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Medicinus : Jurnal Kedokteran
  • Medicinus : Jurnal Kedokteran
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Published by Universitas Pelita Harapan
ISSN : 19783094     EISSN : 26226995     DOI : -
Core Subject : Health,
Medicine & Pharmacology Public Health
Medicinus: Jurnal Kedokteran is an official journal of the Faculty of Medicine, Universitas Pelita Harapan launched in the year 2007. Medicinus is a peer-reviewed and open-access journal that covers basic, translational, or clinical aspects of health and medical science. Medicinus accepts original research articles, review articles, and also interesting case reports. Medicinus: Jurnal Kedokteran is published three times a year in February, June, and October.
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Articles 10 Documents
 1 
Search results for , issue "Vol. 15 No. 1 (2025): October" : 10 Documents clear
Efficacy and Safety of Stem Cell Therapy for Spinal Cord Injury in Adults: A Systematic Review and Meta-Analysis Rhadika, Anadya; Romano, Sultan Adhitya; Widyatmiko, Himawan; Tanuwijaya, Andrew Wilbert; Putra, Putu Surya Pradipta Hariantha; Amanah, Salma Rizqi; Elashry, Abdelrahman Ramadan; Javaid, Sarmad; Inggas, Made Agus Mahendra; Wijaya, Jeremiah Hilkiah
Medicinus Vol. 15 No. 1 (2025): October
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v15i1.10762

Abstract

Background: Despite encouraging early results, clinical outcomes remain inconsistent across trials. This study aimed to systematically evaluate the efficacy and safety of stem cell therapy in adults with spinal cord injury (SCI). Methods: A systematic review and meta-analysis were conducted following PRISMA 2020 guidelines. PubMed, EMBASE, and Scopus were searched until 18 October 2025. Eligible studies included adult SCI patients receiving stem cell therapy with measurable neurological outcomes. Data synthesis was performed using Review Manager 5.4 under a random-effects model, reporting pooled risk ratios (RR) with 95% confidence intervals (CIs). Risk of bias was assessed using ROBINS-I, and evidence certainty was graded via GRADE. Result: Thirteen studies involving 470 participants (286 intervention, 184 control) were included. Stem cell therapy significantly improved neurological recovery compared with controls (RR = 2.64; 95% CI 1.70–4.10; p < 0.0001; I² = 0%). Subgroup analyses showed consistent benefits across baseline AIS classifications (RR = 2.61; 95% CI 1.71–3.98) and cell doses (RR = 2.75; 95% CI 1.63–4.64). No major safety signals were identified. GRADE assessment rated the certainty of efficacy evidence as moderate. Conclusions: Stem cell therapy yields significant neurological improvement in adult SCI with a favorable safety profile. The findings support its regenerative potential through neuroprotective and remyelinating mechanisms. However, larger randomized controlled trials are required to validate efficacy, optimize protocols, and assess long-term safety.
A Descriptive Study of Thesis Completion Challenges Among Medical Students Suryadinata, Neneng; Neolaka, Gladies Mercya; Siregar, Rohana Uly Pradita
Medicinus Vol. 15 No. 1 (2025): October
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v15i1.10763

Abstract

Background: The Final Project (FP) is a mandatory course for medical education students, typically undertaken in the sixth semester. It is divided into two stages: Final Project 1 (FP1) and Final Project 2 (FP2). In FP1, students develop, document, and present a research proposal, while in FP2, they execute the planned research, analyze the results, and present their findings. A decline in FP2 completion rates was observed in 2024, raising concerns about factors affecting student performance. Methods: A descriptive analysis methods approach was used, combining quantitative surveys (n=91) and qualitative interviews. The survey, with 10 questions on a 4-point Likert scale, assessed factors affecting FP2 completion. Semi-structured interviews and written responses explored deeper insights, with thematic analysis identifying key barriers. Results: Survey results revealed moderate motivation (mean=2.77) and high procrastination (mean=3.01). Time management (mean=2.86) and personal issues (mean=2.35) were significant challenges. The main delays were lack of motivation (36.26%) and time management issues (27.47%). Themes from interviews included motivation, time management, supervisor support, data access, and mental health. Conclusions: Students face key challenges in completing the FP2 course, particularly low motivation, poor time management, and limited supervisor interaction. Addressing these issues through enhanced intrinsic motivation, effective feedback, and structured time management can foster more successful and high-effort student profiles.
Dietary Intake and Physical Activity of Medical School Students at Universitas Pelita Harapan, Indonesia Rivami, Dwi S.; Siregar, Rohana U.P.; Suryadinata, Neneng
Medicinus Vol. 15 No. 1 (2025): October
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v15i1.10764

Abstract

Background: Medical students face high academic demands, which often lead to irregular eating patterns and a lack of physical activity, which can have a negative influence on their nutritional status and overall well-being. This study aimed to evaluate the dietary intake and physical activity levels among medical students at Universitas Pelita Harapan, Indonesia. Methods: A cross-sectional study was conducted on 70 undergraduate medical students. Demographic data and physical activity levels (assessed using the International Physical Activity Questionnaire, IPAQ) were collected. Dietary intake was evaluated using a semi-quantitative food frequency questionnaire (SQ-FFQ), and nutrient intakes were analyzed and compared with the Indonesian Recommended Dietary Allowances (RDA) for women aged 19–29 years. Data analysis included descriptive statistics for continuous and categorical variables. Results: There were 70 participants, with a mean age was 20.73 ± 0.81 years; the majority were female (n = 62). Physical activity levels were distributed as 35.7% low, 38.6% moderate, and 25.7% high. Mean daily energy intake (1677.58 kcal) was below the RDA, as were intakes of fat, carbohydrates, fiber, calcium, sodium, potassium, and vitamin A. Intakes of protein, phosphorus, iron, vitamin C, riboflavin, and niacin were above RDA recommendations. Conclusions: Medical students at Universitas Pelita Harapan were found to have suboptimal dietary intake, particularly with regard to energy, fiber, and several micronutrients, as well as varying levels of physical activity. These findings emphasize the need for targeted interventions to promote balanced nutrition and regular physical activity in this population.
Exploring the Association Between HIV Knowledge and Prevention Attitudes Among Health Science Students Atmodjo, Wahyuni Lukita; Suryadinata, Neneng; Moningkey, Shirley; Siregar, Rohana Uly Pradita
Medicinus Vol. 15 No. 1 (2025): October
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v15i1.10765

Abstract

ound: HIV continues to be a major public health concern worldwide, and comprehensive understanding has shown that HIV knowledge enhances effective prevention behaviors and helps prevent the transmission of the disease. Previous research conducted indicated that higher levels of knowledge were associated with more positive attitudes toward HIV prevention, specifically, 58.7% demonstrated good knowledge and 70.7% engaged in preventive actions. Health science students are a key group for HIV education, as they are future healthcare providers. However, limited research has been done among health science students. Methods: A cross-sectional study was conducted with 295 health science students consisting of 193 medical and 102 non-medical students. Participants completed two questionnaires, i.e., HIV knowledge with 24 true/false items and HIV prevention attitudes with 23 items on a Likert scale. Descriptive and inferential statistics, including chi-square tests and multivariate logistic regression, were used to analyze the data. Results: Of the respondents, 43.4% demonstrated good HIV knowledge, while 56.6% had poor knowledge. Regarding prevention attitudes, 59.7% exhibited favorable attitudes, while 40.3% had unfavorable attitudes. A significant positive association was found between HIV knowledge and prevention attitudes (p < 0.001, OR: 2.525, 95% CI: 1.546–4.123). Gender differences were noted, with females displaying more favorable attitudes (p < 0.001, OR: 2.551, 95% CI: 1.487–4.379). Medical students showed less favorable attitudes toward HIV prevention compared to non-medical students (p = 0.042, OR: 1.681, 95% CI: 1.017–2.778). Conclusions: This study highlights the influence of HIV knowledge, gender, and faculty on HIV prevention attitudes among health science students, with females and non-medical students showing more engagement in prevention efforts. These findings underscore the need for comprehensive HIV education in university curricula to enhance both knowledge and preventive behaviors.
Knowledge of coronary heart disease risk factors and associated dietary fat intake among medical students Zalukhu, Hansaro Andika; Nugroho, Haddiyya Wardhani; Pradhipta, Hanandhito Satya; Wijaya, Ratna Sari
Medicinus Vol. 15 No. 1 (2025): October
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v15i1.10766

Abstract

Background: Coronary heart disease (CHD) prevalence has increased among young adults. The most common CHD risk factor among young adults was high daily fat intake. Knowledge regarding CHD risk factors was a crucial element in determining health behaviour, including healthy dietary patterns. However, the level of CHD knowledge and its association with dietary fat intake among medical students is still unclear. Methods: The study was performed among preclinical medical students at the Pelita Harapan University, Indonesia. The CHD risk factor knowledge was assessed using the validated Heart Disease Fact Questionnaire (HDFQ), comprising of 25 items. The dietary fat intake was evaluated using the validated Block Dietary Fat Screener (BDFS) questionnaire. Results: A total of 98 participants were included in this study. The median age of the participants was 19 years (IQR 18-20). Of the 98 participants, 71 (72%) participants had adequate knowledge of CHD risk factors. Older age, being female, and being in the third year of medical study were related to higher HDFQ scores. The daily fat intake was classified as high in 33 (34%) of participants and very high in 33 (34%) of participants. No significant difference in dietary fat intake level was observed between participants with and without adequate knowledge of CHD risk factors. Conclusion: This study reveals that most medical students had adequate knowledge of CHD risk factors. However, the knowledge factor did not lead to healthy dietary pattern adoption among medical students, suggesting that the implementation of an education and training program to motivate lifestyle modification was required.
⁠Dapsone Induced Methemoglobinemia in Pediatric Patient: A Case Report Addyanto, Brian; Lukman, Leni
Medicinus Vol. 15 No. 1 (2025): October
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v15i1.10767

Abstract

Background: Acquired methemoglobinemia is significantly more common than the congenital form, though it remains a rare condition. Most cases arise from accidental chemical exposure or the use of topical and local anesthetics. Case Description: We present a case of 14-year-old male presented with complaints of dark grayish discoloration of the skin on the face and hands, persisting for the past two months prior to admission. He was later diagnosed with dapsone induced methemoglobinemia. Patient was then discharged with oral therapy consisting of agents with antioxidant properties and instructed to discontinue dapsone consumption. Conclusions: In pediatric patients undergoing dapsone therapy, the risk of dapsone induced methemoglobinemia should be carefully considered to ensure early identification and prompt management, thus minimizing the potential for severe complications.
Isolated Abducens Nerve Palsy: A Case Report of Cerebral Pseudocyst of Dorello’s Canal Puspitasari, Vivien; Japutri, Josephine; Solansa, Tracy; Cenweikiawan, Anderson
Medicinus Vol. 15 No. 1 (2025): October
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v15i1.10768

Abstract

Background: Abducens nerve is the second longest intracranial path out of all of the cranial nerves. Abducens nerve pasly had a prevalence 11.3/100.000 and mostly seen in adults. Isolated abducens nerve palsy due to neoplastic lesion are rare and mostly related to skull base tumor. Case Description: We present a case of 57 years old woman with complaints of red right eye and worsening headache associates with diplopia on the right lateral gaze for three days prior admission. She was later diagnosed with isolated abducens nerve palsy associated to neoplasm cause in Dorello’s canal. Patient was then discharged with symptomatic therapy and educated for head posturing and avoid triggers. Conclusions: Abducens nerve palsy is the most common isolated ocular nerve palsy. The incidence of mass formation such as neoplastic lesion or cyst are rare.
A Rare Manifestation of ‘Complex’ Post Streptococcus Infection Movement Disorder in Paediatric Patient a Case Report Lalisang, Lilie; Khairani, Arie; Chairy, Abdul; Djuanda, Gerald
Medicinus Vol. 15 No. 1 (2025): October
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v15i1.10769

Abstract

Background: Post Streptococcal Movement Disorder (PSMD) is a rare disease. One of the PSMD diagnosis is Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infection (PANDAS). Case Description: 10 year old female with involuntary movement including myoclonic jerks, chorea and stereotype. Movement duration is 5 minutes, repetitive and sensitive to loud noise. Patient has history of respiratory infection 2 weeks ago with Positive ASTO test. Patients showed improvement after treatment with antibiotics, corticosteroids and antipsychotics. Conclusion: The pathophysiology of PANDAS begins with Group A beta-hemolytic infection that causes cross reaction in cortical structures and basal ganglia due to molecular mimicry. Currently there is no definitive test for PANDAS,where diagnosis is primarly confirmed by identifying signs, symptoms and physical neurological examination.
Investigating the Prognostic Value of Serum Albumin Levels in Patients Undergoing Hemodialysis: A Systematic Review and Meta-analysis Adrya, Jessica; Sasongko, Calvin; Andrean, Melvin; Kartadinata, Muhammad Faishal; Theis, Aveline Maisie; Putri, Syafira Ayudiah Syah; Mukti, A. Muh. Yasser; Moelyadi, Felly; Varsha, Srigita; Dhika, Veriantara Satya
Medicinus Vol. 15 No. 1 (2025): October
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v15i1.10770

Abstract

Background: Hypoalbuminemia, characterized by low serum albumin levels, is frequently observed in patients undergoing hemodialysis and has been identified as a potential predictor of increased mortality risk. This systematic review aims to evaluate the relationship between hypoalbuminemia and mortality in hemodialysis patients, assessing the prognostic value of serum albumin levels as an indicator for patient outcomes. Methods: A comprehensive search was conducted in databases including PubMed, Europe PMC, and Scopus to identify relevant studies. Studies were included if they investigated the association between serum albumin levels and mortality outcomes in adult patients undergoing hemodialysis. Data extraction was performed independently by two reviewers, focusing on study characteristics, patient demographics, albumin levels, and mortality outcomes. Quality assessment of studies was conducted using the Newcastle-Ottawa Scale (NOS). Result: A total of eight studies, encompassing 45,178 hemodialysis patients with a mean age in the 50s, met the inclusion criteria. The studies had a combined male cohort of 22,501 individuals. The definition of hypoalbuminemia varied across studies, with cutoff values ranging from 3.0 to 3.9 g/dL. Follow-up durations spanned from as early as 3 months to a maximum of 6.1 years. The meta-analysis revealed a pooled hazard ratio (HR) of 1.08 (95% CI: 0.94–1.25), suggesting a non-significant association between hypoalbuminemia and increased mortality risk (P = 0.28). However, substantial heterogeneity was present (I² = 79%), indicating variability across studies. Conclusions: Hypoalbuminemia showed a non-significant association with mortality in hemodialysis patients, though variability across studies suggests further research is needed for clarity.
The Role of Glycemic Load, Dairy, and Fatty Acids in Acne Disorders: A Systematic Review and Meta-Analysis Limanda, Claudia Felicia; Mathlubaa, Asya; Istikanto, Ferdian Harum; Sisca; Nabila, Yusra; Amalia, Shania Rizky; Putri, Syafira Ayudiah Syah; Ilmiani, Tasya Khalis; Hartanto, Ericko; Nurfadhila, Melinda
Medicinus Vol. 15 No. 1 (2025): October
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v15i1.10771

Abstract

Background: Modern dietary patterns characterized by high glycemic load, dairy consumption, and imbalanced fatty acid profiles may aggravate acne through insulin, IGF-1, and inflammatory pathways. However, findings across studies remain inconsistent. This systematic review and meta-analysis aimed to evaluate the associations between dietary glycemic load, glycemic index, dairy intake, and fatty acid composition with acne disorders. Methods: Following PRISMA 2020 guidelines, PubMed, EMBASE, and Scopus were systematically searched to September 2025. Eligible human studies assessing quantitative relationships between these dietary exposures and acne risk or severity were included. Random-effects meta-analyses were performed using the Hartung–Knapp–Sidik–Jonkman method, with effect sizes expressed as standardized mean differences (SMD) or risk ratios (RR). Result: Five studies encompassing 716 participants (426 acne, 290 controls) met the inclusion criteria. Pooled estimates indicated no significant associations for glycemic load (SMD = 0.09; 95% CI −0.30 to 0.49), glycemic index (SMD = 0.09; 95% CI −0.30 to 0.49), fatty acids/adiponectin (SMD = 0.11; 95% CI −0.74 to 0.97), or dairy consumption (RR = 1.04; 95% CI 0.25 to 4.25). Heterogeneity ranged from moderate to high (I² = 65–90%). Certainty of evidence was moderate for glycemic and dairy outcomes, and low for fatty acids. Conclusions: No significant pooled associations were observed between dietary glycemic load, dairy intake, or fatty acids and acne risk. Despite biological plausibility linking diet to acne via hormonal and inflammatory mechanisms, evidence remains inconsistent. Larger, controlled trials are warranted to define the role of nutritional interventions in acne management.

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