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Jurnal Farmasi Galenika (Galenika Journal of Pharmacy)

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Published by Universitas Tadulako

ISSN : 24427284 EISSN : 24428744 DOI : https://doi.org/10.22487/j24428744

Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (E-ISSN: 2442-8744) (p-ISSN: 2442-7284), is an open access journal (print and e-journal) focusing on the scientific works in the field of Pharmacy and Pharmaceutical Science. The articles of this journal are published every six months, that is March and October (2 issues per year). This journal is developed by Department of Pharmacy, Faculty of Mathematics and Natural Science, Tadulako University and has been identified in Crossref with the DOI Number : 10.22487/j24428744. Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) has been accredited by Kemenristekdikti as Sinta 3 starting from Volume 5 No 1 2019.

Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi

Articles 247 Documents

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Modifikasi Serat Limbah Kubis Menjadi Nanokristalin Selulosa Melalui Metode Hidrolisis Asam: Waste Cabbage Fibers Modification Into Nano-Crystalline Cellulose Via Acid Hydrolysis Method Arjuna, Andi; Natsir, Selva; Khumaerah, Andi Amelia; Yulianty, Risfah
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 4 No. 2 (2018): (October 2018)
Publisher : Universitas Tadulako

As one of vegetable plants in South Sulawesi, cabbage (Brassica oleracea L.) crops has generated cellulose fibers biomass which is potentially modified into nano-crystalline cellulose, a valuable material in the pharmaceutical formula. Therefore, this study aims to manipulate the natural cellulose fibers of cabbage biomass through acid hydrolysis method within product preliminary evaluation through FT-IR and XRD. The fibers were modified through the bleaching process produce micro crystalline cellulose, which was then hydrolyzed with 65% sulfuric acid to obtain nanocrystalline cellulose. The products have yellow pale to brown colour, with a yield of 10.06% and 31.16% respectively. Based on FT-IR spectra, both products inherit cellulose characteristics, C-O (1232.16 cm-1); C = O (1743.65 cm-1); -OH (1625.99 cm-1); C-H (2920.23 cm-1); O-H (3414 cm-1). The increasing trend of crystallinity index during the process was also observed in XRD diffractogram. It is identifiable from 7.41% for natural fiber, 69.68% for crystalline microcrystalline, and 78.01% for nano crystalline cellulose. Through MatchÂ®, the estimated crystalline product size reaches 58.91 nm.

Analisis Zerumbone Dalam Zingiber zerumbet Dan Aktivitas Penghambatannya Terhadap Bakteri Mycobacterium tuberculosis: Analysis of zerumbone in Zingiber zerumbet and inhibitory activity against Mycobacterium tuberculosis Lallo, Subehan; Kasim, Syaharuddin; Tayeb, Rosany; Hasan, Asril Damiyanto; Sere, Hartina; Ismail, Ismail; Arifin, Tamsil
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 4 No. 2 (2018): (October 2018)
Publisher : Universitas Tadulako

Zerumbone has been reported for their several biological activities. In our interest to this compound, we have identified and analyzed its content in Zingiber zerumbet, a medicinal plant from Indonesian traditional medicine and investigated its inhibitory activity against Mycobacterium tuberculosis, a known infection bacteria of tuberculosis. Analysis of zerumbone was performed with densitometry to leave, rhizome, flower, and stem of Z. zerumbet which was extracted with various solvent system and extraction methods to determine the best method to isolate zerumbone from Z. zerumbet. Result showed that the highest zerumbone was in rhizome while was not observed in other part. Analysis with various solvent and extraction methods showed the highest yield of zerumbone can be extracted by n-hexane (maceration) and reflux extraction method (methanol). Furthermore, inhibitory activity of zerumbone against M. tuberculosis was tested using Lowenstein Jensen medium by counting the number of M. tuberculosis colony growth in medium. Resulted inhibitory activity of zerumbone at all test concentration (0.5, 0.1, 0.05, 0.01, 0.005%) with the growth of 10, 12, 14, 15, and 50 colonies of M. tuberculosis was observed, respectively. This is indicate that zerumbone can be used as an alternative choice for treatment tuberculosis in the future.

Efektivitas Kombinasi Ekstrak Etanol Daun Bunga Matahari dan Tanaman Anting-Anting sebagai Antimalaria Secara In Vivo: Effectiveness of Ethanol Extract Combinations of Sunflower (Helianthus annuus) Leaves and Anting-anting (Acalypha indica Linn) as In Vivo Antimalarial Ngibad, Khoirul
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 5 No. 1 (2019): (March 2019)
Publisher : Universitas Tadulako

Sunflower (Helianthus annuus) and anting-anting (Acalypha indica Linn), can be studied as efficacious malaria medicinal plants for preventing the development of malaria plasmodium resistance. This study aims to determine the effectiveness of the combination of 80% ethanol extract of sunflower leaves and anting-anting as antimalarials. This study included extraction of sunflower leaves and anting-anting plant separately using the maceration method for 24 hours with 80% ethanol. Stirring is aided by a 3 hour shaker and then the obtained extracts were mixed and tested in vivo antimalarial activity against mice test animals. Data of the parasitemia degree was analyzed for the determination of Effective Dose (ED50) using probit analysis then determination of Combination Index (CI) value. The results of the antimalarial activity test on tested mice were ED50 of 1.23 mg/kg human body with a Combination Index (CI) of 0.46 (CI <1) which means synergistic potency.

Edukasi Anti Penyalahgunaan Obat Kepada Siswa SD Di Kota Palu Melalui Media Kartu Kuartet: Education of Anti-drug Abuse for Elementary School Students in Palu Citythrough Quartet Card Media Hannan, Hannan; Wikaningtyas, Pratiwi; Adnyana, I Ketut
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 5 No. 1 (2019): (March 2019)
Publisher : Universitas Tadulako

Cases of illegal drugs and drug abuse in the elementary school community in Indonesia is increasingly massive and alarming. An innovation to protect elementary school students from that situation is through the colaboration of academics from Bandung Institute of Technology with FDA in Palu in the form education of anti-drug abuse for elementary school students through quartet card media. The aim of the study was to determine the effect of the education on anti-drug abuse knowledge in fifth grade students in Palu City. The research method used pre-experimental design with the design of one group pretest-posttest on three elementary schools which were representatives of three ranks namely; good, quite good and not good based on the results of the Smart-Accurate Quiz FDA in Palu for elementary school level in 2017. The sampling technique used purposive sampling. Observation of knowledge of elementary students using questionnaires that have been tested for validity and reliability had been carried out. The pretest and posttest were conducted before and after education. The comparison of pretest and posttest data in each elementary school was analyzed using paired T test whereas for all elementary school data analyzed using the Wilcoxon test with hypotheses. There was an influence of anti-drug abuse education through quartet card media on anti-drug abuse knowledge in fifth grade students in Palu City. The results showed that there was an influence of education on anti-drug abuse knowledge in fifth grade students from elementary school representatives â€œgood and quite good rankingâ€ with p values of 0.005 and p â‰¤ 0.001, while in elementary schools representatives â€œnot good rankingâ€, the education did not influence their knowledge with a p value of 0.149. Analysis of the Wilcoxon test in all elementary schools showed a p value p â‰¤ 0,001, which meant that education had an influence on the knowledge of fifth grade students in elementary schools in Palu City.

Kajian Heat Shock Protein 90 (HSP90) dalam Pencarian Kandidat Penghambatnya melalui Ekplorasi Bahan Alam Indonesia: Review On Heat Shock Protein 90 (HSP90) for Exploration of Its Inhibitor Candidates through Indonesian Natural Resources Sitepu, Rehmadanta
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 5 No. 1 (2019): (March 2019)
Publisher : Universitas Tadulako

Exploration on anticancer candidates on inhibition of Heat Shock Protein (HSP) activity are increasing in the past ten years. Some of HSP90 inhibitor candidates were in third phase of clinical trials. However, this issue is not followed by the emergency of HSP90 inhibitor research in Indonesia, not only study on natural source but also on synthetic candidates. This study aims to look the development of tracking HSP90 inhibitor candidates globally so that it can initiate the related research in Indonesia. Study of HSP90 and its inhibitors were taken from scientific articles in the range from 2009 to 2018. HSP90 and its inhibitors have important values in the dynamics of functions and stability of proteins to maintain survival of cells. This also include the oncogene proteins that involve in cell proliferation such as tyrosine kinases, transcription factors, and regulatory proteins that expression and interaction depend on HSP90. Expression of the transcription factor p53, Alk gene, Wnt gene, glucocorticoid receptors have also links with HSP90 protein activity. Some candidates for inhibitor of HSP90 have been entering clinical trials such as geldanamycin analogues, resorcinol derivatives, and purines analog. Candidates from natural sources that are also being developed such as luteolin, licochalcone A, oleochantal, novobiocin, epigallocathecin gallat, silybin, deguelin, and celastrol from terpenoid class, Apigenin from flavon class, Curcumin, and Gambogat Acid. HSP90 inhibitors which are entering the third phase of clinical trial are ganetespib from the resorcinol derivative and retaspimycin from geldanamisin analog group. Exploration of HSP90 inhibitors from Indonesia natural resources still have great potential to be developed because they have high impact values as anticancer candidates.

Fungi Endofit dari Tanaman Secang (Caesalpinia sappan L) Sebagai Penghasil Senyawa Antioksidan: Endophytic Fungi from Secang (Caesalpinia sappan L) as Producer of Antioxidant Compounds Amirullah, Amirullah; Sartini, Sartini; Nainu, Firzan
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 5 No. 1 (2019): (March 2019)
Publisher : Universitas Tadulako

Endophytic fungi are microbes that reside symbiotically in the plant tissues with undetected negative impacts to their host plants. These fungi are able to produce elements similar to those produced by their host plants. Secang (Caesalpinia sappan L.) has been known as one of the medicinal plants that contains compounds with antioxidant activity thus promote a hypothesis that its endophytic fungi may yield a similar antioxidant effect. In this study, the isolation of endophytic fungi from Secang as the producer of antioxidant compounds was carried out. At the initial stage, endophytic fungi were isolated from the leaves, the twigs, the stems, and the rootsof Secang using the agar plate method. Pure fungi isolates were then subjected to fermentation process using the PDBgrowth medium supplemented with yeast extractand wereconstantly shaken for 12 days at a speed of 200 rpm to produce secondary metabolites. Fermentatesobtained from all fungi isolates were then extracted using ethyl acetate and further tested for their antioxidant activities. In this study, of 19 isolates that were obtained from four parts of the Secang, five fungi isolates, coded as IFD1, IFD4, IFR5, IFA1, and IFA2 were found to yield antioxidant activities demonstrated by the presence of yellow spots on the chromatogram. elementary schools representatives â€œnot good rankingâ€, the education did not influence their knowledge with a p value of 0.149. Analysis of the Wilcoxon test in all elementary schools showed a p value p â‰¤ 0,001, which meant that education had an influence on the knowledge of fifth grade students in elementary schools in Palu City.

Korelasi Antara Kadar Total Flavonoid dan Fenolik dari Ekstrak dan Fraksi Daun Jati Putih (Gmelina Arborea Roxb.) Terhadap Aktivitas Antioksidan: Correlation Between Total Phenolic and Flavonoid Contents of Jati Putih (Gmelina arborea Roxb.) Leaves Extract and Fraction Toward Antioxidant Activity Nur, Syamsu; Sami, Fitriyanti Jumaetri; Awaluddin, Akbar; Afsari, Mutiara Indah Ayu
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 5 No. 1 (2019): (March 2019)
Publisher : Universitas Tadulako

This experiment aims to determine the correlation of total phenolic and flavonoid content of jati putih leaves fraction (Gmelina arborea Roxb.) towards Antioxidant activity . Sample was extracted by maceration method using ethanol 70% to obtain the ethanol extract (EE), followed by liquid-liquid extraction method to obtain fraction of ethyl acetate (EA) and n-Hexane (EH). The phytochemical screening and determination of total phenolic and flavonoid content were done by colorimetric method. Antioxidant activity were done by DPPH, FRAP and ABTS methods. Phytochemical screening showed positive results for flavonoids, phenolic and saponins. The largest total phenolic content was found on EA (11,59 Âµg/ml Â± 0,3 %b/b EAG) and the largest total flavonoid content was on EA (3,88 Âµg/ml Â± 0,02 %b/b EK). The total phenolic and flavonoid content of Jati putih leaves has a correlation with antioxidant activity. The coefficient correlation of activity on reducingDPPH radical was 56,7% (total of phenolic content) and 57,8% (total of flavonoid content) and on iron reduction power in FRAP method was 99,9% (total of phenolics and flavonoids content). The relationship with the activity in reducing radical ABTS obtained coefficient correlation of 57,0% and 58,1% for total phenolic and flavonoids contents, respectively.

Validasi Metode Analisis Cemaran DNA Babi pada Bakso Sapi Menggunakan Primer Mitokondria D-Loop22 dengan Metode Polymerase Chain Reaction (PCR): Analysis Method Validation of Pig DNA Contamination in Cow Meatballs Using Mitochondrial Primer D-Loop22 by Polymerase Chain Reaction (PCR) Method Wahyuni, Sri; Maryam, Siti; Aminah, Aminah
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 5 No. 1 (2019): (March 2019)
Publisher : Universitas Tadulako

The frequency of non-halal ingredient mixing, such as porkin on the food processed products of meatballs, has become an issue to the public, especially for moslems. Therefore, a reliable and valid method with high sensitivity is needed to specifically detect the pig contamination. This research aims to obtain a valid and reliable method by proposing polymerase chain reaction (PCR) using mitochondrial D-Loop22 primer as a method in handing halal food authentication. The sample consisted of beef as a negative control, pork and pork meatballs as a positivecontrol, and five samples of meat balls found in Makassar for halal inspection.The method validation assay was conducted by testing the primary specificity on the fresh tissue (beef and pork) and testing the sensitivity by making a series of pig DNA dilution (1:10; 1:102; 1:103; 1:104) and the variations of contaminated pig:cow (%b/b) : 0.05% , 0.1%, 1%, and 5%. The result of PCR amplification on agarose gel electrophoresis of 0.8% showed that method was able to detect the pig DNA contamination specifically in pigs and not amplify other DNA, and could still be detected up to pig contamination specifically in pigs and not amplify the other DNAs and could still be detected up to pig contamination of 0.05% and on DNA dilution of 1:103. Meanwhile, on the five samples analyzed, there were not found pig DNA contamination characterized by no formed amplification bands.

Analisis Cemaran DNA Tikus pada Bakso Daging Sapi yang Beredar di Makassar dengan Metode Polymerase Chain Reaction (PCR): Analysis of Rat DNA Contamination on Beef Meatballs Circulating in Makassar by Polymerase Chain Reaction (PCR) Method Aminah, Aminah; Ramadini, Ristieyen; Naid, Tadjuddin
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 5 No. 1 (2019): (March 2019)
Publisher : Universitas Tadulako

Analysis of rat DNA contamination in meatball meat circulating in Makassar by PCR (Polymerase Chain Reaction) method has been carried out. In this study, a polymerase chain reaction method will be developed to analyze the presence of rat meat contamination in beef meatballs. There are three stages in the PCR amplification process carried out with 30 cycles, which are 95oC temperature denaturation, 51oC attachment, and 72oC extension. DNA analysis included agarose gel electrophoresis, measurement of concentration and purification, and analysis of rat DNA using PCR. The results of PCR amplification using mouse-specific primers namely primary ND1 (NADH dehydrogenase 1) showed no bands seen in UV light. So that it can be proven that beef meatball samples in the Makassar region did not contain rat DNA. t.

Review: Farmasi Sosial dan Administratif: Review: Social and Administrative Pharmacy Saud, Anshar
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 5 No. 1 (2019): (March 2019)
Publisher : Universitas Tadulako

In the health care system, pharmaceutical care systems are one of the core components and pharmacists play a very important role. With the dynamic changes that occur in health services, diseases, communication and regulatory information technology, the roles and responsibilities of pharmacists are becoming increasingly important than before. Pharmacists are dedicated and in a strategic position to maintain and advance public health. Their efforts improve the quality of life of individuals by helping people to live as freely as possible from illness, pain, and suffering. One of the obligations of pharmacists is to educate the public about health and drug use. Pharmacy practices involve pharmacists, patients, other professional health personnel and the public can be conceptualized as a social process. Therefore, understanding the concepts and principles behind social pharmacy disciplines is very essential and useful for a pharmacist and pharmacy student. The purpose of this article review is to briefly review a number of important topics concerning social, behavioral and administrative aspects in pharmacy to achieve a stronger understanding of dynamic and complex interactions between patients, pharmacists, drugs, teams of health workers, organizations and larger social systems. Mastery of students and pharmacists on this issue â€“ asa consequence of the inclusion of social and administrative aspects into the pharmacy's higher education curriculumâ€“willenable them to be professionally responsible for improving patient drug therapy outcomes as individuals, communities, society, and state systems; and have a greater impact on population health through drug-related public policies.

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Muhammad Sulaiman Zubair

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Jurusan Farmasi Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Tadulako

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Kota palu,

Sulawesi tengah

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Home Page

OAI Link

Editorial Team

Contact

Reviewer

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Contact Name Muhammad Sulaiman Zubair

Contact Email sulaiman_zubair80@yahoo.co.id

Phone +6285242083654

Journal Mail Official jurnalgalenika.farmasiuntad@gmail.com

Editorial Address Jurusan Farmasi Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Tadulako

Location Kota palu, Sulawesi tengah INDONESIA

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Contact Name
Muhammad Sulaiman Zubair

Contact Email
sulaiman_zubair80@yahoo.co.id

Phone
+6285242083654

Journal Mail Official
jurnalgalenika.farmasiuntad@gmail.com

Editorial Address
Jurusan Farmasi Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Tadulako

Location
Kota palu,

Sulawesi tengah

INDONESIA