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Nurul Marfu'ah
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INDONESIA
Pharmasipha
Published by Universitas Darussalam Gontor
ISSN : 25810820     EISSN : 25809202     DOI : http://dx.doi.org/10.21111/pharmasipha.v5i1.5706
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Clinical Pharmacy; Biology Pharmacy; Natural Product Pharmacy; Drug, food and cosmetics analysis; Chemistry Pharmacy; and Islamization of Pharmacy
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 186 Documents
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Formulasi sediaan deodoran spray ekstrak daun sirih merah (Piper crocatum Ruiz&Pav) dengan variasi alum (tawas) Kurniawan, Kurniawan; Kusumasary, Dhiyah Ayu; Estikomah, Solikah Ana; Marfu’ah, Nurul
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol. 7 No. 2 (2023): September
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v7i2.10665

Abstract

ABSTRACT One way to overcome body odor is by using deodorant. One of the herbal ingredients that can be used in deodorant formulations is Piper crocatum leaves. Piper crocatum leaves have numerous bioactive compounds as an antibacterial agent. Beside, the deodorants can be added with other ingredients for example, alum (KAl(SO4)2.12H2O) an antiperspirant. This study aims to determine the result of physical stability tests in deodorant spray formulations from Piper crocatum extract with variation of alum. Piper crocatum leaves were extracted using a maceration method with 70% ethanol solvent. The deodorant spray formulation uses Piper crocatum leaf extract with variation of alum at 0% (control), 10% (F-1), 20% (F-2) and 25% (F-3). The result were then tested for pH, organoleptic, homogeneity, spray power, dry time, and cloth effect. The result were then analyzed by comparing with the standard deodorant spray in the 1995 Pharmacopoeia and the 1998 Indonesian National Standard. The results showed that F-1 has the most standard test results covering organoleptic test results, homogeneity, pH, spray power, dry time and effect on fabrics. Keywords: alum, extract, deodorant spray, Piper crocatum,   ABSTRAK Salah satu cara untuk mengatasi bau badan adalah dengan cara menggunakan deodoran. Salah satu bahan herbal yang dapat digunakan dalam formulasi deodoran adalah daun sirih merah. Daun sirih merah memiliki senyawa yang memiliki kemampuan antibakteri. Selain bahan aktif, deodoran dapat ditambahi dengan bahan lain misalnya aluminium kalium sulfat yang berfungsi debagai antiperspiran. Penelitian ini bertujuan untuk mengetahui hasil uji stabilitas fisik dalam formulasi deodran spray dari ekstrak sirih merah dengan variasi alumunium kalium sulfat. Daun sirih merah diekstrak menggunakan metode maserasi dengan pelarut etanol 70%. Formulasi deodorant spray menggunakan ekstrak daun siirh merah dengan variasi aluminium kalium sulfat sebesar 0% (control), 10% (F-1), 20% (F-2) dan 25% (F-3). Hasil sediaan kemudian di uji pH, organoleptik, homogenitas, daya semprot, waktu kering, dan efek kain. Hasil pengamatan dianalisis dengan cara membandingkan dengan standar deodoran spray yang ada di Farmakope 1995 dan Standar Nasional Indonesia 1998. Hasil penelitian menunjukkan bahwa sediaan F-1 adalah sediaan yang memiliki hasil uji paling memenuhi standar meliputi hasil uji organoleptic, homogenitas, pH, daya semprot, waktu kering dan efek terhadap kain.     Kata kunci : alum, deodoran spray, ekstrak, sirih merah
Pengaruh Variasi Humektan pada Formulasi Hand Sanitizer serta Evaluasi Sediaan dan Daya Hambat terhadap Stapyhlococcus aureus Haryanto, Qurrah A'yuniyyah; Kurniawan, Kurniawan; Estikomah, Solikah Ana; Marfu'ah, Nurul
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol. 6 No. 2 (2022): September
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v6i2.7572

Abstract

The habits of the Indonesian people in carrying out hand hygiene activities are still very low with an average of only 12%. Along with the density of community activities, which consider hand washing a troublesome activity, it is also caused by the lack of clean water availability in the community. Therefore, there are hand sanitizer products that are practical without using water or commonly referred to as hand sanitizers. Hand sanitizer contains antiseptic substances that can kill germs on the palms due to the presence of alcohol (ethanol, propanol and isopropanol) and the phenol group (chlorhexidine and triclosan). Alcohol has the ability to inhibit bacterial growth, both against gram-positive and gram-negative bacteria, including MRSA (Methicilin Resistant of Staphylococcus aureus). The purpose of this study was to determine the effect of humectant variations on the evaluation of the preparation and the inhibition of Staphylococcus aureus bacteria. The results of the evaluation of the preparation of the hand sanitizer formulation are in accordance with the SNI No. 06-2588-1992, namely on the parameters of homogeneity, pH and dispersion. Meanwhile, the viscosity parameter is not in accordance with the standard. Variations in humectant concentration affect the evaluation of the preparation of the hand sanitizer gel formulation on the parameters of pH and dispersion. The formulation that had the greatest inhibition zone against Staphylococcus aureus was the formulation with the highest humectant concentration of propylene glycol, namely formulation 3 with an inhibitory power of 22.8 mm.
Gambaran perilaku vulva hygiene dan swamedikasi yang dilakukan oleh mahasiswi UNIDA Gontor dalam mengatasi keputihan Marfu'ah, Nurul; Khodijah, Alisya; Fatihah, Nadia Iha
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol. 8 No. 2 (2024): September
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v8i2.7575

Abstract

Keputihan adalah salah satu permasalah yang sering dialami wanita. Gangguan ini dapat disebabkan karena perilaku vulva hygiene yang kurang tepat seperti menggunakan celana dalam yang tidak menyerap keringat, jarang mengganti pembalut, dan cara membersihkan daerah kewanitaan yang kurang tepat. Berdasarkan latar belakang di atas, maka penelitian ini dilakukan dengan tujuan untuk mengetahui prevalensi, gambaran perilaku vulva hygiene, dan swamedikasi penyakit keputihan pada mahasiswi UNIDA Gontor. Penelitian ini merupakan penelitian non eksperimental yang dilakukan dengan metode observasional menggunakan kuisioner dan wawancara. Teknik pengambilan sampel dilakukan menggunakan metode purposif sampling sehingga diperoleh 95 orang mahasiswi sebagai responden (yang mengalami keputihan normal maupun tidak normal). Data yang didapatkan kemudian diberi skor menggukan 4 skala linkert dan selanjutnya dipersenkan. Analisis data menggunakan metode deskriptif kuantitatif. Hasil penelitian menunjukkan bahwa prevalensi keputihan pada mahasiswi tahun 2021 dari jumlah mahasiswi sebanyak 1.652 orang, terdapat mahasiswi yang jarang mengalami keputihan sebanyak 82% (1.348 orang), sering mengalami keputihan sebanyak 15% (257 orang), dan tidak pernah mengalami keputihan sebanyak 3% (47 orang). Perilaku vulva hygiene pada mahasiswi dari 95 responden didapatkan hasil perilaku dalam menjaga kebersihan organ kewanitaan kategori sangat baik sebanyak 65,26% dan kategori baik sebanyak 34.74%. Swamedikasi yang dilakukan mahasiwi dari 95 responden didapatkan hasil mahasiswi yang dapat melakukan swamedikasi dalam mengatasi keputihan kategori sangat baik sebanyak 80% dan kategori baik sebanyak 20%.   Kata Kunci: keputihan, vulva higiene, swamedikasi
Hubungan Pengetahuan dan Sikap terhadap Pola Pemilihan Obat Tradisional untuk Pengobatan Sendiri (Self Medication) pada Masyarakat DesaKalisoro Crisdian, Hanugrah Ardya; Prawistya, Agnes; Zuzvita, Ersta; Fitriana, Rufaida Nur
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol. 6 No. 2 (2022): September
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v6i2.7645

Abstract

Self medication is the use of drugs by the public to reduce the symptomps of minor illnesses without a doctor’s advice. Self medication behavior may be influenced by gender, age, education level, employments status, income level and atitudes about self medication. Increased education and awerness of students about helath, the use of drugs for self medication will also increase. This study aims to identify the reklationship between knowledge anattitudes toward the pattern of using traditional medcine in the Kalisoro village. This research ia an observasional study with a cross sectional reseacrh design. The sampling thecnique was non- random sampling. Collecting data using a quistionnaire, Ehich has been tasted for validity and realibily. Data analysis was carried out using two methods, namely descriptive sattistical methods in the fgorm of respondents charateristic, knowledge, attitude and patterns, while correlation using the Eta Correlation Cooeficient. Inthis study there were many as 60 respondents who participated, with high level of knowledge as many as 95% of respondents who have positive attitude or partially. There is very low or very weak relationship in terms of knowledge, while in attitude there is a high or strong relation ship with each pattern of traditional medcine use which includes the frequency of use traditional medcines used, drug prices and sources of information.
Aktivitas Antibakteri Fraksi Aquades, Diklorometana dan N-Heksana Daun Majapahit (Crescentia cujete L.) terhadap Bakteri Escherichia coli ATCC 25922 Secara In-Vitro Huda, Choirul; Martha, Rahma Diyan; Wulandhari, Niken Desi
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol. 6 No. 2 (2022): September
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v6i2.8495

Abstract

Escherichia coli is a gram - negative bacteria which is able to cause infectious diseases in humans, including urina ry tract infections, stomach cramps, and diarrhea. The purpose of this study was to determine the antibacterial activity of the Majapahit leaf fraction and the optimum concentration to inhibit Escherichia coli bacteria. Majapahit leaves were extracted by t he maceration method using 70% ethanol f ollowed by fractionation using aqua dest solvent, dichloromethane, and n - Hexane. Phytochemical screening of Majapahit leaf extract for the content of flavonoids, alkaloids, and saponins. Antibacterial activity test us ing paper disc diffusion method with positive control of chloramphenicol and negative control of 10% DMSO. The results of phytochemical screening of extracts were positive to flavonoid compounds, alkaloids, and saponins. The results of the antibacterial ac tivity test of the Majapahit leaf fraction had an antibacterial activity which was indicated by the presence of a clear zone around the disc. The aqua dest fraction is the most active fraction that can inhibit Escherichia coli bacteria. Based on the data a nalysis that has been carried out, it can be concluded that the use of different types of solvents did not produce significant differences in inhibiting Escherichia coli bacteria.
Uji Aktivitas Antibakteri Kombinasi Ekstrak Daun Kelor dan Senggani terhadap Bakteri Escherichia coli dan Staphylococcus aureus secara In Vitro Putri, Amalia Eka; Andini, Mita Uly; Huda, Choirul
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol. 6 No. 2 (2022): September
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v6i2.8557

Abstract

Infection is one of the most common diseases today. One of them is an infection caused by Escherichia coli and Staphylococcus aureus bacteria that attack the digestive tract and cause diarrhea. The purpose of this study was to determine the antibacterial activity of Moringa and senggani leaf extracts against Escherichia coli and Staphylococcus aureus bacteria in vitro. By using the disc diffusion method. Moringa and senggani extract ratios of 1:1, 1:2, and 2:1 were used to test the antibacterial activity compared with positive control of chloramphenicol and negative control of DMSO. The results of the inhibition zone obtained in the Escherichia coli bacteria test at a ratio of 1:1 of 11.2 mm, 1:2 of 12 mm, and 2:1 of 11.3 mm. while in the Staphylococcus aureus test the ratio of 1:1 is 10.3 mm, 1:2 is 15.3 mm, and 2:1 is 13 mm. These results indicate that the resulting inhibition zone is in the strong category. It can be said that the combination of KLSG extract has antibacterial activity against Escherichia coli and Staphylococcus aureus.
Uji Aktivitas Antibakteri Perasan Jeruk Nipis (Citrus aurantifolia) terhadap Pertumbuhan Bakteri Propionibacterium acnes Frihendranus, Jeremia Eden; Sianturi, Sister; Erwina, Wiwi
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol. 6 No. 2 (2022): September
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v6i2.8597

Abstract

The main causes of skin infections is Propionibacterium acnes. The use of antibiotics can be an effective treatment of acne for example: clindamycin. Lime was a plant that is used as a treatment for acne’s inhibition. The lemon part often used to treat acne was the juice. The purpose of this study was to determine the activity of lime juice in inhibiting the growth of Propionibacterium acnes and to determine the minimum inhibitory concentration of lime juice against Propionibacterium acnes. The study used lime juice with various concentrations of 100%, 50%, 25%, and 12.5% on the growth of Propionibacterium acnes bacteria using the disc diffusion method. The data obtained were tested for normality Kolmogorov-Smirnov and homogeneity test. Then the Kruskall Wallis and Mann-Whiteney test were performed. Based on this study, lime juice was proven to be able to inhibit the growth of Propionibacterium acnes bacteria. The inhibition zone with the highest average concentration was at 100% concentration, which was 18.7 mm and the smallest average inhibition zone was found at a concentration of 12.5%, which was 11.5 mm. The results of the statistical test showed a significant difference with p-value= 0.029 between the positive control and the variation of the sample concentration.
Studi Rasionalitas Penggunaan Obat Favipiravir pada Pasien Covid-19 di RSUD Harapan Insan Sendawar Kabupaten Kutai Barat Tahun 2021 Delvi, Teresia; Geografi, Liniati; Sinaga, Clara Ritawany
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol. 6 No. 2 (2022): September
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v6i2.8607

Abstract

Corona Virus Disease 2019 (COVID-19) is an infectious disease caused by the SARS COV-2 virus. One of the antiviral groups that are often used worldwide for the treatment of COVID-19 is Favipiravir. Favipiravir use should be monitored because the accuracy of the drug will maximize the effect of therapy on the patient. Evaluation of Drug Use (EPO) of Favipiravir in terms of rationality needs to be done. Drugs that are not used rationally can cause side effects, the length of treatment will be longer, and even cause death effects in patients. The purpose of this study was to describe the characteristics of COVID-19 patients based on age, gender, and comorbidities and to find out the rationale for using Favipiravir inpatients at the HIS Hospital based on the criteria for the right diagnosis, the right patient, the right drug, the right dose, the right time interval for administration, appropriate duration of administration and clinical outcomes of COVID-19 patients (PCR, TCM, and antigen). This research is a type of nonexperimental research, the research was carried out in a descriptive evaluative way, and the data was collected retrospectively by looking at the medical record data. Determination of the rationale for using Favipiravir was carried out using the literature of the Indonesian COVID-19 Drug Informatorium edition 3, 100% correct patient, 100% correct drug, 100% correct diagnosis, correct dose 50.84%, correct duration of administration 61.01%, correct time interval administration of 81.35% and clinical outcomes (PCR (-) 74.57% %, TCM (-) 16.94%, and Antigen (-) 6.77%.
Mass Spectrometry (MS) Profiling on Potent Anticancer Fractions of Calthropella sp. Susilowati, Fitria
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol. 6 No. 2 (2022): September
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v6i2.8630

Abstract

A research on isolation and in vitro cytotoxic assay of active fractions of marine sponge Calthropella sp. from Krakal Beach Gunungkidul had been carried out. This study aims to analyze the Mass Spectrometry (MS) profile of potent anticancer fractions of marine sponge Calthropella sp. The two potent fractions (F1 and F2) were analyzed by High Resolution Liquid Chromatography-Mass Spectrometry (HR LC-MS) to identify the compounds exist in each fractions. The LC-MS analyses were conducted on the best elution system, isocratic elution of 80% MeCN (with 0.1% formic acid) + 20% milliQ H2O (with 0.1% formic acid). Based on LC-MS analyses, it is strongly predicted that F1 consist of 4'-N-methyl-5'- hydroxystaurosporine, 24-methyleneergost-4-ene-3-one, and one new compound. F2 is predicted to consist bengamide Q, clavepictine A, 4'-N-methyl-5’-hydroxystaurosporine, biemnic acid, carteriofenone A, and one new compound 
Aktivitas Antioksidan Kombinasi Ekstrak Etanol 96 % Kulit Buah Markisa Ungu dan Kuning secara In-Vitro Fitria, Laila; Ngibad, Khoirul
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol. 6 No. 2 (2022): September
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v6i2.8682

Abstract

This study aimed to find the best combination of 96% ethanol extract from purple passion fruit (Passiflora edulis f. edulis Sims) peel and yellow passion fruit (Passiflora edulis Sims f. flavicarpa Deg) peel as in vitro antioxidants using the DPPH method. The 96% ethanol extract of purple and yellow passion fruit peel was obtained by the maceration method using 96% ethanol solvent. The combination treatment of purple and yellow passion fruit peel extracts was made with three comparisons of namely 1:1, 2:1, and 1:2, respectively. In vitro, antioxidant activity was assayed using the DPPH method to obtain the IC50 value. The results showed that the best combination of extracts as in vitro antioxidants was the combination of 96% ethanol extract from purple and yellow passion fruit peel with ratio (1:1) of 12.45 mg/L followed by the combination of extracts 1:2 (51.31 mg/L) and 2:1 (66.23 mg/L). In conclusion, the results suggest that the extracts combination of purple and yellow passion fruit peel with a ratio (1:1) can increase in vitro antioxidant activity.

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