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Jurnal Farmasi Galenika (Galenika Journal of Pharmacy)

Galenika
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Published by Universitas Tadulako

ISSN : 24427284 EISSN : 24428744 DOI : https://doi.org/10.22487/j24428744

Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (E-ISSN: 2442-8744) (p-ISSN: 2442-7284), is an open access journal (print and e-journal) focusing on the scientific works in the field of Pharmacy and Pharmaceutical Science. The articles of this journal are published every six months, that is March and October (2 issues per year). This journal is developed by Department of Pharmacy, Faculty of Mathematics and Natural Science, Tadulako University and has been identified in Crossref with the DOI Number : 10.22487/j24428744. Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) has been accredited by Kemenristekdikti as Sinta 3 starting from Volume 5 No 1 2019.

Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi

Articles 247 Documents

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Uji Aktivitas Antidiabetes dari Ekstrak Metanol Buah Kiwi (Actinidia deliciosa) melalui Penghambatan Aktivitas α-Glukosidase: Antidiabetic Activity of Kiwi Fruit (Actinidia deliciosa) Extract through Inhibition of α-Glucosidase Activity Okpri Meila; Noraini Noraini
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 3 No. 2 (2017): (October 2017)
Publisher : Universitas Tadulako

Diabetes melitus (DM) is defined as a chronic metabolic disease or disorder with multiple etiologies characterized by high blood sugar levels. One way to treat diabetes mellitus is inhibiting the α-glucosidase enzyme. This study aims to determine the inhibition of α-glucosidase of methanol extract of kiwi fruit (Actinidia deliciosa) . Kiwi fruit (Actinidia deliciosa) contains saponins characterized by the formation of foam, positive flavonoid characterized by the formation of a yellow color (orange) and positive alkaloid which is characterized by brown color in wagner test. The inhibition activity test of α-glucosidase enzyme was performed by using spectrophotometric method. The results of the inhibition activity test of α-glucosidase enzyme in acarbose showed the value of 13,672 mg/L, while the methanol extract of kiwi fruit showed IC50 value of 7.219 mg/L. It demonstrated that themethanol extract of kiwi fruit has the inhibition activity greater than acarbose.

Optimasi Formula Gel Antioksidan Ekstrak Etanol Buah Bligo (Benincasa hispida) dengan Metode Simplex Lattice Design (SLD): Antioxidants Gel Formula Optimation of Bligo Fruit Ethanolic Extract (Benincasa hispida) by Simplex Lattice Design (SLD) method Suryani Suryani; Andi Nafisah; Syahrir Mana'an
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 3 No. 2 (2017): (October 2017)
Publisher : Universitas Tadulako

Benincasa hispida has many benefits including as antioxidant. This study aims to evaluate the effect of Carbomer 940, HPMC and NaOH concentrations in antioxidant gel formula and to determine Carbomer 940, HPMC and NaOH concentrations that could produce the optimal antioxidant gel formula. Benincasa hispida was extracted by maceration method and antioxidant activity was tested by DPPH method. The antioxidant gels were formulated with variety combinations of Carbomer 940, HPMC and NaOH. The optimal gel formula was obtained by Design Expert 7.1.5 with Simplex Lattice Design method. The physical characteristic of optimal gel formula was retested and compared with the results of Simplex Lattice Design .The results showed that antioxidant activity of Benincasa hispida ethanolic extract has potent activity with the IC50 40,28 μg/mL. The increasing concentration of Carbomer 940, HPMC and NaOH possessed the high coefficients viscosity (cPs) with the value of 4366, 4133 and 3750 respectively. The increasing concentration of NaOH possessed pH and dispersive power of the gel with coefficients of 11,0 and 5,21 respectively. The desirability values suggested by Simplex Lattice Design were 1,000 with component variation of the optimal formula were Carbomer 940 1,5%, HPMC 0,5% and NaOH 0,4%. The significance test of the optimal formula compared to the results of laboratory experiments showed the significance of viscosity of 0,130, the dispersive power of 0,348 and pH of 0,184 that means there was no significant difference between the prediction values by using Simplex Lattice Design and results of laboratory experiments. It was indicated that significance values of each responses were over 0,05 (p>0.05).

Aktivitas Anti-inflamasi Ekstrak Etanol Daun Beluntas (Pluchea indica L.) pada Model Inflamasi Terinduksi CFA (Complete Freund's Adjuvant) : Anti-inflammatory Activity of Ethanol Extract of Beluntas Leaves(Pluchea indica L.) on Complete Freund's Adjuvant-induced Inflammatory Model Reza Setiawan Sudirman; Usmar Usmar; Abdul Rahim; Muh. Akbar Bahar
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 3 No. 2 (2017): (October 2017)
Publisher : Universitas Tadulako

A research about anti-inflammatory effect of Beluntas leaves extract on CFA (Complete Freund’s Adjuvant) induced inflammatory model has been conducted. The objective of this research was to determine the effect of Beluntas leaves extract in alleviating CFA-induced paw edema in mice (Mus musculus). The number of mice used was 15 and was divided into 5 groups. Group I was treated with NaCMC. Group II, III, and IV were given suspension of Beluntas leaves extract 100 mg/Kg, 300 mg/Kg, and 500 mg/Kg BW, respectively. Group V was a positive control treated with suspension of diclofenac sodium 0.1 ml/10 g orally. The determination of anti-inflammatory potency was based on the average time needed to ameliorate the edema volume. The shortest time period of edema reduction was produced by diclofenac sodium (within 9.33 days), then followed by Beluntas leaves extract with the concentration of 300 mg/Kg (within 12 days), 500 mg/Kg (within 14.33 days), and 100 mg/Kg (within 17.67 days), consecutively. These results are significantly different compared to negative control group which did not reduce the edema volume during 18 days of observation. In conclusion, ethanol extract of Beluntas leaves has an effective anti-inflamatory effect.

Sensor Asam Nukleat Sebagai Aktivator Imunitas Intrinsik Terhadap Patogen Intraseluler: Nucleic Acid Sensors as Activators of Intrinsic Immunity Against Intracellular Pathogens Usmar Usmar; Rudi Arfiansyah; Firzan Nainu
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 3 No. 2 (2017): (October 2017)
Publisher : Universitas Tadulako

Vertebrata, termasuk manusia, dilengkapi dengan sistem imun alamiah dan sistem imun adaptif yang saling bekerjasama untuk melindungi tubuh dari material berbahaya, termasuk berbagai patogen dan sel-sel kanker. Kedua sistem imun tersebut secara rutin melakukan pengecekan terhadap beragam material yang ada di dalam tubuh. Salah satu cara yang digunakan oleh sistem imun dalam melaksanakan tugasnya adalah melalui pengaktifan sensor asam nukleat yang berfungsi untuk memberikan informasi keberadaan DNA atau RNA asing maupun kemungkinan adanya salinan DNA inang di sitoplasma atau lokasi lain yang tidak semestinya. Ketika genom patogen terdeteksi oleh sensor-sensor tersebut, selanjutnya efektor sistem imun akan diaktivasi melalui serangkaian proses dan berakhir dengan eradikasi asam nukleat target atau bahkan induksi apoptosis sel yang bersangkutan. Beberapa sensor asam nukleat yang telah ditemukan antara lain adalah Toll-like receptor (TLR), RIG-I-like receptors (RLRs), cyclic GMP-AMP synthase (cGAS), dan interferon-γ-inducible protein 16 (IFI16). Namun, sejumlah patogen telah memiliki mekanisme untuk menghindari sensor-sensor tersebut sehingga infeksi tetap dapat terjadi. Dengan demikian, berbagai penelitian untuk meningkatkan pengetahuan tentang bagaimana sensor asam nukleat bekerja sebagai salah satu respon imun intraseluler serta mekanisme terbentuknya resistensi patogen terhadap deteksi sensor tersebut sangat penting untuk didorong. Hal ini akan memberikan wawasan baru dalam pengembangan berbagai sediaan farmasi terkait seperti vaksin dan antimikroba intraseluler.

Korelasi Kajian Fisikokimia Ekstrak Klika Faloak (Sterculia populifolia DC.) Menggunakan Variasi Pelarut Terhadap Penghambatan Bakteri Patogen: Correlation of Physicochemical Study of Faloak (Sterculia populifolia DC.) Bark Extract Using Solvent Variation on Pathogenic Bacteria Inhibition Syahruni, Reny; Nur, Syamsu; Amrullah, Akhmad; Tonapa, Novianti; Shelina, Vivi
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 4 No. 1 (2018): (March 2018)
Publisher : Universitas Tadulako

Faloak (Sterculia populifolia DC.) is one of species of sterculiaceae found in East Nusa Tenggara which has potential as a medicinal plant mainly as an antimicrobial. This study aims to determine the correlation of physicochemical study of faloak bark extracts with variation of solvents in inhibiting of pathogenic bacteria. The sample was extracted by maceration method with different polarity level of solvents i.e acetone, acetone 70%, water, ethanol 96%, ethanol 70% and ethanol 50%. The results of extraction through maceration indicate the difference of yield recovery from each of the extraction solvents. The highest yield was obtained from 70% ethanol extract, while the lowest yield of acetone extract. The increase of solvent polarity in this study did not give effect to the amount of recovery of yield. It is also seen from the highest total phenolic content obtained from 70% acetone extract while the lowest in aquadest extract. The antibacterial activity of faloak bark extract on Salmonella typhi was tested using agar diffusion method with 1% of extract solution. Both of ethanol 96% and acetone extracts did not show any inhibitory activity. The largest inhibitory activity was demonstrated by 50% ethanol extract. The polarity level of the extract, the level of total phenolic content and the magnitude of rendement did not show correlation of increased inhibitory activity on Salmonella thypi as well.

Kurkumin Meningkatkan Sensitivitas Sel Kanker Payudara terhadap Tamoksifen Melalui Penghambatan Ekspresi P-glikoprotein dan Breast Cancer Resistance Protein: Curcumin Increased Breast Cancer Cells Sensitivity to Tamoxifen Through Inhibition of P-glycoprotein and Breast Cancer Resistance Protein Expressions Sianipar, Erlia Anggrainy; Louisa, Melva; Wanandi, Septelia Inawati
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 4 No. 1 (2018): (March 2018)
Publisher : Universitas Tadulako

The decreasing of sensitivity or resistance to tamoxifen occured after long-term treatment in breast cancer. One of the major factor in tamoxifen resistance is over expression of efflux transporter P-glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP). Curcumin has known as inhibitor of P-gp and BCRP. The addition of curcumin to the tamoxifen resistant cells is expected to increase the sensitivity of breast cancer cells to tamoxifen. This study aim to know the effect of curcumin in increasing the cell sensitivity to tamoxifen through inhibition of P-gp and BCRP transporter efflux. MCF-7 breast cancer cell line was induced with tamoxifen 1 ÂµM for 10 passage (MCF-7(T)), then cell viability and mRNA expression of P-gp and BCRP were analyzed. To the MCF-7(T) cells, curcumin was given at of 5/10/20 ÂµM with or without tamoxifen for 5 days and cell viability and mRNA expression of P-gp and BCRP were analyzed on day 5th. As positive control, verapamil 50 ÂµM was used as P-gp inhibitor, ritonavir 15 ÂµM and nelfinavir 15 ÂµM were used as BCRP inhibitor. The results showed that MCF-7(T) cells sensitivity to tamoxifen decreased with 11.8 times, the cell viability increased 10.82 fold and mRNA expression of P-gp and BCRP increased 4.04 fold. Then after administration of curcumin with or without tamoxifen for 5 days, the cell viability and the mRNA expression of P-gp and BCRP decreased. As conclusion, curcumin increased the sensitivity of MCF-7(T) to tamoxifen characterized by the decreasing of cell viability and mRNA expression of P-gp and BCRP. However, the administration of combination of curcumin with tamoxifen was more potent than just curcumin. The increased sensitivity was estimated at least partly through the inhibition of P-gp and BCRP mRNA expression by curcumin

Pengaruh Dua Metode Pengeringan Pada Aktivitas Antibakteri Ashitaba (Angelica keiskei ) Terhadap Streptococcus mutans: Effect of Two Different Drying Methods on Antibacterial Activity of Ashitaba Againts Streptococcus mutans Wirasisya, Dyke Gita; Juliantoni, Yohanes; Hajrin, Wahida
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 4 No. 1 (2018): (March 2018)
Publisher : Universitas Tadulako

The aim of this study was to determine a change that occurs in total phenolic content (TPC) and antibacterial activity of ashitaba (Angelica keiskei) after dried using two different methods : sun and oven drying. The effectiveness of the drying methods was evaluated in term of total phenolic content (TPC) by using spectrophotometric assay with Folin-Ciocalteu reagent and antibacterial activity againts Streptococcus mutans by in vitro macrodilution assay. Oven drying at 60oC possessed high TPC (2,98 Â± 0,0935 g EAG/100g) compared to sun drying method (1,72 Â± 0,0142 g EAG/100g). Simillar pattern was also observed in antibacterial activity. Oven drying have higher antibacterial activity with the MBC (minimal bactericidal concentration) value of 0,5 mg/mL againts Streptococcus mutans. Therefore, sun drying is not suggested for drying method of ashitaba in terms of total phenolic content and antibacterial activity compared with oven drying methods.

Pemodelan Farmakokinetika Berbasis Populasi dengan R: Model Dua Kompartemen Ekstravaskuler: Population-Based Pharmacokinetics Modeling with R: Two Compartment Extravascular Model Notario, Dion
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 4 No. 1 (2018): (March 2018)
Publisher : Universitas Tadulako

A Tutorial of two-compartment extravascular population-based pharmacokinetics modeling was performed by differential equations and non-linear mixed effect model approach. First, three-level differential equations of two-compartment pharmacokinetics were generated. Then, covariate and non-covariate models were developed by nlmeODE and nlme packages installed in R. The best model was selected according to AIC, BIC, and LogLik value. A model without covariates model was selected as the best model. The selected model showed a goodness of fit with experimental dataset and residual plot of the model revealed that no violations of model assumtions. In conclusion, nlme and nlmeODE is capable to generate an adequate predictive model of two-compartment population-based pharmacokinetics for extravascular route

Pengaruh Suplementasi Madu Trigona terhadap Parameter Fungsi Hati dan Ginjal Tikus Albino (Rattus norvegicus) yang Diberikan Simvastatin: Effect of Trigona Honey Supplementation on Liver and Kidney Function in SimvastatinAdministered Albino Rats (Rattus norvegicus) Mamada, Sukamto Salang; Usmar, Usmar; Aliyah, Aliyah; Aminullah, Aminullah; Rahayu, Ayu Indah; Hidayat, Khaldun; Salampe, Mirnawati
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 4 No. 1 (2018): (March 2018)
Publisher : Universitas Tadulako

Simvastatin is a drug acting on 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase enzyme leading to decrease of lipid level in plasma. Simvastatin is associated with pleiotropic effects such as cardioprotective, hepatoprotective, and nephroprotective effect. This study aimed to observe effect of supplementation of trigona honey on parameters of liver function (SGPT and SGOT) and kidney function (urea) in albino rats (Rattus norvegicus) given 40 mg/kg simvastatin. Twenty-four male albino rats were divided into 6 groups (n=4). Each group was administered different treatments for 15 days orally. Group I was put as health control without any treatment, group II was given sodium carboxymethylcellulose (1% b/v) as negative control, group III was given simvastatin at the dose of 40 mg/kg, group IV was administered simvastatin (40 mg/kg) and trigona honey (6.5% v/v), while group V and VI were administered simvastatin (40 mg/kg) and ubiquinone (1.43 mg/kg); and simvastatin (40 mg/kg), trigona honey (6.5% v/v), and ubiquinone (1.43 mg/kg), respectively. Upon the treatments, level of SGOT, SGPT, and ureum was determined. The data were analyzed by using Analysis of Variance (ANOVA) and Least Significant Difference tests (p=0.05). According to the analysis, it was concluded that supplementation of trigona honey in rats administered simvastatin showed significantly lower level of all parameters than groups of simvastatin and controls.

Uji Pendahuluan Anti-biofilm Esktrak Teh Hijau dan Teh Hitam Pada Streptococcus mutans melalui Metode Microtiter Plate: An initial study on anti-biofilm activity of green tea dan black tea extracts on Streptococcus mutans via mictotiter plate assay Arjuna, Andi; Pratama, Winda Setya; Sartini, Sartini; Mufidah, Mufidah
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 4 No. 1 (2018): (March 2018)
Publisher : Universitas Tadulako

Tea (Camellia sinensis L.) has an activity as an antibacterial, widely studied to plankton cells, without further researching into biofilm cell. Therefore, this research had been conducted to initially evaluate the activity of green- and black-tea extracts in inhibiting Streptococcus mutans biofilm. Green and black tea leaves were extracted using 70% methanol. Determination of MIC was subsequently performed by microdilution method. Next, the biofilm formation and inhibition were run through microtiter plate method using flexible U-bottom PVC 96 wells, which then observed using microplate reader on Î» = 515 nm. As The results, MIC for green and black tea extract stood at 4 mg/mL, 6 mg/mL respectively. The biofilm inhibitory activity of black tea extract was at 8 and 10 mg/mL inhibiting 6 % and 12.5 % S. mutans. Green tea extract showed that concentration of 4 to 10 mg/mL was able to inhibit biofilm growth by 24%; 45%; 48% and 53%. Thus, through microtiter plate assay, it could be concluded that tea extract has potent antibiofilm to S. mutans, where green tea extract has better activity than black tea extract.

Page 7 of 25 | Total Record : 247

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Muhammad Sulaiman Zubair

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Kota palu,

Sulawesi tengah

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Home Page

OAI Link

Editorial Team

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Contact Name Muhammad Sulaiman Zubair

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Phone +6285242083654

Journal Mail Official jurnalgalenika.farmasiuntad@gmail.com

Editorial Address Jurusan Farmasi Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Tadulako

Location Kota palu, Sulawesi tengah INDONESIA

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Contact Name
Muhammad Sulaiman Zubair

Contact Email
sulaiman_zubair80@yahoo.co.id

Phone
+6285242083654

Journal Mail Official
jurnalgalenika.farmasiuntad@gmail.com

Editorial Address
Jurusan Farmasi Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Tadulako

Location
Kota palu,

Sulawesi tengah

INDONESIA