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JSFK (Jurnal Sains Farmasi & Klinis)
Published by Universitas Andalas
ISSN : 24077062     EISSN : 24425435     DOI : 10.25077
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Jurnal Sains Farmasi & Klinis (J Sains Farm Klin) adalah jurnal ilmiah di bidang kefarmasian yang diterbitkan oleh Fakultas Farmasi Universitas Andalas bekerjasama dengan lembaga profesi "Ikatan Apoteker Indonesia" (IAI) daerah Sumatera Barat sejak tahun 2014.
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Articles 509 Documents
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Pharmacological Profile and Therapeutic Potential of Sungkai Plant (Peronema canescens Jack.): An Emerging Indonesian Herbal Medicine Kokom, Asep; Yasmiwar Susilawati; Sri Adi Sumiwi; Okta Nama Putra
JSFK (Jurnal Sains Farmasi & Klinis) Vol 11 No 2 (2024): J Sains Farm Klin 11(2), August 2024
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.11.2.95-102.2024

Abstract

This study aimed to summarize the pharmacological activities of the sungkai plant (Peronema canescens Jack.) as a potential Indonesian herbal medicine. A literature review was conducted using Google Scholar and Scopus, with keywords such as "pharmacology," "activity," "sungkai," and "Peronema canescens." Inclusion criteria were articles with these keywords, published between 2014 and 2024, in English or Indonesian. Exclusion criteria were review articles, articles not related to sungkai plants, and in vitro and in vivo studies not available in full text. The study identified seven pharmacological activities of the sungkai plant: antioxidant, antibacterial, analgesic, antidiabetic, antihyperuricemic, anti-inflammatory, and immunomodulatory. The antioxidant activity was demonstrated using Thin Layer Chromatography (TLC) and IC50 values. The antibacterial activity was shown through bacterial growth inhibition using the Kirby-Bauer disk diffusion method. The analgesic activity was tested using the writhing test and Hot Plate methods. The antidiabetic activity was studied with alloxan induction method. Overall, the sungkai plant exhibits various pharmacological activities, suggesting its potential as an herbal medicine for treating various diseases.
Comparative Economic and Clinical Utility of Adding Candesartan for Hypertension Management Fitria, Najmiatul; Nguyen, Thang; Machlaurin, Afifah; Al Rizka, Nabila; Ayu Juwita, Dian
JSFK (Jurnal Sains Farmasi & Klinis) Vol 11 No 2 (2024): J Sains Farm Klin 11(2), August 2024
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.11.2.111-117.2024

Abstract

Introduction: Antihypertensive drugs require high costs because they are used over a long period. Therefore, consideration is needed in drug selection requirements, effectiveness, and price. This study aimed to see the beneficial results of hypertension therapy and the non-medical costs incurred by patients using cost-utility analysis (CUA). Method: This research was a prospective study. The incremental Cost-Utility Ratio (ICUR) of antihypertensive treatment was calculated using cost-utility data obtained through EQ-5D-5L questionnaires from outpatients at Universitas Andalas Hospital in January- March 2023 who met the inclusion and exclusion criteria. The costs used were from a patient perspective, consisting of direct medical and non-medical costs. This study compared standard treatment (amlodipine) with the addition of candesartan. Results: The number of respondents in this study was 67, consisting of 23 respondents (34.33%) using amlodipine alone and 44 respondents (65.67%) using the amlodipine-candesartan combination. The ICUR value obtained was IDR7,318,674/QALY. The difference in the average utility value of the amlodipine-candesartan combination with amlodipine alone is -0.02, and the difference in cost is -IDR12,224. Based on the cost-utility diagram, the amlodipine-candesartan combination group is included in the southwest quadrant (quadrant III), which illustrates that the cost required for the amlodipine-candesartan combination group is lower than the cost of the amlodipine single treatment group and the outcome is also not better (slightly lower or the same). Conclusion: It was recommended to prioritize using amlodipine alone for hypertension management, as it provides similar outcomes to the amlodipine-candesartan combination while incurring lower costs.
Formulation and Antioxidant Activity Test of Gel from Fermented Red Pomegranate Peel Juice (Punica Granatum L) Faizatun, Faizatun; Miftahurrohmah, Nur; Rosmawati, Rosmawati
JSFK (Jurnal Sains Farmasi & Klinis) Vol 11 No 2 (2024): J Sains Farm Klin 11(2), August 2024
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.11.2.136-144.2024

Abstract

Red pomegranate (Punica granatum L.) peel has secondary metabolites such as phenolics, flavonoids, and tannins which are known to have antioxidant potential. The purpose of this study was to see the comparison of antioxidant activity of juice before and after fermentation and then formulated into a gel preparation that is physically and chemically stable. Red pomegranate peel juice was dried by freeze drying method and then fermented with Lactobacillus plantarum ATCC 8014 bacteria and measured OD600, pH, and antioxidant activity using DPPH reagent. The results showed that pomegranate peel juice before fermentation had strong antioxidant activity with a value (of IC50 35.64 ± 0.68 ppm) and after fermentation, it was in the very strong category (IC50 8.00 ± 0.01 to 8.11 ± 0.06 ppm); pH before and after (3.96 ± 0.02 and 3.33 ± 0.01). Formula II with juice concentration of 300 x IC50 has the highest antioxidant activity with IC50 values ​​(64.37 ± 1.13 ppm); pH (6.33); spreadability (6.20 ± 0.07); and viscosity (31333.3 ± 577.35 dPas). There was an increase in antioxidant activity of red pomegranate peel juice after fermentation, the resulting gel is physically and chemically stable based on the results of accelerated stability tests for 4 weeks .
Antibiotic Use for Genitourinary Infections in an Indonesian Hospital During COVID-19: A Retrospective Study Abely, Nastasya Anis; Fauziah, Fauziah; Kurniasih, Khamdiyah Indah; Nurkholis, Fiqih; Kusuma, Ikhwan Yuda
JSFK (Jurnal Sains Farmasi & Klinis) Vol 11 No 3 (2024): J Sains Farm Klin 11(3), December 2024
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.11.3.153-160.2024

Abstract

The management of genitourinary infections presents a growing challenge due to antimicrobial resistance, shifting regional patterns, and evolving etiologies. This study aimed to elucidate antibiotic utilization trends and patterns for genitourinary system diseases at an Indonesian teaching hospital during the COVID-19 pandemic. This retrospective, cross-sectional study analyzed antibiotic use in an Indonesian teaching hospital's inpatient department in 2021. Data on systemic antibiotics (ATC: J01) for genitourinary diseases (ICD-10: N00-N99) were extracted from electronic records. Prescription patterns were evaluated by patient characteristics, disease profiles, administration routes, and WHO AWaRe classification. Among the 47,696 hospitalized patients who received antibiotics, 1,752 were treated with J01 antibiotics for genitourinary disorders, mostly in elderly men with prostatic hyperplasia and obstructive uropathy. Cephalosporins, especially ceftriaxone (724 prescriptions) and cefazolin (294 prescriptions), were the most commonly prescribed, while amoxicillin/beta-lactamase inhibitors were the least prescribed. Parenteral administration was more common than oral, and "Watch" category antibiotics were prescribed twice as often as "Access" antibiotics in adults and the elderly. Genitourinary disorders like prostatic hyperplasia and obstructive uropathy significantly impact elderly men. This study reveals a trend of high broad-spectrum antibiotic use, such as ceftriaxone and cefazolin injections, in hospitalized patients with these conditions.
Antibiotic Use Evaluation Based on AWaRe Classification in Hospitalized Patients (Intensive and Non-Intensive Care) at Universitas Indonesia Hospital Syafhan, Nadia Farhanah; Sri Wulandah Fitriani; Dinda Bestari Sutantoputri; Nadhila Hasna Hanifah; Adityo Susilo
JSFK (Jurnal Sains Farmasi & Klinis) Vol 11 No 3 (2024): J Sains Farm Klin 11(3), December 2024
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.11.3.161-168.2024

Abstract

Antibiotic stewardship program has been largely implemented to reduce antibiotic resistance rates. The present study aimed to evaluate antibiotic use based on the AWaRe classification using the ATC/DDD method and Drug Utilization 90% (DU 90%). This analytical descriptive study used a cross-sectional study design and retrospective data collection obtained using a total sampling technique and processed using Microsoft Excel. The sample for this study involved data from inpatients aged ≥ 18 years at Universitas Indonesia Hospital who had been prescribed antibiotics from 1 January - 31 December 2022. Data from patients who only received topical antibiotic or antibiotics without a DDD standard value from WHO, or patients who had incomplete medical record data were excluded from the study. The results of this study indicated that the total use of antibiotics was 427.85 DDD/100 patient-days. Based on the AWaRe (Access, Watch, Reserve) classification, the Watch class became the most frequently used antibiotic group, followed by the Access and Reserve classes. The 90% DU segment was mostly composed of third-generation cephalosporin group and fluoroquinolones which were included in the Watch class. From the result of this study, to optimally reduce resistance rates, antibiotic stewardship programs need to run continuously.
Formulation and Characterization of Solid Self Nano Emulsifying Drug Delivery System (S-SNEDDS) Loading Curcuma xanthorrhiza Extract Syukri, Yandi; Seran, Yuvina; Hannie Fitriani; Ramadhani, Arba Pramundita; Taher, Muhammad
JSFK (Jurnal Sains Farmasi & Klinis) Vol 11 No 3 (2024): J Sains Farm Klin 11(3), December 2024
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.11.3.169-178.2024

Abstract

Curcuma xanthorrhiza has an active component xanthorrhizol that is poorly soluble in water, resulting in limited absorption and bioavailability. Liquid Self Nano Emulsifying Drug Delivery System (SNEDDS) dosage formulations can improve its solubility and absorption due to its small particle size. Solid SNEDDS technology significantly overcomes some of problems in liquid SNEDDS preparations to improve the stability of liquid formulations. This study aims to formulate and characterize Curcuma xanthorrhiza S-SNEDDS preparation. SNEDDS was characterized by particle size and thermodynamic tests. Method of making S-SNEDDS uses two ways, absorption of porous compounds and spray drying. S-SNEDDS were characterized by testing infrared spectra, X-ray diffraction, scanning electron microscopy, microbial contamination and particle flow properties. Optimal S-SNEDDS formulation with 2 formulas namely F7 and F11 mannitol carrier. FTIR testing showed no interacting compounds. SEM and X-ray diffraction testing of F7 showed that the preparation was semicrystalline. While F11 described the preparation as much more crystalline due to the high content of mannitol. The microbial contamination test detected no microorganism compounds. In addition, the particle flow properties obtained a result of 02.53 seconds with a height of 24.95 mm. It is concluded that the S-SNEDDS formula F7 of Curcuma xanthorrhiza has semicrystalline preparation criteria.
Formulation and Characterization Self-Nanoemulsifying Drug Delivery Systems (SNEDDS) Chloroform Extract of Gaharu Leaves (Gyrinops verstegii (Gilg.) Domke Dewi, Siska Noviana; Martien, Ronny; Novitasari, Laras; Nuringtyas, Tri Rini
JSFK (Jurnal Sains Farmasi & Klinis) Vol 11 No 3 (2024): J Sains Farm Klin 11(3), December 2024
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.11.3.179-188.2024

Abstract

Gaharu (Gyrinops versteegii (Gilg.) Domke) is a native Indonesian plant with many potential medicinal compounds. The compounds contained in the chloroform extract of gaharu leaves are mostly nonpolar terpenoids and fatty acids, so their solubility in water is low. Self-nanoemulsifying drugs delivery system (SNEDDS) technology can increase the solubility and bioavailability of drugs or active compounds in cells. This study aims to formulate and characterize SNEDDS from chloroform extract of gaharu leaves. The research began with the extraction of gaharu leaves by soxhletation. Formula optimization was carried out with various oils, surfactants, and cosurfactants. SNEDDS preparations were then characterized by testing particle size, polydispersity index, percent transmittance, and determining globule morphology. The optimal SNEDDS formula contained miglyol® 812N oil and Tween 80 (32%:68%) with particle size 63.25 ± 5.93 nm, polydispersity index 0.272 ± 0.016, and percent transmittance 98.33 ± 0.23%, spherical globule morphology. This study concluded that the optimal formula for SNEDDS chloroform extract of gaharu leaves (Gyrinops versteegii (Gilg.) Domke) had good physical characteristics. Keywords: Gyrinops verstegii (Gilg.) Domke; gaharu; SNEDDS gaharu; miglyol
Exploring the Anti-Inflammatory Activity of Purified Ficus septica Extracts: Insights from In Vitro and In Silico Studies Arfan, Arfan; Ruslin, Ruslin; Yamin, Yamin; Annisa, Finantha; Basrin, Wa Ode Fitrawati
JSFK (Jurnal Sains Farmasi & Klinis) Vol 11 No 3 (2024): J Sains Farm Klin 11(3), December 2024
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.11.3.189-196.2024

Abstract

Ficus septica is a plant that has demonstrated significant potential as an anti-inflammatory agent. This study evaluates the anti-inflammatory activity and molecular mechanisms of compounds from Ficus septica, focusing on their interactions with Bovine Serum Albumin (BSA) and Cyclooxygenase-2 (COX-2). The results show that the purified extracts from Kadia and Batalaiworu exhibited better anti-inflammatory activity, with IC50 values of 32.04 µg/mL and 32.06 µg/mL, respectively, compared to the crude extracts, which had IC50 values of 42.07 µg/mL and 42.44 µg/mL. Despite this, Diclofenac Sodium exhibited a significantly lower IC50 value of 7.99 µg/mL. Computational studies revealed that Genistein had the strongest binding affinity to BSA with a binding energy of -7.52 kcal/mol, comparable to Diclofenac Sodium (-7.51 kcal/mol). Furthermore, Ficuseptine B and Septicine demonstrated strong binding to COX-2, with binding energies of -9.51 kcal/mol and -9.45 kcal/mol, respectively, outperforming Diclofenac Sodium (-8.49 kcal/mol). These findings suggest that compounds from Ficus septica, particularly Genistein, Ficuseptine B, and Septicine, may serve as potential anti-inflammatory agents through their ability to bind to BSA and COX-2.
Formulation of Serum Sunflower (Helianthus annuus L.) Seed Oil as Antiacne Preparation Mita, Soraya Ratnawulan Mita; Sri Agung Fitri Kusuma; Devani Olivia Winardi; Patihul Husni; Yoshihito Shiono
JSFK (Jurnal Sains Farmasi & Klinis) Vol 11 No 3 (2024): J Sains Farm Klin 11(3), December 2024
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.11.3.197-207.2024

Abstract

Acne is caused by a microbial imbalance due to the overgrowth of Propionibacterium acnes in the skin microbiome. Sunflower seed oil (Helianthus annuus L.), which contains linoleic acid and terpenoids, has an antibacterial activity against P. acnes. This study aimed to increase the availability of anti-acne compounds from natural resources by formulating an anti-acne serum containing sunflower seed oil. The research methods included antibacterial activity testing of sunflower seed oil, serum formulation, product evaluation, and serum effectiveness testing. The results of the antibacterial activity test of sunflower seed oil against P. acnes ATCC 6919 showed a minimum inhibitory concentration (MIC) of 100 mg/mL and a minimum bactericidal concentration (MBC) of 200 mg/mL. The result of serum evaluation and stability testing during the freeze-thaw cycling test depicted stable formulation for all formulas based on organoleptic parameters, homogeneity, pH, viscosity, and spreadability. The effectiveness test results of the serum preparation showed that formula 3, containing 200 mg/L of sunflower seed oil, was the best formula with an inhibition zone diameter of 12.76 ± 0.03 mm. In conclusion, sunflower seed oil demonstrates the ability to prevent and treat acne-prone skin, making it a suitable alternative anti-acne compound.
Pengaruh Suhu dan Durasi pada Hasil Ekstraksi Ramah Lingkungan dan Aktivitas Antioksidan dari Stevia rebaudiana Komala, Ismiarni; Qibtiyah, Mariyatul; Muthoharoh; Ratnasari, Flori; Marvel
JSFK (Jurnal Sains Farmasi & Klinis) Vol 12 No 1 (2025): J Sains Farm Klin 12(1), April 2025
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.12.1.1-6.2025

Abstract

Stevia rebaudiana leaves are well-known for their intense natural sweetness, derived from steviol glycosides, which are 100-300 times sweeter than sugar. Besides being a natural sweetener, these leaves also hold the potential for various health benefits. This study compares two eco-friendly extraction methods: maceration using a water bath shaker (Dynamic maceration) and ultrasonic-assisted extraction in a water bath utilizing distilled water as the solvent. The objective was to assess their effects on extraction yield and antioxidant activity. Dynamic maceration was conducted at 25°C for 3 hours and 6 hours, yielding 14.2% and 15.5%, respectively, and at 75°C for 3 hours and 6 hours, yielding 18.6% and 16.7%, respectively. Ultrasonic-assisted extraction was carried out at 25°C for 30 minutes and 60 minutes, yielding 12.1% and 15.2%, respectively, and at 75°C for 30 minutes and 60 minutes, yielding 15.0% and 14.6%, respectively. The antioxidant activity of the extracts, assessed using the DPPH method at a concentration of 100 µg/mL, showed a linear trend corresponding to each extraction condition. For dynamic maceration, inhibition percentages were 33.4% (25°C, 3 h), 30.1% (25°C, 6 h), 25.9% (75°C, 3 h), and 16.7% (75°C, 6 h); for ultrasonic-assisted extraction, values were 39.9% (25°C, 30 min), 33.8% (25°C, 60 min), 31.8% (75°C, 30 min), and 27.1% (75°C, 60 min). The highest yield (18.6%) was obtained from dynamic maceration at 75°C for 3 hours, whereas the highest antioxidant activity (39.9%) was observed in ultrasonic-assisted extraction at 25°C for 30 minutes

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