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All Journal Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Jurnal Fitofarmaka Indonesia FITOFARMAKA: Jurnal Ilmiah Farmasi EKOLOGIA : Jurnal Ilmiah Ilmu Dasar dan Lingkungan Hidup Jurnal Jamu Indonesia Jurnal Farmamedika (Pharmamedica Journal) Journal of Agriculture and Applied Biology Journal of Agriculture and Applied Biology ( JAAB) JCDD JURNAL AGROINDUSTRI HALAL Jurnal Kefarmasian Indonesia Jurnal Bioteknologi & Biosains Indonesia (JBBI) Indonesian Journal of Jamu Jurnal Pengabdian Masyarakat Inovatif Jurnal Pengabdian Masyarakat Inovatif Jurnal Bioteknologi & Biosains Indonesia
Ike Yulia Wiendarlina
Universitas Pakuan
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Combination Effects of African Leaf Ethanol Extract (Vernonia amygdalina Del.) with Red Onion Peel (Allium cepa L.) as Antidiabetes in Streptozotocin-induced Mice Setiani, Lusi Agus; Wiendarlina, Ike Yulia; Marcella, Nurma
Jurnal Jamu Indonesia Vol. 9 No. 3 (2024): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v9i3.299

Abstract

Type 2 diabetes arises when the body becomes resistant to insulin or when the pancreas fails to produce sufficient insulin. This study aimed to evaluate the antidiabetic effects of reducing blood glucose levels in white male mice through the administration of an ethanol extract of African leaves and onion peel, as well as to determine the duration of these effects. Streptozotocin was used to induce diabetes in the mice, and the experiment was conducted over a period of 21 days. The mice were divided into seven groups: Group 1 received a placebo (CMC Na 0.5%), Group 2 received glibenclamide (0.013 mg/20 g body weight), Group 3 received a single dose of African leaf extract (4.2 mg/20 g BW), Group 4 received a single dose of onion peel extract (4 mg/20 g BW), and Groups 5, 6, and 7 received combinations of African leaf and onion peel extracts at ratios of 1:1, 1:2, and 2:1, respectively. The results demonstrated that the combined administration of African leaf and onion peel extracts significantly reduced blood glucose levels, with decreases of 44.701%, 49.929%, and 51.996% in the 1:1, 1:2, and 2:1 group, respectively. The 1:1 combination was particularly effective, showing a reduction in blood glucose levels comparable to the positive control, which achieved a 45.957% decrease. The administration of the test preparations effectively reduced blood glucose levels over 21 days, with significant reductions observed on both the 14th and 21st days.
Immunostimulant Effects of Bitter Leaves (Gymnanthemum amygdalinum (Del.) Sch.Bip.ex Walp.) Leaf Extract Setiani, Lusi Agus; Wiendarlina, Ike Yulia; Rizkyani, Nanda Asyura; Fazri, Syifa Ainun
Jurnal Kefarmasian Indonesia VOLUME 14, NUMBER 2, AUGUST 2024
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

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Abstract

In Indonesia, the widespread impact of COVID-19 has led to an increased interest in exploring natural immunostimulants as complementary therapies. One promising candidate is Gymnanthemum amygdalinum, commonly known as bitter leaf. Bitter leaf is a medicinal plant that can be used as an immunostimulant because it contains flavonoid compounds. This study aims to investigate the immunostimulatory effects of Bitter leaf extract obtained using the MAE method, particularly in enhancing immune function and the effective dosage in rats. The ethanolic extract of bitter leaf was made using the microwave-assisted extraction (MAE) method, which can potentially extract high levels of flavonoid compounds compared to other extraction methods in vivo. There were as many as 25 rats, which were divided into five treatment groups: the negative control was treated with CMC Na 0,5% (w/v); the positive control was treated with 4,5 mg/200 g body weight (BW) of Echinacea purpurea. The treatment groups from Dose 1; Dose 2; and Dose 3 were treated with an ethanol extract of bitter leaf at 14 mg/200 g BW, 28 mg/200 g BW, and 56 mg/200 g BW. Immunostimulant effect testing was carried out using the carbon clearance method, and the number of leukocytes was counted. In carbon clearance testing, each group was given a carbon solution intravenously; blood was taken at 5, 10, and 15 minutes via the tail vein, and its absorbance was measured using UV-Vis 675 nm. The count of leukocytes was observed using the chamber of a hemocytometer through a microscope. The research results showed that administration of doses I, II, and III provided an immunostimulant effect. Based on the results, the ethanolic extract from a bitter leaf from Dose III (56 mg/200 g BW) provided a stronger immunostimulant effect in rats based on the phagocytosis index parameters of (9.005) and the number of leukocytes of (8,370/µL).
THE POTENCY OF PSIDIUM GUAJAVA LEAVES AS A NATURAL DISINFECTANT AND ANTISEPTIC INGREDIENT Mahyuni, Siti; Komala, Oom; Wiendarlina, Ike Yulia; Fatah, Muhammad Fajar Saeful
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 12 No. 1 (2025)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2025.9216

Abstract

Preventing the spread of nosocomial infection are generally carried out by disinfection process of the tools to be used with chemical disinfectant such as phenol, alcohol, chlorine, iodine or sublimate. Excessive use of chemicals can cause health problems. Guava leaves (Psidium guajava L.) have long been empirically used to treat diarrhea and acne. Scientific data shows that guava leaves have positive activity against several types of pathogenic bacteria due to its tannin content. Guava leaves have the potential to be developed as a disinfectant and antiseptic material. This study aims to determine the disinfection activity of guava leaves on surgical instruments using the total plate count method, skin irritation test using patch test method and quantify the tannin content in young and old guava leaves using spectrophotometry method. The results showed that the tannin content in old and young guava leaves was 68.73 ± 0.067 mg/g (6.873%) and young 61.87 ± 0.046 mg/g (6.187%). At concentrations of 10, 20, 30 and 40% guava leaf extract were able to reduce the total plate count in surgical instrument samples by 6.85; 37; 80.82; and 83.56%. The primary irritation index of 0.05 only occurs at a concentration of 40%, classified as non-irritant. It can be concluded that guava leaves have the potential to be further developed as a natural disinfectant or antiseptic.
Co-Authors - Prasetyorini Afifah Marissa Arlindini Akhmad Endang Zainal Hasan Anindita Aulya Pertiwi Anisa Bela Peron Asmara, Herra Indra Bela Peron, Anisa Cantika Zaddana Ceristianto Ceristianto Ceristianto, Ceristianto Cyntia Wulandari D Prasetyorini Dwi Indriati Elsa Mareta Erni Rustiani Fajar Triansyah Gumelar Fatah, Muhammad Fajar Saeful Fazri, Syifa Ainun Firman, Gelline Tama Anindia Fitria Dewi Sulistiyono Gelline Tama Anindia Firman Gumelar, Fajar Triansyah Hermawati, Ema Herra Indra Asmara Indriani, Lusi Indriati, Dwi Ivan Mahardika Putra Toyotatu Julmudia Nurul Annisa Lusi Indriani Mahyuni, Siti Maidatun Hasanah Marcella, Nurma Mila Rosa Mindiya Fatmi Murni Tiradisuci Nanda Asyura Rizkyani, Nanda Asyura Nina Herlina Novadin, Raraseta P Novi Fajar Utami Nurul Safira Oom Komala Prasetyorini Djarot Prasetyorini Prasetyorini Rahmah Sari, Hanifah Rahminiwati, Min Rikkit Runi Sukaesih Sara Nurmala Siti Mahyuni Tiradisuci, Murni Toha, Oktaviana Zunnita Tri Retno Handayani, Marybet Trirakhma Sofihidayati Witdiastuti Witdiastuti Yulianita Zahriani