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Jurnal Farmasi Sains dan Komunitas
Published by Universitas Sanata Dharma
ISSN : 16935683     EISSN : 25277146     DOI : https://doi.org/10.24071/
Core Subject : Health,
Medicine & Pharmacology
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community / J Pharm Sci Community) firstly published in 2003, is a peer-reviewed, open access scientific journal that publishes research articles, review articles, as well as short communication in various pharmaceutical fields, including Pharmaceutical Technology and Pharmaceutics, Pharmaceutical Analysis, Medicinal Chemistry, Pharmacology and Toxicology, Pharmaceutical Biology, Community Pharmacy, and Clinical Pharmacy.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 13 Documents
 1   2 
Search results for , issue "Vol 21, No 1 (2024)" : 13 Documents clear
Curcumin Transethosome Gel: Anti-inflammatory Activity Test in Carrageenan-Induced Sprague Dawley Rat Amalia, Anisa; Efendi, Kriana; Novianti, Amelia
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 1 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.005618

Abstract

Curcumin has anti-inflammatory activities, and is formulated into the transethosome (TE) system to improve penetration. The TE system's stability can be increased by incorporating it into a gel dosage form. This study aims to determine the anti-inflammatory activities of curcumin TE gel. Curcumin TE gel was produced in 3 compositions, each having a curcumin content of 10 mg (F1), 40 mg (F2), or 160 mg (F3). On TE gels, organoleptic, viscosity, pH, particle size, and zeta potential were evaluated. The test animals were divided into five groups for anti-inflammatory activity testing. A 1% carrageenan solution was used to induce edema in the animals, and the volume of edema was measured for comparison with p0.05set as significant difference. Curcumin TE gel's physical properties showed a yellow and homogenous gel with viscosity values of 31.173 – 33.626 cPs, pH 4.75 – 4.84, particle size 208.3 – 319.4 nm, and zeta potential (-) 40.03 – (-) 51.12 mV. On anti-inflammatory tests, the edema volume in the group given curcumin TE gel decreased in the 270th minute. According to statistical analysis, the test group had a significant difference (p 0.05) from negative controls and no significant difference (p 0.05) from positive controls in F1 and F2 anti-inflammatory activity. According to these results, the curcumin TE gel exhibited anti-inflammatory activity equivalent to the positive control, while F3 had anti-inflammatory activity better than the positive control. 
Computational Studies of Donepezil and Acetylcholinesterase Dynamics Interactions Windah, Axl Laurens Lukas; Istyastono, Enade Perdana
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 1 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.006967

Abstract

Donepezil is an acetylcholinesterase (AChE) inhibitor commonly used as an anti-dementia medication for patients with Alzheimer's Disease. This research aims to determine the stability of each enantiomer R and S of donepezil as an AChE inhibitor using molecular dynamics (MD) simulations. The MD simulations were performed on a Cloud Protein Simulator (CPS) with YASARA-Structure as the main software and PyPLIF HIPPOS as the software to identify protein-ligand interactions. The MD simulations were performed in three replications of 50 ns for each enantiomer complexed to AChE. The stabilities of the AChE-donepezil complexes were analyzed by assessing the root-mean-squared deviation (RMSD) values of the AChE backbone atoms (RMSDBb) and the ligand (RMSDLigMov) during the last 5 ns of simulation time. The dynamics of the protein-ligand interactions were also analyzed during the last 5 ns. The results of these MD simulations indicate that the S-donepezil serves as a better AChE inhibitor compared to the R-donepezil. 
Antibacterial Activity Test of Noni Leaves (Morinda citrifolia L.) Ethanol Extract Ointment Against Staphylococcus aureus Bacteria Arifin, Arfiani; Djide, Natsir; Muhtar, Mardiyana
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 1 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.005763

Abstract

Noni leaves (MorindacitrifoliaL.) are known to provide antibacterial properties and can be used in ointment formulations to prevent or eliminate germs that might cause infections, such as Staphylococcus aureus. This research aimedto formulate an ointment containing noni leaf ethanol extract that fulfills the physical quality test standards and to determine the antibacterial activity of various concentrations of ethanol extract of noni leaves in ointment preparations against Staphylococcus aureus bacteria. The extraction technique employed was maceration with 96% ethanol. The extracted substance was formulated into ointments with concentrations of 2.5%, 5%, and 10%. The antibacterial activity of the ointment was evaluated using the agar diffusion method with wells. Organoleptic, homogeneity, pH, spreadability, and adhesion tests demonstrated that the ointment at the three concentrations of 2.5%, 5%, and 10% satisfied the physical quality test standards. The antibacterial activity test revealed that a 96% ethanol extract of noni leaves inhibited the growth of Staphylococcus aureus bacteria with the maximum diameter of the inhibition zone at a concentration of 10% (15.26 mm) and was classified as strong. 
Isolation and Protein Profile of Chicken, Pork and Processed Products Nugget with Sodium Dodecyl Sulphate Polyacrylamide Gel Electrophoresis (SDS-PAGE) Method Orbayinah, Salmah; Widada, Hari; Anindita, Nosa Septiana; Mohdar, Adhe Filiyahtri
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 1 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.007099

Abstract

Chicken nuggets are known as a nutritious processed meat food ingredient and are widely available in supermarkets and are very popular with consumers. Nugget is made by mixing it with various other additives, so that it raises a bit of concern about the ingredients used in terms of halal. The purpose of this study was to determine and analyze the protein profile of chicken, pork, nugget references, and nugget commercials. The method used in this study is an experimental laboratory analysis of variables using SDS-PAGE (Sodium Dodecyl Sulphate Polyacrylamide Gel Electrophoresis). The data were obtained from observing the description of protein bands, calculations were carried out using linear regression, and descriptive analysis was carried out. The results of this study showed 4 protein bands in pork that were not found in chicken meat with a molecular weight of 62.95 kDa, 41.86 kDa, 31.28 kDa and 17.46 kDa. Based on the protein fraction, the protein referred to as BM 31.28 kDa is Tropomyosin and BM 17.46 kDa is Troponin C. Nugget reference shows similarities to the protein bands found in pork, whereas nugget commercially did not show specific similarity. 
The Effect of Combination of Porang Tuber Starch (Amorphophallus muelleri Blume) with Lactose on the Physical Properties of Bajakah Root (Spatholobus littoralis Hassk) Water Extract’s Tablet Ermawati, Dian Eka; Tambunan, Rido Rohana; Darojati, Ulfa Afrinurfadhilah
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 1 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.005765

Abstract

Kalimantan's people drink bajakah roots as a traditional medicine to restore stamina and treat various diseases. The infusion is less practical and unstable, so it was developed into a tablet. Porang is a local tuber that contains amylum and amylopectin. The combination of starch-lactose has been widely used as a tablet filler and produces tablets with good physical properties. This study aimed to determine the effect of the combination of porang starch-lactose on the granules and tablets' physical properties. Bajakah roots were infused and dried using a freeze-dryer. The antioxidant activity was measured using the DPPH method. Tablets of bajakah root water extract were made with a 1:1 porang tuber starch-lactose ratio using the dry granulation. Physical evaluations of granules and tablets were conducted, including flow rate, angle of repose of granules, and weight uniformity, hardness, friability, and disintegration time of tablets. Porang tubers-lactose with a ratio of 1:1 produced tablets with good evaluation results with a granule flow rate of 9.70±0.92 g/s and an angle of repose of 26.15±1.79°. Uniformity of tablet weight met acceptance value, with hardness of 5.38±0.90 Kg, friability of 0.26±0.05%, and disintegration of 10.60±1.33 min. Porang tuber fulfills the requirements of a good tablet filler and can be developed as a tablet filler.  
Optimization of Naringenin Self-Nano Emulsifying Drug Delivery System (SNEDDS) Formula with D-optimal Mixture Design Method Yudanti, Gendis Purno; Kuncahyo, Ilham; Ikasari, Endang Diyah
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 1 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.004319

Abstract

This study aimed to optimize and formulate the poorly water-soluble naringenin in the Self-Nano Emulsifying Drug Delivery System (SNEDDS) using D-optimal mixture design. D-optimal mixture design was used to optimize SNEDDS loading naringenin by selecting SNEDDS composition as an independent factor and SNEDDS characterization as a response. SNEDDS in the optimal formula were characterized, including transmittance, particle size, emulsification time, and drug loading. Triacetin, Tween 80, and transcutol p were respectively the selected oil, surfactant, and co-surfactant phases for their greatest ability to dissolve naringenin. The optimization results showed that the optimal formula was that using 10% triacetin, 70% of Tween 80, and 20% of transcutol p. SNEDDS loading naringenin produced nanoemulsion with 88.74±2.27 % of transmittance, 14.8 nm of particle size, 51.13 ± 4.53 mg/L of drug loading, and 18.58 ± 0.62 second of emulsification time. This study concludes that the D-optimal mixture design can be used to optimize and prepare the SNEDDS loading poorly-water soluble naringenin.  
Evaluation of Diabetic Wound Healing Activity of Novel Quercetin Topical Preparations Nastiti, Christofori Maria Ratna Rini; Michelina, Ellisia; Wijayanti, Fabiola Rani; Gani, Michael Raharja
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 1 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.007288

Abstract

Diabetic wound needs effective pharmacotherapy in order to accelerate the wound healing process and to prevent further infection. Quercetin (QUE) is one of flavonols which ispotential as an active ingredient for diabetic wound therapy, due to its anti-inflammatory and antioxidant activities.  This current study evidenced wound healing activity of QUE topical preparations on the open wound of diabetic-induced subjects preclinically. The investigation focused on topical administration of QUE nanoemulgels and QUE micellar gels (0.2% w/w of QUE) on groups of diabetic-induced male Wistar rats. The quality of preparations in terms of organoleptic performance, pH, viscosity and spread-ability was physically characterized prior to topical administration to the wound. Punch biopsy (5mm) was applied to create the open wound. The visual observation of wound contraction area (in mm2) was carried out every three days. On the day 12th, after sacrificing the subjects, the wounded tissues were removed, fixed in 10% formalin and prepared for histology examination-hematoxylin and eosin staining. The results showed that the QUE nanoemulgels and QUE micellar gels were relatively comparable onthe physical quality as well as the wound healing activity. Their wound healing activities were remarkably faster compared to the untreated control group and it was showed fromthe histology study that the QUE nanoemulgels and QUE micellar gels successfully accelerate the wound healing process to the proliferation step if it was compared the untreated. In conclusion, QUE nanoemulgels and QUE micellar gels were potential to develop to accelerate the diabetic wound healing process.    
Effectiveness of the Combination of Spirulina platensis and Stichopus variegatus on Prevention of Caspase-3 Gene Expression of Dementia Rat Models Safira, Rizka; Botutihe, Lisa Agustina; Yuliani, Sapto; Kintoko, Kintoko
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 1 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.006051

Abstract

The death of cells in the brain, especially the hippocampus, manifests in a decrease in memory, language, and behavior. Golden sea cucumber (Stichopus variegatus) andblue-green algae (Spirulina platensis) are reported to have high antioxidant content which has the potential to prevent cell death in the brain due to oxidative stress thereby preventing memory decline.This study aimed to investigate the effect of the combination of Stichopus variegatus and Spirulina platensis on preventing caspase 3 gene expression in pyramidal hippocampal cells in a rat model of trimethlytin-induced dementia (TMT). This study used Sprague Dawley rats, about 2 months old, weighing 180-200 g, divided into 6 treatment groups, with each group consisting of 8 rats. The hippocampus was taken from the right cerebral hemisphere for histological observations of pyramidal caspase-3 gene expression in the CA1 and CA2-CA3 regions.The combination of Spirulina platensis and Stichopus variegatus with a dose 200 mg/kg BB can prevent the expression of caspase-3 in the CA1 and CA2-CA3 areas of the hippocampus. Conclusion: The combination of spirulina and golden sea cucumber extracts has the potential to prevent caspase 3 gene expression in pyramidal cells of TMT-induced dementia rat models. 
Synthesis and Characterization of Ethanolic Extract of Red Betel Leaf as an Antiseptic Gel Harimurti, Sabtanti; Hidayaturahmah, Rizky; Arsito, Puguh Novi; Febriansah, Rifki; Widada, Hari
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 1 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.006555

Abstract

Hand hygiene is one way to maintain health. There are several ways to clean hands, namely by washing hands and applying a hand sanitizer. The use of hand sanitizer is increasing due to its practical nature. Utilizing natural materials for preparing hand sanitizer widely available around us will be beneficial, one of which is red betel leaf which some people of Indonesia empirically use for antiseptic. This study aims to develop antiseptic gel preparations with ethanolic extracts from red betel leaves. The extraction was done using maceration with 70% ethanol solvent. The formula for choosing a carbomer as a gelling agent with the red betel leaf extract concentration was 0%, 2.5%, 5%, 10%, and 15%. The assessments of the gel were physical and antiseptic evaluations. The physical evaluations included an organoleptic, pH, viscosity, adhesion, and dispersion tests. The antiseptic activity was determined by a replica method. The physical evaluation results of red betel gel revealed that the higher the red betel leaf extract levels are, the darker the green color will be, and the lower the pH and viscosity will be. Furthermore, the antiseptic activity showed that red betel extract gel effectively reduced the number of bacterial colonies. 
The Formulation of Effervescent Granules with Oxalis dehradunensis Raizada Ethanol Extract as an Antioxidant Mahyuni, Eka Lestari; Harahap, Urip
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 1 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.004492

Abstract

Antioxidants and their health implications are widely studied related to their benefits in reducing free radical exposure. Oxalis dehradunensisRaizada is a type of wild mountain clover containing flavonoids and polyphenols. These contents allow the leaves to be consumed in a more practical, effective, and efficient way by processing the extract into effervescent granules. This experimental study used samples of Oxalis dehradunensisRaizadaethanol extract formulated in the form of effervescent granules. The content included citric acid, tartrate acid, lactose and sodium bicarbonate. The antioxidant activity assays were conducted by DPPH methods including testing the total phenol and flavonoid contents for the extracts and forms of effervescent granules. The total phenol content analysis used the Folin-Ciocalteu method while the total flavonoid content used the colorimetry method. The results identified the extract as the hygroscopic extract which had increasing IC50 for upgraded content of the formula but looked wet and was not stable. The experiment for the formula of effervescent granules was fulfilled by adding povidone, aspartame and polyethylene glycol. It required angle of repose which was 200-400 with a flow time not exceeding 10 seconds. The tap density also fulfilled the requirements, with the smaller the granule tap density, the greater the compression volume. The extract has a good antioxidant with IC50 value which reached near moderate to high levels. Although the formula 4 of effervescent granules was the best, it did not have the best antioxidant activity. Based on the results from the antioxidant activity assays, the extract has good antioxidant activity but it decreased when made into effervescent granules. 

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