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MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan
Published by Universitas Muhammadiyah Semarang
ISSN : 24070505     EISSN : -     DOI : https://doi.org/10.26714/magnamed
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Magna Medica is a medical journal of APKKM contains papers and scientific articles created as a form of realization Tridharma college. The journal is published every six months, April and October of three articles in the form of: - Research article - Case report - Literature review The scope of this journal is all the field of medicine such as: -Internal medicine (including Pulmonary medicine and cardiovascular medicine) -Surgery (including urology, orthopaedic and traumatologic, plastic surgery, neurosurgery) -Anesthesia and Emergency Medicine -Neurology -Dermatology -Obstetric and Gynecologic -Forensic and Medicolegal -Clinical Pathology -Anatomical Pathology -Psychiatric -Ophthalmology -Otolaryngology -Pediatric -Radiology -Microbiology and parasitology -Basic Science of Medicine (including biochemistry, physiology, anatomy and Histology) -Public health and Health Management
Arjuna Subject : Kedokteran - Review dan Referensi, Kedokteran
Articles 14 Documents
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Search results for , issue "Vol 11, No 2 (2024): August" : 14 Documents clear
Mediastinal T-Cell Lymphoblastic Lymphoma: A Rare Case in a Limited Resources Setting Sutrisno, Sutrisno; Kusumastuti, Etty Hary; Ridholia, Ridholia; Hasan, Hasan
MAGNA MEDIKA Berkala Ilmiah Kedokteran dan Kesehatan Vol 11, No 2 (2024): August
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/magnamed.11.2.2024.251-258

Abstract

Background: Lymphoblastic Lymphoma (LBL) is a rare neoplasm which represents 1-2% of all Non-Hodgkin’s Lymphomas (NHLs).Objectives: To present challenges in diagnostic of a rare case in limited resources settingCase Presentation: A 36-year-old male came to Dr. Soetomo hospital with shortness of breath, facial edema and chest pain. Physical examination revealed a decreased breath sound and dull percussion in the right chest. CT scan showed solid mass 10.4 x 5.9 x 14.6 cm in the anterior - medius of mediastinum. Fine needle aspiration biopsy guided by CT scan showed the spread of lymphoid cells, big in size, anaplastic, rounded and hyperchromatic nuclei. Core biopsy showed diffuse and monotonous pattern of pleomorphic cells, round to oval and hyperchromatic nuclei. Immunostaining were positive for CD3 and Tdt, high Ki67 proliferation index 98%, and negative for CD20.Conclusion: T-LBL is a rare neoplasm, that generally occurs in adolescents and young adults, and is most common in males. It is an aggressive neoplasm, which can involve mediastinal mass and cause superior vena cava syndrome. Immunostaining would be positive for Tdt, and variably express CD1a, CD2, CD3, CD4, CD5, CD7, and CD8. The prognosis was poor due to the aggressiveness and the relapse.
In Vitro Antimicrobial Activity of Eichornia crassipes and Pistia stratiotes Extracts as Natural Disinfection Agents Kaidah, Siti; Budiarti, Lia Yulia; Azhari, Nazla Puteri; Ihsanti, Shofia Hilwa
MAGNA MEDIKA Berkala Ilmiah Kedokteran dan Kesehatan Vol 11, No 2 (2024): August
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/magnamed.11.2.2024.154-168

Abstract

Background:  Eichornia crassipes and Pistia stratoites are aquatic weeds that contain various antimicrobial compounds and have the potential to disinfectants. Objective: This study aims to analyze the antimicrobial activity of extract of Eichornia crassipes and Pistia stratoites as In Vitro disinfection agentsMethods: This in vitro experimental study tested E.crassipes and P.statoites extracts in combined (EC+PS)  forms against several species of bacteria and Candida albicans. The testing of antimicrobial activity using the diffusion method and effectiveness as a disinfectant were tested through the phenol coefficient test. Results: The results of the data analysis of the EC+PS 25%-100% (ratio 1:1) treatment using the ANOVA test and Duncan's posthoc (significance 95%), obtained different inhibition zones for gram-positive, gram-negative bacteria, and C.albicans; EC100%+PS100 extract produced the widest inhibition zone. The inhibitory power of EC+PS extracts ranged from moderate to strong (> 5 mm - > 20 mm). In the phenol coefficient test using a dilution of 1:20-1:250, a good coefficient value (> 1) was obtained from the EC+PS extract treatment and the disinfectant control for all test organisms.  Conclusion: E.crassipes and P.stratoites extracts can produce antimicrobial activity with a good phenol coefficient value, which makes their combination a natural disinfectant.
Description of Toddler Mother's Knowledge of Stunting in Forestry Hamlet, Secanggang Village, Langkat District Nurhayati, Nurhayati; Andin, Munanda; Purba, Dwi Syahputri; Panggabean, Diani Sari
MAGNA MEDICA Berkala Ilmiah Kedokteran dan Kesehatan Vol 11, No 2 (2024): August
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/magnamed.11.2.2024.205-213

Abstract

Background:  Lack of nutritional intake is a significant factor causing stunting in children, affecting their growth and development. The role of maternal knowledge and parenting practices is crucial in preventing stunting.Objective: In This study aims to determine the relationship between maternal knowledge and stunting in toddlers in Forestry Hamlet, Secanggang Village, Langkat Regency.Methods: A descriptive quantitative research design was employed. Data were collected using questionnaires from a sample of 30 mothers of toddlers. The study analyzed the knowledge levels of these mothers regarding stunting.Results: The analysis revealed that 70% of mothers had good knowledge, 26.7% had sufficient knowledge, and 3.3% had poor knowledge about stunting. The findings suggest that higher education levels among mothers are associated with better knowledge about preventing stunting.Conclusion: There is a significant relationship between maternal knowledge and the incidence of stunting in toddlers. Enhancing health education and promoting better understanding of toddler nutrition among mothers can contribute to reducing stunting rates. Health services and authorities should focus on disseminating information through various media to improve maternal knowledge and practices related to child nutrition.
Integrating Important Vaccination Issues into the Banjar Community Religious and Socio-Cultural Values Husairi, Ahmad; Husin, Gt. Muhammad Irhamna; Rumboko, Raihan Febri; Kurniawan, Muhammad Immas
MAGNA MEDIKA Berkala Ilmiah Kedokteran dan Kesehatan Vol 11, No 2 (2024): August
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/magnamed.11.2.2024.130-144

Abstract

Background:  The important issues of vaccination need to be integrated between medical science, the Islamic religion and the religious-social-cultural values of the community. The integration is important to build public trust in the vaccination program.Objective: to integrate the important issues of vaccination into the religious and socio-cultural values of the Banjar community.Methods: The research was designed qualitatively based on a phenomenological paradigm through field observations and in-depth interviews with Banjar community participants who did not vaccinate and participants who were experts in medicine-immunology-Islamic law-social-cultural in the Banjar community. Results: The research showed that some Banjar people still did not understand the principles of vaccination, the concept of istihalah and herd immunity. The Banjar community was a religious society, that liked to work together and care about their fellow citizens.Conclusion: The principles of vaccination, istihalah, and herd immunity can be integrated with the Banjar community who are religious, like working together, and care about their fellow citizens to build public trust in the vaccination program.
Differences in Chest X-Ray Imaging in Pulmonary Tuberculosis across Various Comorbidities Subkhan, Mohammad; Rezacharawa, Meltritania Arief; Putra, Muslim Andala; Laitupa, Afrita Amalia; Permana, Putu Bagus Dharma; Irfana, Laily
MAGNA MEDIKA Berkala Ilmiah Kedokteran dan Kesehatan Vol 11, No 2 (2024): August
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/magnamed.11.2.2024.169-180

Abstract

Background:  Tuberculosis (TB) remains a significant public health concern in Indonesia, with a high prevalence of cases, particularly in patients with comorbidities such as HIV infection, chronic obstructive pulmonary disease (COPD), diabetes mellitus (DM), and chronic kidney disease (CKD). Evidence suggested radiological variations in chest X-ray findings among these complex condition, which may pose significant challenges in accurately diagnosing pulmonary TB in clinical practice.Objective:  This study aimed to provide a comprehensive understanding of the variations in chest X-ray imaging in pulmonary TB patients with specific comorbidities, focusing on DM, CKD, and COPD.Methods: A cross-sectional study was conducted at Siti Khodijah Muhammadiyah Sepanjang Hospital by utilizing standardized medical records and chest X-ray results of 50 pulmonary patients with comorbidities.Results: The most prevalent comorbidity was DM, with radiological findings including fibroinfiltrates, consolidations, and cavities. CKD patients exhibited radiological features such as infiltrates, cavitations, and pleural effusion, while COPD patients presented with infiltrates and consolidations. Conclusion: The study provides valuable insights into the radiological manifestations of pulmonary TB and its comorbidities, offering a basis for improved management and treatment strategies for patients with pulmonary TB and comorbidities. Further research employing longitudinal designs and balanced representation of comorbid conditions is recommended to enhance the understanding of the interplay between TB and associated health conditions.
Exclusive Breastfeeding Support and Barriers for Working Mothers in Sukoharjo, Indonesia Judging from Theory of Planned Behavior and Social Cognitive Theory Ichsan, Burhanuddin; Candrasari, Anika; Maulana, Faiz; Anam, Zahra Hafizha Fitria
MAGNA MEDIKA Berkala Ilmiah Kedokteran dan Kesehatan Vol 11, No 2 (2024): August
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/magnamed.11.2.2024.214-226

Abstract

Background:  The World Health Organization (WHO) recommends exclusive breastfeeding for six months. Many intervention programs to increase the coverage of exclusive breastfeeding have been carried out, but the coverage of exclusive breastfeeding has not increased significantly. A systematic review analyzed several factors that influence exclusive breastfeeding in developing countries. Mother's occupation was found to be the most frequently mentioned obstacle.Objective: These studies show that the working status of the mother is something that greatly influences the success of exclusive breastfeeding.Methods: This research is a qualitative phenomenological study to see the support and barriers to exclusive breastfeeding for mothers who work in Sukoharjo.Results: The theme found in this study is the support and inhibition of exclusive breastfeeding for working mothers as seen from the Theory of Planned Behavior and Social Cognitive Theory. The obstacles are: 1) incorrect knowledge about exclusive breastfeeding, 2) barriers from some health workers/institutions, 3) families do not support exclusive breastfeeding, 4) there is no regulation on exclusive breastfeeding in the workplace, 5) the workplace does not yet have a special place for pumping and storing breast milk, 6) does not have a role model, 7) breast milk is reduced by working, 8) already has the intention to mix with formula milk, 9) low self-efficacy, and 10) barriers from the baby's internal factors. The supports are: 1) support from health workers/institutions, 2) the workplace provides a special room for pumping and/or storing breast milk, 3) there is an opportunity for pumping breast milk in the workplace, 4) peer support, 5) there is a high expectation of health. good, 6) intention to exclusively breastfeed, 7) good self-efficacy, 8) family support, 9) leave from work and light workload, 10) skills in breastfeeding, 11) no obstacles from the leadership, and 12) smooth mother's milk.Conclusion: This shows that SCT and TPB can be used as a theory to see the variables that influence the practice of exclusive breastfeeding. There is one finding that cannot be directly included in the SCT and/or TPB constructs, namely: skills in providing breast milk.
Factors Affecting Mortality of Sepsis Patients in General Hospital Dr. M. Djamil Padang Aribowo, Kornelis; Sari, Wiwi Monica
MAGNA MEDIKA Berkala Ilmiah Kedokteran dan Kesehatan Vol 11, No 2 (2024): August
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/magnamed.11.2.2024.114-121

Abstract

Background: The high sepsis mortality rate is a significant problem that must be managed properly and comprehensively. Studies showed 30% mortality due to sepsis, 50% for severe sepsis, and 80% for sepsis shock. Data in Indonesia showed that 30.29% of sepsis patients were admitted, and 11.56% to 49% died. Vitamin D deficiency is associated with an increased risk of infection in sepsis.Objective:This study aims to determine the factors that play a role in the death of sepsis patients.Methods: This study used a cross-sectional analytic design. Data were tak-en from 42 patients who died from sepsis in the Intensive care unit of Dr. M. Djamil Padang Hospital from July 2022 to Sep-tember 2022. Patients were previously checked for vitamin D levels—data analysis using the Man Whitney test.Results:The average age of sepsis patients is 56 years old, female (59.9%), vitamin D deficiency (82.5%), obesity (64.3%), most comorbid with chronic kidney injury (CKD) (16.7%). Sepsis pa-tients who died of vitamin D deficiency had a mean Hb of 11.5 g/dl; leukocytosis (14.490/mm3), thrombocytopenia (225.000/mm3), hypoalbumin (2.4 g/dl) and high risk to sepsis based on procalcitonin levels (15.47 ng/ml). There was no sta-tistically significant relationship to the laboratory results (pValue>0.05).Conclusion:Vitamin D deficiency, female, obesity, CKD, thrombocytopenia, and hypoalbumin increase the mortality risk of sepsis patients in the intensive care Unit. The importance of recognizing demo-graphic and laboratory risk factors helps clinicians in preventing sepsis mortality.Background: The high sepsis mortality rate is a significant problem that must be managed properly and comprehensively. Studies showed 30% mortality due to sepsis, 50% for severe sepsis, and 80% for sepsis shock. Data in Indonesia showed that 30.29% of sepsis patients were admitted, and 11.56% to 49% died. Vitamin D deficiency is associated with an increased risk of infection in sepsis.Objective:This study aims to determine the factors that play a role in the death of sepsis patients.Methods: This study used a cross-sectional analytic design. Data were tak-en from 42 patients who died from sepsis in the Intensive care unit of Dr. M. Djamil Padang Hospital from July 2022 to Sep-tember 2022. Patients were previously checked for vitamin D levels—data analysis using the Man Whitney test.Results:The average age of sepsis patients is 56 years old, female (59.9%), vitamin D deficiency (82.5%), obesity (64.3%), most comorbid with chronic kidney injury (CKD) (16.7%). Sepsis pa-tients who died of vitamin D deficiency had a mean Hb of 11.5 g/dl; leukocytosis (14.490/mm3), thrombocytopenia (225.000/mm3), hypoalbumin (2.4 g/dl) and high risk to sepsis based on procalcitonin levels (15.47 ng/ml). There was no sta-tistically significant relationship to the laboratory results (pValue>0.05).Conclusion:Vitamin D deficiency, female, obesity, CKD, thrombocytopenia, and hypoalbumin increase the mortality risk of sepsis patients in the intensive care Unit. The importance of recognizing demo-graphic and laboratory risk factors helps clinicians in preventing sepsis mortality. 
The Cytoxic Effects Of Forest Honey (Apis dorsata) On T47D Breast Cancer Cells Adnan, Malik Hisyam; Rakhmawatie, Maya Dian; Tursinawati, Yanuarita
MAGNA MEDIKA Berkala Ilmiah Kedokteran dan Kesehatan Vol 11, No 2 (2024): August
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/magnamed.11.2.2024.181-188

Abstract

Background: In 2018, an estimated 2 million people had breast cancer. Forest honey (Apis dorsata) can have antioxidant activity due to the presence of flavonoid saponin, alkaloid, and tannin compound, therefore can be used as anticancer through the induction of apoptosis.Objective: To determine the IC50 of forest honey (Apis dorsata) on T47D breast cancer cells and see the morphology of T47D cells after administration of forest honey.Methods: This study is an in vitro test of the cytotoxic activity of forest honey against T47D breast cancer cells using the MTT assay method. The concentration of forest honey was prepared by the two-fold microdilution method in the range of 1000 - 31.25 µg/mL. Doxorubicin was used as a control drug with a concentration of 20 - 0.675 µg/mL. The morphology of T47D cells after treatment was observed with an inverted microscope with 400x magnification.Results: Forest honey (Apis dorsata) from any concentration did not show any inhibition of growth of T47D breast cancer cells. Meanwhile, doxorubicin had an IC50 of 3.746 µg/mL. The morphology of T47D cells with honey administration showed many live cells with formazan crystals.Conclusion: Forest honey has no cytotoxic activity against T47D breast cancer cells.
The Effects of Exercise on Working Memory in Adults Yustin, Annisa; Irfana, Laily; Indrawati, Nina Devi; Prasetya, Era Catur; Alwi, Muhammad Najib Mohamad
MAGNA MEDICA Berkala Ilmiah Kedokteran dan Kesehatan Vol 11, No 2 (2024): August
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/magnamed.11.2.2024.227-239

Abstract

Background: Working memory (WM) is a crucial element of cognitive function. A reduction in WM capacity may adversely impact the quality of life and elevate the risk of developing neurodegenerative diseases in the future. Presently, no established medication can effectively prevent cognitive decline. Objective: Over the past decade, numerous research articles have investigated the consequences of exercise on cognitive function, mainly focusing on WM in adults.Methods: Critical reading of several pieces of literature discussing exercise's effect on WM. A search for scientific articles was conducted using online databases such as PubMed and Google Scholar.Results: Exercise improves WM through neuroplasticity. Post-exercise improvement in WM can be seen in every age studied. Exercise can reduce the risk of neurodegenerative diseases by maintaining the integrity of the substantia alba.Conclusion: Exercise emerges as a cost-effective strategy accessible to many individuals. It can potentially prevent declines in cognitive function, positively impacting both present and future quality of life.
The Effect of Neutrophil Lymphocyte Ratio and Bacterial Co-Infection on Mortality and Length of Hospital Stay of COVID-19 Patients Renata, Felicia; Adhiputri, Artrien; Suyatmi, Suyatmi
MAGNA MEDICA Berkala Ilmiah Kedokteran dan Kesehatan Vol 11, No 2 (2024): August
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/magnamed.11.2.2024.122-129

Abstract

Background:  The new coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly contagious disease. The disease has spread rapidly and widely around the world, and was declared as pandemic in March 2020 by WHO. The neutrophil lymphocyte ratio (NLR) is a biomarker that provides important information about the status of systemic inflammation, including in COVID-19. Bacterial co-infection is commonly identified in viral respiratory tract infections such as SARS-CoV-2 and is an important cause of morbidity and mortality.Objective: This study aims to retrospectively analyze clinical data of COVID-19 patients who were treated at Dr. Moewardi General Hospital in Surakarta, to determine the effect of NLR and bacterial co-infection with mortality and length of hospital stay of COVID-19 patients.Methods: This study is an analytical observational study with a cross-sectional design using secondary data from 87 adult COVID-19 patients at Dr. Moewardi Hospital in August 2021. The sampling method used was purposive sampling of all adult patients aged 18 years or above who had been diagnosed with COVID-19 and hospitalized.Results: It was found that there was a strong effect of bacterial co-infection on NLR (r= 0.528). It was also found that NLR and bacterial co-infection simultaneously affected the length of hospital stay (Sig.= 0.02) and mortality (Sig.= 0.027). Partially, the effect of NLR on length of hospital stay was found (Sig.= 0.045).Conclusion: NLR and bacterial co-infection have an effect on mortality and length of hospital stay of COVID-19 patients.

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