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APLIKASI KAYU SECANG (Caesalpinia sappan L.) DALAM UPAYA PREVENSI KERUSAKAN DNA AKIBAT PAPARAN ZAT POTENSIAL KARSINOGENIK MELALUI MNPCE ASSAY Sugiyanto, Raisatun Nisa; Putri, Shofy Rahmadani; Damanik, Ferina Septiani; Sasmita, Gusti Made Aryandana
Program Kreativitas Mahasiswa - Penelitian PKM-P 2013
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (339.832 KB)

Genotoxic effect is related to the mutation of the gene in the DNA. Caesalpinia sappan L. is one of Caesalpiniaceae family found in Indonesia containing brazilin and brazilein. It has been reported to have antioxidant activity and could potentially be used in the prevention of DNA damage. The aim of this study is to know the activity of Caesalpinia sappan L. ethanolic extract (CEE) as antigenotoxic agent. Caesalpinia sappan L. heartwood was macerated with 70% ethanol. The antigenotoxic activity was observed by micronucleus assay in vivo modeled by cyclophosphamide-induced female Swiss mice. CEE treatment was done with the dosage of 250, 500, and 1000 mg/kgBW. Mice peripheral blood was taken in the end of the study and observed for the number of mononuclear polychromatic erythrosite (MNPCE) by Giemsa staining. Molecular docking was done to evaluate the affinity of brazilin, brazilein, and cyclophosphamide to CYP 3A4 enzyme. Based on the study, CEE has antigenotoxic activity showed by the number of MNPCE which is reduced significantly compared to cyclophosphamide control group. The mechanism of antigenotoxic activity is probably because of the inhibition of cyclophosphamide binding to CYP 3A4 enzyme by brazilin and brazilein, as the affinity to CYP 3A4 of brazilin and brazilein were higher than cyclophosphamide.Â Â Â Â Â Â Â Â Â Â Â Keyword: Antigenotoxic, MNPCE Assay, Caesalpinia sappan L.

USER ACCEPTANCE OF MOBILE-JKN: INSIGHTS FROM THE TECHNOLOGY ACCEPTANCE MODEL Damanik, Ferina Septiani; Widayanti, Anna Wahyuni; Wiedyaningsih, Chairun
Indonesian Journal of Health Administration (Jurnal Administrasi Kesehatan Indonesia) Vol. 12 No. 2 (2024): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jaki.v12i2.2024.206-217

Background: Technological advancements in healthcare have driven BPJS Kesehatan Indonesia to develop the Mobile JKN application to enhance accessibility, efficiency, and quality of services. Despite its potential benefits, the implementation of this application faces various challenges, such as application errors, differing levels of digital literacy, and data security issues, necessitating an evaluation of its adoption and acceptance. Aims: To analyse the public acceptance of Mobile JKN based on the Technology Acceptance Model (TAM) variable while also exploring user experiences towards the application. Methods: A descriptive-analytical approach with a cross-sectional design. Data were collected through a questionnaire developed based on the TAM model, involving 406 respondents across Indonesia. Data analysis was performed using a regression linear test with SPSS after all basic assumptions were met. Results: Perceived Ease of Use, Perceived Usefulness, and Attitude Toward Use individually and simultaneously impact Actual System Use (Sig. 0.000; R-Square 0.827). Respondents generally answered “Agree” to all TAM indicators, with mean scores of 4.20 for Perceived Usefulness, 4.16 for Perceived Ease of Use, 4.25 for Attitude Toward Use, and 4.33 for Actual System Use. Most users accessed the app through self-access (48%), frequently used features were membership information (28%), and encountered issues such as application errors (25%). Conclusion: The app was deemed relevant, accurate, easy to use, and beneficial. To enhance public acceptance, BPJS Kesehatan should focus on developing a user-friendly Mobile JKN app by incorporating key TAM factors, optimizing popular features, improving technical stability, and regularly addressing user feedback to ensure effective health administration and service delivery. Keywords: Adoption, Application, BPJS Kesehatan, Mobile JKN, TAM

Exploring Technology Acceptance Models: A Systematic Review of Health Application Adoption in Asian Countries Damanik, Ferina Septiani; Widayanti, Anna Wahyuni; Wiedyaningsih, Chairun
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 15, No 2
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.96755

Background: Health applications are a crucial technological advancement in healthcare, enhancing service quality and access to essential information. Despite this, challenges in implementation and user adaptation remain. Evaluating these applications is vital, and the Technology Acceptance Model (TAM) provides a dependable framework for assessing user acceptance and meeting its intended goals.Objectives: This review aims to explore the use of the TAM method for evaluating health applications adoption in Asia, focusing on ease of use, usefulness, user attitudes, and factors affecting technology acceptance.Methods: The method used is Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Articles were gathered using PubMed and ScienceDirect employing Boolean search terms. The search focuses on technology acceptance and health applications, combined with the names of Asian countries. Eligible studies must describe the technology acceptance model of a health application in Asia. Quality assessment is performed using JBI and data are systematically extracted and analyzed.Results: A total of 11 original articles meet the inclusion criteria from 2428 articles. TAM plays a pivotal role in understanding the adoption of healthcare technology in Asia. TAM original constructs are widely used, with some integrating additional factors. Continued integration and modification of TAM will enhance its utility in addressing evolving healthcare challenges, ultimately improving healthcare outcomes across diverse user settings. TAM's adaptability and integration with theories like PMT and SUS improve its relevance across various healthcare settings and user contexts.Conclusion: Future research should mitigate biases, employ longitudinal and comparative analyses, and integrate TAM with complementary theories to advance healthcare technology adoption.

An analysis of the unified theory of acceptance and use of technology (UTAUT) to the adoption of electronic medical records in hospital settings Ghozali, Muhammad Thesa; Rassyifa, Aloina Jean; Faradiba, Faradiba; Damanik, Ferina Septiani; Sari, Seftika; Satibi, Satibi; Fortwengel, Gerhard
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1693

Electronic Medical Records (EMRs) are increasingly recognized as vital tools for enhancing the efficiency, accuracy, and quality of healthcare delivery. Despite regulatory mandates in Indonesia, the adoption of EMRs remains uneven, particularly in rural healthcare settings. This study applied the Unified Theory of Acceptance and apply of Technology (UTAUT) to investigate the behavioral intention of healthcare professionals working in private hospitals to use electronic medical records. A quantitative, cross-sectional design was implemented involving 90 participants selected through purposive sampling in an Indonesian hospital. The study's data were gathered between October 2024 and January 2025 using a validated 18-item UTAUT-based questionnaire. Data analysis was conducted with SPSS and SmartPLS software. Results indicated that all four UTAUT construct – Performance Expectancy (β = 0.200, p = 0.016), Effort Expectancy (β = 0.353, p < 0.001), Social Influence (β = 0.291, p < 0.001), and Facilitating Conditions (β = 0.262, p = 0.008 – had statistically significant positive effects on Behavioral Intention. The model demonstrated moderate explanatory power (R² = 0.655) and strong predictive relevance (Q² = 0.512). These results validate the UTAUT model's suitability in this context and provide practical insights for strengthening EMR implementation strategies. Future research should consider longitudinal approaches and multi-site comparisons to enhance generalizability and policy relevance.

Gel Pembersih Wajah Berbasis Ekstrak Daun Sengani: Inovasi Herbal untuk Terapi Anti-Jerawat yang Menargetkan Cutibacterium acnes Candrika Candrika; Ziza Putri Aisyia Fauzi; Cut Intan Annisa Puteri; Ferina Septiani Damanik; Dinda Sari Utami; Putri Tri Hartini
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1454

Senggani is a traditional Asian plant commonly used as an alternative medicine, particularly in Indonesia. The leaves of the senggani plant contain secondary metabolites, including tannins, alkaloids, flavonoids, and saponins. Among these, tannins and flavonoids are believed to have antibacterial properties. This study investigates whether a facial wash gel made from the ethanol extract of senggani leaves possesses stable properties and meets established standards. Additionally, the study aims to evaluate its antibacterial activity against Cutibacterium acnes, the bacteria responsible for acne. A maceration method with 70% ethanol was used to prepare the ethanol extract from senggani leaves. This extract was then formulated into a facial wash gel using carbopol polymer at 5%, 7.5%, and 10%, followed by tests to assess its antibacterial activity. The antibacterial activity was determined using the disc diffusion method at the same concentrations. The results indicated that the diameter of the bacterial inhibition zone was 9.93 mm at 5%, 11.66 mm at 7.5%, and 13.93 mm at 10%. The gel preparation of the ethanol extract from senggani leaves demonstrated stable properties, with physical stability evaluations confirming compliance with the quality standards for facial washes set by Indonesian national regulations. Furthermore, the senggani leaf ethanol extract gel effectively inhibited the growth of Cutibacterium acnes, indicating its potential as an effective face wash.

Pemanfaatan Daun Kelor (Moringa Oleifera) untuk Pencegahan dan Pengobatan Penyakit Hipertensi Sri Wahyuni; Gabena Indrayani Dalimunthe; Ferina Septiani Damanik; Cut Intan Annisa Puteri
Jurnal Bakti Nusantara Vol. 3 No. 3 (2026): Jurnal Bakti Nusantara
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/jutira.v3i3.137

Hipertensi merupakan penyakit tidak menular dengan prevalensi yang terus meningkat secara global dan nasional. Menurut World Health Organization (WHO), satu dari lima orang dewasa menderita hipertensi. Di Indonesia, prevalensi hipertensi juga mengalami peningkatan berdasarkan data Riskesdas. Salah satu upaya pengendalian hipertensi dapat dilakukan melalui terapi non farmakologi, seperti pemanfaatan daun kelor (Moringa oleifera). Namun, pengetahuan masyarakat mengenai manfaat daun kelor masih rendah. Kegiatan pengabdian masyarakat ini bertujuan meningkatkan pengetahuan masyarakat di Desa Pulau Banyak terkait pemanfaatan daun kelor untuk pencegahan dan pengobatan hipertensi. Metode yang digunakan berupa penyuluhan dengan ceramah interaktif serta edukasi pengolahan dan konsumsi daun kelor. Daun kelor mengandung flavonoid, polifenol, kalium, dan antioksidan yang berperan dalam menurunkan tekanan darah melalui mekanisme vasodilatasi dan pengurangan stres oksidatif. Hasil kegiatan menunjukkan peningkatan pengetahuan masyarakat. Edukasi ini menjadi strategi efektif dalam pengendalian hipertensi berbasis sumber daya lokal.

Peran Farmasi Klinis Dalam Edukasi Masyarakat Sebagai Strategi Promotif dan Preventif Penyakit ISPA Kiki Rawitri; Syilvi Rinda Sari; Cut Intan Annisa Puteri; Ziza Putri Aisyia Fauzi; Ferina Septiani Damanik
Jurnal Bakti Nusantara Vol. 3 No. 3 (2026): Jurnal Bakti Nusantara
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/jutira.v3i3.170

Infeksi Saluran Pernapasan Akut (ISPA) masih menjadi masalah kesehatan masyarakat yang signifikan, dengan tingginya angka kejadian yang tidak hanya dipengaruhi oleh rendahnya literasi kesehatan, tetapi juga oleh praktik penggunaan obat yang kurang rasional di masyarakat. Dalam konteks farmasi klinis, peran farmasis menjadi krusial dalam memberikan edukasi terkait deteksi dini, pencegahan, serta penggunaan obat yang tepat untuk menghindari komplikasi dan resistensi, khususnya akibat swamedikasi yang tidak rasional. Temuan awal di Puskesmas Teladan Kota Medan menunjukkan bahwa masyarakat belum mampu mengenali gejala awal ISPA secara tepat dan cenderung melakukan swamedikasi tanpa informasi yang memadai. Kegiatan pengabdian kepada masyarakat ini bertujuan untuk mengoptimalkan edukasi berbasis farmasi klinis sebagai intervensi promotif dan preventif dalam meningkatkan pengetahuan masyarakat terkait deteksi dini, pencegahan, dan penggunaan obat yang rasional pada ISPA. Metode yang digunakan adalah penyuluhan dan edukasi interaktif dengan desain quasi-eksperimental one group pre-test–post-test terhadap 17 responden. Materi edukasi mencakup pengenalan ISPA, tanda dan gejala, faktor risiko, pencegahan berbasis Perilaku Hidup Bersih dan Sehat (PHBS), serta prinsip penggunaan obat yang rasional. Hasil menunjukkan peningkatan signifikan tingkat pengetahuan (p<0,05), dengan peningkatan kategori pengetahuan baik dari 11,76% menjadi 52,94% dan penurunan kategori kurang dari 58,82% menjadi 11,76%. Temuan ini mengindikasikan bahwa edukasi berbasis farmasi klinis efektif dalam menunjang upaya promotif dan preventif sekaligus meningkatkan rasionalitas penggunaan obat dalam pengendalian ISPA di masyarakat.

Formulasi Gel Antiseptik Sediaan Obat Luka Dari Ekstrak Etanol Rimpang Kunyit Rahmadani Rahmadani; Ferina Septiani Damanik; Cut Intan Annisa Puteri; Lilik Septiana
Jurnal Ners Vol. 10 No. 3 (2026): JULI 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i3.59179

Pendahuluan: Luka merupakan kerusakan jaringan yang rentan mengalami infeksi akibat kontaminasi mikroorganisme sehingga diperlukan sediaan antiseptik yang efektif dan aman. Rimpang kunyit memiliki kandungan kurkumin, flavonoid, dan minyak atsiri yang diketahui memiliki aktivitas antibakteri, antiinflamasi, dan mempercepat penyembuhan luka sehingga berpotensi diformulasikan dalam bentuk gel antiseptic. Penelitian ini bertujuan untuk memformulasikan gel antiseptik sediaan obat luka dari ekstrak etanol rimpang kunyit serta mengevaluasi mutu fisik dan aktivitas antiseptiknya. Metode: Penelitian ini merupakan penelitian eksperimental laboratorium menggunakan desain post test only. Populasi penelitian adalah sediaan gel ekstrak etanol rimpang kunyit dengan sampel berupa tiga formula konsentrasi ekstrak yaitu 5%, 10%, dan 15% yang dibuat menggunakan metode maserasi dengan pelarut etanol 96%. Variabel penelitian meliputi mutu fisik gel dan aktivitas antiseptik. Pengumpulan data dilakukan melalui uji organoleptik, homogenitas, pH, daya sebar, daya lekat, dan uji aktivitas antibakteri menggunakan metode difusi cakram terhadap bakteri Staphylococcus aureus. Data dianalisis secara deskriptif dan dibandingkan antarformula.Hasil: Hasil penelitian menunjukkan bahwa seluruh formula memiliki bentuk semi padat, homogen, berwarna kuning kecoklatan, dan berbau khas kunyit. Nilai pH gel berada pada rentang 5,2–6,1 sehingga sesuai dengan pH kulit. Formula dengan konsentrasi ekstrak 15% memberikan daya hambat terbesar terhadap Staphylococcus aureus dibandingkan formula lainnya. Simpulan: Ekstrak etanol rimpang kunyit dapat diformulasikan menjadi gel antiseptik sediaan obat luka dengan mutu fisik yang baik dan memiliki aktivitas antibakteri terhadap bakteri penyebab infeksi luka. Formula 15% menunjukkan efektivitas terbaik sebagai gel antiseptik luka.

Optimalisasi Terapi Antidiabetik Oral pada Diabetes Mellitus Tipe 2: Studi Komparatif Monoterapi dan Kombinasi terhadap Outcome Glikemik Optimalisasi Terapi Antidiabetik Oral pada Diabetes Mellitus Tipe 2: Studi Komparatif Monoterapi dan Kombinasi terhadap Outcome Glikemik Kiki Rawitri; Sri Wahyuni; Syilvi Rinda Sari; Ziza Putri Aisyia Fauzi; Ferina Septiani Damanik; Cut Intan Annisa Puteri; Anggitha Ningtias
JURNAL FARMASI DAN MAKANAN Vol 9 No 2 (2026): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v9i2.7854

Type 2 diabetes mellitus (T2DM) is a chronic disease with a high prevalence in primary healthcare settings; however, real-world evidence regarding the effectiveness of oral antidiabetic therapies remains limited. This study aimed to compare the effectiveness of oral antidiabetic monotherapy and combination therapy in patients with T2DM at the Teladan Community Health Center (Puskesmas) in Medan. A non-experimental observational study with a cross-sectional design was conducted on 78 patients selected via systematic random sampling, utilizing medical records and data from the "referral-back" program covering the period from September to November 2025. Effectiveness was assessed using random blood glucose (RBG) levels and analyzed with the Kruskal–Wallis test. The results indicated that the combination of glimepiride and metformin was the most frequently used regimen (64.10%), followed by metformin monotherapy (26.92%) and glimepiride monotherapy (8.97%). The lowest mean RBG level was observed in the metformin monotherapy group (147.80±47.27 mg/dl), followed by the metformin-glimepiride combination group (168.72 ± 60.56 mg/dl) and the glimepiride monotherapy group (178±61.31 mg/dL); however, no statistically significant difference was found among the treatment groups (p=0.322). The study concludes that there is no significant difference in effectiveness between monotherapy and combination therapy regarding glycemic control, although metformin showed a trend toward better outcomes. These findings underscore the importance of an individualized approach to therapy for T2DM patients in primary healthcare facilities.

Analisis Waktu Tunggu Pelayanan Resep dan Faktor-Faktor yang Mempengaruhi di Rumah Sakit Pemerintah, Surabaya Muhammad Thesa Ghozali; Aloina Jean Rassyifa; Faradiba Faradiba; Ferina Septiani Damanik; Seftika Sari; Satibi Satibi; Gerhard Fortwengel
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 23 No. 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1693

Electronic Medical Records (EMRs) are increasingly recognized as vital tools for enhancing the efficiency, accuracy, and quality of healthcare delivery. Despite regulatory mandates in Indonesia, the adoption of EMRs remains uneven, particularly in rural healthcare settings. This study applied the Unified Theory of Acceptance and apply of Technology (UTAUT) to investigate the behavioral intention of healthcare professionals working in private hospitals to use electronic medical records. A quantitative, cross-sectional design was implemented involving 90 participants selected through purposive sampling in an Indonesian hospital. The study's data were gathered between October 2024 and January 2025 using a validated 18-item UTAUT-based questionnaire. Data analysis was conducted with SPSS and SmartPLS software. Results indicated that all four UTAUT construct – Performance Expectancy (β = 0.200, p = 0.016), Effort Expectancy (β = 0.353, p < 0.001), Social Influence (β = 0.291, p < 0.001), and Facilitating Conditions (β = 0.262, p = 0.008 – had statistically significant positive effects on Behavioral Intention. The model demonstrated moderate explanatory power (R² = 0.655) and strong predictive relevance (Q² = 0.512). These results validate the UTAUT model's suitability in this context and provide practical insights for strengthening EMR implementation strategies. Future research should consider longitudinal approaches and multi-site comparisons to enhance generalizability and policy relevance.

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