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Journal Syifa Sciences and Clinical Research (JSSCR)
Published by Universitas Negeri Gorontalo
ISSN : 26568187     EISSN : 26569612     DOI : 10.37311/jsscr
Core Subject : Health, Science,
Chemistry Medicine & Pharmacology
Journal Syifa Sciences & Clinical Research (JSSCR) is a national journal intended as a communication forum for scientists from many practitioners who use Pharmacology Development in research.
Arjuna Subject : -
Articles 196 Documents
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Uji pH dan Nilai SPF ( Sun Protecting Factor) Terhadap Krim Sunblock Ekstrak Daun Kelor (Moringa oleifera L.) Muthmainna B; Ardilla Amra
Journal Syifa Sciences and Clinical Research Vol 4, No 1 (2022): Volume 4 Edisi 1 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i1.13512

Abstract

pH is an important parameter in cosmetic products because it is very high or low pH can caused skin irritation. SPF (Sun Protecting Factor) is a universal indicator that describes the effectiveness of a product or substance that is UV protector. The Moringa plant which has a Latin name called Moringa oleifera or in English it is called a drumstick plant is a plant that is a vegetable that is full of nutrients and has various types of uses. This study aims to determine the pH levels and SPF (Sun Protecting Factor) values contained in the sunblock cream of Moringa leaf extract (Moringa oleifera L.). In this study, pH levels were tested by weighing sunblock cream with a concentration of 1%, 3%, 5% then dissolved into aquadest and then tested for pH levels using a pH meter which resulted in pH levels of 6.89 for a concentration of 1%, 6.73 for a concentration of 3% and 6.60 for 5% concentration. While the determination of the SPF (Sun Protecting Factor) value was carried out by weighing the sunblock cream with a concentration of 1%, 3%, 5% then dissolved in ethanol then precipitated using a centrifuge and the absorption was measured using a spectrophotometer which resulted in a SPF (Sun Protecting Factor) value of 7.012 with the category of extra protection, for 1% concentration that 7.275 with extra protection category for 3% concentration and 9.397 with maximum protection for 5% concentration.
Uji Aktivitas Antibakteri Sediaan Sabun Cair Ekstrak Daun Mengkudu (Morinda citrifolia L.) Terhadap Staphylococcus aureus Fajrin Noviyanto; Siti Nuriyah; Hadi Susilo
Journal Syifa Sciences and Clinical Research Vol 2, No 2 (2020): Volume 2 Edisi 2 2020
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v2i2.7016

Abstract

The bacteria Staphylococcus aureus are round bacteria that are shaped like a cocci, and are Gram-positive. These bacteria can be found on the skin, genitals, nasal cavity, mouth and around the anus. One of the pharmaceutical products that can maintain skin health and protect the skin is soap. The leaves of noni (M. citrifolia L.) contain various compounds such as flavonoids, tannins, saponins, alkaloids, and triterpenoids which are capable of being antibacterial. This study aims to make a liquid soap formulation from M. citrifolia L. leaf extract and its activity as an antibacterial to S aureus. The leaves of M. citrifolia L. were extracted using 96% ethanol solvent by maceration method until a thick extract was obtained. Soap formulations are made with a concentration of 20% 40% and 60%. Evaluation of soap quality includes organoleptic test, high foam test and pH test. The method of antibacterial testing is carried out in vitro by means of well diffusion. The results on the quality test of the liquid soap formulation showed that the pH and height of the foam had good results and had met the SNI 1996 Standards. From the results showed that formulation III with an extract content of 60% had a large antimicrobial activity with a value of 16.83 mm which was categorized as strong. In positive control (Dettol) 60% antimicrobial activity showed a value of 14.83 mm. The results of statistical tests were carried out by One-Way ANOVA analysis followed by LSD analysis Post hoc, liquid soap extract of M. citrifolia L. had greater antimicrobial potential than the positive control (Dettol).
Analisis Tingkat Pengetahuan Mahasiswa Program Studi Farmasi terhadap Swamedikasi Influenza Yulnalia Mariella Delavega; Liza Pratiwi; Shoma Rizkifani
Journal Syifa Sciences and Clinical Research Vol 4, No 2 (2022): Volume 4 Edisi 2 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i2.14024

Abstract

The percentage of the population using self-medication to treat minor illnesses, such as influenza, continues to increase. Self-medication using over-the-counter drugs or without a doctor's prescription is not a completely safe treatment, so knowledge about the influenza and the drugs to be used is required. The purpose of this study was to determine the percentage of knowledge and behavior of self-medication for influenza, to determine the relationship between semester level and level of knowledge and behavior, and to determine the relationship between the level of knowledge and behavior of self-medication for influenza in Pharmacy students, Tanjungpura University. This method with a cross-sectional approach that is descriptive analytic. Respondents involved as many as 232 people including inclusion and exclusion criteria taken by stratified random sampling technique and the data were analyzed using Spearman rank correlation test. The results indicated that the respondents' knowledge level was good (39.7%), sufficient (50.0%), less (10.3%) and the respondent's behavior was right (96.6%) and inappropriate (3.4%). Relationship between semesters and the level of knowledge obtained sig (2-tailed) 0.000 and the value of r is 0.422; semester on the behavior of sig (2-tailed) 0.004 and the r value is 0.190; the level of knowledge on the behavior of the value of sig (2-tailed) is 0.007 and r is 0.178. The conclusion of this study is that the level of knowledge is in the sufficient category and the behavior is appropriate and there is a moderate undirectional relationship between semesters and the level of knowledge, a very low unidirectional relationship between semesters and behavior and there is a very low unidirectional relationship between the level of knowledge and behavior of influenza self-medication.
Pengaruh Pemberian Kombinasi Ekstrak Kulit Pisang dan Kulit Nanas terhadap Indeks Organ Tikus Wistar Melania Niken Safira; Pratiwi Apridamayanti; Hadi Kurniawan; Inarah Fajriaty; Fajar Nugraha; Siti Nani Nurbaeti; Liza Pratiwi
Journal Syifa Sciences and Clinical Research Vol 4, No 1 (2022): Volume 4 Edisi 1 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i1.13910

Abstract

Banana peel and pineapple peel contain potassium which may be developed into health supplements. The development of banana peels and pineapple peels as ingredients for potassium supplements must meet safety aspects that can be proven by subchronic toxicity tests. This subchronic toxicity test aimed to determine the effect of repeated administration of a combination of banana peel and pineapple peel extract for 28 days on the liver, kidney, kidney, lung, heart, and spleen index of Wistar rats. This research used male and female white rats which were divided into six treatment groups, namely the control group, low dose, middle dose, high dose, satellite control, and high dose satellite. The results showed that there was a significant increase in the liver and kidney organ index, and a significant decrease in the adrenal gland organ index after administration of a combination of banana peel and pineapple peel extract. This research concludes that the combination of banana peel and pineapple peel extract has an effect on the liver, kidney, and adrenal gland organ index in Wistar white rats.
EFEK WAKTU HENTI PENDARAHAN (BLEEDING TIME) DAUN BANDOTAN (Ageratum conyzoides L.) PADA MENCIT (Mus musculus) M Sidrotullah Sidrotullah
Journal Syifa Sciences and Clinical Research Vol 3, No 1 (2021): Volume 3 Edisi 1 2021
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v3i1.9909

Abstract

Bandotan (Ageratum conyzoides L) merupakan tanaman yang berfungsi sebagai agen hemostatik eksternal Bleeding time merupakan waktu saat mulai terjadinya perdarahan hingga terbentuk sumbat trombosit dan vasokontriksi pembuluh darah sehingga darah berhenti mengalir. Penelitian ini bertujuan untuk mengetahui efektivitas dan konsentrasi ekstrak etanol daun bandotan (Ageratum conyzoides L.) dalam menghentikan pendarahan pada mencit jantan dengan menggunakan penelitian eksperimental. Metode yang digunakan adalah Metode Duke. Ekstraksi daun bandotan dilakukan dengan cara maserasi menggunakan pelarut etanol 96% kemudian diuji skrining fitokimia. Hasil skrining menyatakan positif mengandung flavonoid dan tannin. Hewan uji yang digunakan sebanyak 25 ekor mencit, dibagi dalam 5 kelompok. Kelompok 1 diberi Aquadest, Kelompok 2 diberi obat Epinefrin 1mg/1ml, Kelompok 3 diberikan ekstrak etanol daun bandotan 10%, Kelompok 4 diberikan ekstrak etanol daun bandotan 20%, dan kelompok 5 diberikan ekstrak etanol daun bandotan 40%. %. Data dianalisis dengan uji statistik ANNOVA (p0,01) Hasil analisis menunjukkan perbedaan yang signifikan waktu henti pendarahan dari setiap kelompok perlakuan dan dilanjutkan dengan uji LSD (Least Significant Different). Konsentrasi ekstrak daun bandotan yang memiliki efektivitas dalam menghentikan pendarahan terbaik adalah konsentrasi 40%.
The Effect of Telmisartan on Collagen Percentages by Picrosirius Staining in the Glomerular Renal Organ of 8% NaCl-Induced Rats Khairil Pahmi; M Sidratullah; M Ricky Ramadhian
Journal Syifa Sciences and Clinical Research Vol 2, No 2 (2020): Volume 2 Edisi 2 2020
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v2i2.6976

Abstract

Excessive salt consumption is one of the hypertension and kidney disease factors, while telmisartan is one of antihypertensive drugs used in the therapy. Telmisartan not only blocks angiotensin receptor which leads to the decrease of blood pressure, but also activates peroxisome proliferator activated receptor gamma (PPAR-γ) and inhibits transforming growth expression factor of beta-1 (TGFβ-1). Whether telmisartan decreases the kidney collagen volume fraction of excessive NaCl-induced Wistar rats are studied in this experiment. Twenty five male Wistars 2.5-3 months of age and 100-150 g BW rats were used in this research. They were grouped into 5, each consists of 5 rats. Group I (G I) as first negative control did not receive NaCl and telmisartan. G II as second negative control received NaCl but not telmisartan. G III, IV and V received NaCl and telmisartan 3, 6 and 12 mg/kg BW. The treatments were given every day within 8 weeks. At the day of 56 all rats were sacrificed by mean of neck dislocation and operated to take the kidney. The collagen was stained by picrosirius red staining. Data were expressed as mean ± standard deviation. They were analyzed by parametric test (analysis of variance-ANOVA and paired samples t-test) or nonparametric test (Kruskal-Wallis). A value of p0.05 was considered statistically significant. The results showed that intraglomerular and extraglomerular collagen volume fraction were lower in telmisartan-treated Wistar rats group than negative control group (0.05p0.05). In conclusion, intraglomerular and extraglomerular collagen volume fraction were lower in 8% sodium chloride-induced and telmisartan-treated male Wistar rats than the items of negative control group.
Studi Penjaminan Mutu (Quality Assurance) Dalam Pelayanan Kefarmasian di Apotek Nurchamidin Gobel; Teti S. Tuloli; Madania Madania
Journal Syifa Sciences and Clinical Research Vol 4, No 1 (2022): Volume 4 Edisi 1 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i2.13956

Abstract

Low Quality Assurance in Pharmacy Award Ipilo Gorontalo include pharmaceutical, security, procurement, storage, and distribution or drug delivery, drug management, on a prescription drug services, drug information services, as well as drug development, medicinal materials and traditional medicine. The impact of the implementation of activities in the pharmacy pharmacy services Anugerah Ipilo errors may occur treatment (medication errors) in the service process. Quality Assurance (QA) is one dimension that is used in the measurement of quality of service, where the application of QA in pharmacies Ipilo Award aims to provide quality assurance of pharmaceutical products and the quality of services provided to patients. This research is descriptive, the source of primary data obtained from the questionnaires with QA standard indicator framework on pharmaceutical services in pharmacies Anugerah Ipilo. The assessment results then classified based on criteria appropriate, relatively appropriate and not appropriate. The results showed that the Quality Assurance (Quality Assurance) on the quality of the equipment and the safety assurance of Pharmaceutical Services in Pharmacy Award Ipilo there are seven questions (70%) had a very good criteria, three questions (30%) had a good criterion. Quality Assurance (Quality Assurance) on the Process of Pharmaceutical Services in Pharmacy Award Ipilo there are 4 questions (40%) had a very good criteria, one question (10%) had a pretty good and 5 questions (50%) had less good. Pharmacies merely focused on the administration and management of medication alone is not the overall pharmacy services, in addition because the pharmacy Anugerah Ipilo prefer the function of the economy (business) rather than its social function, which pharmacies are required to gain / profit in business.
Karakteristik Fisik Serbuk Ekstrak Buncis (Pheseolus vulgaris L) dengan Variasi Lama Penyimpanan Rizki Nugrahani; Yayuk Andayani; Aliefman Hakim
Journal Syifa Sciences and Clinical Research Vol 3, No 1 (2021): Volume 3 Edisi 1 2021
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v3i1.9850

Abstract

Research has been carried out on the analysis of physic properties of green bean extract powder (Phaseolus vulgaris L). This study aims to determine the physical characteristics of the bean extract powder that has been stored in a predetermined time variation. The physic properties tested included water content, solubility and organoleptic tests. The results of the sample water content test with storage variations of less than 1, 1, 2 and 3 months respectively were 5.55%, 2.86%, 3.83% and 3.54% and the solubility was 42.67%, 33, 84%, 44.51% and 34.33% for Artificial Gastrid Fluid (AGF) solvents and 31.79%, 35.08%, 43.24 and 34.52% for Water solvents. The results of the organoleptic test showed that the color of the bean extract powder sample with a storage time of ± 2 months was the most preferred by the panelists, Fresh samples had the highest average scores for taste and aroma, of the panelist samples preferred the samples that had been stored for ± 3 months
IDENTIFIKASI JAMU YANG BEREDAR DI KOTA KENDARI MENGGUNAKAN METODE SPEKTROFOTOMETRI UV-VIS Muhamad Handoyo Sahumena; Ruslin Ruslin; Asriyanti Asriyanti; Endah Nurrohwinta Djuwarno
Journal Syifa Sciences and Clinical Research Vol 2, No 2 (2020): Volume 2 Edisi 2 2020
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v2i2.6977

Abstract

Jamu is a traditional medicine that contains ingredients or ingredients derived from plants, animals, minerals, or mixtures of these ingredients that have been hereditary for medicinal use. However, some industry players add Medicinal Chemicals (BKO) such as mefenamic acid into herbal medicine. This study aims to determine the validity of the method in the analysis of mefenamic acid by UV-Vis spectrophotometry on herbs circulating in several markets in Kendari City. The sampling technique used in this study is purposive sampling method so that it gets 5 herbal samples. The study began with method validation to ensure the accuracy of the method in determining the level of mefenamic acid in the sample. The results of the method validation show that this method is good for detecting the presence of mefenamic acid BKO in herbal medicine with a validation parameter value that is the correlation value (r) of 0.998; detection limit (LOD) 0.48 µg / mL; limit of quantification (LOQ) 1.63 µg / mL; intraday and interday precision expressed with the value of relative standard deviation% respectively 0.014% and 0.013%; and the accuracy stated in% recovery is 95.41% (80%), 99.04% (100%), and 102.5% (120%). The results of the analysis of the sample using a validated method showed that there were herbs with mefenamic acid BKO content of 0.8%.
Pengaruh Isolasi Cangkang Telur Ayam Ras Petelur Terhadap Kadar Abu Rico Arianto; Siti Nani Nurbaeti; Fajar Nugraha; Inarah Fajriaty; Hadi Kurniawan; Adnan Pramudio
Journal Syifa Sciences and Clinical Research Vol 4, No 2 (2022): Volume 4 Edisi 2 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i2.13982

Abstract

Eggshell powder for laying hens contains calcium carbonate CaCO3 (98%) and calcium (28%), efficacious as an antiseptic, antibacterial, and the development of the mineral apatite in the formation of bones and teeth. Eggshell powder is an organic waste that has the potential to be used as a supplement material for calcium sources for humans. However, the content of eggshells consists of inorganic compounds that produce ash. Eggshells as a supplement material must meet quality and safety standards, but this has never been done. Therefore, in this study, an ash content test was carried out with the aim of knowing the inorganic content in the isolation of eggshells of laying hens. Eggshells were isolated by demineralization and deproteination processes. The test results showed that the ash content in the eggshells of laying hens was 95.13%, while in the isolation results the ash content was 96.13%.

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