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All Journal Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Jurnal Fitofarmaka Indonesia FITOFARMAKA: Jurnal Ilmiah Farmasi EKOLOGIA : Jurnal Ilmiah Ilmu Dasar dan Lingkungan Hidup Jurnal Jamu Indonesia Jurnal Farmamedika (Pharmamedica Journal) Journal of Agriculture and Applied Biology Journal of Agriculture and Applied Biology ( JAAB) JCDD JURNAL AGROINDUSTRI HALAL Jurnal Bioteknologi & Biosains Indonesia (JBBI) Indonesian Journal of Jamu Jurnal Pengabdian Masyarakat Inovatif Jurnal Pengabdian Masyarakat Inovatif
Ike Yulia Wiendarlina
Universitas Pakuan
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Acute toxicity test of water and ethanol extract from african leaf (Gym-nanthemum amygdalina Del.) on zebra fish embrio (Danio rerio) Lusi Agus Setiani; Ike Yulia Wiendarlina; Afifah Marissa Arlindini
Journal of Agriculture and Applied Biology Vol 4 No 1 (2023): Journal of Agriculture and Applied Biology
Publisher : Future Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jaab.04.01.03

Abstract

Bitterleaf or African Leaf is a herbal plant empirically used to relieve fever and kidney disease. Pharmacological research reports that the leaves have antibacterial, anti-inflammatory, and antidiabetic properties, and a toxicity test was also conducted to ensure their safety. Therefore, this experiment aimed to obtain LC50 of African Leaf (Gymnanthemum amygdalina Del.) ethanol and water extract with the ZFET (Zebra Fish Embryo Acute Toxicity) method and also to observe the toxicity effect of zebrafish (Danio rario) embryo's morphology after the induction of the extract. The experiment refers to the OECD No.236 of 2013 as a guideline, and it was shown that African Leaf's ethanol extract LC50 values were obtained at 6.3629 ppm. Furthermore, the water extract LC50 value was obtained at 25.0520 ppm, and the African Leaf extract was categorized in the toxic category. The leaf extract has a harmful effect on zebrafish embryos, resulting in malformations of the tail, notochord, pericardium, and yolk sac.
Acute toxicity test of water and ethanol extract from african leaf (Gym-nanthemum amygdalina Del.) on zebra fish embrio (Danio rerio) Lusi Agus Setiani; Ike Yulia Wiendarlina; Afifah Marissa Arlindini
Journal of Agriculture and Applied Biology Vol 4 No 1 (2023): Journal of Agriculture and Applied Biology
Publisher : Future Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jaab.04.01.03

Abstract

Bitterleaf or African Leaf is a herbal plant empirically used to relieve fever and kidney disease. Pharmacological research reports that the leaves have antibacterial, anti-inflammatory, and antidiabetic properties, and a toxicity test was also conducted to ensure their safety. Therefore, this experiment aimed to obtain LC50 of African Leaf (Gymnanthemum amygdalina Del.) ethanol and water extract with the ZFET (Zebra Fish Embryo Acute Toxicity) method and also to observe the toxicity effect of zebrafish (Danio rario) embryo's morphology after the induction of the extract. The experiment refers to the OECD No.236 of 2013 as a guideline, and it was shown that African Leaf's ethanol extract LC50 values were obtained at 6.3629 ppm. Furthermore, the water extract LC50 value was obtained at 25.0520 ppm, and the African Leaf extract was categorized in the toxic category. The leaf extract has a harmful effect on zebrafish embryos, resulting in malformations of the tail, notochord, pericardium, and yolk sac.
UJI EFEKTIVITAS ANTIBAKTERI PERASAN SEGAR DAN SERBUK UMBI BAWANG PUTIH (Allium sativum L.) TERHADAP BAKTERI Salmonella typhi Oom Komala; Herra Indra Asmara; Ike Yulia Wiendarlina
Ekologia: Jurnal Ilmiah Ilmu Dasar dan Lingkungan Hidup Vol 14, No 2 (2014): Ekologia : Jurnal Ilmiah Ilmu Dasar dan Lingkungan Hidup
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/ekol.v14i2.216

Abstract

Herbs and spices are very important and useful as therapeutic agent against typhoid fever. Increasing multidrug resistance of pathogens forces to find alternative compounds for treatment of these infectious diseases. Garlic contained volatile oil and alisin which containing sulfur. The present study was to evaluate the antibacterial potential of fresh and powder of garlic (Allium sativum L.) extracts against the bacterial pathogens  Salmonella typhi  and describes the phytochemical analysis. Methods: In the present study the antimicrobial potency of fresh and powder of garlic  was carried out by  disc  diffusion and dilution method against Salmonella typhi bacterial and qualitatively tested for the presence of chemical constituents for the identification of flavonoids, saponins, tannins, alkaloids by the method described previously. The results of the present study showed the  fresh and powder of garlic (Allium sativum L.) same as susceptible  for Salmonella typhi. The (minimum inhibitory concentration) MIC of fresh of garlic  at 10% and the powder of garlic  at 8%. The most effective concentration of fresh and powder of garlic  for Salmonella typhi is 90 %.  Phytochemical screening of ethanol extract of Allium sativum L revealed the presence of various bioactive components of flavonoids, saponins, tannins and alkaloids were the most prominent.   Key words : Allium sativum, Antibacterial, Salmonella typhi
FORMULASI DAN UJI STABILITAS GRANUL EFERVESEN SARI BUAH SIRSAK (Annona muricata L.) - Prasetyorini; Ike Yulia Wiendarlina; Murni Tiradisuci
Ekologia: Jurnal Ilmiah Ilmu Dasar dan Lingkungan Hidup Vol 15, No 2 (2015): Ekologia : Jurnal Ilmiah Ilmu Dasar dan Lingkungan Hidup
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/ekol.v15i2.202

Abstract

This event will be based on research by the large number of reports on the benefits of soursop for various diseases especially antihipertensi and antihiperuresemia. Forms need to be developed so that a more practical preparations and ketersediannya continuous, one of which is in the form of effervescen granule juice. This research aims to find out whether the soursop fruit juice can be a formulation in granule material of efervesen who meet the requirements of quality, standards and terms of efervesen granule and making it acceptable in society. In the study of fruit juice made with the soursop fruit flesh filter using Batiste, juice drained using Freezedryer with the addition of maltodekstrin 20%. The powder is then made 3 fruit formula granule effervesent with the difference of acid-catalyzed and the manufacturing process is done by the method of smelting using alcohol 70% without binder. Test results show the BSLT fruit pollen have toxic effects against larvae of shrimp Artemiasalina Leach with LC50 108.914 ppm. The results of the evaluation of the third shows the formula for granule corner quietly and solubility are eligible, cohesive, and the granule flow values test froth above 70%, the test results of licentious formula2 has the most preferred taste. Stability test for efervesen granule 8 weeks the most stable at a temperature of 15 ° C containing Sodium ion levels 3, 97g/100 ggranul, potassium of 0, 24g/100 ggranul, 2, 19mg SAG polyphenols/ggranul and vitamins C51, 91mg/100ggranul. Key words : granul, efervesen, stabilitas, sirsak
Preparation of Single Garlic, Red Ginger, Lemon and Apple Vinegar Combination Tablets By Wet Granulation Method Wiendarlina, Ike Yulia; Fatmi, Mindiya; Indriati, Dwi; Novadin, Raraseta P
FITOFARMAKA: JURNAL ILMIAH FARMASI Vol 13, No 2 (2023): FITOFARMAKA: Jurnal Ilmiah Farmasi
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jf.v13i2.9320

Abstract

Garlic, red ginger, lemon, and apple cider vinegar are spices in Indonesia that can be useful for increasing the body's resistance and preventing degenerative diseases. Tablet preparations are preferred because they are practical, easy to use, and easy to carry anywhere. The aim of this research is to see the effect of differences in the concentration of internal and external disintegrants, binders, gliders, and lubricants in each formula. Tablets are made with the single active ingredients of garlic, red ginger, apple cider vinegar, and lemon. The wet granulation method was chosen because natural materials have poor flow properties, so by using the wet granulation method, the flow rate, compressibility, and binding capacity of the granules can be improved for the better so that they can be molded into tablet preparations. The research results showed that all tablet formulas met the tablet evaluation requirements. The concentration of external and internal disintegrants, binders, gliders, and anti-adherents does not make a difference in flow time or angle of repose but provides different water content values in formula 3.There is an influence of differences in the concentration of additional ingredients on the quality of the tablets produced. The greater the concentration, the better the weight uniformity, the harder the resulting tablet, and the longer the disintegration time. Tablet fragility on F2 is high than formula 1 and 3, but still meets tablet quality requirements.
Combination Effects of African Leaf Ethanol Extract (Vernonia amygdalina Del.) with Red Onion Peel (Allium cepa L.) as Antidiabetes in Streptozotocin-induced Mice Setiani, Lusi Agus; Wiendarlina, Ike Yulia; Marcella, Nurma
Jurnal Jamu Indonesia Vol. 9 No. 3 (2024): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v9i3.299

Abstract

Type 2 diabetes arises when the body becomes resistant to insulin or when the pancreas fails to produce sufficient insulin. This study aimed to evaluate the antidiabetic effects of reducing blood glucose levels in white male mice through the administration of an ethanol extract of African leaves and onion peel, as well as to determine the duration of these effects. Streptozotocin was used to induce diabetes in the mice, and the experiment was conducted over a period of 21 days. The mice were divided into seven groups: Group 1 received a placebo (CMC Na 0.5%), Group 2 received glibenclamide (0.013 mg/20 g body weight), Group 3 received a single dose of African leaf extract (4.2 mg/20 g BW), Group 4 received a single dose of onion peel extract (4 mg/20 g BW), and Groups 5, 6, and 7 received combinations of African leaf and onion peel extracts at ratios of 1:1, 1:2, and 2:1, respectively. The results demonstrated that the combined administration of African leaf and onion peel extracts significantly reduced blood glucose levels, with decreases of 44.701%, 49.929%, and 51.996% in the 1:1, 1:2, and 2:1 group, respectively. The 1:1 combination was particularly effective, showing a reduction in blood glucose levels comparable to the positive control, which achieved a 45.957% decrease. The administration of the test preparations effectively reduced blood glucose levels over 21 days, with significant reductions observed on both the 14th and 21st days.
KESESUAIAN DAN CLINICAL OUTCOME PENGGUNAAN ANTIBIOTIK PROFILAKSIS PADA PASIEN OPERASI MIOM (MYOMA UTERI) DI INSTALASI RAWAT INAP RS PMI BOGOR PERIODE 2019-2021 Toha, Oktaviana Zunnita; Yulia Wiendarlina, Ike; Rahmah Sari, Hanifah
Jurnal Farmamedika (Pharmamedika Journal) Vol 9 No 2 (2024): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47219/ath.v9i2.366

Abstract

Mioma uteri adalah neoplasma jinak yang berasal dari sel-sel otot polos uterus dan jaringan ikat yang menopangnya. Berdasarkan Survey Demografi dan Kesehatan Indonesia (SDKI) angka kasus mioma uteri diperkirakan sebesar 20 dari 1000 wanita dewasa. Tujuan dari penelitian ini untuk mengetahui karakteristik pasien mioma uteri, mengetahui kesesuaian penggunaan antibiotik profilaksis ditinjau dari jenis dan dosis, waktu pemberian, lama pemberian, dan penambahan pemberian antibiotik profilaksis saat operasi, serta mengetahui clinical outcome penggunaan antibiotik profilaksis. Penelitian ini menggunakan pendekatan retrospektif dengan teknik pengambilan sampel yaitu purposive sampling. Berdasarkan hasil penelitian terhadap 92 pasien rawat inap operasi mioma uteri, 52,2% pasien pada rentang usia 36-45 tahun. Mioma uteri terjadi pada wanita yang belum pernah melahirkan (Nullipara) sebanyak 56,5%; jenis operasi tertinggi yaitu histerektomi supracervical sebanyak 56,5%. Pemberian antibiotik profilaksis pada pasien mioma uteri terbanyak adalah Ceftriaxone 1 gram. Pemilihan jenis dan dosis menurut Formularium RS telah sesuai sebesar 100%. Berdasarkan waktu pemberian dan lama pemberian 100% sesuai. Penambahan pemberian antibiotik profilaksis saat operasi dilakukan pada 26 pasien disebabkan oleh durasi operasi yang lebih dari 3 jam. Clinical outcome yang ditandai dengan nilai leukosit normal, tidak adanya demam, tidak adanya peradangan pada luka operasi sebanyak 64,1%.
Combination Effects of African Leaf Ethanol Extract (Vernonia amygdalina Del.) with Red Onion Peel (Allium cepa L.) as Antidiabetes in Streptozotocin-induced Mice Lusi Agus Setiani; Ike Yulia Wiendarlina; Nurma Marcella
Jurnal Jamu Indonesia Vol. 9 No. 3 (2024): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v9i3.299

Abstract

Type 2 diabetes arises when the body becomes resistant to insulin or when the pancreas fails to produce sufficient insulin. This study aimed to evaluate the antidiabetic effects of reducing blood glucose levels in white male mice through the administration of an ethanol extract of African leaves and onion peel, as well as to determine the duration of these effects. Streptozotocin was used to induce diabetes in the mice, and the experiment was conducted over a period of 21 days. The mice were divided into seven groups: Group 1 received a placebo (CMC Na 0.5%), Group 2 received glibenclamide (0.013 mg/20 g body weight), Group 3 received a single dose of African leaf extract (4.2 mg/20 g BW), Group 4 received a single dose of onion peel extract (4 mg/20 g BW), and Groups 5, 6, and 7 received combinations of African leaf and onion peel extracts at ratios of 1:1, 1:2, and 2:1, respectively. The results demonstrated that the combined administration of African leaf and onion peel extracts significantly reduced blood glucose levels, with decreases of 44.701%, 49.929%, and 51.996% in the 1:1, 1:2, and 2:1 group, respectively. The 1:1 combination was particularly effective, showing a reduction in blood glucose levels comparable to the positive control, which achieved a 45.957% decrease. The administration of the test preparations effectively reduced blood glucose levels over 21 days, with significant reductions observed on both the 14th and 21st days.
THE POTENCY OF PSIDIUM GUAJAVA LEAVES AS A NATURAL DISINFECTANT AND ANTISEPTIC INGREDIENT Mahyuni, Siti; Komala, Oom; Wiendarlina, Ike Yulia; Fatah, Muhammad Fajar Saeful
Jurnal Bioteknologi dan Biosains Indonesia Vol. 12 No. 1 (2025)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Preventing the spread of nosocomial infection are generally carried out by disinfection process of the tools to be used with chemical disinfectant such as phenol, alcohol, chlorine, iodine or sublimate. Excessive use of chemicals can cause health problems. Guava leaves (Psidium guajava L.) have long been empirically used to treat diarrhea and acne. Scientific data shows that guava leaves have positive activity against several types of pathogenic bacteria due to its tannin content. Guava leaves have the potential to be developed as a disinfectant and antiseptic material. This study aims to determine the disinfection activity of guava leaves on surgical instruments using the total plate count method, skin irritation test using patch test method and quantify the tannin content in young and old guava leaves using spectrophotometry method. The results showed that the tannin content in old and young guava leaves was 68.73 ± 0.067 mg/g (6.873%) and young 61.87 ± 0.046 mg/g (6.187%). At concentrations of 10, 20, 30 and 40% guava leaf extract were able to reduce the total plate count in surgical instrument samples by 6.85; 37; 80.82; and 83.56%. The primary irritation index of 0.05 only occurs at a concentration of 40%, classified as non-irritant. It can be concluded that guava leaves have the potential to be further developed as a natural disinfectant or antiseptic.
Training on Making Herbal Drink to Increase Immunity in Pagelaran Village, Ciomas, Bogor Tri Retno Handayani, Marybet; Yulianita; Wiendarlina, Ike Yulia; Utami, Novi Fajar; Mahyuni, Siti; Sulistiyono, Fitria Dewi; Komala, Oom; Hermawati, Ema; Rikkit
Jurnal Pengabdian Masyarakat Inovatif Vol. 1 No. 2 (2023): JPMI (Jurnal Pengabdian Masyarakat Inovatif)
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jpmi.v1i2.79

Abstract

Health is a very valuable factor in life. One way to improve health or immunity is by consuming herbal drinks. Herbal drinks are believed to have beneficial properties for healing disease. Livelihoods in Pagelaran Village are dominated by laborers, farmers, traders and domestic workers, with educational levels dominated by junior high and high school levels. The problems found in Pagelaran Village are public health problems, so it is necessary to improve welfare, one of which is by consuming healty drinks made from herbal plants. Red ginger is widely used to treat various diseases such as colds, digestive disorders, antipyretic, anti-inflammatory and also analgesic. Compounds of lemongrass that have a good prospects for increasing immune system activity are usually flavonoids, curcumin, limonoids, vitamin C, vitamin E (tocopherol) and catechins. Lemons also contain quercetin which can increase the body's immunity. This PKM activitiy was carried out in Agroeduwisata Lembah Watu, Pagelaran Village, Bogor Regency, took the form of training in making herbal drinks to increase body’s immunity for women of PKK and KWT. The implementation of this PKM activity can increase the knowledge of utilizing, processing and packaging herbal plants into herbal drink products. This PKM activity, it is hoped that people will be able to make and consume health drinks which can be used to increase the body’s immunity so that the quality of life can improves too.
Co-Authors - Prasetyorini Afifah Marissa Arlindini Akhmad Endang Zainal Hasan Anindita Aulya Pertiwi Anisa Bela Peron Asmara, Herra Indra Bela Peron, Anisa Cantika Zaddana Ceristianto Ceristianto Ceristianto, Ceristianto Cyntia Wulandari D Prasetyorini Dwi Indriati Elsa Mareta Erni Rustiani Fajar Triansyah Gumelar Fatah, Muhammad Fajar Saeful Firman, Gelline Tama Anindia Fitria Dewi Sulistiyono Gelline Tama Anindia Firman Gumelar, Fajar Triansyah Hermawati, Ema Herra Indra Asmara Indriani, Lusi Indriati, Dwi Ivan Mahardika Putra Toyotatu Julmudia Nurul Annisa Lusi Indriani Mahyuni, Siti Maidatun Hasanah Marcella, Nurma Mila Rosa Mindiya Fatmi Murni Tiradisuci Nina Herlina Novadin, Raraseta P Novi Fajar Utami Nurma Marcella Nurul Safira Oom Komala Prasetyorini Djarot Prasetyorini Prasetyorini Rahmah Sari, Hanifah Rahminiwati, Min Rikkit Runi Sukaesih Sara Nurmala Siti Mahyuni Tiradisuci, Murni Toha, Oktaviana Zunnita Tri Retno Handayani, Marybet Trirakhma Sofihidayati Witdiastuti Witdiastuti Yulianita Zahriani