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INDONESIA
Jurnal Ilmu Kefarmasian Indonesia
Published by Universitas Pancasila
ISSN : 16931831     EISSN : 26146495     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health
Jurnal Ilmu Kefarmasian Indonesia (JIFI) mainly focuses on a current topic in Pharmaceutical Sciences are also considered for publication by the Journal. Discussions on a topic in Pharmaceutical Sciences, Clinical Sciences, and Social Behaviour Administration. Detailed scopes of articles accepted for submission to JIFI are: 1. Pharmaceutical Biology 2. Pharmaceutical Chemistry. 3. Pharmaceutical Technology. 4. Biomedical and Clinical Pharmacy. 5. Social Pharmacy and Administration.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 721 Documents
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Analisis Efektivitas Biaya Pengobatan Kombinasi Zidovudin, Lamivudin, Nevirapin dan Kombinasi Tenofovir, Lamivudin, Efavirenz Pada Pasien HIV/AIDS di RSUD Kota Bekasi: COST EFFECTIVENESS ANALYSIS OF ZIDOVUDIN, LAMIVUDIN, NEVIRAPIN (AZT (300)/3TC (150) / NVP (200)) AND TENOFOVIR, LAMIVUDIN, EFAVIRENZ (TDF (300) / 3TC (150) / 3TC (150) / NVP (200)) AND TENOFOVIR, LAMIVUDIN, EFAVIRENZ (TDF (300) / 3TC (150) / 3TC (150) / NVP (200)) / AIDS IN BEKASI HOSPITAL Anggriani, Yusi; Purba, Fredrick Dermawan; Manninda, Reise; Tarsinah, Tarsinah
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 18 No. 2 (2020): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v18i2.905

Abstract

HIV/AIDS has become a global issue in many countries. The implementation of ARV / HAARTprograms is always changing, due to clinical reasons, population factors, and aff ordability. Pharmacoeconomic studies can be one of the considerations in the policy process for procurement and selection of therapy regimens. The aims of this study were to determine the eff ectiveness of treatment based on CD4 increase and cost eff ectiveness analysis of HAART A and HAART B treatment regimens. This study used a cross sectional observation method. Retrospective data collection and non-experimental observation where conducted followes by a quantitative descriptive analysis according to the patient's perspective to obtain costeffectiveness data. Data were statistically analyzed to obtain the cost-eff ectiveness of treatment. The results showed that the cost-eff ectiveness analysis (CEA) of two regimens found that HAART A was more dominant than HAART B with a signifi cant diff erence p<0.05. While ACER regimen HAART A (16,227) was greater than the value ACER therapy B (28,330.7).
Ethanolic extract of Parkia speciosa Hassk leaves innovation of gastroretentive tablet: standardization and optimization Nurfitriyana, Nurfitriyana; Fitriya, Fitriya; Fithri, Najma Annuria; Putri, Dwi Kurnia; Lestari, Siti Marwah; Waluyo, Dyah Ayuwati; Syarif, Hardiyanti
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 23 No. 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1461

Abstract

Parkia speciosa ethanol leaves extract contains flavonoid, tannin, and terpen as ulcus peptic remedy. These compounds exhibit limited activity in the stomach due to the short gastric residence time following oral administration. The formulation of gastroretentive tablets can overcome this limitation. This research aims to control the prolonged release of drugs in the stomach to increase bioavailability and characterize the ethanol leaves extract. Extraction was carried out by maceration using ethanol, followed by standardization based on specific and non-specific parameters extract. Gastroretentive tablet was formulated with combination of HPMC-K4M and chitosan using factorial design 22. Effects of compositional factors and their interactions on gastroretentive tablet was observed on hardness, friability, floating lag/duration time, swelling index, and mucoadhesive time. Results standardization extract showed that extract met the required criteria for both specific parameters (organoleptic properties and phytochemical screening) and non-specific parameters (moisture content, loss on drying, water/ethanol-soluble extract content). Based on with DX®10 analysis, the optimum formulation was achieved with 20.25% of HPMC-K4M and 10.26% of chitosan. The analysis of the optimum formulation characteristics was as follows: friability (0.22%), hardness (29.53 N), mucoadhesive time (22.86 hours), floating lag/duration time (27.54 minutes; 12 hours), and swelling index (312.82%). Result revealed that gastroretentive tablets formulated with ethanol extract of Parkia speciosa leaves improve gastric residence duration and promote better bioavailability.
Cocrystallization of curcumin–isonicotinamide with ultrasonic wave treatment to increase solubility Wicaksono, Yudi; Seva, Any You; Wisudyaningsih, Budipratiwi; Nuri, Nuri; Susanti, Devi Feby
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 23 No. 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1497

Abstract

Curcumin is a polyphenol compound with various biological activities, but its solubility in water is very low (4-8 µg/mL). This research aims to increase the solubility of curcumin through cocrystallization with isonicotinamide coformer. Cocrystallization was carried out using solvent evaporation, which was treated with ultrasonic waves. Cocrystal characterization was carried out using light microscopy, PXRD, DSC, and FTIR. The cocrystal solid was evaluated for solubility using the shaking method, while the dissolution test was carried out in a phosphate buffer medium, pH 6.8, with type II equipment. The results show that cocrystallization with ultrasonic wave treatment produces solid cocrystals (CICoc-Ult) with different solid properties than those without ultrasonic wave treatment (CICoc). CICoc-Ult showed higher solubility and dissolution compared to initial curcumin and CICoc cocrystals. Therefore, ultrasonic wave treatment in the cocrystallization process of curcumin using the solvent evaporation method can be used as a potential strategy to overcome the problem of the solubility properties of curcumin.
Optimizing carrot extract serum (Daucus carota L.) for anti-aging: efficacy in moisturizing and pore size reduction using Box-Behnken design method Iskandar, Benni; Antasya, Vaylia; Nasution, Musyirna Rahmah; Peng, Wei-Ching
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 23 No. 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1566

Abstract

Carrot extract (Daucus carota L.) contains various bioactive compounds, including vitamins A, B, and C, alkaloids, flavonoids, tannins, anthraquinones, saponins, diterpenes, steroids, beta-carotene, phenols, terpenoids, and minerals, all of which possess antioxidant properties. These compounds are known to help slow down the aging process. The aim of this study was to determine the optimal concentrations of gelling and alkalizing agents, assess their interactions, and evaluate the anti-aging effects of the most effective serum formulation. The formulation was optimized using the Box–Behnken design with two key factors: Carbopol 940 concentration (0.5–1%) and triethanolamine (0.5–1%). The effects on pH, adhesion, and spreadability were evaluated. The best formulation was achieved with 0.837% Carbopol 940 and 0.855% triethanolamine,  showing a pH error of 2.45%, adhesion error of 0.76%, and spreadability error of 1.01%, all within acceptable limits (errors < 10%). After four weeks of stability testing, the formulation remained stable, well-mixed, with a pH of 5.16, an adhesion time of 1.60 seconds, and spreadability of 6.73 cm, with no discomfort. The combination of Carbopol 940 and triethanolamine improved the physical properties, enhancing anti-aging effects compared to the base formula. The optimized serum increased skin moisture by 84.62%, reduced pore size by 64.71%, lightened spots by 62.79%, and reduced wrinkles by 67.50%. This indicates the optimized carrot extract serum is stable, safe, and effective as an anti-aging agent, making it a promising natural skincare product.
Characteristic and therapeutic effect of lemongrass leaf encapsulation with a different ratio of chitosan and NaTPP Kurniawan, Florencia Livia; Komariah, Komariah; Octarina, Octarina; Anggreani, Febry; Annisa, Fauziah Rahma; Nurlidar, Farah
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 23 No. 1 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i1.1570

Abstract

The lemongrass plant (Cymbopogon citratus) in Indonesia has great potential as a natural ingredient for medicines because it contains various compounds such as neral, citral, geranial acetate, flavonoids, and tannins. Previous research has demonstrated various pharmacological activities of kitchen lemongrass leaves, including antibacterial, antifungal, and anti-inflammatory properties. Encapsulation technology in the form of chitosan-NaTPP nanoparticles is used to maintain the activity of kitchen lemongrass leaf compounds. This research aims to determine the physical characteristics of the encapsulation of kitchen lemongrass leaf extract with several comparisons of chitosan and NaTPP by testing PSA (particle size analysis test), FTIR (functional group analysis test), viscosity, and stability, including pH and turbidity tests. Encapsulation with a 1:1 ratio of chitosan and NaTPP has a particle size of 524 nm and a PdI value of 0.481, classified as monodisperse (PdI <0.7). The pH value ranges from 6.46 to 7.30, and the viscosity value was 2.134–2.169 cP, which is still within mouthwash standards. The turbidity test showed stable encapsulation results. Therefore, encapsulation with a 1:1 ratio of chitosan and NaTPP is the most optimal choice and has potential for developing the therapeutic effect of mouthwash.
Optimizing plant exosome isolation: a systematic review of PEG-based precipitation, ultracentrifugation, and hybrid methodologies for biomedical applications Dewi, Rika Sari; Sandhiutami, Ni Made Dwi; Louisa, Melva; Pratomo, Irandi Putra
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 23 No. 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1582

Abstract

Plant-derived exosome-like nanoparticles (PDELNs) represent a promising frontier in nanomedicine, offering natural alternatives to synthetic drug delivery systems. These membrane-bound vesicles, typically 30-150 nm in size, contain bioactive compounds and demonstrate potential for cross-kingdom communication with mammalian cells. This objective study is to evaluate PEG-based and ultracentrifugation methods, benchmark hybrid approaches, compare emerging alternatives, and assess their impact on biomedical applications. A systematic analysis of diverse studies employing comparative yield, purity, bioactivity, scalability, and complexity metrics was conducted. A systematic search of 3 databases SciSpace Deep Search; Google Scholar; MEDLINE (2016-2024) following PRISMA guidelines, 52 studies met the inclusion criteria with combined terms : ``plant exosome'' AND (``PEG precipitation'' OR ``polyethylene glycol'' OR ``ultracentrifugation'' OR ``hybrid methods'') AND ``biomedical applications''. Findings indicate that PEG-based precipitation offers higher or comparable yields with greater scalability and cost-effectiveness but lower purity due to protein co-precipitation; ultracentrifugation yields purer exosomes with preserved bioactivity yet is resource-intensive and less scalable; hybrid methods combining PEG precipitation with ultracentrifugation or size-exclusion chromatography balance yield and purity while increasing procedural complexity. Emerging techniques, such as immunoaffinity capture, enhance specificity but face limitations in plant systems. Overall, optimized hybrid protocols improve isolation quality and bioactivity retention, supporting translational potential. These insights underscore the need for standardized, scalable isolation strategies tailored to plant exosomes to advance their clinical and biomedical applications.
Assessment on the antioxidant, photoprotective, and antimicrobial properties of Siraitia grosvenorii Figo, Figo; Candra, Tasya Mariska; Novia, Jessica; Sugata, Marcelia
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 23 No. 1 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i1.1588

Abstract

Exogenous antioxidants from plant-based sources, such as polyphenols, show potential in maintaining a balance of cellular oxidation in biological systems. Additionally, the rise of antimicrobial resistance and the harmful effects of UV radiation on skin necessitate the exploration of medicinal plants for drug development and photoprotective agents. This study specifically focused on Siraitia grosvenorii or Luo Han Guo, and aimed to assess its phenolic and flavonoid content, as well as its antioxidant, antimicrobial, and photoprotective properties. The study involved the preparation of Siraitia grosvenorii extracts from seeds and fruit peels, determination of total phenolic and flavonoid content using Folin-Ciocalteu reagent and AlCl3, evaluation of antioxidant activity using the DPPH method, and analysis of antimicrobial activity against Escherichia coli using turbidity assays. Photoprotective activity was examined by calculating the Sun Protection Factor (SPF) using a UV spectrophotometer and a normalized function. The results showed that fruit peel of Siraitia grosvenorii had a higher total phenolic content than the seed, and no significant difference in flavonoid content between seed and fruit peel extract. Additionally, Siraitia grosvenorii fruit peel and seed had low SPF value and DPPH reduction. Both fruit peel and seed showed highest antimicrobial activity at the concentration of 100 ppm.
The antiglycation activity test of peel off mask containing gold nanoparticles synthesized from kacip fatima extract (Labisia pumilla) Ong, Putri Stephanie; Abdulah, Sutriyo; Vardhani, Afifah Kusuma
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 23 No. 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1594

Abstract

Skin aging, which is influenced by intrinsic and extrinsic factors, can accelerate skin damage, with one of the main mechanisms being the glycation reaction that results in Advanced Glycation End Products (AGEs). AGEs are the result of indirect reaction between reducing sugars and amino acids, lipids, or proteins. This reaction is also known as the glycation reaction or the Maillard reaction. This research aims to develop a peel-off mask based on gold nanoparticles synthesized with Kacip Fatima extract as an anti-aging agent. Gold nanoparticles have the potential to inhibit the formation of AGEs and improve skin quality. In this study, gold nanoparticles were synthesized by the green synthesis method using Kacip Fatima extract as a reducing agent. The method used for gold characterization is by measuring the wavelength and absorbance, polydispersity index, and zeta potential value of gold nanoparticles. The method used for antiglycation is by using microplate reader, which is stored for 3 days and tested with excitation wavelength of 365 nm and emission wavelength of 415-445 nm. The characterization results showed that the gold nanoparticles had an average size of about 79.61 nm at week 0 and increased to 101.1 nm at week 9. Glycation testing revealed that masks with 20% gold nanoparticles inhibited glycation by up to 95%, higher than the concentration of 10%. This study successfully synthesized gold nanoparticles using Kacip Fatimah extract as a reducing agent, with particles ranging from 79.61 nm to 101.1 nm over 9 weeks. The nanoparticles showed antiglycation effects, with 10% nanoparticles inhibiting glycation by 78%, suggesting potential for environmentally friendly cosmetic applications like peel-off masks.
Statin prescribing pattern and the outcomes for acute coronary syndrome as primary and secondary prevention: a comprehensive review Dewi, Pramitha Esha Nirmala; Chairani, Farahdina; Himawan, Wahyu
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 23 No. 1 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i1.1604

Abstract

Cardiovascular disease is the highest rate of total burden non-communicable disease worldwide in these 5 recent years. Reducing the LDL-c level is closely related to reducing the risk of cardiovascular events recurrences among Acute Coronary Syndrome (ACS) patients. This study aims to explore the statin prescribing pattern among the ACS population and population at risk of ACS and to sum up the reported clinical outcomes, cost-effectiveness, or quality of life-related to statin utilization. The literature searching was conducted by using PubMed and Scopus databases from January 2020 to December 2021. Ten eligible studies were included, examining outcomes such as Major Adverse Cardiovascular Events (MACE), quality of life, and cost-effectiveness. Atorvastatin emerged as the most frequently prescribed statin for both primary and secondary prevention. In high-risk ACS populations, the delayed or underutilization of high-intensity statins led to suboptimal cardiovascular outcomes. Conversely, early administration, particularly within 48 hours post-event or post-PCI, significantly reduced MACE. Importantly, low to moderate intensity statin regimens showed cost-effectiveness primarily among low-risk ACS groups only when treatment was fully subsidized. In settings without government coverage, statin inaccessibility may affect the increased of recurrent events and elevated healthcare costs. The strategic use of statins—especially timely initiation and risk-based intensity selection—offers measurable benefits in reducing cardiovascular events. However, the lack of universal healthcare coverage for statin therapy in low- to middle-income settings presents a substantial barrier to cost-effective care, particularly for high-risk individuals. These findings underscore the need for policy interventions and expanded access to guideline-directed statin therapy.
Formulation of a peel-off gel mask containing mundu fruit extract (Garcinia dulcis (roxb.) kurz) for antioxidant and anti-elastase activity Ambarwati, Neneng Siti Silfi; Desmiaty, Yesi; Chandra, Amelia; Noviani, Yuslia; Triyani, Yulia; Hakim, Ratu Mayra; Amanda, Reistha Fazlia; Wahyudi, Dion
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 23 No. 1 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i1.1607

Abstract

The skin serves as a protective barrier against ultraviolet (UV) radiation. However, exposure to UV radiation can lead to various skin problems, including changes in the dermis. To prevent UV-induced damage, antioxidants and anti-elastase agents are needed to protect the skin from oxidative stress. This study aims to evaluate the antioxidant and anti-elastase activities of Mundu fruit extract (Garcinia dulcis (Roxb.) Kurz) and to formulate a peel-off gel mask using the concentrated extract. Antioxidant activity was assessed using the FRAP and ABTS methods, while anti-elastase activity was determined by measuring the release of p-nitroaniline from a substrate degraded by the elastase enzyme. The results showed that the IC50 value for antioxidant activity using the ABTS method is 29.57 ppm 0.72, and the FRAP value was 185.02 10.23 AAE/g. The anti-elastase activity showed IC50 of 82.21 ppm. Three peel-off gel mask formulations were developed, with Formula 3 (containing extract at 200 x IC50). showing the best performance. These findings suggest that the thick Mundu fruit extract, which tested positive for phenolic compounds, exhibits promising antioxidant and anti-elastase activities and is suitable for use in topical formulations.

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