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Jurnal Farmasi Galenika (Galenika Journal of Pharmacy)
Published by Universitas Tadulako
ISSN : 24427284     EISSN : 24428744     DOI : https://doi.org/10.22487/j24428744
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (E-ISSN: 2442-8744) (p-ISSN: 2442-7284), is an open access journal (print and e-journal) focusing on the scientific works in the field of Pharmacy and Pharmaceutical Science. The articles of this journal are published every six months, that is March and October (2 issues per year). This journal is developed by Department of Pharmacy, Faculty of Mathematics and Natural Science, Tadulako University and has been identified in Crossref with the DOI Number : 10.22487/j24428744. Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) has been accredited by Kemenristekdikti as Sinta 3 starting from Volume 5 No 1 2019.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 247 Documents
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Review : Penggunaan Drosophila melanogaster Sebagai Organisme Model Dalam Penemuan Obat: Review : Application of Drosophila melanogaster as Model Organism in Drug Discovery Nainu, Firzan
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 4 No. 1 (2018): (March 2018)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (571.176 KB) | DOI: 10.22487/j24428744.2018.v4.i1.9969

Abstract

Uji pra-klinis kandidat obat baru menggunakan organisme model yang sesuai adalah salah satu fase yang wajib dilaksanakan dalam proses penemuan obat. Namun, seiring dengan meningkatnya perhatian masyarakat dunia terhadap etika penggunaan organisme model tradisional seperti mencit dan tikus, keberadaan organisme model alternatif pun sangat diperlukan. Untuk tujuan tersebut, lalat buah Drosophila melanogaster merupakan salah satu model yang patut diperhitungkan. Selain sejarah penggunaannya yang telah cukup lama, organisme model ini merupakan serangga di balik kesuksesan ilmuwan dalam mempelajari patogenesis penyakit mulai dari penyakit neurodegeneratif hingga sindrom metabolik terkait obesitas dan diabetes melitus. Oleh karena itu, tidaklah mengherankan jika delapan medali Nobel telah diberikan kepada para peneliti yang menggunakan Drosophila dalam eksperimen mereka. Pemetaan genom yang telah berhasil dilakukan menunjukkan bahwa Drosophila memiliki kemiripan genetik sekitar 75% dengan manusia. Ditunjang dengan ketersediaan berbagai model penyakit baik melalui manipulasi genetik (mutan/transgenik) maupun melalui induksi secara kimiawi, Drosophila merupakan organisme model yang sangat menjanjikan untuk digunakan dalam riset biomedik. Dengan tersedianya berbagai model penyakit dan informasi terkait Drosophila melanogaster yang mudah untuk diakses, penggunaan model penyakit berbasis lalat buah dalam proses penemuan obat merupakan salah satu terobosan yang layak untuk dipertimbangkan. Bukan tidak mungkin jika di kemudian hari model mungil ini akan menggantikan penggunaan hewan model tradisional dalam pengujian pra-klinik kandidat obat baru.
Pemberian Citicoline pada Tikus Cedera Saraf Mentalis: Ekspresi Gen SIRT1 Ganglion Trigeminal: The Administration of Citicoline on Rat Model with Mental Nerve Crush Injury: Gene Expression of Trigeminal Ganglion SIRT1 Pakaya, David; Tinta, Iniche; Ibrahim, Elfiana; Amri, Imtihanah
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 4 No. 1 (2018): (March 2018)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (231.861 KB) | DOI: 10.22487/j24428744.2018.v4.i1.10005

Abstract

Cedera saraf perifer menyebabkan jumlah neuron menurun di ganglion sensorik, sehingga regenerasinya tidak baik. Pemberian Citicoline telah dilaporkan dapat memperbaiki kondisi fungsi motorik dan mencegah nyeri neuropati pada model tikus cedera saraf perifer. Pada ganglion sensorik, peningkatan regenerasi terkait dengan SIRT1 yang mendorong kelangsungan hidup neuron. Penelitian ini bertujuam untuk menguji hipotesis bahwa pemberian citicoline meningkatkan ekspresi gen SIRT1 fase akut pada model tikus cedera saraf mentalis. Setelah dianestesi, saraf mentalis kanan dijepit dengan klem tanpa gerigi selama 30 detik. Tikus-tikus dibagi menjadi 3 kelompok, kelompok operasi sham, kelompok cedera dan kelompok citicoline. Citicoline diberikan secara i.p. 50 mg/kg BB/hari selama 7 hari. Tikus dinekropsi pada hari ke-1, 3 dan 7 setelah cedera. Pada hari ke-1,3,7 (3 tikus per kelompok), ganglion trigeminal kanan dipotong dan diekstraksi RNA, reverse transcriptase PCR dan qPCR untuk melihat ekspresi gen SIRT1. Hasil penelitian menunjukkan peningkatan ekspresi SIRT1 hari ke-7 setelah cedera saraf mentalis tikus yang diberikan terapi citicoline i.p. Sebagai kesimpulan, pemberian citicolin segera setelah cedera saraf mentalis meningkatkan ekspresi SIRT1 pada hari ke-7.
Studi Perbandingan Komposisi Asam Lemak Daging Ikan Sidat (Anguilla marmorata (Q.) Gaimard) Fase Yellow Eel Dari Sungai Palu Dan Danau Poso: Comparative Study of Fatty Acid Composition of Sidat Fish Meat (Anguilla marmorata (Q.) Gaimard) Yellow Eel Phase From Palu River and Poso Lake Jamaluddin, Jamaluddin; Amelia, Putri; Widodo, Agustinus
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 4 No. 1 (2018): (March 2018)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (635.33 KB) | DOI: 10.22487/j24428744.2018.v4.i1.10035

Abstract

Ikan sidat (Anguilla marmorata (Q.) Gaimard) memiliki keunggulan gizi atau nutrisi yang tinggi seperti vitamin A, vitamin B, vitamin C, vitamin D, vitamin E, protein, mineral, dan asam lemak yang baik bagi kesehatan. Penelitian ini bertujuan untuk menentukan kadar asam lemak, dan membandingkan komposisi asam lemak dari ikan sidat fase yellow eel asal sungai Palu dan danau Poso. Penelitian ini menggunakan metode kromatografi gas dengan mengubah ekstrak lemak menjadi metil ester asam lemak. Hasil analisis komposisi asam lemak daging ikan sidat (Anguilla marmorata (Q.) Gaimard) fase yellow eel asal sungai Palu dan Danau Poso menunjukan kadar asam lemak jenuh masing-masing 2,766g/100g dan 0,275g/100g; asam lemak tak jenuh tunggal 4,029g/100g dan 0,276g/100g; dan asam lemak tak jenuh ganda 0,541g/100g dan 0,102g/100g. Terdapat perbedaan secara statistik (p<0.05) komposisi dan kadar asam lemak antara daging ikan sidat fase yellow eel asal sungai Palu dan danau Poso. Komposisi asam lemak ikan sidat fase yellow eel asal sungai Palu dan danau Poso masing-masing adalah 23 dan 18 jenis. Asam lemak yang ditemukan pada daging ikan sidat sungai Palu dan tidak ditemukan pada ikan sidat danau Poso adalah asam heneikosenoat, asam miristoleat, Cis-10-pentadekanoat, asam gamma linoleat, dan Cis-11,14,17-eikosatrinoat.
Mutu Minyak Jelantah Dengan Adsorben Biji Salak (Salacca zalacca (Gaertn.)Voss) menggunakan Parameter Bilangan Peroksida dan Asam Lemak Bebas: Quality of Used Cooking Oil With Snake Fruit (Salacca zalacca (Gaertn.) Voss) Seed Adsorbent Using Parameters of Peroxide Value and Free Fatty Acids Ihwan Ihwan; Fadlia Fadlia; Syariful Anam
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 5 No. 2 (2019): (October 2019)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (256.421 KB) | DOI: 10.22487/j24428744.2019.v5.i2.10070

Abstract

Quality of used cooking oil with snake fruit (Salacca zalacca (Gaertn.) Voss) seed adsorbent has been conducted. This study aims to determine the ability of snake fruit seed in reducing peroxide value and free fatty acids in used cooking oil which can improve the quality and extend usage lifespan of the used cooking oil. The oil sampled in this study was packaged cooking oil which is usually used to fry food untill 7th frying. The oil was then neutralized using snake fruit activated charcoal. The test refers to the Indonesian National Standard (SNI) 7709: 2012 as the quality requirements of cooking oil. The results showed that snake fruit activated charcoal can reduce peroxide value as much as 56.18% and free fatty acid 76.04% in the used cooking oil.
Green Synthesis Nanopartikel Perak (Agnps) Terkonjugasi Etil Parametoksi Sinamat (Epms) sebagai Bahan Tabir Surya: Green Synthesis of Nanopartikel Perak (Agnps) Terkonjugasi Etil Parametoksi Sinamat (Epms) Sebagai Bahan Tabir Surya Agustina, Agustina; Munawarah, Munawarah; Lumi, Stefanus Agustinus; Nur, Syamsu
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 4 No. 2 (2018): (October 2018)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (333.247 KB) | DOI: 10.22487/j24428744.2018.v4.i2.10440

Abstract

Green Synthesis is a method to make silver nanoparticles (AgNPs) by utilizing natural materials as bioreductors. One of the natural materials that can reduce metal ions is Kaempferia galanga rhizome because it has a chemical component that can penetrate the metal. The compounds are ethyl paramethoxycinnamate (EPMC) which is used as sunscreen. This study aims to produce AgNPs conjugated with EPMC that can be used as raw material sunscreen. This study was conducted by extracting EPMS from the Kaempferia galanga rhizome and synthesizing the AgNPs conjugated with EPMC. The synthesis results were characterized by UV-Vis Spectrophotometry, FTIR, SEM, PSA and sunscreen activity. Extracted result was obtained crystalline is ethyl paramethoxycinnamate compound with yield 2,3%. The characterization of EPMC with UV-Vis spectrophotometer was obtained maximum wavelength of 308 nm and FTIR analysis result at wave number 1701,27 cm-1 indicated the presence of carbonyl group (C = O) and 1165,97 cm-1 presence of C-O and showed specific characteristic from EPMS. Characterization of AgNPs using Uv-Vis spectrophotometer was obtained maximum wavelength of 469 nm. Characterization of AgNPs using SEM are spherical and monodispers forms. Then, particle size using PSA obtained an average diameter of 182 nm. AgNPs conjugated with EPMS has a sunscreen activity with sunblock category and successfully provide protection against UV exposure at low concentration (200 ppm) categorized as ultra protection with SPF value 36,4.
The Incidence and Risk Factor Analysis of Drug Induced Liver Injury (Dili) in a Surabaya Hospital Arrang, Sherly Tandi; Widyati, Widyati
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 4 No. 2 (2018): (October 2018)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (314.696 KB) | DOI: 10.22487/j24428744.2018.v4.i2.10459

Abstract

The research has been conducted on the incident and analysis of risk factors drug liver injury (DILI) in a Surabaya Hospital. The aim of this study was to determine the incident of DILI, know which drugs cause DILI, and see the association of risk factors to DILI. The research method was descriptive and analytical observational (prospective cohort). Danan-Benichou scale is a tool used to ascertain drugs that cause DILI. Based on data collected for 3 months, the population was 1202 patients. Samples fulfilling the inclusion and exclusion criteria were 310 patients, the risk drug group of DILI were 285 patients (11 DILI, 274 Non-DILI), and the non-risk drug group 25 patients (11 DILI, 14 Non-DILI). The incident of DILI was 3.55%. Drugs that cause DILI are ranitidine (4 cases), omeprazole (1 case), rifampicin (2 cases), meropenem (1 case), ciprofloxacin (1 case), methotrexate (1 case), and dexamethasone (1 case). Characteristic of patients with DILI (11 patients) are average age of 59.27 ± 15.54 years (23-73 years), belonging to high risk group (54.55%), male gender (81,82%), have moderate comorbid disease (54.55%), and are not comsumsing alcohol (100%). This research use logistic regression analysis through SPSS 17.0 program to see the relation of risk factor to DILI incident. The p results were obtained from sex (0,156), age (0,534), and comorbid isease (0,213)> α (0,05) which means gender, age, and comorbid disease do not significantly affect the incident of DILI.
Efek Sinergitas Ekstrak Kulit Jeruk (Citrus sinensis L) Pada Patch Bioselulosa Dalam Meningkatkan Penyembuhan Luka Bakar: Synergetic Effect of Orange Peel Extract in Biocellulose Patch Toward Burn Wound Healing Roska, Tri Puspita; Sahati, Syahidah; Fitrah, Andi Dinul; Juniarti, Nana; Djide, Natsir
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 4 No. 2 (2018): (October 2018)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (128.748 KB) | DOI: 10.22487/j24428744.2018.v4.i2.10472

Abstract

Burns is one of the incidents that can lead to death (mortality). One of the natural products that have potential to serve as an alternative treatment of burns is orange peel. Orange peel has a chemical composition such as ascorbic acid, vitamin E, vitamin A, and polyphenols as antioxidants that inhibit free radicals responsible in the pathogenesis of both acute and chronic inflammatory. In this study, formulation was made in the form of biocellulose which is the primary metabolism product of bacteria. The purpose of this research was to obtain the concentration of the extract of orange peel on bioselullose that have the effect of decreasing the burn wound in rats. Orange peel was extracted then fortified into biocellulose with a concentration of 3%, 6%, and 9%. After that, the wound healing was tested on animals in the form of decreasing the wound diameter. The results showed that the concentration of extract of orange peel 3% on the fortification of biocellulose showed the good percentage of burn wound decreasing i.e. 45.52% with diameter average of 18.35 mm. This result indicates the concentration of extract of orange peel 3% is better than others.
Sinergitas Aktivitas Antibakteri dari Kelopak Bunga Rosella dan Kitosan Terhadap Staphylococcus aureus: Synergistic Antibacterial Activity of Roselle Calyx and Chitosan against Staphylococcus aureus Haeriah, Haeriah; Djide, Natsir; Alam, Gemini; Sartini, Sartini
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 4 No. 2 (2018): (October 2018)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (233.522 KB) | DOI: 10.22487/j24428744.2018.v4.i2.10590

Abstract

Currently, the antibacterial research is increasingly promoted primarily from natural materials, due to the increasing number of pathogenic bacteria that have been resistant to existing antibiotics. One of the pathogenic bacteria that has been much resistant to antibiotics is Staphylococcus aureus. Rosella calyx (Hibiscus sabdariffa L.) and chitosan are known to have antibacterial activity. The aim of this study to find out the antibacterial synergy of the roselle calyx extract and chitosan against. S.aureus ATCC 33592. Rosella calyx was extracted by maceration using 80 % ethanol, while chitosan is obtained from deasetilation chitin of shrimp husk. Test antibacterial synergism using checkboard assay method by calculating the minimum inhibitory concentration (MIC) using microdilution assay. The results showed minimum inhibitory concentration (MIC) value of roselle calyx extract and chitosan were 1250 ppm and 50 ppm, respectively. MIC value of rosella calyx extract in the presence of chitosan was 625 ppm, while the value of MIC chitosan in the presence of rosella calyx extract was < 0.19 ppm. Fractional Inhibition Concentration Index (FICI) was < 0.5 which concluded that the combination of roselle calyx extract with chitosan has a synergistic antibacterial effect on S.aureus ATCC 33592.
Mikroenkapsulasi Antosianin Kulit Buah Kakao (Theobroma cacao L.) Dengan Metode Koaservasi Kompleks: Microencapsulation of Anthocyanine of Kakao (Theobroma cacao L.) Bark with Complex Coaservation Lubis, Siska Syahfitri; Sulastri, Evi; Zubair, Muhammad Sulaiman
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 4 No. 2 (2018): (October 2018)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (282.959 KB) | DOI: 10.22487/j24428744.2018.v4.i2.11077

Abstract

Anthocyanin is a class of antioxidants that are widely found in the skin of cocoa fruit (Theobroma cacao L.). Anthocyanin degradation occurs not only during the extraction process from plant tissues but also during the storage process. The microencapsulation process can protect the active substance from environmental influences or improve the stability of the preparation. This study aims to characterize anthocyanin microcapsules from cocoa (Theobroma cacao L.) fruit peel using a complex coacervation method, therefore, it can provide economic value added from this plant. Anthocyanin microencapsulation was formulated using a coating of gelatin: arabic gom with different concentrations of 1:1, 3:2, and 2:1. Microcapsule characterization was organoleptic and morphological test, particle size distribution, moisture content test, absorption efficiency, recovery test, antioxidant activity of the preparation, and FTIR analysis. The results showed that extract yield was 39.82%, optimum microcapsule characterization was obtained from 1: 1 concentration with 36.65% recovery test, 80.40% absorption efficiency, and antioxidant activity with IC50 of 20.52 ppm.
Aktivitas Ekstrak Etanol Kulit Batang Kayu Jawa (Lannea coromandelica) terhadap Penyembuhan Luka Sayat pada Tikus Putih (Rattus Norvegicus L.): Activity of Ethanolic Extract of Jawa Bark (Lannea coromandelica) on Healing Wound at White Rat (Rattus Norvegicus L.) Calsum, Umi; Khumaidi, Akhmad; Khaerati, Khildah
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 4 No. 2 (2018): (October 2018)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (138.494 KB) | DOI: 10.22487/j24428744.2018.v4.i2.11078

Abstract

Jawa bark (Lannea coromandelica) is a part of the plant that can be used empirically for handling wounds. This study aims to determine the activity of ethanol extract of Jawa bark on healing wound and determine the effective dose compared with povidone iodine. The test animals used were white rats (Rattus norvegicus L.) consisting of 5 groups, namely negative control (vaseline without extract), positive control (povidone iodine), dose of 250 mg/kg BW, dose of 500 mg/kg BW, dose of 750 mg/kg BW. Each rat made an incision in the area parallel to the spine with 2 cm long and 2 mm deep. Measuring the length of the wound was done every day for 14 days. The data obtained were analyzed statistically using One Way Anova and followed by Post Hoc Duncan test. Statistical results showed that the ethanol extract of Jawa bark has an activity in curing slice where the effective dose is a dose of 500 mg/kg BW with a wound healing time of 12 days.

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