Mansur s Mansur S Margaretha Rika W G L Margaretha Rika Wahyu Gabrella Lorenza Maria Alvensia Lute Maria Fatima Neno Maria Filestina Hiko Maria Helvina Maria Marcelina Dua Nurak Maria Marcelina Dua Nurak Maria Yuniati Nona Ade Marsiana Coo Mogi Marsiana Coo Mogi Maximus M Taek Meak, Lydia Efliani Coriessa Mira Kurniawati Misa, Aljefridus Mogi, Marsiana Coo Ngongo, Yosefina Nita, Angeliana Desimaris Nur Dina Camelia Nurak, Maria Marcelina Dua Nurul Imaniyah AHmad Oktavius Yoseph Tuta Mago Paula Yunita Seku Ra'o Paula Yunita Seku Ra'o Paulina Bewu Lele Ratna Susana Dawa S, Mansur Saputra, Mansur Sari, Dewi Ratih Tirto Selmin, Yosefina Sizi, Yosefina Sri Sulistyaningsih Natalia Daeng Tiring Sri Sulystyaningsih Natalia Daeng Tiring Sukarman Hadi Jaya Putra Taek, Maximus M Tematan, Yohanes Boli Theopilus W Watuguly Theresia Nona Elci Theresia Nona Elfi Ujiana, Wa Ode Ule, Kristina Novita Ustiatik, Reni Vincentius, Angelinus Wa Ode Ujiana Yoga Tribakti Rachmad Yoga Tribakti Rachmad Yohanes Boli Tematan Yohanes Boli Tematan Yohanes Nong Bunga