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INDONESIA
Jurnal Ilmu Kefarmasian Indonesia
Published by Universitas Pancasila
ISSN : 16931831     EISSN : 26146495     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health
Jurnal Ilmu Kefarmasian Indonesia (JIFI) mainly focuses on a current topic in Pharmaceutical Sciences are also considered for publication by the Journal. Discussions on a topic in Pharmaceutical Sciences, Clinical Sciences, and Social Behaviour Administration. Detailed scopes of articles accepted for submission to JIFI are: 1. Pharmaceutical Biology 2. Pharmaceutical Chemistry. 3. Pharmaceutical Technology. 4. Biomedical and Clinical Pharmacy. 5. Social Pharmacy and Administration.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 721 Documents
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Evaluation of drug services based on prescription indicators and patient care according to who at the hospital general practitioner (GP) outpatient clinic in Depok, Indonesia Syafhan, Nadia Farhanah; Risni, Hindun Wilda; Salsabila, Azzahra Fahira; Purnama Putri, Raden Jacinda Yasmin; Prasetyaningrum, Marchen
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 23 No. 1 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i1.1609

Abstract

The World Health Organization (WHO) has developed prescription and patient care indicators, accompanied by optimal benchmarks, aimed at promoting the rational and optimal medicine use. This study aims to evaluate drug services utilizing WHO prescription and patient care indicators at the hospital General Practitioner (GP) outpatient clinic. The research was conducted retrospectively for prescription indicators, consisting of 1505 prescriptions totaling 4647 medication items administered for 804 individuals between January and December 2022. Prospective data collection to evaluate patient care was conducted from April to May 2023. Evaluation of WHO prescription indicators yielded the following results: the average number of drugs prescribed per patient was 3.09 ± 2.00; the percentage of drug prescribed by generic drug names was 47.47%; the percentage of antibiotic prescriptions was 5.46%; the percentage of injectable drug prescriptions was 6.80%; and the percentage of prescriptions in accordance with the national formulary was 75.91%. The percentages of antibiotic and injectable drug prescriptions met the optimal WHO prescription values. In terms of patient care, the results showed that the average duration of a medical consultation was 12.44±8.1 minutes, the average duration of a drug dispensing was 45.65±28.8 minutes, 96.25% of the drugs were dispensed appropriately, 100% of the drugs were labeled adequately, and 78.78% of the patients were knowledgeable. Age (p=0.111) and gender (p=0.075) showed no significant correlation with patient knowledge. There was a significant relationship between education level (p=0.014) and patient knowledge. Prescription and patient care indicators are aspects of improvement to meet the optimal benchmarks according to WHO standards.
The utilization of red dragon fruit peel extract (Hylocereus polyrhizus) in nanoemulsion as an antioxidant Agustin, Eriska; Zahara, Ega
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 23 No. 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1614

Abstract

The red dragon fruit plant (Hylocereus polyrhizus) contains bioactive substances, one of which functions as an antioxidant from anthocyanin and betacyanin. The Dragon Fruit Peel (DFP) has not been widely used by the community in the health sector, and it is only becomes waste. The preparation of nanoemulsion aims to increase the low antioxidant activity of dragon fruit peels. The preparation of DFP nanoemulsion using 8% Tween 80 as emulsifier, 1% oleic acid, and 2% transcutol, with variations in extract concentrations of 1% and 2%. The globule size is reduced to nanoemulsion using a sonicator bath for 60 minutes. The testing of antioxidant activity using the DPPH method. The results of the organoleptic test showed that the DFP extract nanoemulsion had a transparent yellow color with a globule size and Polidispersity Index (PI) of 165±5.54 nm (PI=0.2±0.03) and 115±3.46 nm (PI=0.3±0.02) at an extract concentration of 1 % and 2%. The globule morphology using TEM shows a spherical shape. The results of the pH test showed a range of 4.5-5.3. In testing the antioxidant activity, the DFP extract nanoemulsion showed an increase in IC50 values at 1% and 2% extract concentrations, namely 85.39±4.69 and 64.46±3.45, compared to the extract without formula (pure extract), namely 167.34±8.98. The DFP nanoemulsion preparations produced globule sizes in the nano range, and antioxidant activity testing showed an increase in the IC50 value of 2 concentrations compared to conventional extracts (p<0.05).
Bibliometric analysis on pharmaceutical care publications in Southeast Asia: prospective research trends Riyadi, Rahmat; Alfian, Sofa Dewi
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 23 No. 1 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i1.1621

Abstract

Studies related to bibliometric analysis have been conducted globally to determine the development of pharmaceutical care. However, the prospective trends of scientific research associated with pharmaceutical care in Southeast Asia remain unclear. This study sets out to analyze and compare the results of pharmaceutical care research in Southeast Asian countries in terms of bibliometric indices. An investigation on the main electronic database Scopus was conducted for research purposes on pharmacy care in Southeast Asia until August 6, 2023. The analysis derived from the investigation included an evaluation of published document by year; lead author; country or territory, institutional affiliation, document type, subject area analysis; citation and co-citation analysis; journals that published the most articles, and the most researched topics. Microsoft Excel and VOSviewer were utilized to conduct a qualitative analysis on this dataset. This study adopted the co-authorship analysis, co-citation analysis and keyword analysis in order to gain an insight onto the research prospects and trends in pharmaceutical care. A total of 1,261 studies correlating to pharmaceutical care in Southeast Asia met the criteria for qualitative analysis. The top three countries with the highest number of publications were Malaysia, Thailand and Indonesia. Malaysia had the highest citation count (n=4670, 27.45%), followed by Thailand (n=3292, 19.35%), and Vietnam (n=3096, 18.20%). From networks of co-authorship analysis of authors, there were no collaborations found among authors in Southeast Asia. Prospective research analyzing keywords related to the theme of pharmaceutical care includes pharmacy practice, medication adherence, and qualitative research. Bibliometric analysis provides a comprehensive view of the field and status of pharmaceutical care research to develop prospective future trends and collaborations in Southeast Asia. A bibliometric analysis suggests that stronger teamwork among Southeast Asian researchers is crucial for future advancements.
Tyrosinase inhibitory activity and physicochemical properties of microalgae extract (Spirulina platensis)-loaded nanostructured lipid carriers gel Faizatun, Faizatun; Abdullah, Abdullah
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 23 No. 1 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i1.1622

Abstract

Microalgae (Spirulina platensis) belongs to the family Cyanobacteria contains phycocyanin which is efficacious as a tyrosinase inhibitor. The purpose of the study was to make gel of Nanostructured Lipid Carriers (NLC) from the Microalgae extract (Spirulina platensis). Extracts were made by maceration with 70% ethanol solvent and evaluation of the enzyme tyrosinase inhibitory activity. The extract was made by NLC with solvent evaporation method and characterized which included particle size, polydispersity index, zeta potential and Transmission Electron Microscope (TEM). NLC extract was made into gel preparations by adding gelling agent, and evaluation included organoleptic homogeneity, viscosity and flow properties, pH, and the enzyme tyrosinase inhibitory activity. The enzyme tyrosinase inhibitory activity of Microalgae extract (Spirulina platensis) with the result IC50 in the amount of 150.22 µg/mL. Five of NLC formulas was made based on the characterization obtained the best formula is NLC formula 2, which includes particle size of 119.6 nm, polydispersity index of 0.356, zeta potential of -37.8 mV, and spherical shape. The evaluation results of the gel were semi-solid, brown, typical smell, homogeneous, viscosity of 19500 cPs, plastic thixotropic flow properties, and pH 5.06. The enzyme tyrosinase inhibitory activity of NLC gel Microalgae extract (Spirulina platensis) with the result IC50 in the amount of 173.38 µg/mL. It can be formulated into a physically and chemically stable gel preparation and has activity as a tyrosinase inhibitor.
Anticancer activity of Stichopus vastus extract against MCF-7 and HeLa cells from Natuna waters Sukmiwati, Mery; Nurjanah, Nurjanah; Diharmi, Andarini; Putri, Indah Prasetya
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 23 No. 1 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i1.1631

Abstract

Sea cucumbers (Stichopus vastus) contain bioactive compounds with potential anticancer properties, making them a promising alternative raw material for pharmaceutical development. This study aimed to isolate and fractionate bioactive compounds from S. vastus and evaluate their anticancer activity against MCF-7 and HeLa cell lines. Isolation was performed using Thin Layer Chromatography (TLC), and cytotoxic activity was assessed in vitro using the MTT assay. Phytochemical screening revealed the presence of steroids, terpenoids, and saponins. IC₅₀ values were calculated through linear regression analysis. The methanol extract exhibited IC₅₀ values of 13.50 µg/mL (HeLa) and 17.25 µg/mL (MCF-7), indicating active anticancer potential. The n-hexane fraction showed IC₅₀ values of 10.09 µg/mL (HeLa) and 15.11 µg/mL (MCF-7), also categorized as active. Notably, the ethyl acetate fraction demonstrated superior activity, with an IC₅₀ of 7.00 µg/mL against HeLa (very active) and 13.32 µg/mL against MCF-7 (active). These findings suggest that the ethyl acetate fraction of S. vastus holds significant promise as an anticancer agent, particularly against HeLa cells.
Evaluation of antipsychotic utilization among outpatient schizoprenia patients at the mental health facility in West Java Sutrisno, Entris; Selifiana, Nita; Sodik, Jajang Japar; Fajarrini, Uvika Nurul
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 23 No. 1 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i1.1632

Abstract

Rational use of drugs aims to give therapy according to patient’s clinical needs. Based on Ni komang's research (2021) there are still inaccuracies in the use of antipsychotic drugs. The purpose of this study was to determine the evaluation of the use of Antipsychotics based on the parameters of right indications, drugs, dosage, and frequency in outpatient schizophrenia patients at the West Java Provincial Mental Hospital. The study used a method with descriptive presentation of data and retrospective data collection. Data obtained period October-December 2022 from 130 patients, this study evaluated the use of Antipsychotics with the parameters of right indications, drugs, dosage, and frequency then the data will be analyzed based on the criteria for drug use from Pharmacotherapy A Pathophysiologic Approach 11th and PIONAS. The results of the study on the use of Antipsychotics in schizophrenic patients at the Java Provincial Mental Hospital based on Pharmacotherapy A Pathophysiologic Approach 11th and PIONAS obtained the right indications as much as (100%), the right drugs (100%), the right dose (98%), and the right frequency (98%).
Effectiveness of Artocarpus heterophyllus lamk. serum in eliminating dark spot in the guinea pig melasma model due to UV-a exposure Mas Tiari, Ida Ayu Dwi Putri; Mardiyanti Putri, Ni Putu Kania; Marliani, Ni Luh Setia; Sari, Ni Made Elma Agustini; Malelak, Julia Eva; Adrianta, Ketut Agus
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 23 No. 1 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i1.1639

Abstract

Indonesia's high UV-A exposure significantly contributes to skin hyperpigmentation conditions such as melasma. This study investigated the effectiveness of Jackfruit (Artocarpus heterophyllus Lamk.) leaf serum in reducing dark spots in a guinea pig model of melasma induced by UV-A radiation. Crude extracts were prepared and purified from Jackfruit (Artocarpus heterophyllus Lamk.) leaves, then formulated into serums at 4% and 5% concentrations. These formulations underwent physical quality evaluations, including organoleptic properties, pH, homogeneity, spread ability, adhesion, and viscosity. Anti-hyperpigmentation effects were assessed using Masson Fontana staining on UV-A-exposed guinea pigs treated for 14 days. The results demonstrated a reduction in melanin content, with mean values of 17.97±1.68 (negative control), 1.17±0.28 (positive control), 3.56±2.77 (4% serum), and 2.56±1.25 (5% serum). Histological analysis showed that fibroblast proliferation and epidermal hyperplasia were significantly reduced with serum treatment. These effects are attributed to the flavonoid content in Jackfruit (Artocarpus heterophyllus Lamk.) leaves, which exhibit antioxidant and anti-melanogenesis properties. In conclusion, Jackfruit (Artocarpus heterophyllus Lamk.) leaf serum, particularly at 5% concentration, is effective in reducing melasma-related hyperpigmentation and may offer a safer alternative to synthetic treatments.
Nanostructured lipid carrier (NLC) in topical preparations: a narrative review of components, manufacturing methods, characteristics and activities Rizikiyan, Yayan; Sugihartini, Nining; Rais, Ichwan Ridwan
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 23 No. 1 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i1.1643

Abstract

Nanostructured Lipid Carries NLCs have gained attention in formulation science and nanotechnology due to their biocompatible material and ability to enhance skin penetration. The goal is to create products that can effectively deliver active compounds to desired skin layers with minimal side effects. This review focuses on the use of functionalized NLCs in dermocosmetics, specifically looking at their composition, manufacturing method, characteristics, and role in delivering active compounds. The review obtained articles from databases such as Scopus, Pubmed, and Google Scholar, covering the years 2014-2024. Data search was conducted in May 2024. The search used keywords such as "NLC OR formulation OR dermal OR activity”. By considering factors such as NLC composition, manufacturing method, and impact on compound delivery, researchers aim to optimize NLCs for use in topical preparations. This research contributes to the development of dermocosmetics that can address various skin problems more effectively. The search results from 32 articles gave an overview of the widely used NLC components: solid lipids: glycerol monostearate, compitrol 888 ATO, and tristearin; liquid lipids: myglyol, transcutol, and oleic acid; surfactants: poysorbat 80 and polysorbate 20. The widely used methods were ultrasonication and high pressure homogenization. Frequently performed characterizations include particle size, polydispersity index (PDI), zeta potential, and Entrapment Efficiency (EE). The pharmacological activity of active components loaded into NLCs increased than without NLCs. The active ingredient formulated in NLC can produce better activity compared to the active substance formulated directly in the conventional preparation. The application of nanostructured lipid carrier (NLC) nanoparticles on the skin is very beneficial. These nano systems have shown promising results and more commercial formulations, so it is expected to be done in further research.
Spray gel film-forming system formulation of Vernonia amygdalina as diabetic wound healer Novitasari, Putri Rachma; Nuari, Yudha Rizky; Firdausi, Azzahro Aulia
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 23 No. 1 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i1.1645

Abstract

Poorly managed diabetes mellitus may elevate the risk of having a diabetic wound that may lead to non-traumatic lower limb amputation. Therefore, wound healing management in diabetic patients is essential to prevent such complications. African leaves (Vernonia amygdalina) has been widely used for wound treatment empirically for years including diabetic wounds. The current study focuses on developing an African leaves-based spray using a film-forming system for diabetic wound healing. The African leaves extract is formulated with polyvinyl alcohol (PVA) to create a viscous liquid and is then made into a spray gel-film form. The spray gel film formulation was further characterized and tested for its wound closure efficacy in animal testing. The characterization include watery form, green colour and a characteristic odour of African leaf extract. The spray gel film preparation of Vernonia amygdalina 1;2;4% extract have pH of 5.92±0.0011; 5.96±0.0011 and 5.42±0.0011. The viscosity value of the spray gel film 1;2 and 4% were 7.98±0,0012; 8.43±0.0019 and 5.70±0.0013 cPs. Dry time of Spray Gel Film of Vernonia amygdalina 1;2;4% extract were 1.47±0.0013; 1.50±0.0010; and 1.56±0.0010 minutes. The wound healing was evaluated using diabetic Wistar rats by measuring daily wound diameter. The result showed at a concentration 1%; 2%; 4% the percentage diameter of wound healing were 81.52±±0.06; 82.28±±0.05; and 100±±0.00 %. They were effective for wound healer in diabetic rats and it had antibacterial activities.
Analysis of pharmaceutical service improvement based IPA (Importance Performance Analysis) at pharmacy Kimia Farma Ijen, Malang Nurmawati, Dian; Priyono, Tridoso Sapto Agus; Siswidiasari, Arifani
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 23 No. 1 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i1.1646

Abstract

Pharmaceutical services are direct and responsible services to patients related to pharmacy to achieve real results and improve patients' quality of life. This study aims to analyze the improvement of pharmaceutical services at the Kimia Farma 36 Ijen Pharmacy using the IPA (Importance Performance Analysis) method. The method used is descriptive research with a quantitative approach through questionnaire instruments. The SERVQUAL (Service Quality) model was used to measure the pharmaceutical service questionnaire. Sampling by the Accidental sampling technique. Questionnaires were distributed to patients or families of patients who redeem prescriptions at the Pharmacy in February 2023. The questionnaire refers to the research of Parasuraman, A., Zeithaml, V. A., & Berry adapted to the research context in the pharmacy. The dimensions are empathy, reliability, responsiveness, assurance, and tangibility, which are divided into importance and performance. The IPA method will analyze performance as the X axis and Importance as the Y. The results show that the service aspects require urgent improvement to improve service quality and patient satisfaction. Aspects that need to be improved include product completeness, the physical appearance of the pharmacy building, cleanliness, comfort, and neatness of the pharmacy, as well as the appearance and service of pharmacy officers. Overall, the results of this analysis provide clear guidance on the priorities for improvements that need to be made at Pharmacy Kimia Farma 36 Ijen.

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