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Journal Syifa Sciences and Clinical Research (JSSCR)
Published by Universitas Negeri Gorontalo
ISSN : 26568187     EISSN : 26569612     DOI : 10.37311/jsscr
Core Subject : Health, Science,
Chemistry Medicine & Pharmacology
Journal Syifa Sciences & Clinical Research (JSSCR) is a national journal intended as a communication forum for scientists from many practitioners who use Pharmacology Development in research.
Arjuna Subject : -
Articles 196 Documents
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AKTIVITAS DIURESIS Leucaena leucocephala.L PADA MENCIT JANTAN (Mus musculus) Muhammad Ricky Ramadhian; Khairil Pahmi; Muhammad Taupik
Journal Syifa Sciences and Clinical Research Vol 3, No 1 (2021): Volume 3 Edisi 1 2021
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v3i1.9894

Abstract

Diuretics are compounds or drugs that can increase urine volume. This study focused on exploring the activity and concentration of ethanol extract of lamtoro leaves (Leucaenaleucocephala L.) as a diuretic in male house mice (Musmusculus) using experimental research. The method used was to observe the physical activity of urine produced for 120 minutes. Lamtoro leaves extraction was done by maceration using solvent ethanol, then phytochemical screening tests. The screening results stated positively contained alkaloids, flavonoids, terpenoids, and tannins. The animals used were 25 house mice, divided into 5 groups. Group 1 was given Na-CMC 1% w/v suspension, group 2 with furosemide suspension 0.0041% w/v, group 3 with 25% w/v lamtoro leaf ethanol extract, group 4, ethanol extract 50% w/l lamtoro leaf , and group 5 was ethanol extract 75% w/v of lamtoro leaves. Urine volume of the house mice was measured at 15, 30, 45, 60, 75, 90, 105, and 120 minutes.
Hipoglikemia Pada Pasien Diabetes Melitus Mesa Sukmadani Rusdi
Journal Syifa Sciences and Clinical Research Vol 2, No 2 (2020): Volume 2 Edisi 2 2020
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v2i2.4575

Abstract

Diabetes mellitus (DM) is a metabolic disorder characterized by an increase in insulin due to decreased insulin secretion by pancreatic beta cells and/ or insulin resistance. Hypoglycemia is one of the main risks that DM patients often to suffer. in Type 2 DM, hypoglycemia is the most common side effect of the use of insulin and sulfonylureas. It is because of their modes of action . Hypoglycaemia presents a major barrier to satisfactory long term glycemic control and remains a feared complication of diabetes treatment. Acute and chronic complications of hypoglycemia can interfere with life, such as social interactions, sleep, sexual activity, driving, sports, and other activities. Blood glucose monitoring needs to be done to prevent the risk of hypoglycemia. Patients treated with insulin, sulfonylureas/glinides are advised to check blood glucose any time hypoglycemia is going to happen.
Pengaruh Variasi Gula Terhadap Karakteristik Sediaan Minuman Serbuk Instan Kombinasi Rimpang Jahe Dan Temu Putih Desy Siska Anastasia; Sri Luliana; Rise Desnita; Isnindar Isnindar; Nur Atikah
Journal Syifa Sciences and Clinical Research Vol 4, No 2 (2022): Volume 4 Edisi 2 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i2.14003

Abstract

The combination of ginger and white turmeric is the right way to make instant powder drink preparations. The content of gingerol in ginger and curcumin in white turmeric is useful as a natural diuretic (urine laxative). Instant powder drink preparations are made of 2 formulas with different variations of sweeteners, namely formula 1 with 100% granulated sugar and formula 2 with a combination of granulated sugar and brown sugar (3:1). This study was to determine the effect of variations in sugar on physical characteristics and the level of preference of panelists for the preparation of an instant powder drink containing a combination of ginger rhizome and white turmeric. Making instant powder drinks using the crystallization method Physical test data was analyzed by the Independent Sample T-Test. The test results showed that the two formulas met the powder test requirements with the pH value, setting, moisture content, flow time, and angle of repose in formula 1 each being 6.53; 9.3%; 0.26%; 15.63 grams/second; and 31.62, while formula 2 is 6.19; 5.6%; 1.04%; 11.55 grams/second; and 36.44. The hedonic test shows that there is a significant difference in preference values where formula 2, with a combination of sugar and brown sugar (3:1), is more preferred by the panelists.
Pengaruh Pemberian Lozenges Kombinasi Kulit Pisang dan Kulit Nanas terhadap Tikus Putih (Rattus norvegicus L.) galur Wistar Adelita Ahyanurri; Liza Pratiwi; Hadi Kurniawan; Inarah Fajriaty; Siti Nani Nurbaeti; Nugraha Fajar; Pratiwi Apridamayanti
Journal Syifa Sciences and Clinical Research Vol 4, No 1 (2022): Volume 4 Edisi 1 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i1.13811

Abstract

Banana peel and pineapple peel have high potassium content. The banana peel and pineapple peel combination can be used as lozenges in potassium supportive therapy. The safety of banana peel and pineapple peel combination lozenges must be ensured by the acute toxicity test. One of the parameters observed during toxicity testing is the organ index. This study aims to determine the relationship between dose and toxicity in acute oral administration of banana peel and pineapple peel combination lozenges on the heart, lungs, liver, spleen, and kidneys organ index in white rats (Rattus norvegicus L.) Wistar strain. Acute toxicity based on OECD 425 guidelines for the Up-and-Down Procedure (UDP) method. Rats were grouped into 2000 mg/kg BW and 5000 mg/kg BW dose groups, consisting of 5 rats. Organ indexes were analyzed using SPSS Independent Sample T-test with 95% confidence level (p0.05). The result showed no significant difference between both doses (P0.05) in heart, lungs, liver, spleen, and kidneys organ index. Based on the results, it can be concluded that banana peel and pineapple peel combination lozenges did not affect white rats’ heart, lungs, liver, spleen, and kidney organ index.
Formulasi Sediaan Masker Gel Peel-Off dari Ekstrak Buah Tomat (Solanum Lycopersicum L.) Beserta Uji Aktivitas Antioksidan Wa Ode Sitti Zubaydah; Selly Septi Fandinata
Journal Syifa Sciences and Clinical Research Vol 2, No 2 (2020): Volume 2 Edisi 2 2020
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v2i2.6980

Abstract

Tomatoes are well-known as the source of antioxidants due to the content of lycopene, i.e., a potential free radical inhibitor. Gel peel-off masks are among the chemical products containing antioxidants. The first step of the study was extracting tomato fruits by macerating the fruits using alcohol solvents 96%. The obtained thick extract was used as the material of the gel mask; the percentage of the extract comprised 3% (F1), 5% (F2), and 7% (F3), and it used PVA basis 11% and viscolam 3%. According to the result, the gel peel-off masks meet the requirements of physical and storage stability evaluation. The result of the antioxidant test reveals that the IC50 value of the three masks is F1 189.22 µg/mL, F2 89.34 µg/mL, and F3 36.77 µg/mL. Further, the result of T-Test reveals that P-value = 0.019 (α = 0.05), indicating a difference in the result of the antioxidant test of the three formulae in day one (t0) and day 28 (t28).
Analisis Tingkat Pengetahuan Mahasiswa Program Studi Farmasi Terhadap Swamedikasi Obat Bebas dan Bebas Terbatas Felisitas Feli; Liza Pratiwi; Shoma Rizkifani
Journal Syifa Sciences and Clinical Research Vol 4, No 2 (2022): Volume 4 Edisi 2 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i2.14027

Abstract

Over-the-counter and over-the-counter drugs are the two classes of drugs commonly used for self-medication. The high risk caused by irrational use of drugs must be considered by each individual in order to increase knowledge and good behavior in self-medication. This study aims to analyze the level of knowledge and behavior level of the students of the Pharmacy Study Program, Tanjungpura University and analyze the relationship between the semester level and the two variables. This research method uses the Spearman rank correlation test with the SPSS Version 26 application in the bivariate analysis test with a cross-sectional approach. Respondents used as many as 232 people with the method of taking Statified Random Sampling. The results showed that the majority of respondents were female, aged 17-22 years, and mostly used paracetamol purchased at pharmacies without a doctor's prescription to treat fever. Respondents have a level of knowledge that falls into the category of less (40.5%) with appropriate self-medication behavior (97.4%). The variable level of knowledge and level of behavior has a significant relationship (p-value = 0.006). The semester level variable and the level of knowledge have a significant relationship (p-value = 0.000). Semester level and behavioral level variables have a significant relationship (p-value = 0.026). The conclusion is that there is a relationship between the semester level and the level of knowledge and behavior of the students of the Pharmacy Study Program at Tanjungpura University towards the use of over-the-counter and over-the-counter drugs in self-medication.
Pengaruh Ekstrak Kulit Pisang dan Kulit Nanas terhadap Aktivitas Motorik dan Perilaku Tikus Wistar Novia Novia; Fajar Nugraha; Siti Nani Nurbaeti; Inarah Fajriaty; Pratiwi Apridamayanti; Hadi Kurniawan; Liza Pratiwi
Journal Syifa Sciences and Clinical Research Vol 4, No 1 (2022): Volume 4 Edisi 1 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i1.13908

Abstract

Banana peel and pineapple peel are organic wastes that contain potassium, so it can potentially be developed into lozenges form as supportive antihypertensive therapy. Banana peel and pineapple peel as health supplement ingredients must meet safety requirements. The study of subchronic toxicity test was aimed to determine the toxic effect of repeated administration of a combination of banana peel and pineapple peel extract on motor activity and behavior of Wistar rats. The study was conducted by giving the test preparations repeatedly for 28 days in the control group, doses of 100 mg/KgBW, 400 mg/KgBW, 1000 mg/KgBW, control satellite, and satellite at 1000 mg/KgBW dose, as well as additional 14 days of observation in the satellite group to observe the reversibility effect. The test results showed that administering a combination of banana peel and pineapple peel extract showed normal observation on motor activity and behavior of Wistar rats. This study concludes that the combination of banana peel and pineapple peel did not give toxic effect on motor activity and behavior of Wistar rats.
IDENTIFIKASI SENYAWA FLAVANOID DAUN SEMBUNG (Blumea balsamifera L.) Ahmad Ruhardi; Muhamad Handoyo Sahumena
Journal Syifa Sciences and Clinical Research Vol 3, No 1 (2021): Volume 3 Edisi 1 2021
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v3i1.9925

Abstract

The purpose of this study was to determine the levels of flavonoids contained in the sembung leaf methanol extract. To identify the flavonoid content, Spectrophotometry UV-Vis method. Further, the analysis of methanol extract flavonoid in sembung leaves was carried out at a wavelength of 382 nm with successive absorbance values of 0.094; 0.090; 0.084. The total content of flavonoids in the sample was calculated by calibrating the absorbance value of the example with a standard linear equation of quercetin, y = 0.060 x -0.016 with a correlation coefficient (R2) = 0.997, and; the average total flavonoid content in the methanol extract of the leaves was 0.175%.
Formulasi Sediaan Salep Bisul dari Ekstrak Daun Bungur (Lagerstroemia speciosa L. Pers) Musdalifah Musdalifah; Muhammad Iqbal
Journal Syifa Sciences and Clinical Research Vol 4, No 2 (2022): Volume 4 Edisi 2 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i2.14140

Abstract

Staphylococcus aureus is a normal flora of the skin and mucous membranes in humans, it can cause human infection in the form of boils. One example of antimicrobials that can be obtained from nature is the flower plant because it contains active substances, namely saponins, flavonoids, and tannins. To increase the effectiveness and convenience of using bungur leaves, it is necessary to formulate it in a more practical form such as a preparation. This study aims to identify the active fraction of the leaf extract of bungur (Lagerstroemia speciosa L. Pers) in boils ointment against Staphylococcus aureus bacteria. The extraction method was used  the maceration method, which was followed by the preparation of a boil ointment formulation, then tested against the Staphylococcus aureus bacteria. The diameter of the resistance formed was measured and statistically analyzed using the Completely Randomized Design (CRD) method. The results showed that the average resistance diameter of 1% bungur leaf ointment was 11.5 mm, 5% was 12.7 mm, 10% was 15.8 mm, and positive control was 16.5 mm. It was concluded that the effective concentration of bungur leaf extract in the ointment preparation in inhibiting the growth of Staphylococcus aureus was 1%.
Kualitas Hidup Pasien Diabetes Melitus Tipe 2 Berdasarkan Terapi Antidiabetik Aulia Dwi Rahmadani; Nera Umilia Purwanti; Muhammad Akib Yuswar
Journal Syifa Sciences and Clinical Research Vol 4, No 2 (2022): Volume 4 Edisi 2 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i2.14400

Abstract

Diabetes Mellitus (DM) is a metabolic disease characterized by hyperglycemia. Ninety percent of DM cases are type 2 DM. DM patients often receive effective treatment but have not been able to control glucose levels, this causes the quality of life of DM patients to decrease. This study aims to assess the quality of life of type 2 DM patients based on antidiabetic therapy used at the Siantan Hilir Health Center, Pontianak City in December 2021-January 2022. The research method used was observational with a cross-sectional design. Data was collected using purposive sampling technique and 30 patients met the inclusion criteria. The research data was obtained using the Diabetes Quality of Life Clinical Trial Questionnaire (DQLCTQ). The results of the questionnaire will be converted into numbers to get a score which will be processed into the average for each domain and the total value of quality of life. Quality of life is said to be low if the value is 62.2 which is obtained from the average total value of quality of life. More patients received monotherapy (62.69%) than combination therapy (37.31%). The most widely used type of therapy was metformin (52.24%). The quality of life of patients with type 2 DM with monotherapy is higher than the quality of life of patients with combination therapy.

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