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Jurnal Biomedika dan Kesehatan
Published by Universitas Trisakti
ISSN : 2621539x     EISSN : 26215470     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Jurnal Biomedika dan Kesehatan is an official publication of Faculty of Medicine Trisakti University. Jurnal Biomedika dan Kesehatan is a third-monthly medical journal that publishes new research findings on a wide variety of topics of importance to biomedical science and clinical practice. Jurnal Biomedika dan Kesehatan online contains both the current issue and an online archive that can be accessed through browsing, advanced searching, or collections by disease or topic.
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Articles 270 Documents
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Ketergantungan Nikotin dan hubungannya dengan Perceive Stres selama Pandemi Ryansyah, Irgie Catur; Setyaningrum, Dyah Ayu Woro
Jurnal Biomedika dan Kesehatan Vol 6 No 1 (2023)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2023.v6.108-118

Abstract

Background The development of COVID-19, which continues to increase in Indonesia, impacts the Indonesian people and causes stress due to the impact of the COVID-19 pandemic. Prior studies in several countries have shown that stress affects smokers during the COVID-19 pandemic. It affects smokers in two different ways, either they increase smoking or decrease smoking. This study aimed to determine the effect of Nicotine, smoking history, and changes in smoking habits during the COVID-19 pandemic on stress in smokers. Methods We conducted an online survey among active smokers in one of the villages in the South Lampung district, Indonesia November 2020 (n = 150). The survey includes sex, marital status, age of smoking initiation, duration as a smoker, changes in smoking frequency, questionnaire for nicotine dependence (the Fagerstrom Test for Nicotine Dependence questionnaire) and The Perceived Stress Scale (PSS). Data were analyzed with Chi-square<0.05). Results The results showed that the PSS score had a significant association with changes in smoking frequency (p=0.004) and nicotine dependence (p=0.001). Conclusions The study concluded that variations in nicotine dependence and changing smoking habits impacted perceived stress in smokers during the pandemic. There is a significant relationship between age at starting to smoke, number of cigarettes per day, duration of smoking habits, degree of smoking habits, and changes in smoking habits with stress levels in smokers in the COVID-19 pandemic era, and there is no relationship between types of cigarettes consumed, and stress levels in smokers in COVID-19 pandemic era.
Fenomena Gejala Pilek paling Sering pada Pasien COVID-19 Joekly Wahidan Muharaam; Diana Samara
Jurnal Biomedika dan Kesehatan Vol 5 No 3 (2022)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2022.v5.136-143

Abstract

BackgroundCOVID-19 is an infectious disease caused by SARS-CoV-2, a new coronavirus that has never been identified in humans that causes various symptoms. Symptoms of COVID-19 that are quite often found are cough, runny nose, fever. Antigen rapid test is an examination with high sensitivity and specificity, often used in COVID-19 detection. This study aims to determine the relationship between cough, cold, and fever symptoms with positive results of COVID-19 antigen rapid test. MethodsThis study used cross-sectional design using medical records. The variables assessed were cough, cold, fever, and the results of COVID-19 antigen rapid test. Data analysis was performed using chisquare test and logistic regression test with significance level of p<0.05. ResultsSubject are mostly are 31-45 years old and female. Subjects had symptoms of cough (88.2%), fever (80%), and runny nose (60%). The results of the COVID-19 rapid test antigen were found to be more reactive (80%). The distribution of reactive results of the COVID-19 rapid antigen test was 86.7% in cough, 92.2% in colds, and 91.2% in fever. There was a significant relationship between cough (p=0.000), runny nose (p=0.001), and fever (p=0.000) with reactive results of the COVID-19 rapid test antigen. Patients with cold symptoms have an 8.67 times greater risk of reactive COVID-19 antigen rapid tests. ConclusionsThere is a relationship between symptoms of cough, runny nose, and fever with reactive results in patients aged 17 years and over. Complaints of a cold have a higher risk of reactive results on the COVID-19 rapid test antigen examination compared to cough and fever. This means that patients with colds need to be more aware of being infected with COVID-19.
Clostridium difficile Problematik Infeksi Clostridium difficile: Infeksi C. difficile Tjampakasari, Conny Riana; Hanayurianingtyas, Deajeng Laras
Jurnal Biomedika dan Kesehatan Vol 6 No 2 (2023)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2023.v6.235-249

Abstract

Clostridium difficile is a Gram-positive, strictly anaerobic, spore-forming bacterium. The virulence factor of this bacterium is the toxins it produces, namely enterotoxin A (TcdA ) and cytotoxin B (TcdB). Transmission occurs fecally orally by ingesting the spores of this bacteria. Clostridium difficile is the most common cause of fulminant-associated in hospitals and other healthcare facilities and is of significant concern because of the increasing morbidity and mortality rates as well as increased healthcare costs. Elderly patients or patients with compromised immune systems are patients at the highest risk for this case. Clostridiosis present a varied spectrum of infection, ranging from self-limited diarrhea, mild to moderate diarrhea, to serious diarrhea, pseudomembranous colitis, and life-threatening fulminant colitis which can be life-threatening and can cause death. The diagnosis is made by direct detection of Clostridium difficile toxin in the feces. Although empiric therapy known as vancomycin and fidaxomycin have been used as the antibiotic choice, prompt identification of patients with symptoms of Clostridium difficile infection is very important because most patients respond quickly to antimicrobial therapy. may result in death. Prompt identification of patients with symptomatic Clostridium difficile infection is essential as the majority of patients respond quickly to antimicrobial therapy. Prevention is best achieved by implementing infection control measures and appropriate use of antimicrobial agents. Health professional education regarding preventive measures such as hand washing, wearing gloves, decontamination of medical equipment, and the proper environment is highly recommended.
Hubungan Tingkat Stres Dan Dukungan Sosial Pada Ibu Terhadap Pemberian Asi Eksklusif di Samarinda Wisnuwardani, Ratih Wirapuspita; Afiah, Nurul; A’isyah, Siti; Noviasty, Reny; Agustini, Rina Tri
Jurnal Biomedika dan Kesehatan Vol 7 No 1 (2024)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2024.v7.24-33

Abstract

Background The COVID-19 pandemic is causing stress in all aspects of life, including nursing mothers. This situation may affect exclusive breastfeeding coverage, which was only 66% in 2020. Factors contributing to low breastfeeding rates include maternal stress and social support. The aim of this study was to determine the association between maternal stress levels and social support for exclusive breastfeeding during the COVID-19 pandemic in Wonorejo Health Center, East Kalimantan. Methods The study design was cross-sectional with a sample of 165 mothers with children aged 6-24 months. Data collection was conducted online via a questionnaire on a Google Form link provided to subjects through their WhatsApp contacts. Data were analyzed using the chi-square test and the Kolmogorov-Smirnov test. Results 55.8% of mothers had high levels of social support supporting exclusive breastfeeding, and 81.2% of mothers experienced moderate stress. Data analysis using the chi-square test and Kolmogorov-Smirnov test showed no relationship between social support (p=0.056) and stress level (p=0.969) during exclusive breastfeeding. Conclusions There was no significant association between stress levels and social support among mothers of exclusively breastfed children aged 6 to 24 months during the COVID-19 pandemic at the Wonorejo Health Center in Samarinda, East Kalimantan. Wonorejo Health Center is encouraged to continuously improve its breastfeeding promotion programs for mothers and families.
The Perbedaan Jumlah Blast pada Hitung Manual dengan Alat Hematologi Siemens Advia 2120i Mario, Mario; PB, Notopuro
Jurnal Biomedika dan Kesehatan Vol 6 No 2 (2023)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2023.v6.186-195

Abstract

Background The development of sophisticated automated blood-cell analyzers caused the proportion of bloodcount samples requiring a manual different count to diminish steadily. Blood smear remains a crucial diagnostic aid in determining the type of leukemia by the appearance and blast numbers in blood smear. Siemens ADVIA 2120i has a parameter of blast cell percentage. This study was undertaken to determine the difference in blast number between manual count and Siemens ADVIA 2120i automatic hematology analyzer. Methods This was an analytical observational study with a cross-sectional design. Thirty samples (22 peripheral blood and eight bone marrow) detected blast numbers from Siemens ADVIA 2120i were examined. Samples were collected from November 2015 to August 2016. A manual count was performed on each sample using a blood smear and bone marrow evaluation. Results Twenty-three cases of AML and 7 cases of ALL were found. Blast percentage from the manual count was between 0 to 95% (Mean 28.5%); from Advia 2120i was between 0.1 to 99% (Mean 16.2%). There was a significant difference in conformity results from blast number between manual count and Siemens ADVIA 2120i with p<0.05. Discussion The difference in blast numbers between manual count and Siemens ADVIA 2120i could be caused by: (1) in manual count, determining blast cells is based on cytoplasm characteristics, granules, nuclear cells, nuclear chromatin, and nucleoli. (2) in ADVIA 2120i, determining blast cell is based on complexity and resistance from BASO reagent. Conclusion Blast numbers were significantly different between manual count and Siemens ADVIA 2120i.
Hubungan Asupan Vitamin B6 dengan Sindrom Pramenstruasi pada Siswi SMP Carissa Maharani Amry; Purnamawati Tjhin
Jurnal Biomedika dan Kesehatan Vol 5 No 3 (2022)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2022.v5.144-152

Abstract

BackgroundMany women complain of uncomfortable symptoms a few days before menstruation in the form of emotional problems to discomfort in the abdominal area, this condition is called premenstrual syndrome. Lack of nutrients, one of which is vitamin B6, is a risk factor for premenstrual syndrome. This study was conducted to assess the relationship between vitamin B6 intake and premenstrual syndrome in junior high school students. MethodsThe study used an analytical observational method with a cross-sectional design, in 162 students of SMPN 75 Jakarta, which was taken with cluster random sampling and simple random samplingtechniques. Measurement of the incidence of premenstrual syndrome was carried out using sPAF questionnaires and vitamin B6 intake using SQ-FFQ questionnaires. The data from the study were analyzed using the chi-square test. The research was conducted after obtaining the approval of the number ethics 7/KER-FK/II/2022. ResultsThe results showed that female students who experienced premenstrual syndrome were mostly aged 15-16 years (20.8%), had menarche at the age of under 12 years (16.4%), did less exercise (15.6%), had a body mass index (BMI) in the category of excess nutrition (25.0%), and consumed foods that contained enough vitamin B6 (15.0%). The results of the bivariate analysis between free and dependent variables found no meaningful relationship between premenstrual syndrome and age (p = 0.054), menarche age (p = 0.630), exercise (p = 0.726), BMI (p = 0.131), and vitamin B6 intake (p = 1.000). ConclusionsThere was no relationship between vitamin B6 intake, sociodemographic characteristics (age, menarche age), exercise, and body mass index (BMI) and premenstrual syndrome.
Laporan Kasus: Diagnosis dan Tatalaksana Meningoensefalitis Tuberkulosis dan Ensefalitis Toksoplasma pada Pasien dengan HIV Positif Della Septa; Yudhisman Imran; Ronny Yoesyanto Pragono
Jurnal Biomedika dan Kesehatan Vol 5 No 3 (2022)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2022.v5.221-227

Abstract

Background Tuberculous meningoencephalitis (TBME) and toxoplasma encephalitis (TE) are the most frequent cerebral opportunistic infections in positive HIV patients in developed countries. This study aims to determine a presumptive diagnosis of TBME and TE based only on clinical, CD4-count, and radiology features and to attend suitable early treatment for better patient outcomes. Case Description A 40-year-old presented to the emergency unit of dr. Mintohardjo Naval Hospital with decreased consciousness. History of positive HIV status, pulmonary tuberculosis for six months and anti-tubercular-treatment (ATT) drop-out. The GCS was E2M5V2, lung crackles, nuchal rigidity, positive Babinski reflex, and duplex hemiparesis. CD4-count: 4 cells/mm3. Multiple hypodense lesions, “finger-like-oedema”, featured on non-contrast head CT-scan. A lumbar puncture was not performed. Treatment of TBME included an ATT regimen, pyridoxine, cotrimoxazole, anti-oedema, and TE treatment included clindamycin and pyrimethamine. Based on the clinical and radiological diagnosis of TBME (nuchal rigidity, history of ATT drop-out, multiple hypodense lesions on CT-scan) and TE (altered mental status, duplex hemiparesis, CD4-count, “finger-like-oedema” projections on CT-scan), ATT and TE treatment were given for ten days. There were significant clinical improvements by GCS E4M6V3, negative nuchal rigidity after being treated early by ATT and TE treatment. Conclusions Presumptive Diagnosis of TBME and TE in HIV patients can be determined only based on clinical, CD4-count, and radiology examination. However, there are significant clinical improvements in giving ATT along with TE treatment immediately in positive HIV patients.
Pengaruh Cotrimoxazole Terhadap Perkembangan Neural Tube Embrio Ayam Pamuji, Alifia Shafanaura; Fauziah, Cut; Tjang, Yanto Sandy; Thadeus, Maria Selvester
Jurnal Biomedika dan Kesehatan Vol 7 No 2 (2024)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2024.v7.190-198

Abstract

Background In Indonesia, congenital abnormalities are still very high. Neural Tube Defect (NTD) is one of the most common congenital abnormalities. NTD occurs due to the failure of neural plate closing. One of the risk factors for NTD is folic acid deficiency. Drug use during pregnancy is one of the risk factors for congenital abnormalities. Cotrimoxazole is an anti-folate drug that still has pros and cons regarding its potential to cause NTD. Human embryonic brain development can be simulated using chicken embryos. This study aimed to determine the effect of Cotrimoxazole on the development of the chicken embryo's neural tube. Methods This study used a post-test-only control group design. The number of samples is 30 eggs and the sampling method was simple random sampling. The dose of Cotrimoxazole used was 0; 60; and 120 mg/kg per egg then the eggs were incubated for 72 hours. Data analysis was based on sample characteristics and bivariate analysis using the comparative Kruskal-Wallis test with the post-hoc test. Results In this study, 11 out of 30 eggs could be analyzed. The results were obtained by observing the number of brain vesicles. There was a significant difference in the number of brain vesicles (p= 0.046) between the study groups from the Kruskal-Wallis test. Conclusions Cotrimoxazole administration showed an effect on neural tube development of chicken embryos when compared to controls.
Derajat Miopia Berhubungan dengan Ketebalan Kornea Sentral pada Usia 18-40 Tahun Elizabeth Ravinka Rossabel ER; Kartini Kartini
Jurnal Biomedika dan Kesehatan Vol 5 No 3 (2022)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2022.v5.203-213

Abstract

BackgroundThe central corneal thickness (CCT) is important in assessing the cornea’s condition and correlates with refractive errors in which myopic eyes have the thinnest central cornea. Based on the 2018 Riskesdas, 2,133,017 people suffer from severe low vision, of which 42% were connected to refractive errors. One of the treatments for myopia is to perform LASIK surgery, but complications may occur during its process. One of the risk factors for post-LASIK complications is a CCT of less than 500 microns. This study aimed to assess the association between the degree of myopia and CCT at 18-40 years old. MethodsThis study was a cross-sectional design with data taken from 124 medical records from the Gading Laser Eye Center with subjects aged 18-40 years consisting of 88 males and 36 females. Variables collected were initials, age, gender, CCT, and degree of myopia. Data analysis was carried out using the Chi-Square test with a significance level of p<0.05. ResultsThe age category was 18-28 (87.9%), dominated by males (71.0%). Most degrees of myopia were mild (48.4%), and CCT was dominated by thinning corneas (63.7%). Data analysis based on the Chi-Square test regarding the degree of myopia and CCT showed a significant association (p=0.001). ConclusionsThis study showed an association between the degree of myopia and CCT at the age of 18-40 years.
Hepatitis Akut pada Anak Fairuza, Firda
Jurnal Biomedika dan Kesehatan Vol 5 No 2 (2022)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2022.v5.57-60

Abstract

Hepatitis adalah proses terjadinya inflamasi dan atau nekrosis jaringan hati yang dapat disebabkan oleh infeksi, obat-obatan, toksin, gangguan metabolik, maupun kelainan autoimun.(1) Hepatitis pada anak masih merupakan masalah kesehatan utama baik di negara maju dan berkembang . Etiologi utama penyakit hepatitis adalah infeksi virus hepatotropik ( liver merupakan target organ utama ) dan non-hepatotropik (menyerang sistemik dan organ hati) . Saat ini telah ditemukan virus hepatotropik penyebab utama infeksi akut, yaitu A, B, C, D, E, dan G. V irus B adalah virus DNA , sedangkan jenis lainnya adalah virus RNA . Selain virus hepatotropik ( virus herpes simplek (HSV), virus sitomegalo (CMV), virus epsteinbarr (EBV) , virus varicella -zoster , rubella, virus HIV, adeno, entero, arbo, parvo) dapat memberi kan gejala hepatitis .(2,3) Sekitar 10-15% penyebab kasus hepatitis akut tidak diketahui, termasuk hepatitis akut misterius (unknown hepatitis) yang saat ini sedang marak terjadi di sejumlah negara di dunia termasuk Indonesia. WHO menyatakan dari kejadian luar biasa unknown hepatitis ditemukan terlibatnya Adenovirus type 41 sebagai koinfeksi SARS-CoV-2

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