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Indonesian Journal of Medicine

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Published by Universitas Sebelas Maret

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Medicine & Pharmacology Public Health

Indonesian Journal of Medicine (IJM) is an international, open-access, and double-blind peer-reviewed journal, focusing on the intersection of biomedical science, clinical medicine, and community medicine. The journal began its publication on August 20, 2015, and is published online three times yearly. It is academically designed for all physicians, health researchers, and health care professionals, regardless of their medical specialties, or type of employment.

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Search results for , issue "vol. 6 no. 4 (2021)" : 12 Documents clear

Meta Analysis the Effect of Acupunctur Therapy and Ultrasound Therapy to Reduce Pain Caused by Carpal Tunnel Syndrome Noer, Afifah; Rahardjo, Setyo Sri; Prasetya, Hanung
Indonesian Journal of Medicine Vol. 6 No. 4 (2021)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background: Carpal tunnel syndrome is a condition of health problems in the form of pain, numbness, and tingling that occurs in a person's hands. This sensation can be felt in the thumb, index finger, middle finger, and 1/2 ring finger on the radial side, this occurs when the median nerve that passes through the carpal tunnel at the wrist is compressed or compressed. This study aims to estimate the effect of acupuncture therapy and ultrasound therapy on reducing pain in carpal tunnel syndrome cases.Subjects and Method: This was a systematic review and meta-analysis conducted using PRISMA flow diagrams. Article searches through journal databases include: PubMed, Science Direct, Scopus, Google Scholar, Springer Link, Hindawi, BMC. The PICOs of this study were, Population: carpal tunnel syndrome sufferers, Intervention: acupuncture therapy and ultrasound therapy, Comparison: no acupuncture and ultrasound therapy, Outcome: pain reduction. Using search keywords: (“acupuncture” OR “acupuncture therapy”) AND (“carpal tunnel syndrome” OR “cts”) AND (“ultrasound” OR “ultrasound therapy”) AND (“randomized controlled trial”) AND (“ acupuncture for carpal tunnel syndrome”) AND (“ultrasound for carpal tunnel syndrome”). Inclusion criteria were full paper articles with Randomized Controlled Trial (RCT) research method, the relationship measure used was Mean SD, the intervention given was acupuncture and ultrasound, study subjects were aged 18-85 years. Eligible articles were analyzed using the Revman 5.3 app.Results: Meta-analysis of 16 articles showed acupuncture treatment outcome of -0.34 units compared with other interventions or no intervention (SMD -0.34; 95% CI= -0.83 to 0.16; p=0.180), I2=78%, and treatment outcome. ultrasound as much as -0.76 units compared with other interventions or no intervention, and statistically significant value (SMD -0.76; 95% CI= -1.37 to -0.16; p=0.001), I2= 92%.Conclusion: Acupuncture therapy and ultrasound therapy have an effect on reducing pain in cases of carpal tunnel syndrome.Keywords: Acupuncture, ultrasound, carpal tunnel syndromeCorrespondence: Afifah Noer. Masters Program in Public Health. Universitas Sebelas Maret, Jl.Ir. Sutami 36A, Surakarta 57126, Jawa Tengah, Indonesia. Email: Afifahnoer97@gmail.com. Mobile: 085601564681.Indonesian Journal of Medicine (2021), 06(04): 399-411https://doi.org/10.26911/theijmed.2021.06.04.06

The Use of Modified Cervical Colar in Reducing Neck Pain Zubaidi, Alfan; Fadli, Arif
Indonesian Journal of Medicine Vol. 6 No. 4 (2021)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background: One of the conditions of pain in the neck area where there is a stiff neck, so sometimes there is pain radiating from the shoulder to the hand, the symptom is often called cervical syndrome. This condition occurs because the vertebral root is compressed for a long time in the use of activities. In the long term, the pain can even radiate to both shoulders and even to the arms of the arch, this situation will result in abnormal and rapid fatigue. According to studies conducted by researchers, this situation may be prevented by giving a special cervical collar design to Tafidz Ouran students. In this study, it will be investigated how effective the special collar model is to overcome the problems/prevention of cervical syndrome for Tafidz Ouran students in Karanganyar. The purpose of this study was to determine how effective a special cervical collar design is to reduce pain in cervical syndrome.Subjects and Method: This research is a Randomized Controll Trial (RCT) where in this study before being randomized in determining the control and treatment groups, matching was done first. In the control group in this study were students who used regular collars (collars sold in the market) and in the intervention group were given special collars. The sample in this study was the students of the Tahfidz boarding school in the Karanganyar area as many as 160 students who experienced cervical syndrome. Each group in this study amounted to 80 students. The sampling technique was simple random sampling. The variables in this study, the dependent variable is the cervical syndrome condition of the Tafidz Quran students and the use of a special cervical collar model as the independent variable. Analysis of the data using the Independent samples t test if the data is normal, and using the Mann Whitney test if the data is not normal.Results: After the intervention, it was shown that pain in the special cervical collar group (mean = 2.51; SD = 0.50) was lower than that in the regular collar group (mean = 5.50; SD = 0.59) and was statistically significant (p value = 0.000).Conclusion: The use of a special cervical collar is better than a regular cervical collar to reduce neck pain.Keywords: cervical syndrome, cervical collar, special cervical collarCorrespondence: Alfan Zubaidi. Department of Orthotic Prosthetic, Ministry of Health Surakarta. Jl. Letjen Sutoyo, Mojosongo, Surakarta, Central Java, Indonesia. Email: drsalfanzubaidi@gmail.com.Indonesian Journal of Medicine (2021), 06(04): 460-464https://doi.org/10.26911/theijmed.2021.06.04.12

Meta-Analysis the Efficacy of Turmeric (Curcuma domestica) in Reducing Pain in Patients of Knee Osteoarthritis Ardiyanto, Danang; Tamtomo, Didik Gunawan; Murti, Bhisma
Indonesian Journal of Medicine Vol. 6 No. 4 (2021)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background: Osteoarthritis (OA) of the knee joint has the highest prevalence among all types of rheumatic diseases. The most common symptom of knee OA is pain around the joint. Patients with OA require long treatment, especially using analgesic and anti-inflammatory drugs. Turmeric is efficacious as a pain reliever and anti-inflammatory. This study aims to estimate the magnitude of the effect of turmeric extract (Curcuma domestica) on pain in patients with knee OA compared to placebo and non-steroidal anti-inflammatory drugs (NSAIDs), based on the results of a number of previous similar studies.Subjects and Method: This study is a systematic review and meta-analysis with the following PICO, population: patients with knee OA. Intervention: turmeric extract. Comparison: placebo and NSAIDs. Outcome: pain reduction. The articles used in this study were obtained from three databases, namely Google Scholar, Pubmed, and Science Direct. Keywords to search for articles: “Knee Osteoarthritis” OR “Knee OA” AND “Curcuma longa” OR “Curcuma domestica” OR “Turmeric extract” AND “Placebo” OR “NSAID” AND “pain” OR “visual analogue scale” OR “ VASE". The articles included are full-text with RCT study designs from 2011 to 2021. The selection of articles is carried out using PRISMA flow diagrams. Articles were analyzed using the Review Manager 5.3 application.Results: A total of 15 RCT studies were selected for systematic review and meta-analysis. Data collected from 10 studies showed that patients with knee OA who received turmeric extract experienced 1.60 units lower joint pain than placebo (SMD= -1.60; 95% CI= -2.23 to -0.97; p<0.001). Data from 5 studies showed that patients with knee OA who received turmeric extract experienced 0.06 units higher joint pain than NSAIDs. The comparison between the turmeric extract group and the NSAID group did not show any significant difference (SMD= 0.06; 95% CI= -0.10 to -0.22; p= 0.490).Conclusion: Administration of turmeric extract was more effective than placebo and not inferior to non-steroidal anti-inflammatory drugs in reducing pain in patients with knee OA.Keywords: osteoarthritis, turmeric, painCorrespondence: Danang Ardiyanto. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: drdanank@gmail.com. Mobile: 08122762579.Indonesian Journal of Medicine (2021), 06(04): 364-376https://doi.org/10.26911/theijmed.2021.06.04.02

The Effects of Skipping Rope Exercise, Brisk Walking Exercise, and Weight Training on Cardiorespiratory Endurance in Physiotherapy Students Kusumaningtyas, Mei; Handari, Herdianty Kusuma
Indonesian Journal of Medicine Vol. 6 No. 4 (2021)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background: There is a mutually influencing relationship between physical activity and fitness level, especially the cardiorespiratory endurance component. Types of exercise that can increase cardiovascular endurance are skipping rope, fast walking, and weight lifting. Thoses exercises are simple and easy to do. This study aimed to determine whether or not there was a difference in influence and which one was the most influential between skipping rope, fast walking, and weight training on the cardiorespiratory endurance of physiotherapy students.Subjects and Method: This was a randomized control trial study, conducted at the Department of Physiotherapy, School of Health Polytechnics, Ministry of Health, Surakarta, from July to August 2020. A total of 36 students was selected by random sampling, and allocated into 4 groups consisted of 9 students: (1) Skipping rope exercise group; (2) Fast walking group; (3) Weight training group; and (4) Control group. The dependent variable was cardiorespiratory endurance. The independent variable was skipping rope, fast walking, and weight training. Cardiorespiratory endurance was measured by the Cooper method to measure VO2 max. Data were analyzed using paired t test, Wilcoxon, and One Way ANOVA.Results: After intervention, cardiorespiratory endurance was increased in all intervention groups. There was no statistically significant different effects on cardiorespiratory endurance between skipping rope group (Mean= 1.48; SD= 0.42), fast walking group (Mean= 1.42; SD= 0.30), weight training group (Mean= 1.38; SD= 0.22), and control group (Mean= 1.17; SD= 0.28) with p value of 0.218.Conclusion: Skipping rope and weight training significantly increase cardiorespiratory endurance. There is no difference in the effect of skipping rope, fast walking, and weight training on cardiorespiratory endurance.Keywords: skipping rope, fast walking, weight training, cardiorespiratory endurance, cooper test, VO2maxCorrespondence: Mei Kusumaningtyas. Physiotherapy Department, Health Polytechnics, Ministry of Health. Jl. Adi Sumarmo, Tohudan, Colomadu, Karanganyar, 57173, Central Java. Email: meikusumaningtyas@gmail.com. Mobile: 085725646444.Indonesian Journal of Medicine (2021), 06(04): 423-429https://doi.org/10.26911/theijmed.2021.06.04.08

Association between Community Perception and Willingness to Vaccinated Againts COVID-19 in Surakarta, Central Java, Indonesia Dewi, Annita Viesta Nirmala; Kharisma, Alya Ayu; Inas, Nailah Salma; Habiba, Chusna; Indriyani, Okti; Dharmawan, Caroline; Jihadillah, Syarifah; Mujahidah, Hibah; Trisiadewi, Kharisma; Ramadhani, Nabila; Wahidah, Nurul Jannatul; Novika, Revi Gama Hatta
Indonesian Journal of Medicine Vol. 6 No. 4 (2021)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background: Covid-19 has been declared a pandemic since March 2020 until now, so the government requires the provision of a covid-19 vaccine for all people. The government's vaccination campaign has received various responses from the public, some people accept and some reject the Covid-19 vaccine. This study aims to determine the relationship between public perception of the acceptance of the COVID-19 vaccine in Surakarta.Subjects and Methods: The cross sectional study was conducted in Surakarta. A sample of 65 people aged >12 years was selected by random sampling. The dependent variable was the willingness to receive the covid-19 vaccine. Tthe independent variable was perception. Data was collected by online questionnaire (google form). Data were analyzed by chi square test.Results: There is a relationship between public perception of vaccination and acceptance of the covid-19 vaccine (OR=5.45 ; 95% CI= 2.57 to 11.53 ; p<0.001)Conclusion: There is a significant relationship between perceptions related to vaccines and people's willingness to receive the COVID-19 vaccine.Keywords: covid-19, acceptance, knowledge, rejection, vaccinationCorrespondence: Annita Viesta Nirmala Dewi. Midwifery Study Program, Faculty of Medicine, Universitas Sebelas Maret. Jl. Ir Sutami 36 Surakarta, Central Java. Email: contact.anitaviee@gmail.com. Mobile: +6285103027268.Indonesian Journal of Medicine (2021), 06(04): 430-438https://doi.org/10.26911/theijmed.2021.06.04.09

The Effect of Physical Exercise on Quality of Life of Breast Cancer Survivors: A Systematic Review Jadmiko, Arief Wahyudi; Kristina, Tri Nur; Sujianto, Untung; Prajoko, Yan Wisnu; Dwiantoro, Luky; Widodo, Aris Puji
Indonesian Journal of Medicine Vol. 6 No. 4 (2021)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background: Exercise generally improves the quality of life (QoL) in adult populations especially for patients with chronic health problems such as breast cancer. The purpose of this study was to investigate the effect of physical exercise/activity on the quality of life of breast cancer survivors. Subjects and Method: This was a systematic review study that used articles from online databases, such as PubMed, Science Direct, ProQuest dan Medline, which was published from 2000 to 2021. The author used keywords of “physical exercise”, “physical activity”, “quality of life”, “breast cancer survivor”. The dependent variable was quality of life. The independent variable was physical exercise/ activity. As many as 5 articles were selected for this study from 837 articles located in South Korea, Iran, Malaysia, and China.Results: Moderate or high levels of physical activity had positive relationship on the quality of life related to overall physical health among breast cancer survivors.Conclusion: Moderate to high physical activity improve the quality of life among breast cancer survivors.Keywords: physical exercise, physical activity, quality of life, breast cancer survivor Correspondence: Arief Wahyudi Jadmiko. Nursing Department, Faculty of Health, Universitas Pembangunan Nasional Veteran Jakarta. Jl. Raya Limo Depok 16515 West Java, Indonesia Email: ariefwjadmiko@gmail.com. Mobile: 085647213628. ORCID ID https://orcid.org/0000-0002-9691-0986.Indonesian Journal of Medicine (2021), 06(04): 377-386https://doi.org/10.26911/theijmed.2021.06.04.03

Effect of Ethanolic Extract in Moringa oleifera, Lam. Leaf on Uric Acid Levels and Body Surface Area of Kidney Glomerulus in Wistar Rats (Rattus novergicus) Induced Metabolic Syndrome Model Darmawan, Muhammad Dzaki; Subandono, Jarot; Setyawan, Novan Adi; Budiani, Dyah Ratna
Indonesian Journal of Medicine Vol. 6 No. 4 (2021)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background: There has been an increasing prevalence of metabolic syndrome (MS) caused by life style such as sedentary behavior and western diet. Metabolic syndrome causes degeneration in ren’s structure and processes the elimination of by product in metabolism, which is uric acid. Moringa oleifera Lam. leaves contain antioxidant that can repair damages caused by MS. Studies about improvement of ren’s structure and uric acid level related to Moringa oleifera Lam. leaves’ consumption has not been found yet. Therefore, this study was intended to examine the effects of ethanolic extract in Moringa oleifera Lam. leaves to uric acid and glomerular surface area in male wistar rat (Rattus norvegicus) with induced metabolic syndrome model.Method: This study is an experimental laboratory study. The subjects of this study consisted of 30 rats which were divided into 5 groups with 6 in each group. K1 is control group, K2 is MS group, and K3, K4, and K5 are MS groups given variety of ethanolic extract doses. The induction of MS was done by giving high-fat diet in 28 days and injection of streptozotocin-nicotinamide (STZ-NA) in the 25th day. Rats in group K3, K4, and K5 were given doses of 150, 250, and 350 mg/kgBW in 28 days.Results: The administration of high-fat diet for 28 days and injection of STZ-NA caused MS condition in rats. Repeated ANOVA and One-Way Anova test showed that the administration of ethanolic extract in Moringa oleifera Lam. leaves with doses of 150, 250, and 350 mg/kgBW in 28 days decreased uric acid significantly (p= 0.001; p=0.001; p= 0.001). Another result also found that ethanolic extract from Moringa oleifera Lam. leaves with doses of 250 and 350 mg/kgBW increased area of glomerular surface area in rats significantly.Conclusion: The administration of ethanolic extract from Moringa oleifera Lam. leaves with doses of 150, 250, and 350 mg/kgBW for 28 days decreased uric acid level in rats. Ethanolic extract of Moringa oleifera Lam. leaves 250 and 350 mg/kgBw doses increase glomerular surface area.Keywords: Moringa Oleifera, uric acid, glomerular cross-sectional area, metabolic syndrome, kidneyCorrespondence: Muhammad Dzaki Darmawan. Study Program of Medical Doctor Education, Faculty of Medicine, Universitas Sebelas Maret. Email: mdddzaki@student.uns.ac.id.Indonesian Journal of Medicine (2021), 06(04): 412-422https://doi.org/10.26911/theijmed.2021.06.04.07

Bilateral Pulmonary Arteriovenous Malformation in Female Patient Based on Computed Tomography Imaging: A Rare Case Report Sutrisno, Sony
Indonesian Journal of Medicine Vol. 6 No. 4 (2021)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background: Pulmonary arteriovenous malformations (PAVMs) is an extremely rare vascular anomaly due to a direct connection between the pulmonary artery and pulmonary vein, potentially causing irreversible damages to the systemic circulation. This condition requires a prompt diagnostic approach to ensure early diagnosis and treatment.Case Report: A 53-year-old Indonesian female was referred to our department with unexplained dyspnoea and cyanosis. Physical examination revealed low oxygen saturation and remarkable finding on pulmonary auscultation. Further investigation revealed the findings suggesting PAVM based on contrast-enhanced chest computed tomography (CT) scan, with multiple nidus on bilateral lungs with feeder arteries from the pulmonary artery and draining veins in the pulmonary vein. Hence, this case emphasizes the rare finding of a female PAVMs patient with bilateral PAVMs.Conclusion: CT scan is a reliable and effective imaging approach to establish the diagnosis of PAVMs. This modality should be first considered to visualize PAVMs lesions, particularly in adult patients with unexplained dyspnoea and cyanosis.Keywords: arteriovenous malformations, CT scan, rare case, embolizationCorrespondence: Sony Sutrisno. Department of Radiology, Faculty of Medicine and Health Sciences, Krida Wacana Christian University, Jakarta, Indonesia. Email: sonysutrisnodr@gmail.com. Mobile: +62-8128-9290-414. Indonesian Journal of Medicine (2021), 06(04): 393-398https://doi.org/10.26911/theijmed.2021.06.04.05

Effectiveness of Hibiscus sabdariffa Linn for Obesity Treatment: A Systematic Review of Randomized Controlled Trials Anggraini, Suci; Kartinah, Neng Tine
Indonesian Journal of Medicine Vol. 6 No. 4 (2021)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background: Hibiscus sabdariffa Linn. (H. sabdariffa), commonly known as Rosella plants in Indonesia, has had various uses in the food and beverage industry and traditional medicines for hundreds of years. The main compounds of H. sabdariffa have been stated to have anti-obesity effects through its biologically active compounds. This review systematically evaluates the evidence from human randomized clinical trials on the effects of H. sabdariffa extract in obesity, including decreased bodyweight, normalizing the blood lipid profile, and modulating appetite-related biomarkers.Subjects and Method: This review is based on the patient, intervention, comparison, and outcome (PICO) procedure, with the patient is people with obesity, the intervention is the administration of H. sabdariffa extract compared to control that given placebo, and the outcomes are reduced body weight and fat accumulation, normalize blood lipid profiles, and regulate biomarkers related to appetite. Articles used are limited to the publication year between 2013 and 2021. Search is done through PubMed, ScienceDirect, Wiley Online Library, Scopus, and Google Scholar with the keywords “hibiscus sabdariffa and obesity”, “hibiscus sabdariffa and lipogenesis”, “hibiscus sabdariffa and energy metabolism”, and “hibiscus sabdariffa and appetite”.Results: The search resulted in 10 studies involving 453 subjects. We proved several significant effects of H. sabdariffa extract on obese subjects. Administration of H. sabdariffa extract for several doses and several days can improve anthropometry measurement, fat accumulation, increased satiety sensation, while the appetite sensation mainly for fatty, sweet, and salty foods was decreased.Conclusion: This review suggests that the benefit of H. sabdariffa to people with obesity are associated with body weight and blood lipid profile-lowering effect; however, more high-quality clinical trials are needed.Keywords: Hibiscus sabdariffa, obesity, appetiteCorrespondence: Suci Anggraini, Masters Program in Biomedical Science, Faculty of Medicine, Universitas Indonesia. Jl. Salemba Raya 4, Jakarta Pusat, DKI Jakarta 10430. Email: suci.angraini@ui.ac.id . Mobile: 081363397973.Indonesian Journal of Medicine (2021), 06(04): 439-451https://doi.org/10.26911/theijmed.2021.06.04.10

Meta-Analysis of the Role of Varenicline in Smoking Cessation Lafif, Muhammad Zainul; Murti, Bhisma; Prasetya, Hanung
Indonesian Journal of Medicine Vol. 6 No. 4 (2021)
Publisher : Masters Program in Public Health, Sebelas Maret University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2021.6.4.443

Background: Smoking is the leading cause of premature death in both developed and developing countries. Smoking cessation efforts can be classified into pharmacological and therapeutic strategies. Varencline is the latest discovery for pharmacological therapy for smoking cessation programs. This study aims to determine the role of varenicline on smoking cessation efforts.Subjects and Method: This was a systematic review and meta-analysis conducted using PRISMA flow diagrams. Search articles through journal databases including: Google Scholar, MEDLINE/ PubMed, Science Direct, Scopus, and Spinger Link by selecting articles published in 2011-2021. The keywords used are “varenicline” OR “pharmacotherapy” AND tobacco OR smoke OR smoked OR smoker AND “smoking cessation”. The research instrument used to assess smoking cessation efforts was the Fagerstrom Test for Nicotine Dependence (FTND). The inclusion criteria were full paper articles with Randomized Controlled Trial (RCT) research methods, the relationship measure used was Mean SD, the intervention given was varenicline, the research subjects were adult smokers who wanted to quit smoking. Eligible articles were analyzed using the Revman 5.3 application.Results: Meta-analysis of 9 articles showed results (SMD -0.11; 95% CI = -0.17 to -0.05; p<0.001).Conclusion: Varenicline has a statistically significant effect in reducing the frequency of smoking per day.Keywords: Varenicline, smoking cessation, quitting smokingCorrespondence: Muhamad Zainul Lafif. Masters Program in Public Health. Universitas Sebelas Maret, Jl.Ir. Sutami 36A, Surakarta 57126, Central Java, Indonesia. Email: zainullafif@gmail.com. Mobile: 082137179433.Indonesian Journal of Medicine (2021), 06(04): 354-363https://doi.org/10.26911/theijmed.2021.06.04.01

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